BRPI0820494A8 - Métodos para preparar capecitabina e composto de carbonato de trialquila rico em beta-anômero usado no mesmo - Google Patents

Métodos para preparar capecitabina e composto de carbonato de trialquila rico em beta-anômero usado no mesmo

Info

Publication number
BRPI0820494A8
BRPI0820494A8 BRPI0820494A BRPI0820494A BRPI0820494A8 BR PI0820494 A8 BRPI0820494 A8 BR PI0820494A8 BR PI0820494 A BRPI0820494 A BR PI0820494A BR PI0820494 A BRPI0820494 A BR PI0820494A BR PI0820494 A8 BRPI0820494 A8 BR PI0820494A8
Authority
BR
Brazil
Prior art keywords
preparing
carbonate compound
compound used
capecitabin
beta
Prior art date
Application number
BRPI0820494A
Other languages
English (en)
Inventor
Lee Jaeheon
Park Gha-Seung
Ki Yang Weon
Hee Kim Jin
Hyun Park Cheol
An Yong-Hoon
Ju Lee Yoon
Chang Young-Kil
Sun Lee Gwan
Original Assignee
Hanmi Pharm Ind Co Ltd
Hanmi Holdings Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd, Hanmi Holdings Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of BRPI0820494A2 publication Critical patent/BRPI0820494A2/pt
Publication of BRPI0820494A8 publication Critical patent/BRPI0820494A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

MÉTODOS PARA PREPARAR CAPECITABINA E COMPOSTO DE CARBONATO DE TRIALQUILA RICO EM BETA-ANÔMERO USADO NO MESMO. A presente invenção refere-se a um método para preparar capecitabina e um método para preparar um composto de carbonato de trialquila rico em B-anômero usado aqui, e uma capecitabina altamente pura pode ser eficientemente preparada com uma produção elevada pelo método da presente invenção usando o composto de carbonato de trialquila rico em B-anômero como um intermediário.
BRPI0820494A 2007-11-19 2008-11-07 Métodos para preparar capecitabina e composto de carbonato de trialquila rico em beta-anômero usado no mesmo BRPI0820494A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020070118062A KR101013312B1 (ko) 2007-11-19 2007-11-19 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법
PCT/KR2008/006565 WO2009066892A1 (en) 2007-11-19 2008-11-07 Methods for preparing capecitabine and beta-anomer-rich trialkyl carbonate compound used therein

Publications (2)

Publication Number Publication Date
BRPI0820494A2 BRPI0820494A2 (pt) 2015-06-16
BRPI0820494A8 true BRPI0820494A8 (pt) 2015-11-03

Family

ID=40667680

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0820494A BRPI0820494A8 (pt) 2007-11-19 2008-11-07 Métodos para preparar capecitabina e composto de carbonato de trialquila rico em beta-anômero usado no mesmo

Country Status (18)

Country Link
US (1) US8097706B2 (pt)
EP (1) EP2220090A4 (pt)
JP (1) JP2011503228A (pt)
KR (1) KR101013312B1 (pt)
CN (1) CN101861320A (pt)
AR (1) AR069319A1 (pt)
AU (1) AU2008327061B2 (pt)
BR (1) BRPI0820494A8 (pt)
CA (1) CA2704815C (pt)
CL (1) CL2008003386A1 (pt)
IL (1) IL205832A0 (pt)
MX (1) MX2010005015A (pt)
NZ (1) NZ585129A (pt)
PE (1) PE20091358A1 (pt)
RU (1) RU2439064C1 (pt)
TW (1) TWI356061B (pt)
WO (1) WO2009066892A1 (pt)
ZA (1) ZA201003216B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102858791A (zh) * 2009-07-23 2013-01-02 台湾神隆股份有限公司 制备氟胞苷衍生物的方法
CN102516338B (zh) * 2011-12-09 2014-04-02 海南锦瑞制药股份有限公司 一种卡培他滨化合物、其药物组合物及其制备方法
CN103374052B (zh) * 2012-04-19 2016-04-20 齐鲁制药有限公司 卡培他滨晶型及其制备方法
US10435429B2 (en) 2017-10-03 2019-10-08 Nucorion Pharmaceuticals, Inc. 5-fluorouridine monophosphate cyclic triester compounds
AU2019207626B2 (en) 2018-01-10 2023-10-05 Nucorion Pharmaceuticals, Inc. Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
US11427550B2 (en) 2018-01-19 2022-08-30 Nucorion Pharmaceuticals, Inc. 5-fluorouracil compounds
CN111801339B (zh) * 2018-01-19 2025-06-24 纽科利制药公司 5-氟尿嘧啶化合物
WO2021011692A1 (en) 2019-07-17 2021-01-21 Nucorion Pharmaceuticals, Inc. Cyclic deoxyribonucleotide compounds
EP4143199B1 (en) 2020-04-21 2025-11-19 Ligand Pharmaceuticals, Inc. Nucleotide prodrug compounds
WO2021216431A1 (en) 2020-04-21 2021-10-28 Ligand Pharmaceuticals, Inc. Benzyloxy phosph(on)ate compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1135258A (en) 1979-06-15 1982-11-09 Richard D'souza Process for the preparation of 5'deoxy-5-fluorouridine
US5272949A (en) 1992-09-23 1993-12-28 Buckeye Bluegrass Farms, Inc. Device for cutting sod grown over plastic sheeting
AU671491B2 (en) 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
TW254946B (pt) 1992-12-18 1995-08-21 Hoffmann La Roche
US5476932A (en) 1994-08-26 1995-12-19 Hoffmann-La Roche Inc. Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
KR100908363B1 (ko) * 2007-02-28 2009-07-20 한미약품 주식회사 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법

Also Published As

Publication number Publication date
KR20090051595A (ko) 2009-05-22
KR101013312B1 (ko) 2011-02-09
EP2220090A1 (en) 2010-08-25
EP2220090A4 (en) 2011-03-16
US8097706B2 (en) 2012-01-17
NZ585129A (en) 2011-11-25
PE20091358A1 (es) 2009-09-23
ZA201003216B (en) 2011-07-27
RU2439064C1 (ru) 2012-01-10
TW200927754A (en) 2009-07-01
IL205832A0 (en) 2010-11-30
CL2008003386A1 (es) 2009-04-13
AU2008327061A1 (en) 2009-05-28
CN101861320A (zh) 2010-10-13
AR069319A1 (es) 2010-01-13
AU2008327061B2 (en) 2011-03-24
WO2009066892A1 (en) 2009-05-28
JP2011503228A (ja) 2011-01-27
TWI356061B (en) 2012-01-11
US20100249395A1 (en) 2010-09-30
MX2010005015A (es) 2010-05-27
CA2704815C (en) 2012-03-13
CA2704815A1 (en) 2009-05-28
BRPI0820494A2 (pt) 2015-06-16

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: HANMI HOLDINGS CO., LTD. (KR)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.