BRPI0814177A2 - Derivados de 1-oxo-1,2-di-hidroisoquinoleína-5-carboxamidas e de 4-oxo-3,4-di-hidroquinazolina-8-carboxamidas, sua preparação e sua aplicação em terapêutica - Google Patents

Derivados de 1-oxo-1,2-di-hidroisoquinoleína-5-carboxamidas e de 4-oxo-3,4-di-hidroquinazolina-8-carboxamidas, sua preparação e sua aplicação em terapêutica

Info

Publication number: BRPI0814177A2
Authority: BR; Brazil
Prior art keywords: oxo; hydroisoquinolein; hydroquinazoline; carboxamides; preparation
Prior art date: 2007-07-27

Application number

BRPI0814177-0A2A

Other languages

English (en)

Inventor

Michel Evers

Arielle Genevois-Borella

Andreas Karlsson

Jean-Luc Malleron

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-27

Filing date

2008-07-25

Publication date

2015-01-20

2008-07-25 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2015-01-20 Publication of BRPI0814177A2 publication Critical patent/BRPI0814177A2/pt

Links

ODYHMCPYNKFVHM-UHFFFAOYSA-N 4-oxo-1h-quinazoline-8-carboxamide Chemical class N1C=NC(=O)C2=C1C(C(=O)N)=CC=C2 ODYHMCPYNKFVHM-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

BRPI0814177-0A2A 2007-07-27 2008-07-25 Derivados de 1-oxo-1,2-di-hidroisoquinoleína-5-carboxamidas e de 4-oxo-3,4-di-hidroquinazolina-8-carboxamidas, sua preparação e sua aplicação em terapêutica BRPI0814177A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0705500A FR2919286A1 (fr)	2007-07-27	2007-07-27	Derives de derives de 1-oxo-1,2-dihydroisoquinoleine-5- carboxamides et de 4-oxo-3,4-dihydroquinazoline-8- carboxamides,leur preparation et leur application en therapeutique.
PCT/FR2008/001109 WO2009044018A2 (fr)	2007-07-27	2008-07-25	Dérivés de 1-0x0-1,2-dihydroisoquinoleine-5-carboxamides et de 4-oxo-3,4-dihydroquinazoline-8-carboxamides, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number	Publication Date
BRPI0814177A2 true BRPI0814177A2 (pt)	2015-01-20

Family

ID=39106736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0814177-0A2A BRPI0814177A2 (pt)	2007-07-27	2008-07-25	Derivados de 1-oxo-1,2-di-hidroisoquinoleína-5-carboxamidas e de 4-oxo-3,4-di-hidroquinazolina-8-carboxamidas, sua preparação e sua aplicação em terapêutica

Country Status (16)

Country	Link
US (1)	US8030320B2 (pt)
EP (1)	EP2185523A2 (pt)
JP (1)	JP2010534640A (pt)
KR (1)	KR20100047294A (pt)
CN (1)	CN101790518A (pt)
AU (1)	AU2008306762A1 (pt)
BR (1)	BRPI0814177A2 (pt)
CA (1)	CA2694313A1 (pt)
CO (1)	CO6290668A2 (pt)
EA (1)	EA201070196A1 (pt)
FR (1)	FR2919286A1 (pt)
MA (1)	MA31629B1 (pt)
MX (1)	MX2010001081A (pt)
NZ (1)	NZ582995A (pt)
WO (1)	WO2009044018A2 (pt)
ZA (1)	ZA201000583B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5450407B2 (ja) *	2007-07-06	2014-03-26	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	置換アミノ−キナゾリノン、前記化合物を含む薬物、それらの使用及び製造方法
FR2919285B1 (fr) *	2007-07-27	2012-08-31	Sanofi Aventis	Derives de 1-oxo-isoindoline-4-carboxamides et de 1-oxo- 1,2,3,4-tetrahydroisoquinoleine-5-carboxamides, leur preparation et leur application en therapeutique.
RU2696572C2 (ru) *	2012-03-07	2019-08-05	Инститьют Оф Кансер Ресёрч: Ройял Кансер Хоспитал (Зе)	3-арил-5-замещенные соединения изохинолин-1-она и их терапевтическое применение
CN103087047B (zh) *	2012-12-10	2016-12-21	南京农业大学	一种含二氢异喹啉基团的吡咯烷‑2,4‑二酮类化合物、制备方法及其应用
CA2922469A1 (en)	2013-09-11	2015-03-19	Institute Of Cancer Research: Royal Cancer Hospital (The)	3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use
TWI915558B (zh)	2019-06-14	2026-02-21	美商基利科學股份有限公司	Cot 調節劑及其使用方法
CA3175541A1 (en)	2020-03-30	2021-10-07	Gilead Sciences, Inc.	Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound
EP4126862B1 (en) *	2020-04-02	2025-05-21	Gilead Sciences, Inc.	Process for preparing a cot inhibitor compound

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR039555A1 (es) *	2001-11-08	2005-02-23	Upjohn Co	Derivados n,n'-sustituidos de 1,3-diamino-2-hidroxipropano
AU2003211428A1 (en)	2002-02-22	2003-09-09	Teijin Limited	Pyrrolopyrimidine derivative
GB0309221D0 (en)	2003-04-23	2003-06-04	Glaxo Group Ltd	Novel compounds
GB0328900D0 (en)	2003-12-12	2004-01-14	Glaxo Group Ltd	Novel compounds
WO2006099352A1 (en)	2005-03-10	2006-09-21	Bristol-Myers Squibb Company	Novel isophthalates as beta-secretase inhibitors
GB0506562D0 (en)	2005-03-31	2005-05-04	Glaxo Group Ltd	Novel compounds

2007
- 2007-07-27 FR FR0705500A patent/FR2919286A1/fr active Pending
2008
- 2008-07-25 WO PCT/FR2008/001109 patent/WO2009044018A2/fr not_active Ceased
- 2008-07-25 MX MX2010001081A patent/MX2010001081A/es not_active Application Discontinuation
- 2008-07-25 JP JP2010517452A patent/JP2010534640A/ja not_active Withdrawn
- 2008-07-25 BR BRPI0814177-0A2A patent/BRPI0814177A2/pt not_active IP Right Cessation
- 2008-07-25 EA EA201070196A patent/EA201070196A1/ru unknown
- 2008-07-25 CN CN200880104537A patent/CN101790518A/zh active Pending
- 2008-07-25 EP EP08835688A patent/EP2185523A2/fr not_active Withdrawn
- 2008-07-25 AU AU2008306762A patent/AU2008306762A1/en not_active Abandoned
- 2008-07-25 KR KR1020107004332A patent/KR20100047294A/ko not_active Withdrawn
- 2008-07-25 CA CA2694313A patent/CA2694313A1/fr not_active Abandoned
- 2008-07-25 NZ NZ582995A patent/NZ582995A/en not_active IP Right Cessation
2010
- 2010-01-26 ZA ZA2010/00583A patent/ZA201000583B/en unknown
- 2010-01-26 US US12/693,598 patent/US8030320B2/en not_active Expired - Fee Related
- 2010-01-26 CO CO10007694A patent/CO6290668A2/es not_active Application Discontinuation
- 2010-02-24 MA MA32646A patent/MA31629B1/fr unknown

Also Published As

Publication number	Publication date
EP2185523A2 (fr)	2010-05-19
US8030320B2 (en)	2011-10-04
EA201070196A1 (ru)	2010-08-30
JP2010534640A (ja)	2010-11-11
WO2009044018A2 (fr)	2009-04-09
ZA201000583B (en)	2011-04-28
KR20100047294A (ko)	2010-05-07
FR2919286A1 (fr)	2009-01-30
WO2009044018A3 (fr)	2009-06-18
CN101790518A (zh)	2010-07-28
CO6290668A2 (es)	2011-06-20
MA31629B1 (fr)	2010-08-02
MX2010001081A (es)	2010-03-24
WO2009044018A9 (fr)	2010-10-14
US20100197706A1 (en)	2010-08-05
CA2694313A1 (fr)	2009-04-09
AU2008306762A1 (en)	2009-04-09
NZ582995A (en)	2012-04-27

Legal Events

Date	Code	Title	Description
2015-12-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.
2016-03-29	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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