BRPI0819092A2 - Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. - Google Patents
Evolução direcionada usando proteínas que compreendem aminoácidos não naturais.Info
- Publication number
- BRPI0819092A2 BRPI0819092A2 BRPI0819092A BRPI0819092A2 BR PI0819092 A2 BRPI0819092 A2 BR PI0819092A2 BR PI0819092 A BRPI0819092 A BR PI0819092A BR PI0819092 A2 BRPI0819092 A2 BR PI0819092A2
- Authority
- BR
- Brazil
- Prior art keywords
- amino acids
- unnatural amino
- directed evolution
- proteins
- understanding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Ecology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US168107P | 2007-11-02 | 2007-11-02 | |
| US12726208P | 2008-05-08 | 2008-05-08 | |
| US19477308P | 2008-09-29 | 2008-09-29 | |
| PCT/US2008/012363 WO2009061369A2 (en) | 2007-11-02 | 2008-10-31 | Directed evolution using proteins comprising unnatural amino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0819092A2 true BRPI0819092A2 (pt) | 2014-10-14 |
Family
ID=40626380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0819092 BRPI0819092A2 (pt) | 2007-11-02 | 2008-10-31 | Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9249408B2 (pt) |
| EP (1) | EP2217702A4 (pt) |
| JP (1) | JP5513398B2 (pt) |
| KR (1) | KR20100091997A (pt) |
| CN (1) | CN101878303B (pt) |
| AU (1) | AU2008325239A1 (pt) |
| BR (1) | BRPI0819092A2 (pt) |
| CA (1) | CA2704494A1 (pt) |
| IL (1) | IL205238A0 (pt) |
| MX (1) | MX2010004807A (pt) |
| WO (1) | WO2009061369A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL158418A0 (en) * | 2001-04-19 | 2004-05-12 | Scripps Research Inst | In vivo incorporation of unnatural amino acids |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| EP1666604B1 (en) * | 2003-07-07 | 2008-02-13 | The Scripps Research Institute | Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof |
| AU2010273974B2 (en) | 2009-07-17 | 2016-01-14 | Bioatla, Llc | Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| SMT201900495T1 (it) | 2010-08-17 | 2019-11-13 | Ambrx Inc | Polipeptidi di relaxina modificati e loro usi |
| HUE030932T2 (en) | 2010-11-08 | 2017-06-28 | Amicus Therapeutics Inc | Increased stability and increased catalytic activity, altered, recombinant, β-glucocerebrosidase proteins |
| DE102013106462B3 (de) * | 2013-06-20 | 2014-10-09 | Airbus Defence and Space GmbH | Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein |
| JP6560214B2 (ja) * | 2013-11-20 | 2019-08-14 | ダニスコ・ユーエス・インク | プロテアーゼ開裂に対する感受性を低減した変異体α−アミラーゼ、及びその使用方法 |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| WO2018020050A1 (en) | 2016-07-29 | 2018-02-01 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Targeted in situ protein diversification by site directed dna cleavage and repair |
| US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| KR20210005172A (ko) | 2018-05-01 | 2021-01-13 | 암브룩스, 인코포레이티드 | 항체 발현을 최적화하는 방법 |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| CN113785058B (zh) * | 2019-03-04 | 2024-12-24 | 得克萨斯A&M大学系统 | 制作和利用琥珀专性的噬菌体展示文库的方法 |
| WO2021076634A1 (en) * | 2019-10-15 | 2021-04-22 | University Of Massachusetts | Aav production strategy using a cell line expressing an inducible rep gene |
| CN115485286B (zh) * | 2020-02-17 | 2026-01-16 | 南通壹宸生物医药科技有限公司 | 基于光交联的表位靶向抗体筛选方法 |
| WO2024216066A1 (en) * | 2023-04-12 | 2024-10-17 | The Board Of Trustees Of The Leland Stanford Junior University | Orthogonalized human protease |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU662148B2 (en) * | 1991-04-10 | 1995-08-24 | Scripps Research Institute, The | Heterodimeric receptor libraries using phagemids |
| US6190908B1 (en) * | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
| IL158418A0 (en) * | 2001-04-19 | 2004-05-12 | Scripps Research Inst | In vivo incorporation of unnatural amino acids |
| DK1402025T3 (da) | 2001-06-15 | 2006-06-06 | Crucell Holland Bv | Kimære fager |
| FI20021726A0 (fi) | 2002-09-27 | 2002-09-27 | Ctt Cancer Targeting Tech Oy | Menetelmä peptidien tuottamiseksi |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| MXPA05006836A (es) * | 2002-12-22 | 2005-08-16 | Scripps Research Inst | Colecciones ordenadas de proteinas. |
| CN103289960B (zh) | 2003-04-17 | 2017-04-26 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| BRPI0411475A (pt) * | 2003-06-18 | 2006-07-25 | Scripps Research Inst | adições de código genético de aminoácido reativo não natural |
| WO2005007624A2 (en) * | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof |
| US20060160175A1 (en) | 2003-07-07 | 2006-07-20 | The Scripps Research Institute | Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof |
| EP1666604B1 (en) * | 2003-07-07 | 2008-02-13 | The Scripps Research Institute | Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof |
| JP5657850B2 (ja) * | 2003-10-14 | 2015-01-21 | ザ スクリプス リサーチ インスティテュート | 酸化還元機能性アミノ酸のタンパク質への部位特異的組み入れ |
| US7709604B2 (en) | 2003-12-18 | 2010-05-04 | The Scripps Research Institute | Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells |
| AU2005248392A1 (en) | 2004-05-25 | 2005-12-08 | Irm, Llc | Site specific incorporation of heavy atom-containing unnatural amino acids into proteins for crystal structure determination |
| US20060134746A1 (en) | 2004-09-21 | 2006-06-22 | The Scripps Research Institute | Adding photoregulated amino acids to the genetic code |
| US7718410B2 (en) | 2004-09-21 | 2010-05-18 | The Scripps Research Institute | In vivo incorporation of alkynyl amino acids into proteins in eubacteria |
| WO2006036779A2 (en) | 2004-09-22 | 2006-04-06 | The Scripps Research Institute | Site-specific labeling of proteins for nmr studies |
| US7378263B2 (en) | 2004-10-20 | 2008-05-27 | The Scripps Research Institute | In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria |
| WO2006133088A2 (en) * | 2005-06-03 | 2006-12-14 | Ambrx, Inc. | Improved human interferon molecules and their uses |
| WO2006132969A2 (en) * | 2005-06-03 | 2006-12-14 | Ambrx, Inc. | Incorporation of non-naturally encoded amino acids into proteins |
| US8367588B2 (en) | 2005-10-12 | 2013-02-05 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| US20070178554A1 (en) * | 2006-02-01 | 2007-08-02 | Nima Shiva | Orthogonal Aminoacyl Synthetase-tRNA Pairs for Incorporating Unnatural Amino Acids Into Proteins |
| BRPI0709603A2 (pt) * | 2006-03-16 | 2011-07-19 | Scripps Research Inst | expressão de proteìnas geneticamente programada contendo o aminoácido não natural fenilselenocisteìna |
| RU2009110152A (ru) * | 2006-09-21 | 2010-10-27 | Зе Скрипс Ресеч Инститьют (Us) | Генетически закодированная формула селективно-сульфатных белков в эубактерии |
-
2008
- 2008-10-31 US US12/734,416 patent/US9249408B2/en active Active
- 2008-10-31 CA CA 2704494 patent/CA2704494A1/en not_active Abandoned
- 2008-10-31 KR KR20107011772A patent/KR20100091997A/ko not_active Withdrawn
- 2008-10-31 AU AU2008325239A patent/AU2008325239A1/en not_active Abandoned
- 2008-10-31 MX MX2010004807A patent/MX2010004807A/es not_active Application Discontinuation
- 2008-10-31 WO PCT/US2008/012363 patent/WO2009061369A2/en not_active Ceased
- 2008-10-31 BR BRPI0819092 patent/BRPI0819092A2/pt not_active IP Right Cessation
- 2008-10-31 US US12/290,673 patent/US9150849B2/en active Active
- 2008-10-31 EP EP20080847822 patent/EP2217702A4/en not_active Withdrawn
- 2008-10-31 CN CN200880118668.9A patent/CN101878303B/zh not_active Expired - Fee Related
- 2008-10-31 JP JP2010533076A patent/JP5513398B2/ja not_active Expired - Fee Related
-
2010
- 2010-04-22 IL IL205238A patent/IL205238A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009061369A2 (en) | 2009-05-14 |
| US9249408B2 (en) | 2016-02-02 |
| CN101878303A (zh) | 2010-11-03 |
| KR20100091997A (ko) | 2010-08-19 |
| US20090163368A1 (en) | 2009-06-25 |
| IL205238A0 (en) | 2010-11-30 |
| EP2217702A2 (en) | 2010-08-18 |
| AU2008325239A1 (en) | 2009-05-14 |
| WO2009061369A3 (en) | 2009-09-03 |
| JP5513398B2 (ja) | 2014-06-04 |
| CN101878303B (zh) | 2014-04-30 |
| US9150849B2 (en) | 2015-10-06 |
| EP2217702A4 (en) | 2012-05-16 |
| MX2010004807A (es) | 2010-08-02 |
| CA2704494A1 (en) | 2009-05-14 |
| JP2011502507A (ja) | 2011-01-27 |
| US20110065596A1 (en) | 2011-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |