BRPI0820519A2 - intermediário para a síntese do análogo de halicondrina b e reação de dessulfonilação usada para o intermediário - Google Patents
intermediário para a síntese do análogo de halicondrina b e reação de dessulfonilação usada para o intermediárioInfo
- Publication number
- BRPI0820519A2 BRPI0820519A2 BRPI0820519A BRPI0820519A BRPI0820519A2 BR PI0820519 A2 BRPI0820519 A2 BR PI0820519A2 BR PI0820519 A BRPI0820519 A BR PI0820519A BR PI0820519 A BRPI0820519 A BR PI0820519A BR PI0820519 A2 BRPI0820519 A2 BR PI0820519A2
- Authority
- BR
- Brazil
- Prior art keywords
- halicondrin
- analogue
- synthesis
- reaction used
- desulfonylation reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98849607P | 2007-11-16 | 2007-11-16 | |
| JP2007298074 | 2007-11-16 | ||
| PCT/JP2008/071167 WO2009064029A1 (en) | 2007-11-16 | 2008-11-14 | Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0820519A2 true BRPI0820519A2 (pt) | 2017-05-23 |
Family
ID=40344710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0820519A BRPI0820519A2 (pt) | 2007-11-16 | 2008-11-14 | intermediário para a síntese do análogo de halicondrina b e reação de dessulfonilação usada para o intermediário |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090203771A1 (pt) |
| EP (1) | EP2220094A1 (pt) |
| JP (1) | JP5134686B2 (pt) |
| CN (1) | CN101910180A (pt) |
| BR (1) | BRPI0820519A2 (pt) |
| CA (1) | CA2705383A1 (pt) |
| IL (1) | IL205761A0 (pt) |
| MX (1) | MX2010005340A (pt) |
| RU (1) | RU2010118063A (pt) |
| WO (1) | WO2009064029A1 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4454151B2 (ja) | 1998-06-17 | 2010-04-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 大環状類似体及びそれらの使用並びに調製方法 |
| SI2522663T1 (sl) | 2004-06-03 | 2015-08-31 | Eisai R&D Management Co., Ltd. | Vmesne spojine za pripravo halihondrina B |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| CA2720632C (en) | 2008-04-04 | 2016-12-20 | Eisai R&D Management Co., Ltd. | Halichondrin b analogs |
| RU2579511C2 (ru) | 2010-01-26 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные фуро[3,2-в]пирана, применимые в синтезе аналогов |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| BR112016009452B1 (pt) | 2013-11-04 | 2022-06-07 | Eisai R&D Management Co., Ltd | Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários |
| EP3077399B1 (en) | 2013-12-06 | 2019-02-20 | Eisai R&D Management Co., Ltd. | Methods useful in the synthesis of halichondrin b analogs |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| JP2017206439A (ja) * | 2014-08-27 | 2017-11-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ホモジナイザーを用いる抗腫瘍剤の製造方法 |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| MX392296B (es) | 2015-05-07 | 2025-03-24 | Eisai R&D Man Co Ltd | Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina. |
| CN108601760A (zh) | 2016-02-12 | 2018-09-28 | 卫材R&D管理有限公司 | 艾日布林的合成中的中间体及相关的合成方法 |
| KR102404629B1 (ko) | 2016-06-30 | 2022-06-02 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 중간체 |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| SMT202200455T1 (it) | 2017-04-05 | 2023-01-13 | Harvard College | Composto macrociclico e relativi usi |
| CN106946906A (zh) * | 2017-05-05 | 2017-07-14 | 重庆泰濠制药有限公司 | 一种化合物及其制备方法和应用 |
| WO2018217894A1 (en) * | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| WO2019010363A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | HALICHONDRINES SYNTHESIS |
| WO2019099646A1 (en) | 2017-11-15 | 2019-05-23 | President And Fellows Of Harvard College | Macrocyclic compounds and uses thereof |
| IL275729B2 (en) | 2018-01-03 | 2023-09-01 | Eisai R&D Man Co Ltd | Prins reaction and compounds useful in the synthesis of helicondrin macrolides and their analogs |
| US11447499B2 (en) | 2019-06-14 | 2022-09-20 | Rk Pharma Inc. | Process for the preparation of eribulin mesylate intermediate |
| US12247239B2 (en) | 2019-06-21 | 2025-03-11 | Council Of Scientific & Industrial Research | Chemo-enzymatic process for the preparation of homopropargylic alcohol |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2522663T1 (sl) * | 2004-06-03 | 2015-08-31 | Eisai R&D Management Co., Ltd. | Vmesne spojine za pripravo halihondrina B |
-
2008
- 2008-11-14 CN CN2008801240310A patent/CN101910180A/zh active Pending
- 2008-11-14 EP EP08850157A patent/EP2220094A1/en not_active Withdrawn
- 2008-11-14 RU RU2010118063/04A patent/RU2010118063A/ru unknown
- 2008-11-14 MX MX2010005340A patent/MX2010005340A/es not_active Application Discontinuation
- 2008-11-14 US US12/271,731 patent/US20090203771A1/en not_active Abandoned
- 2008-11-14 JP JP2010519043A patent/JP5134686B2/ja not_active Expired - Fee Related
- 2008-11-14 WO PCT/JP2008/071167 patent/WO2009064029A1/en not_active Ceased
- 2008-11-14 CA CA2705383A patent/CA2705383A1/en not_active Abandoned
- 2008-11-14 BR BRPI0820519A patent/BRPI0820519A2/pt not_active IP Right Cessation
-
2010
- 2010-05-13 IL IL205761A patent/IL205761A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010118063A (ru) | 2011-12-27 |
| EP2220094A1 (en) | 2010-08-25 |
| JP2011504166A (ja) | 2011-02-03 |
| CN101910180A (zh) | 2010-12-08 |
| MX2010005340A (es) | 2010-12-21 |
| US20090203771A1 (en) | 2009-08-13 |
| IL205761A0 (en) | 2010-11-30 |
| JP5134686B2 (ja) | 2013-01-30 |
| WO2009064029A1 (en) | 2009-05-22 |
| CA2705383A1 (en) | 2009-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |