BRPI0813036A2 - processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina. - Google Patents

processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.

Info

Publication number: BRPI0813036A2
Authority: BR; Brazil
Prior art keywords: purine; nucleoside derivatives; dioxolane nucleoside; dioxolane; polysilylated
Prior art date: 2007-07-30

Application number

BRPI0813036A

Other languages

English (en)

Inventor

J Coats Steven

Original Assignee

Rfs Pharma Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-30

Filing date

2008-04-27

Publication date

2017-10-24

2008-04-27 Application filed by Rfs Pharma Llc filed Critical Rfs Pharma Llc

2017-10-24 Publication of BRPI0813036A2 publication Critical patent/BRPI0813036A2/pt

Links

-1 purine dioxolane nucleoside derivatives Chemical class 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
230000000707 stereoselective effect Effects 0.000 title 1
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 6
238000000034 method Methods 0.000 abstract 4
150000004862 dioxolanes Chemical class 0.000 abstract 2
YNWUIBSEOAWSHW-HIQWKFPQSA-N 5-[(e)-2-bromoethenyl]-1-[(2s,4s)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidine-2,4-dione Chemical class O1[C@@H](CO)OC[C@H]1N1C(=O)NC(=O)C(\C=C\Br)=C1 YNWUIBSEOAWSHW-HIQWKFPQSA-N 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000006206 glycosylation reaction Methods 0.000 abstract 1
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
150000003212 purines Chemical class 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

BRPI0813036A 2007-07-30 2008-04-27 processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina. BRPI0813036A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US96255007P	2007-07-30	2007-07-30
PCT/US2008/071069 WO2009018106A2 (en)	2007-07-30	2008-07-24	Stereoselective process for preparing purine dioxolane nucleoside derivatives

Publications (1)

Publication Number	Publication Date
BRPI0813036A2 true BRPI0813036A2 (pt)	2017-10-24

Family

ID=40305202

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0813036A BRPI0813036A2 (pt)	2007-07-30	2008-04-27	processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.

Country Status (9)

Country	Link
US (1)	US20100210840A1 (pt)
EP (1)	EP2173350B1 (pt)
KR (1)	KR20100052483A (pt)
CN (1)	CN101801382B (pt)
AT (1)	ATE554090T1 (pt)
BR (1)	BRPI0813036A2 (pt)
CA (1)	CA2697345A1 (pt)
MX (1)	MX2010001139A (pt)
WO (1)	WO2009018106A2 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN103288806A (zh) *	2013-07-02	2013-09-11	山东大学	一种曲沙他滨的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5276151A (en) *	1990-02-01	1994-01-04	Emory University	Method of synthesis of 1,3-dioxolane nucleosides
GB9525606D0 (en) *	1995-12-14	1996-02-14	Iaf Biochem Int	Method and compositions for the synthesis of dioxolane nucleosides with - configuration
CA2399062C (en) *	2000-02-11	2010-01-12	Shire Biochem Inc.	Stereoselective synthesis of nucleoside analogues
ATE548366T1 (de) *	2002-01-25	2012-03-15	Shire Biochem Inc	Verfahren zur herstellung von dioxolan nukleosidanalogavorstufen
DE10335061B4 (de) *	2003-07-31	2005-11-17	Wacker-Chemie Gmbh	Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
US20120142627A1 (en) *	2010-12-06	2012-06-07	Emory University	Monophosphate prodrugs of dapd and analogs thereof

2008
- 2008-04-27 BR BRPI0813036A patent/BRPI0813036A2/pt not_active IP Right Cessation
- 2008-07-24 US US12/670,386 patent/US20100210840A1/en not_active Abandoned
- 2008-07-24 EP EP08782336A patent/EP2173350B1/en not_active Not-in-force
- 2008-07-24 CN CN2008801011839A patent/CN101801382B/zh not_active Expired - Fee Related
- 2008-07-24 KR KR1020107003938A patent/KR20100052483A/ko not_active Withdrawn
- 2008-07-24 AT AT08782336T patent/ATE554090T1/de active
- 2008-07-24 CA CA2697345A patent/CA2697345A1/en not_active Abandoned
- 2008-07-24 MX MX2010001139A patent/MX2010001139A/es active IP Right Grant
- 2008-07-24 WO PCT/US2008/071069 patent/WO2009018106A2/en not_active Ceased

Also Published As

Publication number	Publication date
ATE554090T1 (de)	2012-05-15
EP2173350A4 (en)	2011-01-19
WO2009018106A3 (en)	2009-03-12
CA2697345A1 (en)	2009-02-05
CN101801382A (zh)	2010-08-11
WO2009018106A2 (en)	2009-02-05
US20100210840A1 (en)	2010-08-19
EP2173350B1 (en)	2012-04-18
CN101801382B (zh)	2013-01-23
KR20100052483A (ko)	2010-05-19
MX2010001139A (es)	2010-05-27
EP2173350A2 (en)	2010-04-14

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Legal Events

Date	Code	Title
2017-10-31	B15I	Others concerning applications: loss of priority
2018-02-06	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2018-05-22	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]