BRPI0823085B8 - aparelho de análise de célula e método de retroassentamento de citômetro de fluxo - Google Patents

aparelho de análise de célula e método de retroassentamento de citômetro de fluxo

Info

Publication number
BRPI0823085B8
BRPI0823085B8 BRPI0823085A BRPI0823085A BRPI0823085B8 BR PI0823085 B8 BRPI0823085 B8 BR PI0823085B8 BR PI0823085 A BRPI0823085 A BR PI0823085A BR PI0823085 A BRPI0823085 A BR PI0823085A BR PI0823085 B8 BRPI0823085 B8 BR PI0823085B8
Authority
BR
Brazil
Prior art keywords
axis
technology
orthogonal
detector
illumination
Prior art date
Application number
BRPI0823085A
Other languages
English (en)
Inventor
C Sharpe Johnathan
M Evans Kenneth
Original Assignee
Xy Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xy Llc filed Critical Xy Llc
Publication of BRPI0823085A2 publication Critical patent/BRPI0823085A2/pt
Publication of BRPI0823085B1 publication Critical patent/BRPI0823085B1/pt
Publication of BRPI0823085B8 publication Critical patent/BRPI0823085B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1438—Using two lasers in succession
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1497—Particle shape
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

aparelho de análise de célula e método de retroassentamento de citômetro de fluxo. a presente invenção em modalidades particulares da tecnologia da invenção refere-se à tecnologia de "detector fora de eixo" que emprega um terceiro detector 23 que exibe um eixo de fluxo ortogonal 43 conforme definido por seu ângulo de coleta de emr, onde tal eixo é de 30 graus a 60 graus de uma linha de alinhamento de eixo longo de seção transversal de célula de fluxo ortogonal pretendida 13, em adição ao emprego de um quarto detector 24 que exibe um eixo de fluxo ortogonal 44 conforme definido por seu ângulo ortogonal de coleta, onde tal eixo é ortogonal ao eixo do terceiro detector de fluxo ortogonal 43. modalidades particulares da tecnologia da invenção se referem à tecnologia de "iluminação espaçada axialmente" caracterizando mais do que um local de iluminação de célula onde outro do que o local de iluminação de fluxo ascendente (por exemplo, 121), todo(s) o(s) local(is) de iluminação é/são de fluxo descendente de pelo menos um outro local de iluminação. modalidades particulares da tecnologia da invenção podem caracterizar aspectos de ambas as tecnologias.
BRPI0823085A 2008-08-21 2008-08-21 aparelho de análise de célula e método de retroassentamento de citômetro de fluxo BRPI0823085B8 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2008/073915 WO2010021627A1 (en) 2008-08-21 2008-08-21 Cell analysis apparatus and methods

Publications (3)

Publication Number Publication Date
BRPI0823085A2 BRPI0823085A2 (pt) 2015-06-16
BRPI0823085B1 BRPI0823085B1 (pt) 2018-10-23
BRPI0823085B8 true BRPI0823085B8 (pt) 2021-07-27

Family

ID=41707371

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0823085A BRPI0823085B8 (pt) 2008-08-21 2008-08-21 aparelho de análise de célula e método de retroassentamento de citômetro de fluxo

Country Status (6)

Country Link
US (1) US8603396B2 (pt)
EP (1) EP2316022B1 (pt)
BR (1) BRPI0823085B8 (pt)
CA (2) CA2992239C (pt)
DK (1) DK2316022T3 (pt)
WO (1) WO2010021627A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011077765A1 (ja) * 2009-12-25 2011-06-30 古河電気工業株式会社 検体識別分取装置および検体識別分取方法
US10620213B2 (en) 2012-10-05 2020-04-14 Inguran, Llc High pressure sperm sorting and flow cytometer methods
CA2886782C (en) 2012-10-05 2020-03-10 Inguran, Llc High efficiency methods of sex sorting sperm
US10371622B2 (en) 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
US10662408B2 (en) 2013-03-14 2020-05-26 Inguran, Llc Methods for high throughput sperm sorting
US9757726B2 (en) 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
JP6554100B2 (ja) 2013-08-16 2019-07-31 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド フローサイトメーターにおいて流体ストリームから液滴を分離及び／又は帯電させるタイミング及び／又は位相の調整
CA2905670C (en) 2014-09-26 2025-08-05 Inguran, Llc SEX-SORTED SPERM EXPRESSING A DOSE-RESPONSE AND PRODUCTION METHODS FOR SEX-SORTED SPERM EXPRESSING A DOSE-RESPONSE
KR101681422B1 (ko) * 2015-07-31 2016-11-30 가톨릭대학교 산학협력단 다수의 레이저를 사용하는 세포 분석 장치
JP6796917B2 (ja) * 2015-09-18 2020-12-09 シスメックス株式会社 粒子撮像装置および粒子撮像方法
CN105717036B (zh) * 2016-04-29 2018-04-17 安徽师范大学 一种磁力搅拌式的流式细胞仪流动室
EP3570853B1 (en) 2017-01-20 2024-07-24 Inguran, LLC Sperm processing method, apparatus and related media compositions
CN106918544A (zh) * 2017-03-29 2017-07-04 中国科学院苏州生物医学工程技术研究所 一种基于荧光激发光源的流式分析仪系统
BR112021000339A2 (pt) * 2018-07-10 2021-04-06 Gerrit Jan Van Den Engh Sistema, aparelho e método para iluminação fora do eixo em citometria de fluxo
US11629330B2 (en) * 2019-03-19 2023-04-18 Inguran, Llc Method for improved sperm cell populations
CN113322156B (zh) * 2021-06-16 2022-12-20 复旦大学 一种模拟输卵管微环境的仿生微流控芯片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6784981B1 (en) * 2000-06-02 2004-08-31 Idexx Laboratories, Inc. Flow cytometry-based hematology system
AU2002318269A1 (en) * 2001-07-18 2003-03-03 The Regents Of The University Of Michigan Gas-focusing flow cytometer cell and flow cytometer detection system with waveguide optics
US7312085B2 (en) * 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
BRPI0408857B1 (pt) * 2003-03-28 2018-09-11 Inguran Llc aparelho, métodos e processos para separar partículas e para prover esperma de animal separado por sexo
ES2541121T3 (es) * 2003-05-15 2015-07-16 Xy, Llc Clasificación eficiente de células haploides por sistemas de citometría de flujo
US7460223B2 (en) * 2003-09-19 2008-12-02 Applied Biosystems Inc. Inverted orientation for a microplate
DE102005055825A1 (de) 2005-11-23 2007-05-24 Basf Ag Vorrichtung und Verfahren für die automatische Bestimmung der individuellen dreidimensionalen Partikelform
JP5322922B2 (ja) * 2006-04-11 2013-10-23 イー・エム・デイー・ミリポア・コーポレイシヨン キャピラリ−フローサイトメータの非対称毛管
CN101611323B (zh) * 2006-09-29 2013-02-20 密理博公司 流式细胞术脉冲的区分和应用
US9322834B2 (en) * 2007-05-30 2016-04-26 Sysmex Corporation Sample analyzer, blood analyzer and displaying method

Also Published As

Publication number Publication date
US20110143389A1 (en) 2011-06-16
US8603396B2 (en) 2013-12-10
CA2733259C (en) 2018-03-06
BRPI0823085B1 (pt) 2018-10-23
EP2316022B1 (en) 2016-10-05
BRPI0823085A2 (pt) 2015-06-16
EP2316022A1 (en) 2011-05-04
DK2316022T3 (en) 2017-01-16
EP2316022A4 (en) 2014-05-21
CA2992239C (en) 2020-02-25
CA2992239A1 (en) 2010-02-25
CA2733259A1 (en) 2010-02-25
WO2010021627A1 (en) 2010-02-25

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/10/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/08/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO