BRPI0817433A2 - Moduladores de gama-secretase piperidinila e piperazinila - Google Patents
Moduladores de gama-secretase piperidinila e piperazinilaInfo
- Publication number
- BRPI0817433A2 BRPI0817433A2 BRPI0817433-4A BRPI0817433A BRPI0817433A2 BR PI0817433 A2 BRPI0817433 A2 BR PI0817433A2 BR PI0817433 A BRPI0817433 A BR PI0817433A BR PI0817433 A2 BRPI0817433 A2 BR PI0817433A2
- Authority
- BR
- Brazil
- Prior art keywords
- piperazinyl
- piperidinyl
- gamma secretase
- secretase modulators
- compounds
- Prior art date
Links
- -1 piperazinyl gamma secretase modulators Chemical compound 0.000 title 1
- 125000003386 piperidinyl group Chemical group 0.000 title 1
- 229940124648 γ-Secretase Modulator Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98118907P | 2007-10-19 | 2007-10-19 | |
| PCT/US2008/079905 WO2009052126A1 (en) | 2007-10-19 | 2008-10-15 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF γ-SECRETASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0817433A2 true BRPI0817433A2 (pt) | 2015-06-16 |
Family
ID=40090456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0817433-4A BRPI0817433A2 (pt) | 2007-10-19 | 2008-10-15 | Moduladores de gama-secretase piperidinila e piperazinila |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8252935B2 (pt) |
| EP (1) | EP2212287B1 (pt) |
| JP (1) | JP5439381B2 (pt) |
| KR (1) | KR101569391B1 (pt) |
| CN (1) | CN101903347B (pt) |
| AT (1) | ATE543799T1 (pt) |
| AU (1) | AU2008312612B2 (pt) |
| BR (1) | BRPI0817433A2 (pt) |
| CA (1) | CA2702837A1 (pt) |
| CO (1) | CO6270359A2 (pt) |
| CR (1) | CR11447A (pt) |
| EA (1) | EA017119B1 (pt) |
| ES (1) | ES2378594T3 (pt) |
| IL (1) | IL205045A (pt) |
| MX (1) | MX2010004309A (pt) |
| NI (1) | NI201000064A (pt) |
| NZ (1) | NZ584716A (pt) |
| WO (1) | WO2009052126A1 (pt) |
| ZA (1) | ZA201003519B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0817433A2 (pt) | 2007-10-19 | 2015-06-16 | Janssen Pharmaceutica Nv | Moduladores de gama-secretase piperidinila e piperazinila |
| AU2008312355B2 (en) * | 2007-10-19 | 2013-07-04 | Janssen Pharmaceutica, N.V. | Carbon linked modulators of y-secretase |
| EA018862B1 (ru) * | 2007-10-19 | 2013-11-29 | Янссен Фармацевтика, Н.В. | МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ |
| JPWO2011007819A1 (ja) | 2009-07-17 | 2012-12-27 | 塩野義製薬株式会社 | ラクタムまたはベンゼンスルホンアミド化合物を含有する医薬 |
| US20120129189A1 (en) * | 2009-07-17 | 2012-05-24 | Chulan Kwon | Methods of Controlling Cell Proliferation |
| US8586776B2 (en) * | 2009-11-05 | 2013-11-19 | Fibrostatin, S.L. | GPBP inhibition using Q2 peptidomimetics |
| TWI841592B (zh) | 2018-09-03 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | 雙環雜芳基衍生物 |
| LT3894411T (lt) | 2018-12-13 | 2024-08-26 | F. Hoffmann-La Roche Ag | 7-fenoksi-n-(3-azabiciklo[3.2.1]oktan-8-il)-6,7-dihidro-5h-pirolo [1,2-b][1,2,4]triazol-2-amino dariniai ir susiję junginiai kaip gama sekretazės moduliatoriai alzheimerio ligai gydyti |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2212287A (en) * | 1938-09-13 | 1940-08-20 | William S Stateler | Milk bottle holder |
| BE790287A (fr) * | 1971-10-28 | 1973-04-19 | Delalande Sa | Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique |
| BE826017R (fr) | 1974-03-19 | 1975-08-26 | Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique | |
| US4252951A (en) | 1979-10-09 | 1981-02-24 | Eli Lilly And Company | Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid |
| US5391817A (en) | 1993-12-21 | 1995-02-21 | Bristol-Myers Squibb | Biaryl phospholipase A2 inhibitors |
| US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| US5416187A (en) * | 1994-04-04 | 1995-05-16 | Eastman Chemical Company | Process for the preparation of phenol-functional polyester resins |
| AU5702201A (en) | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
| DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| KR20070010144A (ko) * | 2004-04-05 | 2007-01-22 | 쉐링 코포레이션 | 신규한 감마 세크레타제 억제제 |
| WO2005110963A1 (en) * | 2004-05-19 | 2005-11-24 | Cellzome Ag | (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy |
| WO2006004555A1 (en) | 2004-06-30 | 2006-01-12 | Paysetter Pte Ltd | System and method for facilitating transfer of physical money and/or credit |
| CN101602741A (zh) * | 2004-06-30 | 2009-12-16 | 先灵公司 | 作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺 |
| DE102004033876B4 (de) | 2004-07-13 | 2009-01-15 | Christoph Kaesbohrer | Dreidimensionales Struktursystem |
| GB0416508D0 (en) | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
| EP1650183A1 (en) | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
| WO2006088705A1 (en) * | 2005-02-14 | 2006-08-24 | Wyeth | Terphenyl guanidines as [beta symbol] -secretase inhibitors |
| EP1849762B1 (en) | 2006-04-21 | 2009-07-15 | Cellzome Limited | Substituted biphenyl carboxylic acids and derivatives thereof |
| PL1847524T3 (pl) | 2006-04-21 | 2010-03-31 | Cellzome Ltd | Pochodne terfenylu do leczenia choroby Alzheimera |
| WO2007146838A2 (en) * | 2006-06-09 | 2007-12-21 | Icos Corporation | Substituted phenyl acetic acids as dp-2 antagonists |
| AU2008312771B2 (en) | 2007-10-17 | 2012-11-01 | Janssen Pharmaceutica, N.V. | Biphenyl carboxylic acids and derivatives thereof |
| AU2008312355B2 (en) | 2007-10-19 | 2013-07-04 | Janssen Pharmaceutica, N.V. | Carbon linked modulators of y-secretase |
| BRPI0817433A2 (pt) | 2007-10-19 | 2015-06-16 | Janssen Pharmaceutica Nv | Moduladores de gama-secretase piperidinila e piperazinila |
| EA018862B1 (ru) | 2007-10-19 | 2013-11-29 | Янссен Фармацевтика, Н.В. | МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ |
| CN101903334A (zh) | 2007-10-19 | 2010-12-01 | 詹森药业有限公司 | Gsm中间体 |
| BRPI0817425A2 (pt) | 2007-10-19 | 2015-06-16 | Janssen Pharmaceutica Nv | Moduladores de gama-secretase ligados à amida |
| US7968725B2 (en) | 2008-07-22 | 2011-06-28 | Janssen Pharmaceutica N.V. | Pyridinyl modulators of γ-secretase |
-
2008
- 2008-10-15 BR BRPI0817433-4A patent/BRPI0817433A2/pt not_active IP Right Cessation
- 2008-10-15 NZ NZ584716A patent/NZ584716A/en not_active IP Right Cessation
- 2008-10-15 MX MX2010004309A patent/MX2010004309A/es active IP Right Grant
- 2008-10-15 ES ES08839601T patent/ES2378594T3/es active Active
- 2008-10-15 WO PCT/US2008/079905 patent/WO2009052126A1/en not_active Ceased
- 2008-10-15 EA EA201070495A patent/EA017119B1/ru not_active IP Right Cessation
- 2008-10-15 US US12/251,521 patent/US8252935B2/en not_active Expired - Fee Related
- 2008-10-15 AT AT08839601T patent/ATE543799T1/de active
- 2008-10-15 KR KR1020107010877A patent/KR101569391B1/ko not_active Expired - Fee Related
- 2008-10-15 CN CN200880121603XA patent/CN101903347B/zh not_active Expired - Fee Related
- 2008-10-15 CA CA2702837A patent/CA2702837A1/en not_active Abandoned
- 2008-10-15 JP JP2010530071A patent/JP5439381B2/ja not_active Expired - Fee Related
- 2008-10-15 AU AU2008312612A patent/AU2008312612B2/en not_active Ceased
- 2008-10-15 EP EP08839601A patent/EP2212287B1/en active Active
-
2010
- 2010-04-13 IL IL205045A patent/IL205045A/en not_active IP Right Cessation
- 2010-04-16 NI NI201000064A patent/NI201000064A/es unknown
- 2010-04-30 CO CO10051578A patent/CO6270359A2/es not_active Application Discontinuation
- 2010-05-18 ZA ZA2010/03519A patent/ZA201003519B/en unknown
- 2010-05-19 CR CR11447A patent/CR11447A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA017119B1 (ru) | 2012-09-28 |
| ZA201003519B (en) | 2012-07-25 |
| ES2378594T3 (es) | 2012-04-16 |
| NZ584716A (en) | 2011-12-22 |
| KR101569391B1 (ko) | 2015-11-16 |
| EP2212287B1 (en) | 2012-02-01 |
| EP2212287A1 (en) | 2010-08-04 |
| AU2008312612B2 (en) | 2013-11-28 |
| AU2008312612A1 (en) | 2009-04-23 |
| AU2008312612A8 (en) | 2010-05-27 |
| JP5439381B2 (ja) | 2014-03-12 |
| CN101903347A (zh) | 2010-12-01 |
| ES2378594T8 (es) | 2013-02-27 |
| NI201000064A (es) | 2010-09-13 |
| US8252935B2 (en) | 2012-08-28 |
| US20090105275A1 (en) | 2009-04-23 |
| AU2008312612A2 (en) | 2010-07-22 |
| IL205045A (en) | 2015-08-31 |
| JP2011500700A (ja) | 2011-01-06 |
| CR11447A (es) | 2011-01-14 |
| KR20100083829A (ko) | 2010-07-22 |
| CO6270359A2 (es) | 2011-04-20 |
| CA2702837A1 (en) | 2009-04-23 |
| EA201070495A1 (ru) | 2010-10-29 |
| WO2009052126A1 (en) | 2009-04-23 |
| ATE543799T1 (de) | 2012-02-15 |
| MX2010004309A (es) | 2010-05-03 |
| IL205045A0 (en) | 2010-11-30 |
| CN101903347B (zh) | 2013-03-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |