BRPI0817725A2 - composoção, método para concentrar poliplexos quitosano-ácido nucleico, dispersão concentrada de poliplexos quitosano-ácido nucleico, composoção farmacêutica, e, método para laterar o diâmentro de poliplexos quitosano-ácido nucleico - Google Patents

composoção, método para concentrar poliplexos quitosano-ácido nucleico, dispersão concentrada de poliplexos quitosano-ácido nucleico, composoção farmacêutica, e, método para laterar o diâmentro de poliplexos quitosano-ácido nucleico

Info

Publication number
BRPI0817725A2
BRPI0817725A2 BRPI0817725A BRPI0817725A BRPI0817725A2 BR PI0817725 A2 BRPI0817725 A2 BR PI0817725A2 BR PI0817725 A BRPI0817725 A BR PI0817725A BR PI0817725 A BRPI0817725 A BR PI0817725A BR PI0817725 A2 BRPI0817725 A2 BR PI0817725A2
Authority
BR
Brazil
Prior art keywords
chitosan
nucleic acid
polyplexes
latering
polyplexe
Prior art date
Application number
BRPI0817725A
Other languages
English (en)
Inventor
Cheung Anthony
Fleet Carlos
C Hsu Eric
Gao Jun
Original Assignee
Engene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Engene Inc filed Critical Engene Inc
Publication of BRPI0817725A2 publication Critical patent/BRPI0817725A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
BRPI0817725A 2007-09-28 2008-09-26 composoção, método para concentrar poliplexos quitosano-ácido nucleico, dispersão concentrada de poliplexos quitosano-ácido nucleico, composoção farmacêutica, e, método para laterar o diâmentro de poliplexos quitosano-ácido nucleico BRPI0817725A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97631607P 2007-09-28 2007-09-28
PCT/CA2008/001714 WO2009039657A1 (en) 2007-09-28 2008-09-26 High concentration chitosan-nucleic acid polyplex compositions

Publications (1)

Publication Number Publication Date
BRPI0817725A2 true BRPI0817725A2 (pt) 2017-05-16

Family

ID=40510712

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0817725A BRPI0817725A2 (pt) 2007-09-28 2008-09-26 composoção, método para concentrar poliplexos quitosano-ácido nucleico, dispersão concentrada de poliplexos quitosano-ácido nucleico, composoção farmacêutica, e, método para laterar o diâmentro de poliplexos quitosano-ácido nucleico

Country Status (20)

Country Link
US (3) US8722646B2 (pt)
EP (1) EP2195035B1 (pt)
JP (2) JP5650533B2 (pt)
KR (2) KR20100077155A (pt)
CN (1) CN101873867B (pt)
AU (1) AU2008302979B2 (pt)
BR (1) BRPI0817725A2 (pt)
CA (1) CA2700842C (pt)
DK (1) DK2195035T3 (pt)
ES (1) ES2660846T3 (pt)
IL (1) IL204677A (pt)
MX (1) MX2010003323A (pt)
NO (1) NO2195035T3 (pt)
PL (1) PL2195035T3 (pt)
PT (1) PT2195035T (pt)
RU (1) RU2010116775A (pt)
SG (1) SG187403A1 (pt)
SI (1) SI2195035T1 (pt)
WO (1) WO2009039657A1 (pt)
ZA (1) ZA201002169B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5650533B2 (ja) * 2007-09-28 2015-01-07 エンジーン，インコーポレイティド 高濃度キトサン−核酸ポリプレックス組成物
CA2794923A1 (en) * 2009-03-31 2010-10-07 Engene, Inc. Highly acidic chitosan-nucleic acid polyplex compositions
BR112013009934A2 (pt) 2010-12-07 2016-07-05 Hoffmann La Roche dispositivo para adicionar pelo menos duas soluções de alimentação, aparelho de cultivo celular, uso de um dispositivo e método para obter um polipeptídeo
ES2635990T3 (es) * 2012-03-21 2017-10-05 Engene, Inc. Nanopartículas de quitosano derivado dualmente y los métodos para fabricar y usar las mismas para la transferencia génica in vivo
ITTO20121107A1 (it) * 2012-12-19 2014-06-20 Idea Medical Devices S R L Composizione a base di polidesossiribonucleotidi e relativi usi
EP3049473B1 (en) 2013-09-25 2021-09-22 Engene, Inc. Dually derivatized chitosan nanoparticles and methods of making and using the same for gene transfer in vivo
WO2015125147A1 (en) 2014-02-20 2015-08-27 B. G. Negev Technologies And Applications Ltd Anionic polyplexes for use in the delivery of nucleic acids
EP4353257A3 (en) 2015-04-13 2024-08-07 CureVac Manufacturing GmbH Method for producing rna compositions
WO2017105138A1 (ko) * 2015-12-18 2017-06-22 주식회사 삼양바이오팜 음이온성 약물을 함유하는 고분자 미셀의 제조방법
KR101710639B1 (ko) * 2016-06-07 2017-03-08 주식회사 파마리서치프로덕트 핵산, 키토산 및 히알루론산을 포함하는 조직 증강용 충전 조성물 및 이의 제조방법
CN109310800B (zh) * 2016-07-29 2022-01-07 医药研究有限公司 包含核酸和壳聚糖的肩袖撕裂修复用组合物
EP3538659A4 (en) 2016-11-09 2020-07-15 Engene, Inc. INTESTINAL EXPRESSION OF THE SCHEDULED DEATH LIGAND 1
RU2697527C1 (ru) * 2018-06-06 2019-08-15 Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук" (ФГУ ФИЦ Биотехнологии РАН) Иммуноадъювантная композиция для вакцин против инфекционных агентов вирусной и бактериальной природы
KR20210110791A (ko) * 2018-12-28 2021-09-09 엠리트 제네틱스 리미티드 폴리플렉스의 형성 방법
EP3693024A1 (en) * 2019-02-05 2020-08-12 Altona Diagnostics GmbH Control for nucleic acid preparation and/or detection methods
US20220348900A1 (en) * 2019-08-14 2022-11-03 Modernatx, Inc. Processes for purifying downstream products of in vitro transcription
WO2024219893A1 (ko) * 2023-04-19 2024-10-24 주식회사 파마리서치 조직 수복용 조성물
WO2026085495A1 (en) 2024-10-18 2026-04-23 Generation Bio Co. Synthetic partially single-stranded nucleic acid compositions and uses and methods therefor

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184037B1 (en) * 1996-05-17 2001-02-06 Genemedicine, Inc. Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell
DE69712110T2 (de) * 1996-07-10 2002-12-12 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Ltd., Nottingham Zusammensetzungen zur einführung von genen in epithelzellen
EP1054694A2 (en) * 1998-02-13 2000-11-29 Selective Genetics, Inc. Concurrent flow mixing methods and apparatuses for the preparation of gene therapy vectors and compositions prepared thereby
WO2000009086A2 (en) 1998-08-14 2000-02-24 Valentis, Inc. Protected one-vial formulation for nucleic acid molecules, methods of making the same by in-line mixing, and related products and methods
US6251599B1 (en) * 1998-11-06 2001-06-26 Selective Genetics, Inc. Stabilized nucleic acid compositions and methods of preparation and use thereof
DE10141971A1 (de) 2001-08-28 2003-03-27 Siemens Ag Adaptive Kanalschätzung in einem OFDM-basierten Mobilfunksystem durch Variation der Anzahl der Pilotsymbole
EP1306127B2 (en) * 2001-10-26 2011-09-07 OctoPlus PolyActive Sciences B.V. Method for the preparation of purified microparticles
NO317653B1 (no) * 2002-05-03 2004-11-29 Stiftelsen Biopolymer Formulering som omfatter komplekser av kitosanoligomerer og nukleinsyre, fremgangsmate for a fremstille formuleringen samt anvendelser derav.
NO317654B1 (no) 2002-05-03 2004-11-29 Stiftelsen Biopolymer Formulering som inneholder en nukleinsyre og et kitosan, fremgangsmate for fremstilling av formuleringen, samt anvendelser derav.
KR100613734B1 (ko) * 2004-09-07 2006-08-22 굿젠 주식회사 키토산을 이용한 ｄｎａ 보관방법 및 분석방법 및 이를이용한 ｄｎａ 제품
JP5650533B2 (ja) * 2007-09-28 2015-01-07 エンジーン，インコーポレイティド 高濃度キトサン−核酸ポリプレックス組成物

Also Published As

Publication number Publication date
US8722646B2 (en) 2014-05-13
CN101873867A (zh) 2010-10-27
WO2009039657A1 (en) 2009-04-02
RU2010116775A (ru) 2011-11-10
US10647785B2 (en) 2020-05-12
AU2008302979B2 (en) 2014-09-04
KR20100077155A (ko) 2010-07-07
DK2195035T3 (en) 2018-03-12
IL204677A (en) 2016-12-29
PT2195035T (pt) 2018-03-07
ES2660846T3 (es) 2018-03-26
CA2700842C (en) 2016-10-11
CA2700842A1 (en) 2009-04-02
US20110039917A1 (en) 2011-02-17
JP2010540468A (ja) 2010-12-24
MX2010003323A (es) 2010-07-28
EP2195035B1 (en) 2017-12-06
US20180215839A1 (en) 2018-08-02
KR20150115964A (ko) 2015-10-14
KR101761289B1 (ko) 2017-08-04
CN101873867B (zh) 2015-09-23
EP2195035A4 (en) 2012-02-22
ZA201002169B (en) 2011-05-25
JP2014208696A (ja) 2014-11-06
IL204677A0 (en) 2010-11-30
EP2195035A1 (en) 2010-06-16
SG187403A1 (en) 2013-02-28
PL2195035T3 (pl) 2018-07-31
JP5650533B2 (ja) 2015-01-07
AU2008302979A1 (en) 2009-04-02
NO2195035T3 (pt) 2018-05-05
US20140350091A1 (en) 2014-11-27
US9850323B2 (en) 2017-12-26
SI2195035T1 (en) 2018-05-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]