BRPI0820868A2 - composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado - Google Patents

composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado

Info

Publication number: BRPI0820868A2
Authority: BR; Brazil
Prior art keywords: diseases; prevention; treatment; pharmaceutical composition; composition containing
Prior art date: 2007-12-10

Application number

BRPI0820868A

Other languages

English (en)

Inventor

Steiner Beat

Marthys Boris

Mueller Claus

Lescop Cyrille

Bolli Martin

Nayler Oliver

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-10

Filing date

2008-12-09

Publication date

2019-09-24

2008-12-09 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2019-09-24 Publication of BRPI0820868A2 publication Critical patent/BRPI0820868A2/pt

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000035475 disorder Diseases 0.000 title 1
210000000987 immune system Anatomy 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
230000002265 prevention Effects 0.000 title 1
229930192474 thiophene Natural products 0.000 title 1
-1 thiophene compound Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Neurology (AREA)
Hematology (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0820868A 2007-12-10 2008-12-09 composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado BRPI0820868A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB2007054991		2007-12-10
PCT/IB2008/055156 WO2009074950A2 (en)	2007-12-10	2008-12-09	Thiophene derivatives as agonists of s1p1/edg1

Publications (1)

Publication Number	Publication Date
BRPI0820868A2 true BRPI0820868A2 (pt)	2019-09-24

Family

ID=40640372

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0820868A BRPI0820868A2 (pt)	2007-12-10	2008-12-09	composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado

Country Status (15)

Country	Link
US (1)	US8148410B2 (pt)
EP (1)	EP2222667B1 (pt)
JP (1)	JP5503551B2 (pt)
KR (1)	KR20100095593A (pt)
CN (1)	CN101896482B (pt)
AU (1)	AU2008334297A1 (pt)
BR (1)	BRPI0820868A2 (pt)
CA (1)	CA2706834A1 (pt)
ES (1)	ES2403209T3 (pt)
IL (1)	IL206221A0 (pt)
MA (1)	MA31953B1 (pt)
MX (1)	MX2010005889A (pt)
RU (1)	RU2010128006A (pt)
TW (1)	TW200930363A (pt)
WO (1)	WO2009074950A2 (pt)

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PT2069336E (pt) *	2006-09-07	2013-03-07	Actelion Pharmaceuticals Ltd	Derivados de piridin-4-ilo como agentes imunomoduladores
PL2069335T3 (pl) *	2006-09-08	2013-05-31	Actelion Pharmaceuticals Ltd	Pochodne pirydyn-3-ylu jako środki immunomodulujące
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WO2017081310A1 (en)	2015-11-13	2017-05-18	Basf Se	Substituted oxadiazoles for combating phytopathogenic fungi
MX2018006235A (es)	2015-11-19	2018-08-01	Basf Se	Oxadiazoles sustituidos para combatir hongos fitopatogenos.
JP2018537457A (ja)	2015-11-19	2018-12-20	ビーエーエスエフソシエタス・ヨーロピアＢａｓｆＳｅ	植物病原菌を駆除するための置換オキサジアゾール
RU2018138748A (ru)	2016-04-11	2020-05-12	Басф Се	Замещенные оксадиазолы для борьбы с фитопатогенными грибами
BR112018074569B1 (pt)	2016-06-09	2022-10-04	Basf Se	Compostos, uso de n-(2,4-difluorofenil)-4-[5-(trifluorometil)-1,2,4-oxadiazol-3-il] benzamida, composição agroquímica e método para combater fungos nocivos fitopatogênicos
WO2017211650A1 (en)	2016-06-09	2017-12-14	Basf Se	Substituted oxadiazoles for combating phytopathogenic fungi
BR112019011293A2 (pt)	2016-12-19	2019-10-08	Basf Se	compostos de fórmula i, intermediários, composição agroquímica, uso e método para combater fungos nocivos fitopatogênicos
EP3339297A1 (en)	2016-12-20	2018-06-27	Basf Se	Substituted oxadiazoles for combating phytopathogenic fungi
US11425910B2 (en)	2017-02-21	2022-08-30	Basf Se	Substituted oxadiazoles for combating phytopathogenic fungi
AU2018247768A1 (en)	2017-04-07	2019-10-03	Basf Se	Substituted oxadiazoles for combating phytopathogenic fungi
WO2018188962A1 (en)	2017-04-11	2018-10-18	Basf Se	Substituted oxadiazoles for combating phytopathogenic fungi
WO2018202491A1 (en)	2017-05-04	2018-11-08	Basf Se	Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi
WO2018219797A1 (en)	2017-06-02	2018-12-06	Basf Se	Substituted oxadiazoles for combating phytopathogenic fungi
WO2018234139A1 (en)	2017-06-19	2018-12-27	Basf Se	2-[[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]aryloxy](thio)acetamides for combating phytopathogenic fungi
WO2019002158A1 (en)	2017-06-30	2019-01-03	Basf Se	SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR THE CONTROL OF PHYTOPATHOGENIC FUNGI
WO2019025250A1 (en)	2017-08-04	2019-02-07	Basf Se	SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
WO2019038042A1 (en)	2017-08-21	2019-02-28	Basf Se	SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR THE CONTROL OF PHYTOPATHOGENIC FUNGI
BR112020004441B1 (pt)	2017-09-18	2024-01-16	Basf Se	Compostos da fórmula i, composição agroquímica, semente revestida, uso de compostos e método não-terapêutico de combate de fungos
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2008
- 2008-12-09 MX MX2010005889A patent/MX2010005889A/es unknown
- 2008-12-09 TW TW097147938A patent/TW200930363A/zh unknown
- 2008-12-09 CN CN2008801206875A patent/CN101896482B/zh not_active Expired - Fee Related
- 2008-12-09 RU RU2010128006/04A patent/RU2010128006A/ru not_active Application Discontinuation
- 2008-12-09 JP JP2010537572A patent/JP5503551B2/ja not_active Expired - Fee Related
- 2008-12-09 AU AU2008334297A patent/AU2008334297A1/en not_active Abandoned
- 2008-12-09 KR KR1020107013025A patent/KR20100095593A/ko not_active Withdrawn
- 2008-12-09 CA CA2706834A patent/CA2706834A1/en not_active Abandoned
- 2008-12-09 WO PCT/IB2008/055156 patent/WO2009074950A2/en not_active Ceased
- 2008-12-09 US US12/747,280 patent/US8148410B2/en not_active Expired - Fee Related
- 2008-12-09 BR BRPI0820868A patent/BRPI0820868A2/pt not_active IP Right Cessation
- 2008-12-09 EP EP08859227A patent/EP2222667B1/en not_active Not-in-force
- 2008-12-09 ES ES08859227T patent/ES2403209T3/es active Active
2010
- 2010-06-07 IL IL206221A patent/IL206221A0/en unknown
- 2010-06-30 MA MA32972A patent/MA31953B1/fr unknown

Also Published As

Publication number	Publication date
JP2011506423A (ja)	2011-03-03
JP5503551B2 (ja)	2014-05-28
CN101896482B (zh)	2013-01-09
WO2009074950A3 (en)	2009-08-06
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Publication	Publication Date	Title
BRPI0820868A2 (pt)	2019-09-24	composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado
CL2007003352A1 (es)	2008-07-04	Compuestos derivados de heteromonociclos de nitrogeno; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de enfermedades circulatorias, enfermedades metabolicas y/o enfermedades del sistema nervioso cen
CL2007002641A1 (es)	2008-06-20	Compuestos derivados de pirimidinas; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos alergicos, autoinmunes, enfermedades inflamatorias.
CL2007002920A1 (es)	2008-06-06	Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos.
BR112012000422A2 (pt)	2017-05-09	composto, composição farmacêutica, uso de um composto, e, método para a prevenir tratar ou melhorar doenças do sistema imune
CL2007002594A1 (es)	2008-06-06	Compuestos derivados de piridin-3-il, agentes inmunomoduladores; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades asociadas con un sistema inmunologico activado. .
CL2007003495A1 (es)	2008-05-30	Compuestos derivados de heterociclos condensados sustituidos, inhibidores de la actividad de la akt; composicion farmaceutica; y uso para el tratamiento o prevencion del cancer.
LT2878297T (lt)	2020-07-10	Medikamentai, skirti fibrozinių ligų gydymui arba prevencijai
BRPI1009252A2 (pt)	2016-03-15	composto, pró-droga, composição farmacêutica, métodos para prevenir ou tratar doenças do sistema nervoso central, e mal de alzheimer, e, uso do composto ou de uma pró-droga do mesmo
BRPI0811262A2 (pt)	2014-11-04	Composto, composto ou sal do mesmo, composição farmacêutica, modulador de receptor de glicocorticóide, método para prevenção e/ou tratamento de bistúrbios metabólicos, doenças inflamatórias, doenças auto-imunes, doenças alérgicas, doenças do sistema nervoso central, doenças cardiovasculares, doenças relacionadas com homeostase ou glaucoma, e uso de pelo menos um composto ou um sal do mesmo
BRPI0817028A2 (pt)	2019-09-24	composto inibidor de diacilglicerol acil tranferase, composição farmacêutica que o contém, uso do composto, métodos para o tratamento ou profilaxia de diabetes, obesidade, distúrbios de alimentação e dislidemias e diabetes do tipo ii
DK1984357T3 (da)	2014-01-13	2,4-pyrimidindiaminforbindelser til behandling eller forebyggelse af autoimmunsygdomme
BRPI0816881A2 (pt)	2015-03-17	Composto, composição farmacêutica, uso de um composto, e, métodos para tratar doenças ou distúrbios e para preparar um composto.
BRPI1013763A2 (pt)	2015-08-25	Composto ou sal do mesmo, prodroga, composição farmacêutica, agente diminuidor da proteína de ligação de retinol 4, agente para a profilaxia ou tratamento de diabetes, e, uso de um composto
BR112012028707A2 (pt)	2019-09-24	composto de glucagon da superfamília de peptídeos exibindo atividade do receptor g com proteína acoplada, pró farmaco, dímero ou multímro, composição farmacêutica que o compreendem e método de administração do mesmo.
BRPI0818615A2 (pt)	2015-04-07	Sistema de aspiração para remoção de líquido descarregado pelo corpo humano, e sensor de líquido para o mesmo.
BRPI0720637A2 (pt)	2014-04-15	Composto ou um sal farmaceuticamente aceitável, uma forma estereoisomérica, tautomérica ou polimórfica do mesmo, métodos para o tratamento de um hospedeiro e de tratamento de infecção, composição farmacêutica, e, uso do composto
CL2007003244A1 (es)	2008-04-04	Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
CL2007003520A1 (es)	2008-08-22	Compuestos derivados de heterociclos sustituidos con morfolina, inhibidores de la actividad pi3 quinasa; composicion farmaceutica que comprende a dichos compuestos; kit farmaceutico; y su uso para el tratamiento profilactico o terapeutico del cancer.
BRPI0716696A2 (pt)	2014-03-04	Sistema de aplicação para tratamento remoto de um animal
CL2007001778A1 (es)	2008-05-23	Compuestos derivados de 2-pirazinacarboxamida, antagonistas/agonistas inversos selectivos de cb1; proceso de preparacion; composiciones farmaceuticas; y uso para el tratamiento y/o profilaxis de trastornos de ingestion de comida, diabetes tipo ii y a
BRPI0819582A2 (pt)	2015-05-05	"sistema de tratamento de líquido"
BRPI0917138A2 (pt)	2015-11-17	composto, métodos para tratar doenças alérgicas e outras condições inflamatórias, rinite alérgica, e para tratar ou prevenir doença, composição farmacêutica, uso de um composto, e, combinação.
CL2008000224A1 (es)	2008-05-23	Composicion farmaceutica que comprende un compuesto derivado glucopiranosilo; y uso para el tratamiento de uno o mas trastornos neurodegenerativos.
CL2007001630A1 (es)	2008-02-08	Compuestos derivados de pirrolidinamida; composicion farmaceutica; y uso para el tratamiento de la hepatitis c.