BRPI0816317A2 - Método para tratar o estresse oxidativo e melhorar a memória de trabalho pela administração de pterostilbeno - Google Patents
Método para tratar o estresse oxidativo e melhorar a memória de trabalho pela administração de pterostilbenoInfo
- Publication number
- BRPI0816317A2 BRPI0816317A2 BRPI0816317A BRPI0816317A BRPI0816317A2 BR PI0816317 A2 BRPI0816317 A2 BR PI0816317A2 BR PI0816317 A BRPI0816317 A BR PI0816317A BR PI0816317 A BRPI0816317 A BR PI0816317A BR PI0816317 A2 BRPI0816317 A2 BR PI0816317A2
- Authority
- BR
- Brazil
- Prior art keywords
- pterostilbene
- working memory
- oxidative stress
- subject
- improve working
- Prior art date
Links
- VLEUZFDZJKSGMX-UHFFFAOYSA-N pterostilbene Natural products COC1=CC(OC)=CC(C=CC=2C=CC(O)=CC=2)=C1 VLEUZFDZJKSGMX-UHFFFAOYSA-N 0.000 title abstract 6
- VLEUZFDZJKSGMX-ONEGZZNKSA-N pterostilbene Chemical compound COC1=CC(OC)=CC(\C=C\C=2C=CC(O)=CC=2)=C1 VLEUZFDZJKSGMX-ONEGZZNKSA-N 0.000 title abstract 4
- 230000003936 working memory Effects 0.000 title abstract 4
- 230000036542 oxidative stress Effects 0.000 title abstract 3
- 230000037396 body weight Effects 0.000 abstract 2
- -1 pterostilbene compound Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
MÉTODO PARA TRATAR O ESTRESSE OXIDATIVO E MELHORAR A MEMÓRIA DE TRABALHO PELA ADMINISTRAÇÃO DE PTEROSTILBENO. É revelada uma composição farmacêutica para tratar estresse oxidativo compreendendo uma quantidade terapeuticamente eficaz de um composto substancialmente puro de pterostilbeno e um carreador fisiologicamente aceitável. O pterostilbeno é administrado em uma quantidade entre aproximadamente 2,5 mg a aproximadamente 10 mg por quilograma de peso corporal do indivíduo. É revelado também um método para aumentar a memória de trabalho de um indivíduo, o método compreendendo a administração de uma quantidade eficaz de um composto substancialmente puro de pterostilbeno, no qual a memória de trabalho para um indivíduo aumenta e a eficácia terapêutica é de aproximadamente 10 mg de pterostilbeno por quilograma de peso corporal do indivíduo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97059107P | 2007-09-07 | 2007-09-07 | |
| US12/136,341 US20090069444A1 (en) | 2007-09-07 | 2008-06-10 | Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration |
| PCT/US2008/075170 WO2009032870A2 (en) | 2007-09-07 | 2008-09-04 | Method to ameliorate oxidative stress and improve working memory via pterostilbene administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0816317A2 true BRPI0816317A2 (pt) | 2017-07-25 |
Family
ID=40429677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0816317A BRPI0816317A2 (pt) | 2007-09-07 | 2008-09-04 | Método para tratar o estresse oxidativo e melhorar a memória de trabalho pela administração de pterostilbeno |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20090069444A1 (pt) |
| EP (1) | EP2200597B1 (pt) |
| JP (1) | JP5608082B2 (pt) |
| KR (1) | KR20100075468A (pt) |
| CN (2) | CN101820869B (pt) |
| AU (1) | AU2008296293A1 (pt) |
| BR (1) | BRPI0816317A2 (pt) |
| CA (1) | CA2698661C (pt) |
| ES (1) | ES2526648T3 (pt) |
| WO (1) | WO2009032870A2 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090069444A1 (en) * | 2007-09-07 | 2009-03-12 | The United States Of America, As Represented By Th E Secretary Of Agriculture | Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration |
| WO2010150271A1 (en) * | 2009-06-22 | 2010-12-29 | Indus Biotech Private Limited | Process for obtaining purified pterostilbene and methods of use thereof |
| US20100119499A1 (en) * | 2009-09-17 | 2010-05-13 | Kneller Bruce W | Stilbene-based compositions and methods of use therefor |
| US20110280850A1 (en) * | 2010-05-12 | 2011-11-17 | Starr Elizabeth I | Compositions Containing DNA Repair Enzyme And Anogeissus Extract |
| US20120237494A1 (en) * | 2010-09-30 | 2012-09-20 | Daly Susan M | Compositions Containing Zinc PCA And Anogeissus Extract |
| EP2537513A3 (en) * | 2011-03-11 | 2015-04-29 | ELC Management LLC | Use of anogeissus extract for fibrillin production in skin |
| US9439875B2 (en) * | 2011-05-11 | 2016-09-13 | The United States Of America, As Represented By The Secretary Of Agriculture | Anxiolytic effect of pterostilbene |
| US20130072509A1 (en) * | 2011-09-15 | 2013-03-21 | ChromaDex Inc. | Pterostilbene and statin combination for treatment of metabolic disease, cardiovascular disease, and inflammation |
| JP6155191B2 (ja) * | 2011-10-02 | 2017-06-28 | キユーピー株式会社 | ＲＮＡ干渉によるｍＲＮＡ発現の抑制を促進する促進剤およびその用途 |
| JP5901547B2 (ja) | 2012-03-28 | 2016-04-13 | 富士フイルム株式会社 | 組成物、これを含む皮膚外用剤、又は機能性食品 |
| MX394291B (es) | 2013-10-30 | 2025-03-24 | Chromadex Inc | Composiciones de ribosido de nicotinamida para uso topico en el tratamiento de afecciones de la piel. |
| US20190076376A1 (en) | 2015-07-10 | 2019-03-14 | University Of Miami | Methods for treating mucopolysaccharidosis |
| BR112019003579A2 (pt) | 2016-08-22 | 2019-05-21 | Elysium Health, Inc. | Composições de ribosídeo de nicotinamida e pterostilbeno e métodos para o tratamento dedistúrbios neurodegenerativos |
| CN110662542B (zh) | 2016-11-11 | 2025-04-08 | 英国贝尔法斯特女王大学 | 烟酰基核苷和还原的烟酰基核苷、其改性衍生物、其磷酸化的类似物、其腺苷二核苷酸共轭物、以及其新颖结晶形式的有效且可规模化的合成 |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| US11633421B2 (en) | 2016-11-29 | 2023-04-25 | University Of Iowa Research Foundation | Use of NAD precursors for improving maternal health and/or offspring health |
| BR112020023001A2 (pt) * | 2018-05-15 | 2021-02-02 | Alkahest, Inc. | tratamento de doença associada ao envelhecimento com moduladores da leucotrieno a4 hidrolase |
| JP7345312B2 (ja) * | 2019-08-09 | 2023-09-15 | キユーピー株式会社 | 発酵乳 |
| KR102718991B1 (ko) * | 2020-09-25 | 2024-10-16 | 씨제이제일제당 (주) | 스틸벤계 화합물을 포함하는 항콕시듐증 조성물 및 이의 용도 |
| CN112618520A (zh) * | 2021-01-14 | 2021-04-09 | 姚大纯 | 紫檀芪或白藜芦醇在制备用于治疗或改善孤独症谱系障碍的药物中的应用 |
| EP4426284A4 (en) | 2021-11-01 | 2025-11-12 | Alkahest Inc | Benzodioxane Leukotriene A4 Hydrolase (LTA4H) Modulators for the Prevention and Treatment of Age-Related Diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050038125A1 (en) * | 2003-08-15 | 2005-02-17 | Smit Hobbe Friso | Method for the treatment of arthritis and pain |
| JP4633572B2 (ja) * | 2004-07-30 | 2011-02-16 | イスクラ産業株式会社 | 糖尿病改善剤 |
| US20060057231A1 (en) * | 2004-08-19 | 2006-03-16 | Rimando Agnes M | Pterostilbene as a new agonist for the peroxisome proliferator-activated receptor alpha isoform |
| US20090069444A1 (en) * | 2007-09-07 | 2009-03-12 | The United States Of America, As Represented By Th E Secretary Of Agriculture | Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration |
-
2008
- 2008-06-10 US US12/136,341 patent/US20090069444A1/en not_active Abandoned
- 2008-09-04 BR BRPI0816317A patent/BRPI0816317A2/pt not_active IP Right Cessation
- 2008-09-04 KR KR20107007002A patent/KR20100075468A/ko not_active Ceased
- 2008-09-04 CN CN2008801103188A patent/CN101820869B/zh not_active Expired - Fee Related
- 2008-09-04 ES ES08799127.9T patent/ES2526648T3/es active Active
- 2008-09-04 CA CA2698661A patent/CA2698661C/en active Active
- 2008-09-04 AU AU2008296293A patent/AU2008296293A1/en not_active Abandoned
- 2008-09-04 WO PCT/US2008/075170 patent/WO2009032870A2/en not_active Ceased
- 2008-09-04 CN CN201210421008.6A patent/CN103083288B/zh not_active Expired - Fee Related
- 2008-09-04 EP EP20080799127 patent/EP2200597B1/en active Active
- 2008-09-04 JP JP2010524125A patent/JP5608082B2/ja not_active Expired - Fee Related
-
2011
- 2011-08-08 US US13/204,891 patent/US8809400B2/en active Active
-
2014
- 2014-05-22 US US14/284,901 patent/US9028887B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN103083288A (zh) | 2013-05-08 |
| EP2200597A2 (en) | 2010-06-30 |
| EP2200597A4 (en) | 2010-09-08 |
| JP2010538077A (ja) | 2010-12-09 |
| US20140256827A1 (en) | 2014-09-11 |
| JP5608082B2 (ja) | 2014-10-15 |
| US8809400B2 (en) | 2014-08-19 |
| KR20100075468A (ko) | 2010-07-02 |
| CA2698661A1 (en) | 2009-03-12 |
| AU2008296293A1 (en) | 2009-03-12 |
| CN101820869B (zh) | 2012-12-12 |
| CN101820869A (zh) | 2010-09-01 |
| ES2526648T3 (es) | 2015-01-14 |
| EP2200597B1 (en) | 2014-11-12 |
| US20090069444A1 (en) | 2009-03-12 |
| HK1185257A1 (zh) | 2014-02-14 |
| CA2698661C (en) | 2016-03-29 |
| US20120035272A1 (en) | 2012-02-09 |
| US9028887B2 (en) | 2015-05-12 |
| WO2009032870A2 (en) | 2009-03-12 |
| WO2009032870A3 (en) | 2009-05-22 |
| CN103083288B (zh) | 2016-04-13 |
| HK1148932A1 (en) | 2011-09-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |