BRPI0814771A2 - Sondas de imagem de caspase - Google Patents

Sondas de imagem de caspase

Info

Publication number
BRPI0814771A2
BRPI0814771A2 BRPI0814771-0A2A BRPI0814771A BRPI0814771A2 BR PI0814771 A2 BRPI0814771 A2 BR PI0814771A2 BR PI0814771 A BRPI0814771 A BR PI0814771A BR PI0814771 A2 BRPI0814771 A2 BR PI0814771A2
Authority
BR
Brazil
Prior art keywords
caspase
image probes
probes
image
caspase image
Prior art date
Application number
BRPI0814771-0A2A
Other languages
English (en)
Inventor
Maik Kindermann
Catherine Miniejew
Karl-Ulrich Wendt
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0814771A2 publication Critical patent/BRPI0814771A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0814771-0A2A 2007-08-03 2008-07-17 Sondas de imagem de caspase BRPI0814771A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07015256 2007-08-03
PCT/EP2008/059358 WO2009019115A1 (en) 2007-08-03 2008-07-17 Caspase imaging probes

Publications (1)

Publication Number Publication Date
BRPI0814771A2 true BRPI0814771A2 (pt) 2015-03-03

Family

ID=38723017

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814771-0A2A BRPI0814771A2 (pt) 2007-08-03 2008-07-17 Sondas de imagem de caspase

Country Status (10)

Country Link
US (1) US20100303728A1 (pt)
EP (1) EP2185721B1 (pt)
JP (1) JP2010535167A (pt)
KR (1) KR20100072167A (pt)
CN (1) CN101772577A (pt)
AU (1) AU2008285761A1 (pt)
BR (1) BRPI0814771A2 (pt)
CA (1) CA2695244A1 (pt)
MY (1) MY148484A (pt)
WO (1) WO2009019115A1 (pt)

Families Citing this family (14)

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CN102174319B (zh) * 2011-02-13 2015-01-21 华中科技大学 一类针对半胱氨酸蛋白酶c1家族蛋白酶的透膜荧光小分子探针及其合成、纯化的方法和应用
CN102836443A (zh) * 2011-06-26 2012-12-26 复旦大学 一种多肽修饰的脑靶向纳米器件及制备方法和用途
CN104703971B (zh) 2012-08-02 2018-08-21 株式会社百奥尼 新型偶氮化合物及其利用、以及其制造方法
EP2848696A1 (en) 2013-09-13 2015-03-18 Sanofi-Aventis Deutschland GmbH Caspase-1 imaging probes
US10570173B2 (en) * 2015-01-22 2020-02-25 The Board Of Trustees Of The Leland Stanford Junior University Protease-activated contrast agents for in vivo imaging
IL287136B2 (en) 2016-02-05 2023-09-01 Denali Therapeutics Inc Receptor inhibitors - interacting with protein kinase 1
JP7208137B2 (ja) 2016-12-09 2023-01-18 デナリ セラピューティクス インコーポレイテッド 化合物、組成物および方法
JP6984909B2 (ja) * 2016-12-23 2021-12-22 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 活性ベースのプローブ化合物、組成物、および使用方法
KR102669535B1 (ko) 2017-03-30 2024-05-24 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 생체 내 이미징을 위한 프로테아제 활성화 조영제
JP2020520981A (ja) * 2017-05-24 2020-07-16 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． プロテアーゼのイメージング／検出のための化学発光プローブ
EP3717504A4 (en) * 2017-11-27 2021-10-20 The University of Hong Kong YEATS INHIBITORS AND METHOD OF USING
KR102138256B1 (ko) * 2018-09-13 2020-08-13 한국과학기술연구원 케스페이즈-1 활성 측정용 프로브, 이를 포함하는 염증성 질환 진단용 조성물
TW202334164A (zh) 2022-01-12 2023-09-01 美商戴納立製藥公司 （Ｓ）－５－苄基－Ｎ－（５－甲基－４－側氧基－２，３，４，５－四氫吡啶並［３，２－ｂ］［１，４］氧氮呯－３－基）－４Ｈ－１，２，４－三唑－３－甲醯胺的晶型
CN119701022B (zh) * 2025-02-28 2025-07-25 中国科学院自动化研究所 双模态磁粒子荧光探针及其在制备、示踪和监测树突状细胞疫苗中的应用

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US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5627027A (en) 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5268468A (en) 1991-12-05 1993-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-nitrosophenoxybenzenepropanamine and N-1-chloroethyl carbamate intermediates
CN1504462A (zh) 1994-03-31 2004-06-16 ������˹ҩƷ��˾ 作为白细胞介素抑制剂的嘧啶基衍生物
NZ334887A (en) 1996-10-11 2000-09-29 Basf Ag Sulfonamide substituted aspartic acid interleukin-1'beta' converting enzyme inhibitors
US5696157A (en) 1996-11-15 1997-12-09 Molecular Probes, Inc. Sulfonated derivatives of 7-aminocoumarin
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JP2002539193A (ja) 1999-03-16 2002-11-19 メルク フロスト カナダ アンド カンパニー カスパーゼ−３阻害薬としてのγ−ケト酸ジペプチド類
CA2374369A1 (en) * 1999-05-27 2000-12-07 Merck Frosst Canada & Co. Assays for caspase activity using green fluorescent proteins
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US7001899B2 (en) 2002-06-10 2006-02-21 The Procter & Gamble Company Interleukin converting enzyme inhibitors
US7138395B2 (en) 2002-06-10 2006-11-21 The Procter & Gamble Company Interleukin-1β converting enzyme inhibitors
US7041696B2 (en) 2002-06-17 2006-05-09 The Procter & Gamble Company Interleukin-1β converting enzyme inhibitors
EP1900822B1 (en) 2005-05-24 2016-02-03 Suzuki, Miho Method for simultaneous analysis of multiple biological reactions or changes in in vivo conditions
JP2009506772A (ja) * 2005-09-01 2009-02-19 プロメガ コーポレイション 細胞ベースの発光及び非発光プロテアソームアッセイ

Also Published As

Publication number Publication date
US20100303728A1 (en) 2010-12-02
CA2695244A1 (en) 2009-02-12
WO2009019115A1 (en) 2009-02-12
JP2010535167A (ja) 2010-11-18
CN101772577A (zh) 2010-07-07
KR20100072167A (ko) 2010-06-30
AU2008285761A1 (en) 2009-02-12
EP2185721B1 (en) 2014-04-02
MY148484A (en) 2013-04-30
EP2185721A1 (en) 2010-05-19

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.