BRPI0815358A2 - Compostos 2-(2-oxoindolina-3-ilideno)metil-5-(2-hidróxi-3-morfoli n-4-il-propil)-6,7-di-hidro-1h-pirrol[3,2-c]piridina-4(5h)- ona e uso como inibidores de proteínoquinase - Google Patents

Compostos 2-(2-oxoindolina-3-ilideno)metil-5-(2-hidróxi-3-morfoli n-4-il-propil)-6,7-di-hidro-1h-pirrol[3,2-c]piridina-4(5h)- ona e uso como inibidores de proteínoquinase

Info

Publication number
BRPI0815358A2
BRPI0815358A2 BRPI0815358-2A2A BRPI0815358A BRPI0815358A2 BR PI0815358 A2 BRPI0815358 A2 BR PI0815358A2 BR PI0815358 A BRPI0815358 A BR PI0815358A BR PI0815358 A2 BRPI0815358 A2 BR PI0815358A2
Authority
BR
Brazil
Prior art keywords
oxydoline
propil
ilidene
morpholi
pyrol
Prior art date
Application number
BRPI0815358-2A2A
Other languages
English (en)
Inventor
Jialiang Yang
Yidong Su
Fuqiang Zhao
Peng Cho Tang
Original Assignee
Shanghai Hengrui Pharm Co Ltd
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Hengrui Pharm Co Ltd, Jiangsu Hengrui Medicine Co filed Critical Shanghai Hengrui Pharm Co Ltd
Publication of BRPI0815358A2 publication Critical patent/BRPI0815358A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0815358-2A2A 2007-08-15 2008-07-29 Compostos 2-(2-oxoindolina-3-ilideno)metil-5-(2-hidróxi-3-morfoli n-4-il-propil)-6,7-di-hidro-1h-pirrol[3,2-c]piridina-4(5h)- ona e uso como inibidores de proteínoquinase BRPI0815358A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2007101418749A CN101367801B (zh) 2007-08-15 2007-08-15 吡咯并六元n杂环羟基吗啡啉类衍生物的制备方法及其在医药上的应用
PCT/CN2008/001388 WO2009024016A1 (en) 2007-08-15 2008-07-29 2-(2-oxoindoline-3-ylidene)methyl-5-(2-hydroxy-3-morpholin-4-yl -propyl)-6,7-dihydro -1h- pyrrol[3,2-c]pyridine-4(5h)-one compounds and use as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0815358A2 true BRPI0815358A2 (pt) 2015-02-10

Family

ID=40377816

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815358-2A2A BRPI0815358A2 (pt) 2007-08-15 2008-07-29 Compostos 2-(2-oxoindolina-3-ilideno)metil-5-(2-hidróxi-3-morfoli n-4-il-propil)-6,7-di-hidro-1h-pirrol[3,2-c]piridina-4(5h)- ona e uso como inibidores de proteínoquinase

Country Status (14)

Country Link
US (1) US8299069B2 (pt)
EP (1) EP2179998B1 (pt)
JP (1) JP2010535819A (pt)
KR (1) KR20100059869A (pt)
CN (1) CN101367801B (pt)
AU (1) AU2008288615B2 (pt)
BR (1) BRPI0815358A2 (pt)
CA (1) CA2694380A1 (pt)
MX (1) MX2010001602A (pt)
RU (1) RU2472792C2 (pt)
TW (1) TW201000100A (pt)
UA (1) UA98797C2 (pt)
WO (1) WO2009024016A1 (pt)
ZA (1) ZA201000627B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1973910T3 (da) 2006-01-27 2013-08-12 Shanghai Hengrui Pharm Co Ltd Pyrrolo[3,2-c]pyridin-4-on-2-indolinon-proteinkinaseinhibitorer
WO2012094313A1 (en) * 2011-01-04 2012-07-12 Kinentia Biosciences Llc Pyrazole derivatives as erk inhibitors
CN104109160B (zh) * 2013-04-17 2017-12-15 上海翰森生物医药科技有限公司 吡咯并n杂环类化合物及其制备方法和医药用途
CN106565585A (zh) * 2016-10-13 2017-04-19 云南大学 一种n‑取代亚苄基吡咯烷二酮及其制备方法和用途
CN114057735B (zh) * 2020-08-03 2024-02-20 江苏恒瑞医药股份有限公司 一种多靶点酪氨酸激酶抑制剂的新晶型及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423997D0 (en) * 1994-11-28 1995-01-11 Erba Carlo Spa Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
EP1259514B9 (en) * 2000-02-28 2005-11-09 Sugen, Inc. 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
JP2003535847A (ja) * 2000-06-02 2003-12-02 スージェン・インコーポレーテッド 蛋白質キナーゼ／ホスファターゼ阻害剤としてのインドリノン誘導体
WO2002002551A1 (en) * 2000-06-30 2002-01-10 Sugen, Inc. 4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
WO2002094809A1 (fr) * 2001-05-24 2002-11-28 Yamanouchi Pharmaceutical Co., Ltd. Derives de 3-quinoleine-2-(1h)-ylideneindoline-2-one
US20040209937A1 (en) 2003-02-24 2004-10-21 Sugen, Inc. Treatment of excessive osteolysis with indolinone compounds
DK1973910T3 (da) * 2006-01-27 2013-08-12 Shanghai Hengrui Pharm Co Ltd Pyrrolo[3,2-c]pyridin-4-on-2-indolinon-proteinkinaseinhibitorer
CN101007814A (zh) * 2006-01-27 2007-08-01 上海恒瑞医药有限公司 吡咯并六元杂环化合物及其在医药上的用途
CN101007815B (zh) * 2006-01-27 2010-06-23 江苏恒瑞医药股份有限公司 吡咯并六元杂环化合物及其在医药上的用途
RU2302417C1 (ru) * 2006-03-14 2007-07-10 Иващенко Андрей Александрович 1-оксо-3-(1н-индол-3-ил)-1,2,3,4-тетрагидроизохинолины, способы их получения, комбинаторная библиотека и фокусированная библиотека

Also Published As

Publication number Publication date
ZA201000627B (en) 2011-04-28
WO2009024016A1 (en) 2009-02-26
KR20100059869A (ko) 2010-06-04
US8299069B2 (en) 2012-10-30
AU2008288615A1 (en) 2009-02-26
CN101367801B (zh) 2011-01-12
UA98797C2 (en) 2012-06-25
RU2010104752A (ru) 2011-09-20
AU2008288615B2 (en) 2013-01-10
EP2179998A1 (en) 2010-04-28
EP2179998A4 (en) 2010-07-28
US20100160317A1 (en) 2010-06-24
TW201000100A (en) 2010-01-01
CA2694380A1 (en) 2009-02-26
CN101367801A (zh) 2009-02-18
EP2179998B1 (en) 2012-08-29
MX2010001602A (es) 2010-03-15
JP2010535819A (ja) 2010-11-25
RU2472792C2 (ru) 2013-01-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.