BRPI0815920A2 - Composto, composição farmacêutica, e, uso do composto. - Google Patents

Composto, composição farmacêutica, e, uso do composto.

Info

Publication number
BRPI0815920A2
BRPI0815920A2 BRPI0815920-3A2A BRPI0815920A BRPI0815920A2 BR PI0815920 A2 BRPI0815920 A2 BR PI0815920A2 BR PI0815920 A BRPI0815920 A BR PI0815920A BR PI0815920 A2 BRPI0815920 A2 BR PI0815920A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
iva
formulas
host
Prior art date
Application number
BRPI0815920-3A2A
Other languages
English (en)
Inventor
Cyril Dousson
Dominique Surleraux
Jean-Laurent Paparin
Claire Pierra
Arlene Roland
Original Assignee
Idenix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix Pharmaceuticals Inc filed Critical Idenix Pharmaceuticals Inc
Publication of BRPI0815920A2 publication Critical patent/BRPI0815920A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
    • C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI0815920-3A2A 2007-08-31 2008-08-28 Composto, composição farmacêutica, e, uso do composto. BRPI0815920A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96723707P 2007-08-31 2007-08-31
PCT/US2008/010225 WO2009032180A1 (en) 2007-08-31 2008-08-28 Phosphadiazine hcv polymerase inhibitors iv

Publications (1)

Publication Number Publication Date
BRPI0815920A2 true BRPI0815920A2 (pt) 2015-02-18

Family

ID=39874081

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815920-3A2A BRPI0815920A2 (pt) 2007-08-31 2008-08-28 Composto, composição farmacêutica, e, uso do composto.

Country Status (16)

Country Link
US (4) US20090060872A1 (pt)
EP (1) EP2183260B1 (pt)
JP (1) JP5514108B2 (pt)
KR (1) KR20100072002A (pt)
CN (1) CN101842378A (pt)
AT (1) ATE511514T1 (pt)
AU (1) AU2008296997B2 (pt)
BR (1) BRPI0815920A2 (pt)
CA (1) CA2697546A1 (pt)
ES (1) ES2367550T3 (pt)
MX (1) MX2010002296A (pt)
NZ (1) NZ583545A (pt)
RU (1) RU2483073C2 (pt)
TW (1) TW200927143A (pt)
UA (1) UA95715C2 (pt)
WO (4) WO2009032180A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
EP2389934A1 (en) * 2010-05-25 2011-11-30 Sanovel Ilac Sanayi ve Ticaret A.S. Controlled-Release Tablet Formulations of Pregabalin
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
EP3046924A1 (en) 2013-09-20 2016-07-27 IDENIX Pharmaceuticals, Inc. Hepatitis c virus inhibitors
US20170066779A1 (en) 2014-03-05 2017-03-09 Idenix Pharmaceuticals Llc Solid forms of a flaviviridae virus inhibitor compound and salts thereof
CA3182565A1 (en) 2015-03-06 2016-09-15 Atea Pharmaceuticals, Inc. .beta.-d-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-c-substituted-2-modified-n6-substituted purine nucleotides for hcv treatment
EP3303359B1 (en) 2015-05-27 2024-11-06 Idenix Pharmaceuticals LLC Nucleotides for the treatment of cancer
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
US10711029B2 (en) 2016-07-14 2020-07-14 Atea Pharmaceuticals, Inc. Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
DK3512863T3 (da) 2016-09-07 2022-03-07 Atea Pharmaceuticals Inc 2¿-substituerede-N6-substituerede purinnukleotider til behandling af RNA-virus
CN115477679A (zh) 2017-02-01 2022-12-16 阿堤亚制药公司 用于治疗丙型肝炎病毒的核苷酸半硫酸盐
EP4717317A2 (en) 2017-06-20 2026-04-01 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
EP3773753A4 (en) 2018-04-10 2021-12-22 ATEA Pharmaceuticals, Inc. TREATMENT OF PATIENTS INFECTED WITH THE HEPATITIS C VIRUS WITH CIRRHOSIS
CN111233925B (zh) * 2018-11-28 2021-03-26 上海日馨生物科技有限公司 硫胺类化合物、制备方法及其药物组合物
CN115135984B (zh) 2019-12-23 2025-12-23 10X基因组学有限公司 可逆固定试剂及其使用方法
EP4081656A1 (en) 2019-12-23 2022-11-02 10X Genomics, Inc. Compositions and methods for using fixed biological samples in partition-based assays
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
KR20240022574A (ko) 2021-06-17 2024-02-20 아테아 파마슈티컬즈, 인크. 유리한 항-hcv 조합 요법
CN113698315A (zh) * 2021-09-03 2021-11-26 内蒙古蓝科生物科技有限公司 一种2-三氟甲基苯甲酰胺的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU495317A1 (ru) * 1973-11-14 1975-12-15 Киевский научно-исследовательский институт фармакологии и токсикологии Способ получени этилениминопроизводных 1,2,6-фосфадиазинов
EP1634886A3 (en) 1999-03-05 2006-03-29 Metabasis Therapeutics, Inc. Novel phosphorus-containing prodrug
HUP0200260A3 (en) * 1999-03-05 2002-11-28 Metabasis Therapeutics Inc San Novel phosphorus-containing prodrugs, their preparation and their use
AU4329000A (en) * 1999-04-19 2000-11-02 G.D. Searle & Co. Novel heterocyclic amino carbonyl derivatives useful as nitric oxide synthase inhibitors
WO2003099801A1 (en) * 2002-05-24 2003-12-04 Smithkline Beecham Corporation Novel anti-infectives
RU2007110531A (ru) * 2004-08-23 2008-09-27 Ф.Хоффманн-Ля Рош Аг (Ch) Гетероциклические противовирусные соединения
CN101384587B (zh) * 2006-02-17 2011-03-30 弗·哈夫曼-拉罗切有限公司 抗病毒的杂环化合物

Also Published As

Publication number Publication date
AU2008296997B2 (en) 2013-08-29
NZ583545A (en) 2011-04-29
US20090081158A1 (en) 2009-03-26
US20090060866A1 (en) 2009-03-05
CN101842378A (zh) 2010-09-22
JP5514108B2 (ja) 2014-06-04
UA95715C2 (ru) 2011-08-25
TW200927143A (en) 2009-07-01
MX2010002296A (es) 2010-04-01
EP2183260A1 (en) 2010-05-12
HK1137028A1 (en) 2010-07-16
WO2009032176A1 (en) 2009-03-12
US20090060872A1 (en) 2009-03-05
WO2009032180A1 (en) 2009-03-12
US20090060867A1 (en) 2009-03-05
WO2009032177A1 (en) 2009-03-12
RU2483073C2 (ru) 2013-05-27
JP2010537986A (ja) 2010-12-09
WO2009032179A1 (en) 2009-03-12
KR20100072002A (ko) 2010-06-29
ES2367550T3 (es) 2011-11-04
RU2010112408A (ru) 2011-10-10
ATE511514T1 (de) 2011-06-15
CA2697546A1 (en) 2009-03-12
US7932240B2 (en) 2011-04-26
EP2183260B1 (en) 2011-06-01
AU2008296997A1 (en) 2009-03-12

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]