BRPI0904361A2 - herbal product and its process of obtaining - Google Patents

Abstract

Product formulated based on medicinal plants and its process of obtaining The present invention is a natural product for treatments of nasal congestion caused by sinusitis, sore throats, coughs, thrush, warts and chilblains, also having oral antiseptic actions , insect repellents and favors the healing of small wounds. Formulated with Rosemary (Rosmarinus officinalis L.), Losna (Artemisia absinthium L.), Arruda (Ruta graveolens L.), Melissa (Melissa Officinalis L.), Lemon Eucalyptus (eucalyptus globulus Labili), Elderberry (Sambucus australis Cham & Schltdl ), Common Salvia (Salvia officinalis L.) and Aroeira (Schinus molle L.) It has great use for commercial and medicinal purposes, being suitable for several diseases, mainly those of the respiratory tract.

Description

Descriptive Report

Product formulated with medicinal herbs and its process of obtaining

The present invention is a natural product formulated from medicinal plants and their method for treating nasal congestion caused by sinusitis, sore throat inflammation, coughs, canker sores, warts and chills, also having antiseptic, insect repellents and favors the healing of small wounds. Its formulation consists of Rosemary (Rosmarinus officinalis L.), Losna (Artemisia absinthium L.), Arruda (Ruta graveolens L.), Melissa (Melissa Officinalis L.), Lemon Eucalyptus (eucalyptus globulus Labill), Elderberry (Sambucus australis Cham & Schltdl), Common Salvia (Salvia officinalis L.) and Aroeira (Schinus molle L.)

It is widely used for commercial and medicinal purposes, and is suitable for various disorders, especially those of the airways.

State of the Art

Medicinal plants, used for thousands of years, serve as the basis for studies in the production of new drugs (Macedo et al. 2002). It is estimated that 80% of the population in the Third World makes use of herbal medicines, and 85% of these have medicinal plant extracts (EMBRAPA 1994).

In Brazil, the use of plants in the treatment of diseases has a fundamental influence on indigenous, African and European cultures. Brazilian culture has suffered serious influences from this ethnic mixture, both in the spiritual and material aspects, merging with the existing knowledge in the country. The basis of the formation of folk medicine is now taken over by natural medicine, which takes advantage of its practical knowledge, but gives it a scientific character in an attempt to restore human health in a natural way (De-La-Cruz-Mota & Guarim Neto 1996; Rodrigues & Carvalho 2001) .Currently, there is a resurgence of natural medicine, emphasizing medicinal plants for the restoration of human health. With this happening, countless alternative and natural therapies are emerging to feed the welfare needs of the human being.

One of the factors contributing to the widespread use of plants for medical purposes in Brazil is the large number of plant species found in countries and also imported from Europe. In recent years, the acceptance of phytotherapy in Brazil has increased, resulting in growth of industrial production of laboratories. There is also the emergence of housing crops and new users, with need for guidance to the population.

The use of medicinal plants by the world population has been very significant in recent times. Data from the World Health Organization (WHO) show that about 80% of the world's population has used some kind of weed to relieve some painful or unpleasant symptoms. Of this total, at least 30% was due to medical indication. The use of medicinal plants, has even received incentives from OMS itself. There are many factors that have been contributing to the development of depressive health that include medicinal plants, especially economic and social.

"Brazilian medicinal plants not only cure, they do miracles." In this famous phrase, von Martius clearly defined the capacity of our medicinal herbs. It is very likely that of the approximately 200,000 plant species that may exist in Brazil, in the opinion of some authors, at least half may have some useful therapeutic property to the population, but not even 1% of these potential species has been the subject of adequate studies. Research on these species should receive full support from the government, as, in addition to the economic factor, the importance for national security and preservation of the ecosystems where such species exist. Many Brazilian plant-based substances are patented by companies or foreign government agencies, because national research does not receive undue support. Today, the cost to develop synthetic or semi-synthetic drugs is very high and has been fruitless. Medicinal plant research usually results in less time-consuming medicines, often with lower costs and, consequently, more accessible to the population, who are generally unable to afford the high costs of purchasing drugs. that can be used as part of meeting primary health needs, mainly because most of the time the raw materials used in the manufacture of these drugs are imported. For these reasons or the deficiency of the primary health care redepublic, about 80% of the Brazilian population does not have access to the so-called essential drugs.

Invention

Plants synthesize chemical compounds from the nutrients in water and light they receive. Many of these compounds or groups of them can cause reactions in organisms, these are the active ingredients. Some unsubstances may or may not be toxic, this largely depends on the dosage at which they are to be used. Thus, "Medicinal plant is one that contains one or more of an active ingredient that gives it therapeutic activity." Not always the active ingredients of a plant are known, but even so it may have satisfactory medicinal activity and be used as long as it has no toxic effect.

The aim of this invention is to present a product formulated based on medicinal plants as well as their process of obtaining them.

The form of presentation of the invention are two: spray and sachet. In all forms of presentation, both spray and sachet formulation is composed by: Rosemary (Rosmarinus officinalis L.), Losna (Artemisia absinthium L.), Arruda (Ruta graveolens L.), Melissa (MelissaOfficinalis L.), Lemon Eucalyptus (Eucalyptus globulus Labill), Elderberry (Sambucus australis Cham & Schltdl), Salvia Common (Salvia officinalis L.) and Aroeira (Schinus molle L.) using as extractant solvent ingredients cane organic sugar cane and water.In the spray packaging are packed the active ingredients of the plants quoted by extraction using organic sugar cane brandy.

The sachets are packaged in heat-resistant filter paper packages with approximate dimensions: 10cm χ 6cm where the active ingredients are extracted by preparation with aqueous solution. The plants used in the formulation of the present invention are:

1. Rosemary (Rosmarinus officinalis L.)

A genus of evergreen shrub (rosemary), cultivated to extract its flowers and leaves. Needs sun and well irrigated soil. Prune damaged plants at low temperatures to obtain good quality wood in the spring. It multiplies by germination in summer. This plant in topical use is considered to be healing, anti-microbial against Staphylococcus eMolnilia and scalp stimulant. Orally it is diuretic, collagogue, choleretic, carminative, intestinal inti-inflammatory.

2. Losna, Ajenjo (Artemisia absinthium L.)

Plant of temperate climate, does not resist frost, but sprouts in the spring. The plant needs a regular supply of water. It propagates by seed, by tussock division or by cutting. The seed-originated plants are of much higher quality than those resulting from the split root planting (clumps). On the other hand, a plant or crop made with split roots has a shorter duration and is less productive. In seed propagation it is usual to produce seedlings before sowing and then transplant them. Concealment should be done in beds, well prepared, with organic fertilization, preferring, however, loam and sandy loam, dry and deep. The leaves are harvested before flowering, because in the course of the process they lose some of their therapeutic properties. Its use is internationally accepted as a medication used in cases of loss of appetite, digestive disorders, liver and gallbladder. It is used topically for insect bites and healing for small wounds.

3. Arruda (Ruta graveolens L.)

A perennial genus native to Europe, with well-divided aromatic leaves, cultivated to extract the flowering plant. It needs a bright and soluble irrigated location. It multiplies by budding in the summer. The pharmacophone literature cites its use in the form of tea, in the treatment of menstrual disorders, skin inflammation, earache, toothache, fever, cramps, liver disease, etc.

4. Melissa (Melissa Officinalis L.)

A genus of aromatic plant, belonging to the Labiada family, characterized by having a height of about one meter, taloramified, opaque, serrated petiolate leaves and white gold flowers, 0.75-1.5 cm wide, which appear on the late summer or autumn. It originates in Europe, the Mediterranean region, western Asia and northern Africa, and is later spread in temperate zones. It is considered aromatic, febrifuge, antispasmodic and carmitive, being used in the form of hot baths against joint rheumatism. Studies carried out in Brazil, confirmed its anti-inflammatory and analgesic properties.

5. Lemon Eucalyptus (Eucalyptus globulus Labill)

E. globulus is a large tree (30 to 55 m in height, but may occasionally exceed 90 m in height), trunk and slender, branching only at the end, forming a sparse and irregular canopy at great height. In folk medicine, the leaves of these plants are used to inhale the vapors of boiling water for the treatment of influenza, nasal congestion and sinusitis, with a refreshing and menthol-like bronchial dilator effect.

6. Elderberry (Sambucus australis Cham & Schltdl) (A genus of evergreen tree grown to extract foliage, flowers and fruits. It needs sun and fertile, irrigated soil. Pruning to stimulate flowering. It multiplies by summer germination and sowing in the autumn.This plant is considered to be very effective against respiratory problems, having diuretic, anti-pyretic, antiseptic, healing and anti-inflammatory properties.

7. Common Salvia (Salvia officinalis L.)

A genus of evergreen shrub, grown to extract vividly colored tubular flowers and aromatic leaves. It is multiplied by spring division and evergreen shrubs and secondary branches by germination and other species by spring sowing. Plant used naculinar, also for menopause and menstrual problems. For external use against insect bites, skin infections, gum, throat and naphtha.

8. Aroeira (Schinus molle L.)

A genus of perennial shrubs, native to Mexico and South America and often grown in California under the names of Peper tree and ChiliPepper, grown for leafy fruit extracts. They grow on any soil with continuous irrigation and sunlight. It multiplies by sowing in spring or by sprouting in summer. In Brazil, this plant is used against fevers, urinary tract problems, cystitis, urethritis, blenorrhagia, cough and bronchitis.

Procurement and Preparation Process

The chemical constituents found in plants are synthesized and degraded by numerous reactions that constitute plant metabolism. The synthesis of compounds essential for the survival of plant species, such as sugars, amino acids, fatty acids, nucleotides and their derived polymers, are part of the primary metabolism of plants. While compounds synthesized in other ways that appear to be of little use in species survival are part of secondary metabolism, they are called secondary compounds. Secondary metabolites are characterized by not being vital to plants, most often, as the alkaloids; for presenting qualitative and quantitative differences between the different species, and also for being produced in small quantities. The separation of these two metabolic pathways is much discussed, the classification of compounds into primary and secondary depends largely on the importance of a given compound for a particular species, as well as the stage of development in which it is.

According to Mann (1987), there are three points of origin and production of secondary compost (figure 1), differentiated by their precursors.

The. shikimic acid, as a precursor to numerous aromatic compounds;

B. amino acids, source of alkaloids and peptides;

ç. acetate, which through two biosynthetic routes originates compounds such as polyacetylenes, terpenes, steroids and others.

The concentration of active ingredients in the plant depends, of course, on genetic control and the stimuli provided by the environment, such as climatic, soil (soil-related) factors, exposure to microorganisms, insects, other herbivores and pollutants. The stimuli provided by the environment are usually characterized as "stress" situations, that is, excess or deficiency of some factor of production for aplanta. Among the climatic factors, the photoperiod (number of light hours per day needed by a plant for them to flourish), temperature, water stress (soil water deficiency) can determine in certain species the ideal harvesting season where a greater amount of the desired active ingredient is obtained. The process for obtaining and preparing the present invention in packspray and sachet is as follows:

1- Cutting leaves and branches with a maximum age of 3 years;

2- drying;

The drying of medicinal plants is based on increasing the air's ability to remove moisture from the plant. Thus, methods are used that raise the temperature through a solar dryer and promote ventilation or simply reduce the relative humidity of the air. Increasing temperature will also reduce the relative humidity of the air, while ventilation will facilitate homogenization of the drying air throughout the drying plant mass. The temperature used ranges from 35 to 45 ° C. Temperatures above 45 ° C damage the vegetable organs and their contents, as they provide "cooking" of the palms and not drying, although they inactivate more enzymes. Artificial drying yields better quality material by increasing the speed of the process. Artificial drying gives better quality material by increasing the speed of the process.

3- Extraction of active ingredients and packaging;

In this process, the plant substances are left in contact with the vehicle (liquid used for extraction of active ingredients), organic sugar cane brandy or distilled water at room temperature.

For Spray packaging, the extraction period depends on the material to be used, but leaves, branches and other hard parts are crushed and macerated for 3 (three) months. Although slow, maceration is an excellent method for obtaining the active ingredient in its entirety. The amount of the material follows the 1: 1 weight ratio of all plant components, using 150 to 200 grams of the material for one liter of organic brandy as the extracting solvent. After the maceration period, all material should be filtered and filled into plastic spray containers.

For sachet-type packaging, heat-resistant filter paper is used for this packaging, which is low in weight (8-40 g / m2) in combination with high air permeability and tear resistance, so that there is no retention of product particles. flavors enable full cooking, weighing 3 (three) grams per sachet, with particulate matter passed through crusher sieves up to a maximum size of (three) millimeters.

How to use the sachet: should be boiled in 150 ml of water for 5 minutes; Allow to cool and place the solution in a 50ml plastic spray-nasal container suitable for direct application to the nostrils. Maximum use period of this solution is 7 (seven) days and should be kept under refrigeration.

Claims (9)

1. A product formulated from medicinal herbs and its process of obtaining, characterized by its being Rosemary (Rosmarinusofficinalis L.), Losna (Artemisia absinthium L.), Arruda (Ruta graveolens L.), Melissa (Melissa Officinalis L.), Lemon Eucalyptus (Eucalyptus globulus Labill), Elderberry (Sambucus australis Cham & Schltdl), Common Salvia (Salviaofficinalis L.) and Aroeira (Schinus molle L.); A product formulated from medicinal plants and its process of obtaining according to claim 1, characterized in that the material used consists of leaves, branches and other hard parts of the plants; A product formulated from medicinal herbs and its process of obtaining according to claims 1 and 2 characterized in that the process of obtaining follows the following order: the leaves, branches and other hard parts of the plants are minced and crushed, remain macerated by 3 (three) months, undergo the drying process in a solar dryer at a temperature between 35 ° C and 45 ° C; The active ingredients are extracted into distilled water or organic sugar cane brandy at room temperature. 4. Product formulated based on medicinal plants and its process of obtaining, characterized by being in the form of packets like spray and bag. Medicinal herbal product and its process of obtaining according to claims 1, 2 and 3, characterized in that the product in spray form uses the components in proportion proportional to 1: 1 by weight of all the components of the plants, using 150 to 200 grams of the material to one liter of organic spirit as a solvent extraction, and after the maceration period all the material is filtered and the liquid is filled in spray plastic containers; Product formulated from medicinal herbs and its process of obtaining according to claims 1, 2 and 3, characterized in that the sachet-shaped product uses the components, passing them through a maximum size of 3 (three) millimeters, where it is used. Heat resistant papelfilter suitable for this packaging, with low grammage (8-40 g / m2) in combination with high air permeability and resistance to breakage, so that there is retention of product particles, does not produce changes in taste and allows full cooking, containing weight 3 (three) grams per sachet, with a size of 10 cm X 6 cm .; Medicinal herbal product and process for obtaining it according to claim 6, characterized by the method of using the following order: boiling in 150 ml of water for 5 minutes, allowing to cool and placing the solution in a 50ml plastic spray bottle suitable for direct application to the nostrils, where the maximum use period of this solution is 7 (seven) days and kept under refrigeration. 8. Product formulated from medicinal herbs and its process of obtaining, characterized in that it is a natural product and the spray presents properties for treatment of inflammation in the throat, coughs, canker sores, warts and chilblains, also having mouthwash action, insect repellent action and healing action of small wounds; 9. Product formulated from medicinal herbs and its process of obtaining, characterized in that it is a natural product and the sachet presents properties for nasal congestion treatments caused by sinusitis.