BRPI0819975A2 - Processo para redução dos efeitos da doença de enxerto contra hospedeiros com o uso de células t reguladoras cd4+cd25+ expandidas ex vivo - Google Patents

Processo para redução dos efeitos da doença de enxerto contra hospedeiros com o uso de células t reguladoras cd4+cd25+ expandidas ex vivo

Info

Publication number
BRPI0819975A2
BRPI0819975A2 BRPI0819975-2A BRPI0819975A BRPI0819975A2 BR PI0819975 A2 BRPI0819975 A2 BR PI0819975A2 BR PI0819975 A BRPI0819975 A BR PI0819975A BR PI0819975 A2 BRPI0819975 A2 BR PI0819975A2
Authority
BR
Brazil
Prior art keywords
regulatory
cells
reducing
effects
host disease
Prior art date
Application number
BRPI0819975-2A
Other languages
English (en)
Inventor
Tinghua Cao
Li Li
Original Assignee
Therakos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Therakos Inc filed Critical Therakos Inc
Publication of BRPI0819975A2 publication Critical patent/BRPI0819975A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22—Immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/418—Antigens related to induction of tolerance to non-self
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0819975-2A 2007-11-30 2008-12-01 Processo para redução dos efeitos da doença de enxerto contra hospedeiros com o uso de células t reguladoras cd4+cd25+ expandidas ex vivo BRPI0819975A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99130107P 2007-11-30 2007-11-30
US99234707P 2007-12-05 2007-12-05
PCT/US2008/085117 WO2009073599A1 (en) 2007-11-30 2008-12-01 Process for reducing effects of graft versus host disease using ex vivo expanded cd4+cd25+ regulatory t cells

Publications (1)

Publication Number Publication Date
BRPI0819975A2 true BRPI0819975A2 (pt) 2015-06-16

Family

ID=40394411

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0819975-2A BRPI0819975A2 (pt) 2007-11-30 2008-12-01 Processo para redução dos efeitos da doença de enxerto contra hospedeiros com o uso de células t reguladoras cd4+cd25+ expandidas ex vivo

Country Status (9)

Country Link
US (1) US20090142317A1 (pt)
EP (1) EP2225365A1 (pt)
JP (1) JP2011505378A (pt)
KR (1) KR20100094997A (pt)
CN (1) CN101970643A (pt)
BR (1) BRPI0819975A2 (pt)
CA (1) CA2706458A1 (pt)
MX (1) MX2010005863A (pt)
WO (1) WO2009073599A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106110326A (zh) 2011-10-12 2016-11-16 思佰益药业股份有限公司 移植器官的成活促进剂
WO2013131045A1 (en) 2012-03-02 2013-09-06 The Regents Of The University Of California Expansion of alloantigen-reactive regulatory t cells
WO2013168876A1 (ko) 2012-05-11 2013-11-14 가톨릭대학교 산학협력단 이식 후 면역 상태를 모니터링 하는 키트 및 이를 이용한 면역 상태의 모니터링 방법
WO2014010206A1 (ja) 2012-07-13 2014-01-16 Ｓｂｉファーマ株式会社 免疫寛容誘導剤
EP3028046B1 (en) * 2013-07-31 2020-10-07 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and kits for identifying effector treg cells
KR102769850B1 (ko) 2015-07-03 2025-02-20 인스티튜트 내셔날 드 라 싼테 에 드 라 리셰르셰 메디칼르 조절 t 세포를 수득하는 방법 및 이의 용도
EP3216861A1 (en) * 2016-03-11 2017-09-13 Fropharm GmbH Immunoregulatory cells and methods for their production
CN107164324B (zh) * 2017-07-17 2020-03-27 沃昕生物科技(深圳)有限公司 一种脐血Treg细胞的体外扩增方法
AU2019287370A1 (en) * 2018-06-14 2021-01-07 4D Pharma Research Ltd Compositions comprising bacterial strains
WO2021069754A1 (en) * 2019-10-11 2021-04-15 Kuopio Center for Gene and Cell Therapy Oy New regulatory macrophages and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007538000A (ja) * 2004-01-08 2007-12-27 リージエンツ・オブ・ザ・ユニバーシテイ・オブ・カリフオルニア 制御性ｔ細胞は自己免疫を抑制する
CA2585462A1 (en) * 2004-10-29 2006-05-11 Benaroya Research Institute At Virginia Mason Methods of generating antigen-specific cd4+cd25+ regulatory t cells, compositions and methods of use
US8323969B2 (en) * 2007-05-18 2012-12-04 University Of Kansas Preparation of regulatory T cells using ICAM-1 co-stimulation

Also Published As

Publication number Publication date
CN101970643A (zh) 2011-02-09
JP2011505378A (ja) 2011-02-24
WO2009073599A1 (en) 2009-06-11
MX2010005863A (es) 2010-06-23
US20090142317A1 (en) 2009-06-04
CA2706458A1 (en) 2009-06-11
KR20100094997A (ko) 2010-08-27
EP2225365A1 (en) 2010-09-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B15K Others concerning applications: alteration of classification

Free format text: PROCEDIMENTO AUTOMATICO DE RECLASSIFICACAO. AS CLASSIFICACOES IPC ANTERIORES ERAM: C12N 5/08; A61K 38/14.

Ipc: A61K 39/00 (2006.01), A61K 38/14 (2006.01)

Ipc: A61K 39/00 (2006.01), A61K 38/14 (2006.01)