BRPI0819092A2 - Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. - Google Patents
Evolução direcionada usando proteínas que compreendem aminoácidos não naturais.Info
- Publication number
- BRPI0819092A2 BRPI0819092A2 BRPI0819092A BRPI0819092A2 BR PI0819092 A2 BRPI0819092 A2 BR PI0819092A2 BR PI0819092 A BRPI0819092 A BR PI0819092A BR PI0819092 A2 BRPI0819092 A2 BR PI0819092A2
- Authority
- BR
- Brazil
- Prior art keywords
- amino acids
- unnatural amino
- directed evolution
- proteins
- understanding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Ecology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US168107P | 2007-11-02 | 2007-11-02 | |
| US12726208P | 2008-05-08 | 2008-05-08 | |
| US19477308P | 2008-09-29 | 2008-09-29 | |
| PCT/US2008/012363 WO2009061369A2 (en) | 2007-11-02 | 2008-10-31 | Directed evolution using proteins comprising unnatural amino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0819092A2 true BRPI0819092A2 (pt) | 2014-10-14 |
Family
ID=40626380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0819092 BRPI0819092A2 (pt) | 2007-11-02 | 2008-10-31 | Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9249408B2 (pt) |
| EP (1) | EP2217702A4 (pt) |
| JP (1) | JP5513398B2 (pt) |
| KR (1) | KR20100091997A (pt) |
| CN (1) | CN101878303B (pt) |
| AU (1) | AU2008325239A1 (pt) |
| BR (1) | BRPI0819092A2 (pt) |
| CA (1) | CA2704494A1 (pt) |
| IL (1) | IL205238A0 (pt) |
| MX (1) | MX2010004807A (pt) |
| WO (1) | WO2009061369A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP1649004A4 (en) * | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| SG10201700096VA (en) | 2009-07-17 | 2017-02-27 | Bioatla Llc | Simultaneous, Integrated Selection And Evolution Of Antibody/Protein Performance And Expression In Production Hosts |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| EA030886B1 (ru) * | 2010-08-17 | 2018-10-31 | Амбркс, Инк. | Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение |
| SI2638152T1 (sl) * | 2010-11-08 | 2016-12-30 | Amicus Therapeutics, Inc. | Variantni in rekombinantni proteini beta-glukocerebrozidaze s povišano stabilnostjo in povišano ohranjeno katalitično aktivnostjo |
| DE102013106462B3 (de) * | 2013-06-20 | 2014-10-09 | Airbus Defence and Space GmbH | Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein |
| MX2016006489A (es) * | 2013-11-20 | 2016-08-03 | Danisco Us Inc | Alfa-amilasas variantes que tienen susceptibilidad reducida a la escision por proteasas y metodos de uso. |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| CN109563508B (zh) * | 2016-07-29 | 2023-07-07 | 马克思—普朗克科学促进协会公司 | 通过定点dna裂解和修复靶向原位蛋白质多样化 |
| PE20191716A1 (es) | 2017-02-08 | 2019-12-05 | Bristol Myers Squibb Co | Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos |
| US12404512B2 (en) | 2018-05-01 | 2025-09-02 | Ambrx, Inc. | Method for optimizing antibody expression |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| US12371817B2 (en) * | 2019-03-04 | 2025-07-29 | The Texas A&M University System | Methods of making and utilizing amber-obligated phage display libraries |
| WO2021076634A1 (en) * | 2019-10-15 | 2021-04-22 | University Of Massachusetts | Aav production strategy using a cell line expressing an inducible rep gene |
| WO2021164694A1 (zh) * | 2020-02-17 | 2021-08-26 | 中国科学院生物物理研究所 | 抗体筛选方法 |
| WO2024216066A1 (en) * | 2023-04-12 | 2024-10-17 | The Board Of Trustees Of The Leland Stanford Junior University | Orthogonalized human protease |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| US6190908B1 (en) | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
| WO2002085923A2 (en) | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| ES2257560T3 (es) | 2001-06-15 | 2006-08-01 | Crucell Holland B.V. | Fagos quimericos. |
| FI20021726A0 (fi) | 2002-09-27 | 2002-09-27 | Ctt Cancer Targeting Tech Oy | Menetelmä peptidien tuottamiseksi |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| CA2508939A1 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| EP2410331B1 (en) | 2003-06-18 | 2015-09-23 | The Scripps Research Institute | Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids |
| EP1649004A4 (en) | 2003-07-07 | 2008-04-09 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| PT1687401E (pt) | 2003-10-14 | 2013-02-26 | Scripps Research Inst | Incorporação de aminoácidos activos em oxidação-redução específica do local em proteínas |
| US7741071B2 (en) | 2003-12-18 | 2010-06-22 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| JP2008500050A (ja) | 2004-05-25 | 2008-01-10 | ザ スクリップス リサーチ インスティテュート | 結晶構造決定のための重原子含有非天然アミノ酸の部位特異的蛋白質組込み |
| AU2005286722B2 (en) | 2004-09-21 | 2010-12-02 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| US20080171317A1 (en) | 2004-09-22 | 2008-07-17 | The Scripps Research Institute | Site-Specific Labeling of Proteins for Nmr Studies |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| EP1891092A4 (en) * | 2005-06-03 | 2011-12-21 | Ambrx Inc | INSTALLATION OF NATURALLY CODED AMINO ACIDS IN PROTEINS |
| AU2006255122B2 (en) * | 2005-06-03 | 2010-10-21 | Ambrx, Inc. | Improved human interferon molecules and their uses |
| BRPI0617191A2 (pt) | 2005-10-12 | 2011-07-19 | Scripps Research Inst | modificação pós-traducional de polipeptìdeos expressos em fagos |
| US20070178554A1 (en) * | 2006-02-01 | 2007-08-02 | Nima Shiva | Orthogonal Aminoacyl Synthetase-tRNA Pairs for Incorporating Unnatural Amino Acids Into Proteins |
| WO2007109035A2 (en) | 2006-03-16 | 2007-09-27 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
| JP5385143B2 (ja) | 2006-09-21 | 2014-01-08 | ザ スクリプス リサーチ インスティチュート | 真正細菌における選択的に硫酸化された蛋白質の遺伝的にプログラムされた発現 |
-
2008
- 2008-10-31 JP JP2010533076A patent/JP5513398B2/ja not_active Expired - Fee Related
- 2008-10-31 AU AU2008325239A patent/AU2008325239A1/en not_active Abandoned
- 2008-10-31 MX MX2010004807A patent/MX2010004807A/es not_active Application Discontinuation
- 2008-10-31 KR KR20107011772A patent/KR20100091997A/ko not_active Withdrawn
- 2008-10-31 US US12/734,416 patent/US9249408B2/en active Active
- 2008-10-31 BR BRPI0819092 patent/BRPI0819092A2/pt not_active IP Right Cessation
- 2008-10-31 CN CN200880118668.9A patent/CN101878303B/zh not_active Expired - Fee Related
- 2008-10-31 US US12/290,673 patent/US9150849B2/en active Active
- 2008-10-31 EP EP20080847822 patent/EP2217702A4/en not_active Withdrawn
- 2008-10-31 WO PCT/US2008/012363 patent/WO2009061369A2/en not_active Ceased
- 2008-10-31 CA CA 2704494 patent/CA2704494A1/en not_active Abandoned
-
2010
- 2010-04-22 IL IL205238A patent/IL205238A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL205238A0 (en) | 2010-11-30 |
| CA2704494A1 (en) | 2009-05-14 |
| AU2008325239A1 (en) | 2009-05-14 |
| KR20100091997A (ko) | 2010-08-19 |
| JP2011502507A (ja) | 2011-01-27 |
| CN101878303B (zh) | 2014-04-30 |
| EP2217702A4 (en) | 2012-05-16 |
| CN101878303A (zh) | 2010-11-03 |
| MX2010004807A (es) | 2010-08-02 |
| US9249408B2 (en) | 2016-02-02 |
| US20090163368A1 (en) | 2009-06-25 |
| US9150849B2 (en) | 2015-10-06 |
| US20110065596A1 (en) | 2011-03-17 |
| JP5513398B2 (ja) | 2014-06-04 |
| EP2217702A2 (en) | 2010-08-18 |
| WO2009061369A2 (en) | 2009-05-14 |
| WO2009061369A3 (en) | 2009-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |