BRPI0820043A2 - Novos ativadores do receptor de vitamina d e métodos de fabricação - Google Patents

Novos ativadores do receptor de vitamina d e métodos de fabricação

Info

Publication number: BRPI0820043A2
Authority: BR; Brazil
Prior art keywords: manufacturing methods; receptor activators; new vitamin; vitamin; new
Prior art date: 2007-11-20

Application number

BRPI0820043-2A

Other languages

English (en)

Inventor

Thomas W Von Geldern

Jufang H Barkalow

David M Barnes

Anthony R Haight

John E Hengeveld

Xiaofeng Li

Maureen A Mclaughlin

William T Noonan

Zhonghua Pei

Jinshyun Ruth Wu-Wong

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-11-20

Filing date

2008-11-20

Publication date

2015-05-12

2008-11-20 Application filed by Abbott Lab filed Critical Abbott Lab

2015-05-12 Publication of BRPI0820043A2 publication Critical patent/BRPI0820043A2/pt

2016-03-08 Publication of BRPI0820043A8 publication Critical patent/BRPI0820043A8/pt

Links

239000012190 activator Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
102000009310 vitamin D receptors Human genes 0.000 title 1
108050000156 vitamin D receptors Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C27/00—Processes involving the simultaneous production of more than one class of oxygen-containing compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Neurology (AREA)
Emergency Medicine (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0820043A 2007-11-20 2008-11-20 Atividades do receptor de vitamina d e seus usos BRPI0820043A8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US98916707P	2007-11-20	2007-11-20
US12/205,998 US8377913B2 (en)	2007-11-20	2008-09-08	Vitamin D receptor activators and methods of making
PCT/US2008/084142 WO2009067578A2 (en)	2007-11-20	2008-11-20	New vitamin d receptor activators and methods of making

Publications (2)

Publication Number	Publication Date
BRPI0820043A2 true BRPI0820043A2 (pt)	2015-05-12
BRPI0820043A8 BRPI0820043A8 (pt)	2016-03-08

Family

ID=40642621

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0820043A BRPI0820043A8 (pt)	2007-11-20	2008-11-20	Atividades do receptor de vitamina d e seus usos

Country Status (14)

Country	Link
US (1)	US8377913B2 (pt)
EP (1)	EP2222635A2 (pt)
JP (1)	JP5544298B2 (pt)
KR (1)	KR101643199B1 (pt)
CN (2)	CN101918358B (pt)
AU (1)	AU2008326359A1 (pt)
BR (1)	BRPI0820043A8 (pt)
CA (1)	CA2705987A1 (pt)
IL (1)	IL205764A (pt)
MX (1)	MX2010005530A (pt)
RU (1)	RU2535448C2 (pt)
TW (1)	TWI483728B (pt)
WO (1)	WO2009067578A2 (pt)
ZA (1)	ZA201003324B (pt)

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WO2010120698A1 (en) *	2009-04-17	2010-10-21	Vidasym, Llc	Vitamin d receptor agonists and uses thereof
JP5931845B2 (ja) *	2010-03-23	2016-06-08	ウイスコンシンアラムニリサーチファンデーション	２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー
AU2011232633B2 (en) *	2010-03-23	2014-05-29	Wisconsin Alumni Research Foundation	(20S)-2-methylene-19-nor-22-dimethyl-1alpha,25- dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22- dimethyl-1alpha,25-hydroxyvitamin D3
JP6035331B2 (ja) *	2011-06-14	2016-11-30	ウイスコンシンアラムニリサーチファンデーション	３−デスオキシ−２−メチレン−１９−ノル−ビタミンｄ類似体およびそれらの使用
US8410080B1 (en) *	2011-10-21	2013-04-02	Wisconsin Alumni Research Foundation	2-methylene-vitamin D analogs and their uses
JP6971966B2 (ja) *	2015-08-05	2021-11-24	ウイスコンシンアラムニリサーチファンデーション	カルシトリオールの２−メチレン類似体および関連化合物の合成および生物活性
CN105732307B (zh) *	2016-01-28	2019-04-19	科贝源(北京)生物医药科技有限公司	马沙骨化醇中间体的合成方法
EP4732889A2 (en)	2017-06-07	2026-04-29	Supira Medical, Inc.	Intravascular fluid movement devices, systems, and methods of use
US11511103B2 (en)	2017-11-13	2022-11-29	Shifamed Holdings, Llc	Intravascular fluid movement devices, systems, and methods of use
JP7410034B2 (ja)	2018-02-01	2024-01-09	シファメド・ホールディングス・エルエルシー	血管内血液ポンプならびに使用および製造の方法
WO2020028537A1 (en)	2018-07-31	2020-02-06	Shifamed Holdings, Llc	Intravascaular blood pumps and methods of use
WO2020073047A1 (en)	2018-10-05	2020-04-09	Shifamed Holdings, Llc	Intravascular blood pumps and methods of use
WO2021011473A1 (en)	2019-07-12	2021-01-21	Shifamed Holdings, Llc	Intravascular blood pumps and methods of manufacture and use
US11654275B2 (en)	2019-07-22	2023-05-23	Shifamed Holdings, Llc	Intravascular blood pumps with struts and methods of use and manufacture
EP4010046A4 (en)	2019-08-07	2023-08-30	Calomeni, Michael	Catheter blood pumps and collapsible pump housings
EP4034221B1 (en)	2019-09-25	2024-11-13	Shifamed Holdings, LLC	Catheter blood pumps and collapsible pump housings
EP4034192B1 (en)	2019-09-25	2025-12-24	Supira Medical, Inc.	Intravascular blood pump systems and methods of use and control thereof
WO2021062260A1 (en)	2019-09-25	2021-04-01	Shifamed Holdings, Llc	Catheter blood pumps and collapsible blood conduits
WO2021107646A1 (ko) *	2019-11-27	2021-06-03	연성정밀화학(주)	막사칼시톨의 제조방법 및 그를 위한 중간체
EP4072650A4 (en)	2019-12-11	2024-01-10	Shifamed Holdings, LLC	Descending aorta and vena cava blood pumps
US12599758B2 (en)	2019-12-19	2026-04-14	Shifamed Holdings, Llc	Intravascular blood pumps, motors, and fluid control
KR20250038868A (ko) *	2023-09-12	2025-03-20	(주) 수파드엘릭사	비타민 ｄ 수용체 활성화 펩타이드 및 이를 포함하는 화장료 조성물

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PE28297A1 (es) *	1995-01-26	1997-08-20	Hoffmann La Roche	Empleo dermatologico de derivados de vitamina d
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KR100494205B1 (ko) *	1996-06-04	2005-11-08	레오 파마 에이/에스	신규한비타민d동족체
GB9611603D0 (en) *	1996-06-04	1996-08-07	Leo Pharm Prod Ltd	Chemical compounds
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US6894037B2 (en)	2003-07-03	2005-05-17	Wisconsin Alumni Research Foundation	2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses
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2008
- 2008-09-08 US US12/205,998 patent/US8377913B2/en not_active Expired - Fee Related
- 2008-11-20 CA CA2705987A patent/CA2705987A1/en not_active Abandoned
- 2008-11-20 CN CN200880125199.3A patent/CN101918358B/zh not_active Expired - Fee Related
- 2008-11-20 WO PCT/US2008/084142 patent/WO2009067578A2/en not_active Ceased
- 2008-11-20 MX MX2010005530A patent/MX2010005530A/es active IP Right Grant
- 2008-11-20 AU AU2008326359A patent/AU2008326359A1/en not_active Abandoned
- 2008-11-20 RU RU2010125131/04A patent/RU2535448C2/ru not_active IP Right Cessation
- 2008-11-20 CN CN201310597846.3A patent/CN104211626A/zh active Pending
- 2008-11-20 BR BRPI0820043A patent/BRPI0820043A8/pt not_active IP Right Cessation
- 2008-11-20 EP EP08851351A patent/EP2222635A2/en not_active Withdrawn
- 2008-11-20 KR KR1020107013438A patent/KR101643199B1/ko not_active Expired - Fee Related
- 2008-11-20 TW TW097144952A patent/TWI483728B/zh not_active IP Right Cessation
- 2008-11-20 JP JP2010535053A patent/JP5544298B2/ja not_active Expired - Fee Related
2010
- 2010-05-11 ZA ZA2010/03324A patent/ZA201003324B/en unknown
- 2010-05-13 IL IL205764A patent/IL205764A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
BRPI0820043A8 (pt)	2016-03-08
TWI483728B (zh)	2015-05-11
CN104211626A (zh)	2014-12-17
US8377913B2 (en)	2013-02-19
MX2010005530A (es)	2010-06-02
CN101918358A (zh)	2010-12-15
IL205764A0 (en)	2010-11-30
EP2222635A2 (en)	2010-09-01
JP2011504180A (ja)	2011-02-03
IL205764A (en)	2014-12-31
US20090131379A1 (en)	2009-05-21
WO2009067578A3 (en)	2009-11-26
RU2535448C2 (ru)	2014-12-10
TW200934502A (en)	2009-08-16
WO2009067578A2 (en)	2009-05-28
KR20100099181A (ko)	2010-09-10
JP5544298B2 (ja)	2014-07-09
KR101643199B1 (ko)	2016-07-27
ZA201003324B (en)	2011-10-26
AU2008326359A1 (en)	2009-05-28
RU2010125131A (ru)	2011-12-27
CN101918358B (zh)	2015-10-14
CA2705987A1 (en)	2009-05-28

Legal Events

Date	Code	Title	Description
2016-03-08	B25A	Requested transfer of rights approved	Owner name: ABBVIE INC. (US)
2017-09-19	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2018-01-09	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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