BRPI0812186A2 - Método de rastreio para compostos que reduzem a tensão re - Google Patents

Método de rastreio para compostos que reduzem a tensão re

Info

Publication number
BRPI0812186A2
BRPI0812186A2 BRPI0812186-9A2A BRPI0812186A BRPI0812186A2 BR PI0812186 A2 BRPI0812186 A2 BR PI0812186A2 BR PI0812186 A BRPI0812186 A BR PI0812186A BR PI0812186 A2 BRPI0812186 A2 BR PI0812186A2
Authority
BR
Brazil
Prior art keywords
compounds
voltage
reduce
screening method
screening
Prior art date
Application number
BRPI0812186-9A2A
Other languages
English (en)
Inventor
Christophe Francois Aime Roca
Jose Manuel Bernardo Sousa
Marta Isabel Heitor Cerejo
Alexandra Maria Barros Dos Santos
Catia Santana Reverendo Rodrigues
Ricardo Filipe Antunes Pinheiro
Patricia Ramalhete Mendes Da Silva Calado
Sukalyan Chatterjee
Helena Margarida Moreira De Oliveira Vieira
Original Assignee
Bioalvo Servicos Investigacao E Desenvolvimento Em Biotecnologia S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioalvo Servicos Investigacao E Desenvolvimento Em Biotecnologia S A filed Critical Bioalvo Servicos Investigacao E Desenvolvimento Em Biotecnologia S A
Publication of BRPI0812186A2 publication Critical patent/BRPI0812186A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/34—Vector systems having a special element relevant for transcription being a transcription initiation element
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/70—Vector systems having a special element relevant for transcription from fungi
    • C12N2830/702—Vector systems having a special element relevant for transcription from fungi yeast
    • C12N2830/704—S. cerevisiae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0812186-9A2A 2007-06-07 2008-06-06 Método de rastreio para compostos que reduzem a tensão re BRPI0812186A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0710976.2A GB0710976D0 (en) 2007-06-07 2007-06-07 Am Screening method
PCT/PT2008/000025 WO2008150186A1 (en) 2007-06-07 2008-06-06 A screening method for compounds that reduce er stress

Publications (1)

Publication Number Publication Date
BRPI0812186A2 true BRPI0812186A2 (pt) 2014-10-14

Family

ID=38318927

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0812186-9A2A BRPI0812186A2 (pt) 2007-06-07 2008-06-06 Método de rastreio para compostos que reduzem a tensão re

Country Status (8)

Country Link
US (1) US8236490B2 (pt)
EP (1) EP2162541B1 (pt)
BR (1) BRPI0812186A2 (pt)
CA (1) CA2690113A1 (pt)
ES (1) ES2415729T3 (pt)
GB (1) GB0710976D0 (pt)
PT (1) PT2008150186W (pt)
WO (1) WO2008150186A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011061340A1 (en) * 2009-11-23 2011-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Inhibitors of the pp1/gadd34 complex for the treatment of a condition requiring an immunosuppressive activity
WO2011087766A2 (en) * 2009-12-22 2011-07-21 Cornell University Methods for assessing er stress
CN102071214A (zh) * 2010-06-30 2011-05-25 武汉生之源生物科技有限公司 人胱抑素c真核表达载体的构建及其表达、纯化
US20120028933A1 (en) 2010-07-28 2012-02-02 Baust John M Cell Culture Media Supplement and Method of Molecular Stress Control
KR101791296B1 (ko) * 2014-04-17 2017-10-27 제주대학교 산학협력단 알츠하이머병 관련 돌연변이 유전자를 포함하는 발현 카세트, 벡터, 및 이를 이용하여 형질전환된 세포주
US20180369166A1 (en) * 2017-06-22 2018-12-27 Muhammed Majeed Garcinol compositions for therapeutic management of endoplasmic reticulum stress
WO2019067875A1 (en) * 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. NON-HUMAN ANIMALS COMPRISING A HUMANIZED TTR LOCUS AND METHODS OF USE
CN117821660B (zh) * 2023-12-20 2025-07-22 华南理工大学 一种高活性的未折叠蛋白响应元件及其筛选方法与应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US7439061B2 (en) * 1998-07-21 2008-10-21 The Regents Of The University Of Michigan DNA encoding the novel mammalian protein, Ire1p
WO2002000919A2 (en) 2000-06-23 2002-01-03 Millennium Pharmaceuticals, Inc. Screen for identifying inhibitors of glycosylphosphatidylnositol anchoring
US20030022243A1 (en) 2001-06-20 2003-01-30 Les Kondejewski Protein aggregation assays and uses thereof
WO2003089622A2 (en) 2002-04-22 2003-10-30 University Of Michigan Novel genes, compositions, and methods for modulating the unfolded protein response
EP1380290A1 (en) 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-beta structure pathway and its therapeutic relevance
WO2005034737A2 (en) 2003-10-09 2005-04-21 University Of Massachusetts Methods for diagnosing and treating endoplasmic reticulum (er) stress diseases
US20080249129A1 (en) 2004-04-02 2008-10-09 Whitehead Institute For Biomedical Research Compositions and Methods for Treatment of Protein Misfolding Diseases
AU2005284798B2 (en) * 2004-09-15 2012-02-02 The President And Fellows Of Harvard College Reducing ER stress in the treatment of obesity and diabetes
EP1814578A2 (en) 2004-11-04 2007-08-08 University of Washington Compositions and methods for treatment of protein misfolding and protein aggregation diseases
GB0610792D0 (en) 2006-06-02 2006-07-12 Remynd Nv Methods and tools for the screening of factors affecting protein misfolding

Also Published As

Publication number Publication date
EP2162541A1 (en) 2010-03-17
CA2690113A1 (en) 2008-12-11
PT2008150186W (pt) 2010-09-15
US20100215641A1 (en) 2010-08-26
ES2415729T3 (es) 2013-07-26
US8236490B2 (en) 2012-08-07
GB0710976D0 (en) 2007-07-18
EP2162541B1 (en) 2013-04-10
WO2008150186A1 (en) 2008-12-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]