BRPI0814529A2 - Derivados de 2-3-dihidrobenzo[1,4]dioxin-2-ilmetil como antagonistas alfa2c para o uso no tratamento de doenças do sistema nervoso periférico e central. - Google Patents

Derivados de 2-3-dihidrobenzo[1,4]dioxin-2-ilmetil como antagonistas alfa2c para o uso no tratamento de doenças do sistema nervoso periférico e central.

Info

Publication number: BRPI0814529A2
Authority: BR; Brazil
Prior art keywords: alfa2c; ilmetil; dihydrobenzo; dioxin; antagonists
Prior art date: 2007-07-20

Application number

BRPI0814529-6A2A

Other languages

English (en)

Inventor

David Din Belle

Patrik Holm

Arto Karljalainen

Arto Tolvanen

Gerd Wohlfahrt

Petteri Rummakko

Original Assignee

Orion Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-07-20

Filing date

2008-07-18

Publication date

2015-01-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39884455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0814529(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-07-18 Application filed by Orion Corp filed Critical Orion Corp

2015-01-27 Publication of BRPI0814529A2 publication Critical patent/BRPI0814529A2/pt

2019-09-17 Publication of BRPI0814529B1 publication Critical patent/BRPI0814529B1/pt

2021-05-25 Publication of BRPI0814529B8 publication Critical patent/BRPI0814529B8/pt

Links

239000005557 antagonist Substances 0.000 title 1
208000015114 central nervous system disease Diseases 0.000 title 1
230000002093 peripheral effect Effects 0.000 title 1
208000027232 peripheral nervous system disease Diseases 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0814529A 2007-07-20 2008-07-18 derivados de 2,3-dihidrobenzo[1,4]dioxin-2-ilmetil como antagonistas de alfa2c para uso no tratamento de doenças do sistema nervoso periférico e central BRPI0814529B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US95098307P	2007-07-20	2007-07-20
US60/950,983		2007-07-20
PCT/FI2008/000090 WO2009013390A1 (en)	2007-07-20	2008-07-18	2, 3-dihydrobenzo[1, 4] dioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases

Publications (3)

Publication Number	Publication Date
BRPI0814529A2 true BRPI0814529A2 (pt)	2015-01-27
BRPI0814529B1 BRPI0814529B1 (pt)	2019-09-17
BRPI0814529B8 BRPI0814529B8 (pt)	2021-05-25

Family

ID=39884455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0814529A BRPI0814529B8 (pt)	2007-07-20	2008-07-18	derivados de 2,3-dihidrobenzo[1,4]dioxin-2-ilmetil como antagonistas de alfa2c para uso no tratamento de doenças do sistema nervoso periférico e central

Country Status (31)

Country	Link
US (3)	US8492549B2 (pt)
EP (1)	EP2176252B1 (pt)
JP (1)	JP5460590B2 (pt)
KR (1)	KR101535059B1 (pt)
CN (1)	CN101842369B (pt)
AR (1)	AR069271A1 (pt)
AU (1)	AU2008278924B2 (pt)
BR (1)	BRPI0814529B8 (pt)
CA (1)	CA2693804C (pt)
CL (1)	CL2008002114A1 (pt)
CO (1)	CO6331473A2 (pt)
CY (1)	CY1115789T1 (pt)
DK (1)	DK2176252T3 (pt)
EA (1)	EA017554B1 (pt)
ES (1)	ES2502215T3 (pt)
GE (1)	GEP20125538B (pt)
HR (1)	HRP20141156T1 (pt)
IL (1)	IL202964A (pt)
MA (1)	MA31521B1 (pt)
MY (1)	MY153872A (pt)
NZ (1)	NZ582432A (pt)
PE (1)	PE20090890A1 (pt)
PL (1)	PL2176252T3 (pt)
PT (1)	PT2176252E (pt)
RS (1)	RS53571B1 (pt)
SI (1)	SI2176252T1 (pt)
TN (1)	TN2010000029A1 (pt)
TW (1)	TWI457122B (pt)
UA (1)	UA100695C2 (pt)
WO (1)	WO2009013390A1 (pt)
ZA (1)	ZA201000314B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI457122B (zh)	2007-07-20	2014-10-21	Orion Corp	作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
DK2271638T3 (da) *	2008-04-29	2011-11-28	Nsab Af Neurosearch Sweden Ab	Modulatorer af dopaminneurotransmission
WO2009133107A1 (en) *	2008-04-29	2009-11-05	Nsab, Filial Af Neurosearch Sweden Ab, Sverige	Modulators of dopamine neurotransmission
JP2011519839A (ja) *	2008-04-29	2011-07-14	エヌエスエイビー、フィリアルアヴノイロサーチスウェーデンエービー、スヴェーリエ	ドーパミン神経伝達のモジュレーター
TW201024282A (en) *	2008-11-20	2010-07-01	Orion Corp	New pharmaceutical compounds
US20130267699A1 (en)	2011-06-24	2013-10-10	California Institute Of Technology	Quaternary heteroatom containing compounds
US8822679B2 (en) *	2011-06-24	2014-09-02	California Institute Of Technology	Quaternary heteroatom containing compounds
US9518034B2 (en)	2013-10-14	2016-12-13	California Institute Of Technology	Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof
US10421696B2 (en)	2014-12-18	2019-09-24	California Institute Of Technology	Enantioselective synthesis of α-quaternary mannich adducts by palladium-catalyzed allylic alkylation
CN108752212B (zh) *	2015-03-06	2024-03-12	北京大学	9-脱羧迷迭香酸类似物及其合成方法和应用
CN107922373A (zh)	2015-03-27	2018-04-17	加利福尼亚技术学院	使用低催化剂浓度和稳定的预催化剂的不对称催化脱羧烷基烷基化
AR104882A1 (es) *	2015-06-05	2017-08-23	Orion Corp	DERIVADOS DE 2-(1-HETEROARILPIPERAZIN-4-IL)METIL-1,4-BENZODIOXANO COMO ANTAGONISTAS DE a2C
WO2017156239A1 (en)	2016-03-11	2017-09-14	California Institute Of Technology	Compositions and methods for acylating lactams
EP3478676A1 (en)	2016-06-29	2019-05-08	Orion Corporation	Benzodioxane derivatives and their pharmaceutical use
CN110662541B (zh) *	2017-03-12	2023-02-10	王晓冬	多环胺作为阿片受体调节剂
US10358422B2 (en)	2017-11-01	2019-07-23	California Institute Of Technology	Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
GB201801130D0 (en) *	2018-01-24	2018-03-07	Univ Oxford Innovation Ltd	Compounds
EP3856183A1 (en) *	2018-09-25	2021-08-04	Bayer Aktiengesellschaft	alfa2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONISTS FOR THE TREATMENT OF SLEEP APNEA
US11214568B2 (en)	2018-10-18	2022-01-04	California Institute Of Technology	Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same
MX2024008523A (es)	2022-01-07	2024-07-19	Bayer Ag	Antagonistas del adrenoceptor a2 subtipo c para el tratamiento de la apnea del sue?o.
KR102776660B1 (ko) *	2022-01-25	2025-03-04	재단법인 한국파스퇴르연구소	벤조다이옥세인 유도체 화합물 및 이의 의약 용도

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2056046A (en) *	1933-05-19	1936-09-29	Rhone Poulenc Sa	Manufacture of bases derived from benz-dioxane
US3647790A (en)	1969-04-08	1972-03-07	American Home Prod	Ouinoxalinyl-oxazolidines and -oxazines
GB1411531A (en) *	1972-10-24	1975-10-29	Lafon Labor	Amino derivatives of 1,4-benzodioxan
JPS5163193A (ja)	1974-11-26	1976-06-01	Yoshitomi Pharmaceutical	Tetorahidoropirazoropirijinkagobutsuno seizoho
US4039676A (en) *	1975-06-23	1977-08-02	Ciba-Geigy Corporation	2-piperidinoalkyl-1,4-benzodioxans
US4329348A (en) *	1979-02-26	1982-05-11	Ciba-Geigy Corporation	N-Oxacyclic-alkylpiperidines as psychostimulants
HU181575B (en)	1980-10-03	1983-10-28	Richter Gedeon Vegyeszet	Process for preparing 3-chloro-propyl-malonic acid ester and cyano-acetic acid ester derivatives
FR2525600A1 (fr)	1982-04-21	1983-10-28	Bouchara Emile	Nouvelles carboxamidoguanidines, leur procede d'obtention et les compositions pharmaceutiques en renfermant
GB2167408B (en)	1984-11-23	1988-05-25	Farmos Oy	Substituted imidazole derivatives and their preparation and use
DD250930A1 (de)	1986-06-08	1987-10-28	Isis Chemie Zwickau Veb	Verfahren zur herstellung neuer tetrahydroisochinolinderivate
US4957928A (en) *	1986-06-26	1990-09-18	Ciba-Geigy Corporation	Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
JPH04500075A (ja)	1988-08-16	1992-01-09	イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー	殺菌性ベンゾジオキサンアミン誘導体
CA2104873C (en)	1991-02-26	2000-05-23	James N. Campbell	Compositions and methods of treatment of sympathetically maintained pain
GB9318431D0 (en) *	1993-09-06	1993-10-20	Boots Co Plc	Therapeutic agents
GB9514380D0 (en) *	1995-07-13	1995-09-13	Knoll Ag	Therapeutic agents
FR2744451B1 (fr) *	1996-02-01	1998-04-24	Pf Medicament	Nouvelles imidazolidinones, pyrimidinones, et 1,3-diazepin-2 -ones, leur preparation et leurs applications en therapeutique
WO1998050359A1 (en)	1997-05-06	1998-11-12	Novo Nordisk A/S	Novel heterocyclic compounds
US5902807A (en) *	1997-05-12	1999-05-11	Antti Haapalinna	Method for the treatment of mental illness in mammals and a composition therefor
BR9813381A (pt)	1997-12-04	2000-10-03	Allergan Sales Inc	"derivados de imidazol substituìdo possuindo atividade semelhante a agonista em receptores adrenérgicos alfa 2b ou 2b/2c"
FI20000480A0 (fi)	2000-03-01	2000-03-01	Orion Yhtymae Oyj	Kinoliini- ja naftaleenijohdannaisia alfa-2 antagonisteina
AU2001290873B2 (en) *	2000-09-11	2006-07-27	Sepracor Inc.	Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission)
DE60316672T2 (de)	2002-04-03	2008-07-17	Orion Corp.	Polycyclische verbindungen als potente alpha2-adrenoceptor antagonisten
WO2004067513A1 (en)	2003-01-27	2004-08-12	Oy Juvantia Pharma Ltd	Antagonists for alpha-2 adrenoceptors
TWI457122B (zh)	2007-07-20	2014-10-21	Orion Corp	作為用於治療周邊和中央神經系統疾病之alpha2C拮抗劑的2,3－二氫苯並[1,4]戴奧辛－2－基甲基衍生物
JP5163193B2 (ja)	2008-03-13	2013-03-13	セイコーエプソン株式会社	プリンタシステム及びプリンタシステムにおける制御方法

2008
- 2008-07-02 TW TW097124840A patent/TWI457122B/zh active
- 2008-07-17 CL CL2008002114A patent/CL2008002114A1/es unknown
- 2008-07-17 PE PE2008001216A patent/PE20090890A1/es active IP Right Grant
- 2008-07-17 AR ARP080103087A patent/AR069271A1/es active IP Right Grant
- 2008-07-18 SI SI200831313T patent/SI2176252T1/sl unknown
- 2008-07-18 KR KR1020107003606A patent/KR101535059B1/ko active Active
- 2008-07-18 PT PT87876892T patent/PT2176252E/pt unknown
- 2008-07-18 RS RSP20140510 patent/RS53571B1/sr unknown
- 2008-07-18 CN CN200880025445.8A patent/CN101842369B/zh active Active
- 2008-07-18 JP JP2010516529A patent/JP5460590B2/ja active Active
- 2008-07-18 DK DK08787689.2T patent/DK2176252T3/en active
- 2008-07-18 GE GEAP200811693A patent/GEP20125538B/en unknown
- 2008-07-18 US US12/668,918 patent/US8492549B2/en active Active
- 2008-07-18 UA UAA201001749A patent/UA100695C2/ru unknown
- 2008-07-18 EA EA201070169A patent/EA017554B1/ru not_active IP Right Cessation
- 2008-07-18 CA CA2693804A patent/CA2693804C/en active Active
- 2008-07-18 BR BRPI0814529A patent/BRPI0814529B8/pt active IP Right Grant
- 2008-07-18 MY MYPI2010000086A patent/MY153872A/en unknown
- 2008-07-18 NZ NZ582432A patent/NZ582432A/en unknown
- 2008-07-18 ES ES08787689.2T patent/ES2502215T3/es active Active
- 2008-07-18 EP EP08787689.2A patent/EP2176252B1/en active Active
- 2008-07-18 WO PCT/FI2008/000090 patent/WO2009013390A1/en not_active Ceased
- 2008-07-18 HR HRP20141156AT patent/HRP20141156T1/hr unknown
- 2008-07-18 AU AU2008278924A patent/AU2008278924B2/en active Active
- 2008-07-18 PL PL08787689T patent/PL2176252T3/pl unknown
2009
- 2009-12-24 IL IL202964A patent/IL202964A/en active IP Right Grant
2010
- 2010-01-15 MA MA32515A patent/MA31521B1/fr unknown
- 2010-01-15 ZA ZA201000314A patent/ZA201000314B/xx unknown
- 2010-01-15 TN TNP2010000029A patent/TN2010000029A1/fr unknown
- 2010-01-19 CO CO10004690A patent/CO6331473A2/es active IP Right Grant
2013
- 2013-06-14 US US13/917,745 patent/US8697723B2/en active Active
2014
- 2014-02-27 US US14/192,131 patent/US8809536B2/en active Active
- 2014-11-26 CY CY20141100982T patent/CY1115789T1/el unknown

Also Published As

Publication number	Publication date
PT2176252E (pt)	2014-12-03
HRP20141156T1 (hr)	2015-01-16
BRPI0814529B8 (pt)	2021-05-25
ZA201000314B (en)	2010-10-27
US8697723B2 (en)	2014-04-15
CN101842369A (zh)	2010-09-22
SI2176252T1 (sl)	2014-12-31
US20130281486A1 (en)	2013-10-24
WO2009013390A1 (en)	2009-01-29
TW200908961A (en)	2009-03-01
US8492549B2 (en)	2013-07-23
PE20090890A1 (es)	2009-07-08
MY153872A (en)	2015-03-31
CY1115789T1 (el)	2017-01-25
EP2176252B1 (en)	2014-09-03
RS53571B1 (sr)	2015-02-27
MA31521B1 (fr)	2010-07-01
AU2008278924A1 (en)	2009-01-29
CA2693804A1 (en)	2009-01-29
BRPI0814529B1 (pt)	2019-09-17
EA201070169A1 (ru)	2010-06-30
EA017554B1 (ru)	2013-01-30
TWI457122B (zh)	2014-10-21
AU2008278924B2 (en)	2013-09-26
AR069271A1 (es)	2010-01-13
HK1148530A1 (en)	2011-09-09
PL2176252T3 (pl)	2015-04-30
KR20100044220A (ko)	2010-04-29
CA2693804C (en)	2015-11-24
EP2176252A1 (en)	2010-04-21
US20140179926A1 (en)	2014-06-26
US20120035210A9 (en)	2012-02-09
CN101842369B (zh)	2014-01-22
US20100216836A1 (en)	2010-08-26
UA100695C2 (ru)	2013-01-25
JP5460590B2 (ja)	2014-04-02
ES2502215T3 (es)	2014-10-03
CO6331473A2 (es)	2011-10-20
IL202964A (en)	2013-12-31
GEP20125538B (en)	2012-05-25
US8809536B2 (en)	2014-08-19
TN2010000029A1 (en)	2011-09-26
DK2176252T3 (en)	2014-12-08
JP2010534197A (ja)	2010-11-04
NZ582432A (en)	2012-03-30
CL2008002114A1 (es)	2009-04-03
KR101535059B1 (ko)	2015-07-24

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-02-12	B07E	Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2019-04-02	B07A	Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
2019-08-20	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-09-17	B16A	Patent or certificate of addition of invention granted	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/09/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 17/09/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/07/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

Publication	Publication Date	Title
CL2007002017A1 (es)	2008-06-13	Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple.
SI2176252T1 (sl)	2014-12-31	2,3-dihidrobenzo(1,4)dioksin-2-ilmetilni derivati kot alfa2C antagonisti za uporabo v zdravljenju bolezni perifernega in centralnega živčnega sistema
BRPI0816881A2 (pt)	2015-03-17	Composto, composição farmacêutica, uso de um composto, e, métodos para tratar doenças ou distúrbios e para preparar um composto.
BRPI0812889A2 (pt)	2017-05-23	composto, composição farmacêutica, uso de um composto, e, método para o tratamento ou prevenção de distúrbios neurológicos e psiquiátricos associados com a disfunção de glutamato em um animal.
CL2007002708A1 (es)	2008-04-04	Compuestos derivados de pirrolo[2,3-b]piridina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, caquexia, trastornos inflamatorios, entre otros.
BRPI1009252A2 (pt)	2016-03-15	composto, pró-droga, composição farmacêutica, métodos para prevenir ou tratar doenças do sistema nervoso central, e mal de alzheimer, e, uso do composto ou de uma pró-droga do mesmo
GT200800250A (es)	2009-09-14	Arilimidazolonas y ariltriazolonas sustituidas como inhibidores de receptores de vasopresina
BRPI0821440A2 (pt)	2015-06-16	Derivados de tetra-hidro-imidazo[1,5-a] pirazina, processo de preparação e uso medicinal dos mesmos
CR8642A (es)	2008-11-28	Compuestos, composiciones farmaceuticas y metodos para su uso en el tratameinto de desordenes metabolicos
CL2008001025A1 (es)	2008-10-17	Compuestos derivados de pirimido[5,4-d]pirimidina-2,4,6,8-tetraona; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como trastorno metabolico, dislipidemia y cancer.
BR112012001344A2 (pt)	2016-03-15	derivados de 17hidróxi-17-pentafluoroetil-estra-4,9(10)-dieno-11-arila, método de produção destes e uso destes para o tratamento de doenças
BRPI0814267A2 (pt)	2015-03-31	Agentes citotóxicos compreendendo novos derivados de tomaicmicina e o seu uso terapêutico.
IL192009A0 (en)	2008-12-29	Quinazoline derivatives, process for their preparation and their use as anti-cancer agents
BRPI0812740A2 (pt)	2016-07-19	composto, composição farmacêutica, uso do composto, e, método para tratamento, prevenção ou alívio de um distúrbio do sistema nervoso central de um corpo de animal vivo.
BRPI0816255A2 (pt)	2015-03-17	Produto farmacêutico, uso do produto, método para a profilaxia ou o tratamento de doenças, e, composição farmaceuticamente aceitável
FR2915199B1 (fr)	2010-01-22	Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
BRPI0818690A2 (pt)	2015-04-14	Derivados de quinazolinediona, sua preparação e seus usos terapêuticos.
CL2008001493A1 (es)	2008-08-29	Compuesto derivado de 3-(imidazolil)-pirazolo[3,4-b]piridina; procedimiento de prepararcion de dicho compuesto; y su uso para tratar inflamacion, trastornos inmunorregulatorios, entre otros.
IL203206A (en)	2015-03-31	2-Amino Derivatives, 4-Amido Quinazoline, Drugs Containing and Using Theirs, and Process for Manufacturing
BRPI0818841A2 (pt)	2015-04-22	Compostos para uso em formação de imagem, diagnóstico e/ou tratamento de doenças do sistema nervoso central ou de tumores
BRPI1008727A2 (pt)	2016-03-08	derivados de azol substituídos, composição farmacêutica contendo os derivados, e método para o tratamento de doença de parkinson usando os mesmos
WO2009071689A3 (de)	2009-07-23	5-halogen-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen
CL2012001483A1 (es)	2013-01-18	Compuestos derivados de 3,6-diazabiciclo[3.1.1]heptanos, como ligandos de receptores nicotinicos neuronales de acetilcolina; composicion farmaceutica; y su uso para el tratamiento o la prevencion de demencia presenil, alzheimer, esquizofrenia, dolor agudo o cronico, entre otras enfermedades.
PT2056804E (pt)	2014-07-11	Utilização de derivados de 2,5-di-hidroxibenzeno para o tratamento de doenças oculares
CL2008001563A1 (es)	2008-10-10	Compuestos derivados de benzodioxanos condensados con heterociclos; metodo de preparacion; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como depresion, ansiedad, crisis de panico, entre otras.