BRPI0820738A2 - Separação específica do gênero de células de esperma e embriões - Google Patents

Separação específica do gênero de células de esperma e embriões

Info

Publication number
BRPI0820738A2
BRPI0820738A2 BRPI0820738-0A BRPI0820738A BRPI0820738A2 BR PI0820738 A2 BRPI0820738 A2 BR PI0820738A2 BR PI0820738 A BRPI0820738 A BR PI0820738A BR PI0820738 A2 BRPI0820738 A2 BR PI0820738A2
Authority
BR
Brazil
Prior art keywords
sperm
gender
embryo cells
specific separation
separation
Prior art date
Application number
BRPI0820738-0A
Other languages
English (en)
Inventor
Bradley Didion
Whitney Erwin
Reiner Bleher
Original Assignee
Minitube America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minitube America Inc filed Critical Minitube America Inc
Publication of BRPI0820738A2 publication Critical patent/BRPI0820738A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0612—Germ cells sorting of gametes, e.g. according to sex or motility
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6879—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for sex determination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0820738-0A 2007-12-14 2008-12-15 Separação específica do gênero de células de esperma e embriões BRPI0820738A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1390107P 2007-12-14 2007-12-14
PCT/US2008/086833 WO2009079456A2 (en) 2007-12-14 2008-12-15 Gender-specific separation of sperm cells and embryos

Publications (1)

Publication Number Publication Date
BRPI0820738A2 true BRPI0820738A2 (pt) 2015-06-16

Family

ID=40796115

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0820738-0A BRPI0820738A2 (pt) 2007-12-14 2008-12-15 Separação específica do gênero de células de esperma e embriões

Country Status (6)

Country Link
US (1) US9879222B2 (pt)
EP (1) EP2229457A4 (pt)
AU (1) AU2008338530A1 (pt)
BR (1) BRPI0820738A2 (pt)
CA (1) CA2708751A1 (pt)
WO (1) WO2009079456A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2708751A1 (en) 2007-12-14 2009-06-25 Minitube Of America, Inc. Gender-specific separation of sperm cells and embryos
DE102008064667B4 (de) * 2008-07-15 2011-06-09 Lzh Laserzentrum Hannover E.V. Verfahren zur Herstellung eines Detektionskonjugats
WO2010007117A1 (de) * 2008-07-15 2010-01-21 Laser Zentrum Hannover E.V. Verfahren und vorrichtung zur herstellung metallhaltiger organischer verbindungen
WO2011032034A2 (en) 2009-09-10 2011-03-17 University Of Idaho Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
US8470967B2 (en) 2010-09-24 2013-06-25 Duke University Phase transition biopolymers and methods of use
WO2013013068A2 (en) 2011-07-19 2013-01-24 University Of Idaho Embodiments of a probe and method for targeting nucleic acids
MX2014008299A (es) * 2012-01-04 2014-08-21 Mofa Group Llc Identificacion de genero especifico de celulas espermaticas y embriones utilizando acidos nucleicos bloqueados.
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
WO2016154530A1 (en) 2015-03-26 2016-09-29 Duke University Targeted therapeutic agents comprising multivalent protein-biopolymer fusions
WO2017024182A1 (en) 2015-08-04 2017-02-09 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
WO2018053201A1 (en) 2016-09-14 2018-03-22 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
EP3515928B1 (en) 2016-09-23 2026-01-28 Duke University Unstructured non-repetitive polypeptides having lcst behavior
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
EP3658168A4 (en) 2017-06-30 2021-07-14 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULUS SENSITIVE BIOPOLYMER NETWORKS
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
WO2020051541A1 (en) 2018-09-07 2020-03-12 Duke University Nanoparticulate drug delivery systems
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894529A (en) 1969-04-10 1975-07-15 Bio Controls Inc Method and means for controlling the sex of mammalian offspring and product therefor
US3687803A (en) 1970-11-09 1972-08-29 American Cyanamid Co Acid chloride activators for hydrogen peroxide bleaching
US4009260A (en) 1973-04-19 1977-02-22 Schering Aktiengesellschaft Fractionation of sperm
US4083957A (en) 1974-07-26 1978-04-11 Lang John L Process for the alteration of the sex-ratio of mammals
US3976197A (en) 1974-11-22 1976-08-24 Bhattacharya Bhairab C Thermal convection counter streaming sedimentation method and apparatus for controlling the sex of mammalian offspring
US4092229A (en) 1975-12-17 1978-05-30 Bhattacharya Bhairab C Thermal convection counter streaming sedimentation and forced convection galvanization method for controlling the sex of mammalian offspring
USRE32350E (en) 1974-11-22 1987-02-10 Bhairab C. Bhattacharya Thermal convection counter streaming sedimentation and forced convection galvanization method for controlling the sex of mammalian offspring
AU2154077A (en) 1976-01-27 1978-07-27 Univ Edinburgh Control of sex ratio in mammalian offspring
US4191749A (en) 1977-10-11 1980-03-04 Bryant Bernard J Method and material for increasing the percentage of mammalian offspring of either sex
US4448767A (en) 1977-10-11 1984-05-15 Sumar Corporation Preparation of monospecific male-specific antibody and the use thereof for increasing the percentage of mammalian offspring of either sex
US4225405A (en) 1978-08-16 1980-09-30 Lawson Rommom L Process for separation and collection of viable female and male spermatozoa
US4276139A (en) 1978-08-16 1981-06-30 Lawson Rommon L Process for magnetic separation and collection of viable female and male spermatozoa
US4362246A (en) 1980-07-14 1982-12-07 Adair Edwin Lloyd Method of treating collected mammal semen and separating sperm into X Y components
US4680258A (en) 1981-03-24 1987-07-14 Sloan-Kettering Institute For Cancer Research Process for sex determination in man by use of monoclonal antibodies to the H-Y antigen
US4339434A (en) 1981-08-17 1982-07-13 Gametrics Limited Method of increasing the incidence of female offspring
US4511661A (en) 1982-03-19 1985-04-16 University Patents, Inc. ATCC HB8116 And its monoclonal anti-H-Y antibody, Hyclonalan
EP0171676B1 (en) 1984-07-31 1990-11-07 Hitachi, Ltd. Free-flow electrophoretic separation method and apparatus therefor
US4999283A (en) 1986-01-10 1991-03-12 University Of Kentucky Research Foundation Method for x and y spermatozoa separation
US5346990A (en) 1987-04-08 1994-09-13 Cytogam, Inc. Sex-associated membrane proteins and methods for increasing the probability that offspring will be of a desired sex
US5021244A (en) 1988-12-06 1991-06-04 Cytogam, Inc. Sex-associated membrane antibodies and their use for increasing the probability that offspring will be of a desired sex
FR2619819B1 (fr) 1987-08-27 1990-08-10 Agronomique Inst Nat Rech Sondes moleculaires d'adn specifique du genome male de ruminants, notamment de la sous-famille des bovines et en particulier du genre bos, sequences flanquantes pour l'amplification de ces sondes et applications desdites sondes
US5215884A (en) 1988-01-21 1993-06-01 University Of Georgia Research Foundation, Inc. Sex-specific DNA probes
US5176996A (en) 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
DK0471758T3 (pt) 1989-05-10 1997-03-10 Us Agriculture
FR2648151B1 (fr) 1989-06-08 1991-12-20 Michel Georges Minisatellite bovin specifique au chromosome y des bovines
US5514786A (en) 1990-01-11 1996-05-07 Isis Pharmaceuticals, Inc. Compositions for inhibiting RNA activity
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
JPH08508489A (ja) 1993-03-31 1996-09-10 スターリング ウィンスロップ インコーポレイティド 二官能価ヌクレオシド、それらのオリゴマーならびにそれらの製造方法及び使用方法
US5962426A (en) 1993-06-25 1999-10-05 Yale University Triple-helix forming oligonucleotides for targeted mutagenesis
US5623068A (en) 1994-03-07 1997-04-22 Beckman Instruments, Inc. Synthesis of DNA using substituted phenylacetyl-protected nucleotides
US5514537A (en) 1994-11-28 1996-05-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Process and apparatus for sorting spermatozoa
US5844110A (en) 1995-02-01 1998-12-01 University Of Nebraska Board Of Regents Synthetic triple helix-forming compound precursors
US6610839B1 (en) 1997-08-14 2003-08-26 Geron Corporation Promoter for telomerase reverse transcriptase
US5985216A (en) 1997-07-24 1999-11-16 The United States Of America, As Represented By The Secretary Of Agriculture Flow cytometry nozzle for high efficiency cell sorting
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
JP4238381B2 (ja) 1998-07-17 2009-03-18 株式会社島津製作所 ピレン修飾rna、およびrnaの分析方法
EP1161439B1 (en) 1999-03-18 2010-04-21 Exiqon A/S Xylo-lna analogues
US7084125B2 (en) 1999-03-18 2006-08-01 Exiqon A/S Xylo-LNA analogues
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
NZ514348A (en) 1999-05-04 2004-05-28 Exiqon As L-ribo-LNA analogues
US6472153B1 (en) * 1999-10-26 2002-10-29 Epoch Biosciences, Inc. Hybridization-triggered fluorescent detection of nucleic acids
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6263745B1 (en) 1999-12-03 2001-07-24 Xy, Inc. Flow cytometer nozzle and flow cytometer sample handling methods
EP1307469B1 (en) 2000-08-03 2008-01-23 Boehringer Mannheim Gmbh Nucleic acid binding compounds containing pyrazolo¬3,4-d pyrimidine analogues of purin-2,6-diamine and their uses
WO2002028875A2 (en) 2000-10-04 2002-04-11 Cureon A/S Improved synthesis of purine locked nucleic acid analogues
EP1332150A1 (en) 2000-11-09 2003-08-06 Jyoti Chattopadhyaya Modified nucleosides and nucleotides and use thereof
AU1980202A (en) 2000-11-22 2002-06-03 Pharmacia Corporation Methods and apparatus for producing gender enriched sperm
CA2822983C (en) 2000-11-29 2017-05-09 Xy, Llc System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
JPWO2002051797A1 (ja) 2000-12-26 2004-09-02 池田 壽文 新規な機能性ペプチド核酸モノマーとその製法
US7153954B2 (en) 2001-07-12 2006-12-26 Santaris Pharma A/S Method for preparation of LNA phosphoramidites
WO2003020877A2 (en) 2001-09-01 2003-03-13 Pharmacia Corporation Staining and sorting genomes and chromosomes using sequence-specific polyamides
WO2003020739A2 (en) 2001-09-04 2003-03-13 Exiqon A/S Novel lna compositions and uses thereof
AU2002351077A1 (en) 2001-11-05 2003-05-19 Exiqon A/S Oligonucleotides modified with novel alpha-l-rna analogues
US20050053939A1 (en) 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
WO2003052134A2 (en) 2001-12-18 2003-06-26 Human Genetic Signatures Pty Ltd Oligonucleotides comprising intercalator pseudonucleotide(s) for detection of nucleic acids and mutants hereof
US20040219565A1 (en) 2002-10-21 2004-11-04 Sakari Kauppinen Oligonucleotides useful for detecting and analyzing nucleic acids of interest
GB2395557A (en) 2002-11-22 2004-05-26 Dynal Biotech Ltd Nucleic acid probes
US7002006B2 (en) 2003-02-12 2006-02-21 Isis Pharmaceuticals, Inc. Protection of nucleosides
US7276599B2 (en) 2003-06-02 2007-10-02 Isis Pharmaceuticals, Inc. Oligonucleotide synthesis with alternative solvents
US7202036B2 (en) 2003-06-12 2007-04-10 Los Alamos National Security, Llc Quenching methods for background reduction in luminescence-based probe-target binding assays
CA2921196C (en) 2003-11-26 2019-03-05 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
US7575863B2 (en) 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
AU2005266930B2 (en) 2004-07-22 2010-09-16 Inguran, Llc Process for enriching a population of sperm cells
JP4980219B2 (ja) 2004-09-10 2012-07-18 ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド インターカレート型擬似ヌクレオチド(ipn)を含有するインターカレーティング核酸(ina)を含む増幅ブロッカー
US20060172315A1 (en) * 2005-02-01 2006-08-03 Anderson Amy L Methods for staining cells for identification and sorting
CA2598805A1 (en) 2005-02-24 2006-08-31 Biocern, Inc. Sperm cell separation methods and compositions
US7741294B1 (en) 2005-05-14 2010-06-22 Steven Albert Benner Non-standard nucleobases implementing the isocytidine and isoguanosine hydrogen bonding patterns
US7449571B2 (en) 2005-06-14 2008-11-11 Board Of Regents Of The University Of Nebraska Halogenated aminoquinolines and oligonucleotides containing the same
DK2004847T3 (en) 2006-03-16 2017-08-21 Pentabase Aps Oligonucleotides comprising signaling pairs and hydrophobic nucleotides, "stemless beacons", for detection of nucleic acids, methylation status and mutants of nucleic acids
CA2697960A1 (en) 2006-08-30 2008-03-06 Biocern, Inc. Sperm cell separation methods and compositions containing aptamers or nucleic acid sequences for use therein
AU2007324273A1 (en) 2006-11-22 2008-05-29 Commonwealth Scientific And Industrial Research Organisation Improved hybridisation of nucleic acids
DK2149605T3 (da) 2007-03-22 2013-09-30 Santaris Pharma As Korte RNA antagonist forbindelser til modulering af det ønskede mRNA
EP2149605B1 (en) 2007-03-22 2013-07-03 Santaris Pharma A/S Short RNA antagonist compounds for the modulation of target mRNA
KR20100051795A (ko) 2007-06-22 2010-05-18 키진 엔.브이. 향상된 변형 올리고뉴클레오티드를 이용한 표적화 뉴클레오티드 교환
CN101809171A (zh) 2007-08-03 2010-08-18 生物概念股份有限公司 原位杂交以检测rna和dna标记
KR100886139B1 (ko) 2007-11-13 2009-02-27 주식회사 삼천리제약 올리고뉴클레오타이드의 제조방법
CA2708751A1 (en) 2007-12-14 2009-06-25 Minitube Of America, Inc. Gender-specific separation of sperm cells and embryos
WO2009114543A2 (en) 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
WO2010003420A2 (en) 2008-06-17 2010-01-14 Gentofte Hospital Treatment of psoriasis and related diseases by mirna modulation
US8541569B2 (en) 2008-09-06 2013-09-24 Chemgenes Corporation Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA
US20120040857A1 (en) 2009-02-13 2012-02-16 The General Hospital Corporation Isolation of factors that associate directly or indirectly with chromatin
EP2550360B1 (en) 2010-03-24 2017-08-30 Mirrx Therapeutics A/s Bivalent antisense oligonucleotides
MX2014008299A (es) 2012-01-04 2014-08-21 Mofa Group Llc Identificacion de genero especifico de celulas espermaticas y embriones utilizando acidos nucleicos bloqueados.

Also Published As

Publication number Publication date
US20100311059A1 (en) 2010-12-09
AU2008338530A1 (en) 2009-06-25
EP2229457A4 (en) 2011-01-26
CA2708751A1 (en) 2009-06-25
WO2009079456A3 (en) 2009-12-30
WO2009079456A2 (en) 2009-06-25
US9879222B2 (en) 2018-01-30
EP2229457A2 (en) 2010-09-22

Similar Documents

Publication Publication Date Title
EP2229457A4 (en) SEX-SPECIFIC SEPARATION OF SPERM AND EMBRYOES
DK2185693T3 (da) Differentiering af humane embryoniske stamceller
DK2562248T3 (da) Differentiering af humane embryonale stamceller
BRPI0813787A2 (pt) Cultura de célula-tronco pluripotente isolada
EP3805762C0 (en) IMAGING AND EVALUATION OF EMBRYOS, OOCYTES AND STEM CELLS
DE602007004421D1 (de) Zellkulturvorrichtung
PL2634242T3 (pl) Ulepszony sposób hodowli komórek
DK2574677T3 (da) Fremgangsmåder til celledyrkning
EP2144311A4 (en) Separator
BRPI0818194A2 (pt) meio legível por computador
DE102007063274B8 (de) Mikroskop
EP2191435A4 (en) MONITORING HEALTH CARE
BRPI0920808A2 (pt) hipersustentador disposto na área de sustenção de uma aeronave
EP2115123A4 (en) SELECTIVE LYSE OF SPERM CELLS
EP2176171A4 (en) Separator tank
EP2128242A4 (en) CELL CULTURE MODULE
DE602008002014D1 (de) Sekundärbatterie
DK2234994T3 (da) Fedtsyre-butylester-blandinger
IL210787A0 (en) Methods for the cytological analysis of cervical cells
DE602008006595D1 (de) Überlaufbauwerk
BRPI0817199A2 (pt) Identificaçãob e isolamento de células fetais e ácido nucleico
IL206588A0 (en) Device for the study of living cells
DK2027150T3 (da) Allo-begrænsede peptid-specifikke t-celler
DK2467724T3 (da) Overlevelsesprognoseassay
GB0505378D0 (en) Fluidic devices for cell and embryo culture

Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.