BRPI0814771A2 - Sondas de imagem de caspase - Google Patents

Sondas de imagem de caspase

Info

Publication number
BRPI0814771A2
BRPI0814771A2 BRPI0814771-0A2A BRPI0814771A BRPI0814771A2 BR PI0814771 A2 BRPI0814771 A2 BR PI0814771A2 BR PI0814771 A BRPI0814771 A BR PI0814771A BR PI0814771 A2 BRPI0814771 A2 BR PI0814771A2
Authority
BR
Brazil
Prior art keywords
caspase
image probes
probes
image
caspase image
Prior art date
Application number
BRPI0814771-0A2A
Other languages
English (en)
Inventor
Maik Kindermann
Catherine Miniejew
Karl-Ulrich Wendt
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0814771A2 publication Critical patent/BRPI0814771A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BRPI0814771-0A2A 2007-08-03 2008-07-17 Sondas de imagem de caspase BRPI0814771A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07015256 2007-08-03
PCT/EP2008/059358 WO2009019115A1 (en) 2007-08-03 2008-07-17 Caspase imaging probes

Publications (1)

Publication Number Publication Date
BRPI0814771A2 true BRPI0814771A2 (pt) 2015-03-03

Family

ID=38723017

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814771-0A2A BRPI0814771A2 (pt) 2007-08-03 2008-07-17 Sondas de imagem de caspase

Country Status (10)

Country Link
US (1) US20100303728A1 (pt)
EP (1) EP2185721B1 (pt)
JP (1) JP2010535167A (pt)
KR (1) KR20100072167A (pt)
CN (1) CN101772577A (pt)
AU (1) AU2008285761A1 (pt)
BR (1) BRPI0814771A2 (pt)
CA (1) CA2695244A1 (pt)
MY (1) MY148484A (pt)
WO (1) WO2009019115A1 (pt)

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CN102174319B (zh) * 2011-02-13 2015-01-21 华中科技大学 一类针对半胱氨酸蛋白酶c1家族蛋白酶的透膜荧光小分子探针及其合成、纯化的方法和应用
CN102836443A (zh) * 2011-06-26 2012-12-26 复旦大学 一种多肽修饰的脑靶向纳米器件及制备方法和用途
EP2881385A4 (en) 2012-08-02 2016-06-29 Bioneer Corp NOVEL AZO COMPOUND, USE THEREOF AND METHOD FOR THE PRODUCTION THEREOF
EP2848696A1 (en) 2013-09-13 2015-03-18 Sanofi-Aventis Deutschland GmbH Caspase-1 imaging probes
JP7017410B2 (ja) * 2015-01-22 2022-02-08 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ｉｎ ｖｉｖｏ画像化のためのプロテアーゼ活性化コントラスト剤
SG10201913587WA (en) 2016-02-05 2020-02-27 Denali Therapeutics Inc Inhibitors of receptor-interacting protein kinase 1
RS63203B1 (sr) 2016-12-09 2022-06-30 Denali Therapeutics Inc Jedinjenja korisna kao inhibitori ripk1
ES2964985T3 (es) * 2016-12-23 2024-04-10 Univ Leland Stanford Junior Compuestos sonda basados en actividad, composiciones y métodos de uso
CN110678460A (zh) 2017-03-30 2020-01-10 里兰斯坦福初级大学理事会 用于体内成像的蛋白酶激活的造影剂
JP2020520981A (ja) * 2017-05-24 2020-07-16 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． プロテアーゼのイメージング／検出のための化学発光プローブ
WO2019101195A1 (en) * 2017-11-27 2019-05-31 The University Of Hong Kong Yeats inhibitors and methods of use thereof
KR102138256B1 (ko) * 2018-09-13 2020-08-13 한국과학기술연구원 케스페이즈-1 활성 측정용 프로브, 이를 포함하는 염증성 질환 진단용 조성물
EP4463229A1 (en) 2022-01-12 2024-11-20 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide
CN119701022B (zh) * 2025-02-28 2025-07-25 中国科学院自动化研究所 双模态磁粒子荧光探针及其在制备、示踪和监测树突状细胞疫苗中的应用

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US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5627027A (en) 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5268468A (en) 1991-12-05 1993-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-nitrosophenoxybenzenepropanamine and N-1-chloroethyl carbamate intermediates
NZ283876A (en) 1994-03-31 2001-03-30 Vertex Pharma Pyrimidinyl derivatives as interleukin inhibitors
KR20000049050A (ko) 1996-10-11 2000-07-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 술폰아미드 치환된 아스파르트산 인터루킨-1β 전환 효소 억제제
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
US6130101A (en) 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
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WO2007027653A1 (en) * 2005-09-01 2007-03-08 Promega Corporation Cell-based luminogenic and nonluminogenic proteasome assays

Also Published As

Publication number Publication date
AU2008285761A1 (en) 2009-02-12
US20100303728A1 (en) 2010-12-02
WO2009019115A1 (en) 2009-02-12
EP2185721A1 (en) 2010-05-19
KR20100072167A (ko) 2010-06-30
EP2185721B1 (en) 2014-04-02
CN101772577A (zh) 2010-07-07
MY148484A (en) 2013-04-30
JP2010535167A (ja) 2010-11-18
CA2695244A1 (en) 2009-02-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.