BRPI0817824B8 - derivados de (r)-4-(heteroaril) feniletila e composições farmacêuticas contendo os mesmos - Google Patents
derivados de (r)-4-(heteroaril) feniletila e composições farmacêuticas contendo os mesmosInfo
- Publication number
- BRPI0817824B8 BRPI0817824B8 BRPI0817824A BRPI0817824A BRPI0817824B8 BR PI0817824 B8 BRPI0817824 B8 BR PI0817824B8 BR PI0817824 A BRPI0817824 A BR PI0817824A BR PI0817824 A BRPI0817824 A BR PI0817824A BR PI0817824 B8 BRPI0817824 B8 BR PI0817824B8
- Authority
- BR
- Brazil
- Prior art keywords
- useful
- treatment
- heteroaryl
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 2
- 201000000448 autoimmune hemolytic anemia Diseases 0.000 abstract 2
- 230000003399 chemotactic effect Effects 0.000 abstract 2
- 230000000295 complement effect Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010018364 Glomerulonephritis Diseases 0.000 abstract 1
- 206010034277 Pemphigoid Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 abstract 1
- 208000000594 bullous pemphigoid Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000010410 reperfusion Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
derivados de (r)-4-(heteroaril) feniletila e composições farmacêuticas contendo os mesmos. a presente invenção refere-se a uma nova classe de derivados de (r)-4-(heteroaril) fenilpropiônico de fórmula (i), úteis na inibição de ativação de quimiotática induzida pela fração c5a de complemento. os ditos compostos são úteis no tratamento de patologias dependendo da ativação quimiotática de neutrófilos e monócitos induzida pela fração c5a do complemento. em particular, os compostos da invenção são úteis no tratamento de anemia hemolítica autoimune (ahia), psoríase, penfigoide bulosa, artrite reumatoide, colite ulcerativa, síndrome de distúrbio respiratório agudo, fibrose idiopática, glomerulonefrite e na prevenção e tratamento de dano causado por isquemia e reperfusão.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07020396 | 2007-10-18 | ||
| PCT/EP2008/064023 WO2009050258A1 (en) | 2007-10-18 | 2008-10-17 | (r)-4-(heteroaryl) phenylethyl derivatives and pharmaceutical compositions containing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0817824A2 BRPI0817824A2 (pt) | 2015-03-31 |
| BRPI0817824B1 BRPI0817824B1 (pt) | 2018-12-26 |
| BRPI0817824B8 true BRPI0817824B8 (pt) | 2021-05-25 |
Family
ID=40325746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0817824A BRPI0817824B8 (pt) | 2007-10-18 | 2008-10-17 | derivados de (r)-4-(heteroaril) feniletila e composições farmacêuticas contendo os mesmos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8133911B2 (pt) |
| EP (1) | EP2201006B1 (pt) |
| JP (1) | JP5374511B2 (pt) |
| CN (1) | CN101827841B (pt) |
| AT (1) | ATE501140T1 (pt) |
| AU (1) | AU2008313669B2 (pt) |
| BR (1) | BRPI0817824B8 (pt) |
| CA (1) | CA2702307C (pt) |
| DE (1) | DE602008005488D1 (pt) |
| DK (1) | DK2201006T3 (pt) |
| ES (1) | ES2361233T3 (pt) |
| HR (1) | HRP20110406T1 (pt) |
| IL (1) | IL205029A (pt) |
| PL (1) | PL2201006T3 (pt) |
| PT (1) | PT2201006E (pt) |
| RU (1) | RU2475486C2 (pt) |
| SI (1) | SI2201006T1 (pt) |
| WO (1) | WO2009050258A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2166006A1 (en) * | 2008-09-18 | 2010-03-24 | Dompe' S.P.A. | 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them |
| US8271106B2 (en) | 2009-04-17 | 2012-09-18 | Hospira, Inc. | System and method for configuring a rule set for medical event management and responses |
| AU2012325937B2 (en) | 2011-10-21 | 2018-03-01 | Icu Medical, Inc. | Medical device update system |
| US9539383B2 (en) | 2014-09-15 | 2017-01-10 | Hospira, Inc. | System and method that matches delayed infusion auto-programs with manually entered infusion programs and analyzes differences therein |
| EP3498269A1 (en) * | 2017-12-12 | 2019-06-19 | Dompé farmaceutici S.p.A. | C5ar inhibitors for use in the treatment of chemotherapy-induced iatrogenic pain |
| US11590057B2 (en) | 2020-04-03 | 2023-02-28 | Icu Medical, Inc. | Systems, methods, and components for transferring medical fluids |
| CN115433143B (zh) * | 2021-06-03 | 2023-10-13 | 中国科学院大连化学物理研究所 | 一种异噻唑啉酮类化合物的合成方法 |
| EP4397306A1 (en) | 2023-01-05 | 2024-07-10 | Dompe' Farmaceutici S.P.A. | C5ar1 inhibitors for use in the treatment of ocular mucous membrane pemphigoid and/or oral mucous membrane pemphigoid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1102593C (zh) * | 1996-06-27 | 2003-03-05 | 詹森药业有限公司 | N－[4－(杂芳基甲基)苯基]－杂芳基胺类化合物 |
| ITMI20012025A1 (it) * | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
| ES2597843T3 (es) * | 2005-11-24 | 2017-01-23 | Dompé Farmaceutici S.P.A. | Derivados de (R)-arilalquilamino y composiciones farmacéuticas que los contienen |
-
2008
- 2008-10-17 RU RU2010119705/04A patent/RU2475486C2/ru active
- 2008-10-17 EP EP08840589A patent/EP2201006B1/en active Active
- 2008-10-17 DE DE602008005488T patent/DE602008005488D1/de active Active
- 2008-10-17 CN CN200880112174XA patent/CN101827841B/zh active Active
- 2008-10-17 DK DK08840589.9T patent/DK2201006T3/da active
- 2008-10-17 CA CA2702307A patent/CA2702307C/en active Active
- 2008-10-17 HR HR20110406T patent/HRP20110406T1/hr unknown
- 2008-10-17 PL PL08840589T patent/PL2201006T3/pl unknown
- 2008-10-17 ES ES08840589T patent/ES2361233T3/es active Active
- 2008-10-17 BR BRPI0817824A patent/BRPI0817824B8/pt active IP Right Grant
- 2008-10-17 AT AT08840589T patent/ATE501140T1/de not_active IP Right Cessation
- 2008-10-17 JP JP2010529394A patent/JP5374511B2/ja active Active
- 2008-10-17 SI SI200830268T patent/SI2201006T1/sl unknown
- 2008-10-17 WO PCT/EP2008/064023 patent/WO2009050258A1/en not_active Ceased
- 2008-10-17 PT PT08840589T patent/PT2201006E/pt unknown
- 2008-10-17 AU AU2008313669A patent/AU2008313669B2/en active Active
- 2008-10-17 US US12/681,841 patent/US8133911B2/en active Active
-
2010
- 2010-04-12 IL IL205029A patent/IL205029A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PT2201006E (pt) | 2011-05-05 |
| AU2008313669A1 (en) | 2009-04-23 |
| BRPI0817824A2 (pt) | 2015-03-31 |
| CN101827841B (zh) | 2012-11-28 |
| IL205029A (en) | 2014-09-30 |
| IL205029A0 (en) | 2010-11-30 |
| CN101827841A (zh) | 2010-09-08 |
| AU2008313669B2 (en) | 2014-01-16 |
| HK1146723A1 (en) | 2011-07-08 |
| EP2201006A1 (en) | 2010-06-30 |
| JP2011500643A (ja) | 2011-01-06 |
| SI2201006T1 (sl) | 2011-07-29 |
| DE602008005488D1 (de) | 2011-04-21 |
| US20100249198A1 (en) | 2010-09-30 |
| RU2475486C2 (ru) | 2013-02-20 |
| BRPI0817824B1 (pt) | 2018-12-26 |
| ATE501140T1 (de) | 2011-03-15 |
| RU2010119705A (ru) | 2011-11-27 |
| PL2201006T3 (pl) | 2011-08-31 |
| CA2702307C (en) | 2016-04-05 |
| HRP20110406T1 (hr) | 2011-06-30 |
| DK2201006T3 (da) | 2011-06-27 |
| CA2702307A1 (en) | 2009-04-23 |
| US8133911B2 (en) | 2012-03-13 |
| ES2361233T3 (es) | 2011-06-15 |
| EP2201006B1 (en) | 2011-03-09 |
| JP5374511B2 (ja) | 2013-12-25 |
| WO2009050258A1 (en) | 2009-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: DOMPE FARMACEUTICI S.P.A (IT) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/12/2018, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/10/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |