BRPI0821102A2 - Preparation of dihydropyrrol derivatives as intermediates - Google Patents

Preparation of dihydropyrrol derivatives as intermediates

Info

Publication number
BRPI0821102A2
BRPI0821102A2 BRPI0821102-7A BRPI0821102A BRPI0821102A2 BR PI0821102 A2 BRPI0821102 A2 BR PI0821102A2 BR PI0821102 A BRPI0821102 A BR PI0821102A BR PI0821102 A2 BRPI0821102 A2 BR PI0821102A2
Authority
BR
Brazil
Prior art keywords
preparation
dihydropyrrol
intermediates
derivatives
formula
Prior art date
Application number
BRPI0821102-7A
Other languages
Portuguese (pt)
Inventor
Christophe Pfleger
Paul Spurr
RENé TRUSSARDI
Pius Waldmeier
Shaoning Wang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0821102A2 publication Critical patent/BRPI0821102A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The invention is concerned with a new scalable process for the preparation of compounds of formula I comprising a new process for the preparation of the key intermediate, a dihydropyrrole derivative formula II or a salt thereof.
BRPI0821102-7A 2007-11-29 2008-11-19 Preparation of dihydropyrrol derivatives as intermediates BRPI0821102A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07121841 2007-11-29
PCT/EP2008/065820 WO2009068463A2 (en) 2007-11-29 2008-11-19 Process for the preparation of isoindole derivatives as well as a process for the preparation of their intermediates

Publications (1)

Publication Number Publication Date
BRPI0821102A2 true BRPI0821102A2 (en) 2015-06-16

Family

ID=40551563

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0821102-7A BRPI0821102A2 (en) 2007-11-29 2008-11-19 Preparation of dihydropyrrol derivatives as intermediates

Country Status (13)

Country Link
US (3) US20090143589A1 (en)
EP (1) EP2225202B1 (en)
JP (1) JP5255647B2 (en)
KR (1) KR101196543B1 (en)
CN (1) CN101874019B (en)
AT (1) ATE539054T1 (en)
AU (1) AU2008328951B2 (en)
BR (1) BRPI0821102A2 (en)
CA (1) CA2705950A1 (en)
ES (1) ES2378185T3 (en)
IL (1) IL204936A (en)
MX (1) MX2010004669A (en)
WO (1) WO2009068463A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3527569B1 (en) 2014-02-03 2021-08-25 Vitae Pharmaceuticals, LLC Dihydropyrrolopyridine inhibitors of ror-gamma for use in treating drye eye
TWI675032B (en) 2014-10-14 2019-10-21 美商維它藥物公司 Dihydropyrrolopyridine inhibitors of ror-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
ES2856931T3 (en) 2015-08-05 2021-09-28 Vitae Pharmaceuticals Llc ROR-gamma modulators
EP3868750A1 (en) 2015-11-20 2021-08-25 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
TW202220968A (en) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 Modulators of ror-gamma
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibitors of ror gamma
MA49685A (en) 2017-07-24 2021-04-14 Vitae Pharmaceuticals Llc MMR gamma INHIBITORS
WO2019064071A1 (en) * 2017-09-27 2019-04-04 F. Hoffmann-La Roche Ag Crystalline forms of diazabicyclooctane derivatives and production process thereof
CN111808102B (en) * 2020-08-03 2021-12-31 南通大学 3-methoxy-6, 7-dihydro-5H-pyrrolo [3,4-b ] pyridine hydrochloride and synthetic method thereof
EP4337199A4 (en) * 2021-05-14 2025-03-19 Disc Medicine, Inc. METHODS OF TREATING ERYTHROPOIETIC PROTOPORPHYRIA, X-LINKED PROTOPORPHYRIA, OR CONGENITAL ERYTHROPOIETIC PORPHYRIA WITH GLYCINE TRANSPORT INHIBITORS
US12588582B2 (en) * 2022-08-08 2026-03-31 Cnh Industrial Canada, Ltd. Coated agricultural metering component

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4958029A (en) * 1987-01-13 1990-09-18 Banyu Pharmaceutical Co., Ltd. Process for the production of isoindoline derivatives, novel intermediates and process for their production
JP2832584B2 (en) * 1995-03-27 1998-12-09 日本農薬株式会社 Method for producing carboxylic acid esters
DK0820987T3 (en) * 1996-07-23 2003-02-17 Lonza Ag Process for the preparation of pyridine-2,3-dicarboxylic acid esters
UA91536C2 (en) * 2005-02-07 2010-08-10 Ф. Хоффманн-Ля Рош Аг Heterocyclic substituted phenyl methanones as inhibitors of the glycine transporter 1

Also Published As

Publication number Publication date
CN101874019A (en) 2010-10-27
WO2009068463A9 (en) 2009-11-12
IL204936A0 (en) 2010-11-30
ES2378185T3 (en) 2012-04-09
CN101874019B (en) 2013-06-12
US20090143589A1 (en) 2009-06-04
IL204936A (en) 2013-12-31
MX2010004669A (en) 2010-05-27
ATE539054T1 (en) 2012-01-15
WO2009068463A3 (en) 2009-09-11
JP5255647B2 (en) 2013-08-07
KR20100075664A (en) 2010-07-02
US20130060038A1 (en) 2013-03-07
KR101196543B1 (en) 2012-11-01
AU2008328951B2 (en) 2012-12-13
CA2705950A1 (en) 2009-06-04
AU2008328951A1 (en) 2009-06-04
WO2009068463A2 (en) 2009-06-04
JP2011504896A (en) 2011-02-17
EP2225202A2 (en) 2010-09-08
EP2225202B1 (en) 2011-12-28
US20120041205A1 (en) 2012-02-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]