BRPI0819092A2 - Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. - Google Patents
Evolução direcionada usando proteínas que compreendem aminoácidos não naturais.Info
- Publication number
- BRPI0819092A2 BRPI0819092A2 BRPI0819092A BRPI0819092A2 BR PI0819092 A2 BRPI0819092 A2 BR PI0819092A2 BR PI0819092 A BRPI0819092 A BR PI0819092A BR PI0819092 A2 BRPI0819092 A2 BR PI0819092A2
- Authority
- BR
- Brazil
- Prior art keywords
- amino acids
- unnatural amino
- directed evolution
- proteins
- understanding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Ecology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US168107P | 2007-11-02 | 2007-11-02 | |
| US12726208P | 2008-05-08 | 2008-05-08 | |
| US19477308P | 2008-09-29 | 2008-09-29 | |
| PCT/US2008/012363 WO2009061369A2 (en) | 2007-11-02 | 2008-10-31 | Directed evolution using proteins comprising unnatural amino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0819092A2 true BRPI0819092A2 (pt) | 2014-10-14 |
Family
ID=40626380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0819092 BRPI0819092A2 (pt) | 2007-11-02 | 2008-10-31 | Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9150849B2 (pt) |
| EP (1) | EP2217702A4 (pt) |
| JP (1) | JP5513398B2 (pt) |
| KR (1) | KR20100091997A (pt) |
| CN (1) | CN101878303B (pt) |
| AU (1) | AU2008325239A1 (pt) |
| BR (1) | BRPI0819092A2 (pt) |
| CA (1) | CA2704494A1 (pt) |
| IL (1) | IL205238A0 (pt) |
| MX (1) | MX2010004807A (pt) |
| WO (1) | WO2009061369A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2464532T3 (es) * | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| WO2005019415A2 (en) | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| SG10201700096VA (en) | 2009-07-17 | 2017-02-27 | Bioatla Llc | Simultaneous, Integrated Selection And Evolution Of Antibody/Protein Performance And Expression In Production Hosts |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| PE20140160A1 (es) * | 2010-08-17 | 2014-02-08 | Ambrx Inc | Polipeptidos de relaxina modificados y sus usos |
| US8962564B2 (en) | 2010-11-08 | 2015-02-24 | Amicus Therapeutics, Inc. | Variant, recombinant beta-glucocerebrosidase proteins with increased stability and increased retained catalytic activity |
| DE102013106462B3 (de) * | 2013-06-20 | 2014-10-09 | Airbus Defence and Space GmbH | Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein |
| JP6560214B2 (ja) * | 2013-11-20 | 2019-08-14 | ダニスコ・ユーエス・インク | プロテアーゼ開裂に対する感受性を低減した変異体α−アミラーゼ、及びその使用方法 |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| EP3491131B1 (en) * | 2016-07-29 | 2022-05-25 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Targeted in situ protein diversification by site directed dna cleavage and repair |
| SG10201912034UA (en) | 2017-02-08 | 2020-02-27 | Bristol Myers Squibb Co | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| CA3098910A1 (en) | 2018-05-01 | 2019-11-07 | Ambrx, Inc. | A method for optimizing antibody expression |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| WO2020180971A1 (en) * | 2019-03-04 | 2020-09-10 | The Texas A&M University System | Methods of making and utilizing amber-obligated phage display libraries |
| EP4045636A4 (en) * | 2019-10-15 | 2023-11-29 | University of Massachusetts | STRATEGY FOR AAV PRODUCTION USING A CELL LINE EXPRESSING AN INDUCTIBLE REP GENE |
| WO2021164694A1 (zh) * | 2020-02-17 | 2021-08-26 | 中国科学院生物物理研究所 | 抗体筛选方法 |
| WO2024216066A1 (en) * | 2023-04-12 | 2024-10-17 | The Board Of Trustees Of The Leland Stanford Junior University | Orthogonalized human protease |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT100379B (pt) * | 1991-04-10 | 1999-01-29 | Scripps Research Inst | Bibliotecas de receptores heterodimericos usando fagomideos |
| US6190908B1 (en) * | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
| ES2464532T3 (es) * | 2001-04-19 | 2014-06-03 | The Scripps Research Institute | Métodos y composiciones para la producción de pares ortogonales de ARNt-aminoacil-ARNt sintetasa |
| US7329530B2 (en) | 2001-06-15 | 2008-02-12 | Crucell Holland B.V. | Chimaeric phages |
| FI20021726A0 (fi) | 2002-09-27 | 2002-09-27 | Ctt Cancer Targeting Tech Oy | Menetelmä peptidien tuottamiseksi |
| EP1558747B1 (en) | 2002-10-16 | 2009-10-14 | The Scripps Research Institute | Glycoprotein synthesis |
| EP1583816A4 (en) | 2002-12-22 | 2007-06-13 | Scripps Research Inst | PROTEIN ARRAYS |
| JP5642916B2 (ja) | 2003-04-17 | 2014-12-17 | ザ スクリプス リサーチ インスティテュート | 真核遺伝コードの拡張 |
| JP5275566B2 (ja) | 2003-06-18 | 2013-08-28 | ザ スクリプス リサーチ インスティチュート | 反応性非天然アミノ酸遺伝コード付加 |
| WO2005007624A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| EP1704242A4 (en) * | 2003-07-07 | 2008-06-18 | Scripps Research Inst | COMPOSITIONS WITH PAIRS OF ORTHOGONAL LEUCYL-TRNA AND AMINOACYL-TRNA-SYNTHETASE AND USES THEREOF |
| WO2005019415A2 (en) * | 2003-07-07 | 2005-03-03 | The Scripps Research Institute | Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| CN101532046A (zh) | 2003-10-14 | 2009-09-16 | 斯克利普斯研究院 | 将氧化还原活性氨基酸位点特异地掺入蛋白质 |
| CA2549830A1 (en) * | 2003-12-18 | 2006-01-05 | The Scripps Research Institute | Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells |
| CA2567624A1 (en) * | 2004-05-25 | 2005-12-08 | The Scripps Research Institute | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| MX2007003142A (es) * | 2004-09-21 | 2007-07-04 | Scripps Research Inst | Incorporacion in vivo de alquinil aminoacidos a proteinas en eubacterias. |
| US20090181858A1 (en) | 2004-09-21 | 2009-07-16 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| EP1794312A4 (en) * | 2004-09-22 | 2009-08-12 | Scripps Research Inst | LOCAL LABELING OF PROTEINS FOR NMR STUDIES |
| WO2006045116A2 (en) | 2004-10-20 | 2006-04-27 | The Scripps Research Institute | In vivo site-specific incorporation of n-acetyl-galactosamine amino acids in eubacteria |
| KR20080026135A (ko) * | 2005-06-03 | 2008-03-24 | 암브룩스, 인코포레이티드 | 개선된 인간 인터페론 분자 및 이의 용도 |
| AU2006255280A1 (en) * | 2005-06-03 | 2006-12-14 | Ambrx, Inc. | Incorporation of non-naturally encoded amino acids into proteins |
| CA2624290A1 (en) | 2005-10-12 | 2007-04-26 | Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| US20070178554A1 (en) | 2006-02-01 | 2007-08-02 | Nima Shiva | Orthogonal Aminoacyl Synthetase-tRNA Pairs for Incorporating Unnatural Amino Acids Into Proteins |
| US7790847B2 (en) | 2006-03-16 | 2010-09-07 | The Scripps Research Institute | Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine |
| US8114627B2 (en) * | 2006-09-21 | 2012-02-14 | The Scripps Research Institute | Genetically programmed expression of selectively sulfated proteins in eubacteria |
-
2008
- 2008-10-31 US US12/290,673 patent/US9150849B2/en active Active
- 2008-10-31 WO PCT/US2008/012363 patent/WO2009061369A2/en not_active Ceased
- 2008-10-31 KR KR20107011772A patent/KR20100091997A/ko not_active Withdrawn
- 2008-10-31 CN CN200880118668.9A patent/CN101878303B/zh not_active Expired - Fee Related
- 2008-10-31 US US12/734,416 patent/US9249408B2/en active Active
- 2008-10-31 BR BRPI0819092 patent/BRPI0819092A2/pt not_active IP Right Cessation
- 2008-10-31 EP EP20080847822 patent/EP2217702A4/en not_active Withdrawn
- 2008-10-31 JP JP2010533076A patent/JP5513398B2/ja not_active Expired - Fee Related
- 2008-10-31 AU AU2008325239A patent/AU2008325239A1/en not_active Abandoned
- 2008-10-31 MX MX2010004807A patent/MX2010004807A/es not_active Application Discontinuation
- 2008-10-31 CA CA 2704494 patent/CA2704494A1/en not_active Abandoned
-
2010
- 2010-04-22 IL IL205238A patent/IL205238A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100091997A (ko) | 2010-08-19 |
| MX2010004807A (es) | 2010-08-02 |
| JP2011502507A (ja) | 2011-01-27 |
| AU2008325239A1 (en) | 2009-05-14 |
| IL205238A0 (en) | 2010-11-30 |
| WO2009061369A2 (en) | 2009-05-14 |
| EP2217702A4 (en) | 2012-05-16 |
| US9150849B2 (en) | 2015-10-06 |
| CN101878303A (zh) | 2010-11-03 |
| US20090163368A1 (en) | 2009-06-25 |
| CA2704494A1 (en) | 2009-05-14 |
| US20110065596A1 (en) | 2011-03-17 |
| JP5513398B2 (ja) | 2014-06-04 |
| EP2217702A2 (en) | 2010-08-18 |
| WO2009061369A3 (en) | 2009-09-03 |
| US9249408B2 (en) | 2016-02-02 |
| CN101878303B (zh) | 2014-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |