BRPI0906945A2 - (e)-n-{3-[1-(8-flúor-11h-10-oxa-1-aza-dibenzo[a,d]ciclo-h epten-5-ilideno)-propil]-fenil}-metinsulfona amida como modulador de receptores de glicocorticoides para o tratamento de reumatoide. - Google Patents

(e)-n-{3-[1-(8-flúor-11h-10-oxa-1-aza-dibenzo[a,d]ciclo-h epten-5-ilideno)-propil]-fenil}-metinsulfona amida como modulador de receptores de glicocorticoides para o tratamento de reumatoide.

Info

Publication number
BRPI0906945A2
BRPI0906945A2 BRPI0906945-3A BRPI0906945A BRPI0906945A2 BR PI0906945 A2 BRPI0906945 A2 BR PI0906945A2 BR PI0906945 A BRPI0906945 A BR PI0906945A BR PI0906945 A2 BRPI0906945 A2 BR PI0906945A2
Authority
BR
Brazil
Prior art keywords
treatment
metinsulfone
cyclohepten
ylidene
dibenzo
Prior art date
Application number
BRPI0906945-3A
Other languages
English (en)
Inventor
Matthew William Carson
Michael Joseph Coghlan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0906945A2 publication Critical patent/BRPI0906945A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0906945-3A 2008-01-11 2009-01-08 (e)-n-{3-[1-(8-flúor-11h-10-oxa-1-aza-dibenzo[a,d]ciclo-h epten-5-ilideno)-propil]-fenil}-metinsulfona amida como modulador de receptores de glicocorticoides para o tratamento de reumatoide. BRPI0906945A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2052008P 2008-01-11 2008-01-11
PCT/US2009/030374 WO2009089312A1 (en) 2008-01-11 2009-01-08 (e)-n-{3- [1-(8-fluoro-11h-10-oxa-1-aza-dibenzo [a,d] cycl0hepten-5ylidene)-propyl]-phenyl }-methynsulfon amide as glucocorticoid receptor modulator for the treatment of rheumatoid

Publications (1)

Publication Number Publication Date
BRPI0906945A2 true BRPI0906945A2 (pt) 2015-07-14

Family

ID=40456776

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0906945-3A BRPI0906945A2 (pt) 2008-01-11 2009-01-08 (e)-n-{3-[1-(8-flúor-11h-10-oxa-1-aza-dibenzo[a,d]ciclo-h epten-5-ilideno)-propil]-fenil}-metinsulfona amida como modulador de receptores de glicocorticoides para o tratamento de reumatoide.

Country Status (13)

Country Link
US (1) US8101761B2 (pt)
EP (1) EP2231676B1 (pt)
JP (1) JP2011525474A (pt)
KR (1) KR101237296B1 (pt)
CN (1) CN101910179B (pt)
AT (1) ATE522537T1 (pt)
AU (1) AU2009204155A1 (pt)
BR (1) BRPI0906945A2 (pt)
CA (1) CA2711885A1 (pt)
EA (1) EA017288B1 (pt)
ES (1) ES2370148T3 (pt)
MX (1) MX2010007607A (pt)
WO (1) WO2009089312A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011081173A1 (ja) * 2009-12-29 2011-07-07 協和発酵キリン株式会社 四環系化合物
EP3983015A1 (en) 2019-06-11 2022-04-20 Regeneron Pharmaceuticals, Inc. Anti-pcrv antibodies that bind pcrv, compositions comprising anti-pcrv antibodies, and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2603713B1 (fr) * 1986-09-10 1992-07-24 Canon Kk Derive nouveau de 5h-dibenzo(a,d)cycloheptane-(ene)ylidene, son procede de production et support electrophotographique photosensible le contenant
JPH01161245A (ja) 1987-12-18 1989-06-23 Canon Inc 電子写真感光体
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US5093210A (en) * 1989-06-30 1992-03-03 Ricoh Company, Ltd. Electroluminescent device
US5378701A (en) * 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
US6372779B1 (en) 1997-12-29 2002-04-16 Ortho Pharmaceutical Corporation Anti-inflammatory compounds
EP1154997A4 (en) 1999-01-26 2002-11-04 Dana Farber Cancer Inst Inc PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE
TW200400816A (en) * 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
CN1918151A (zh) * 2003-12-19 2007-02-21 伊莱利利公司 三环甾类激素核受体调节剂
JP5189091B2 (ja) 2006-07-14 2013-04-24 イーライ リリー アンド カンパニー グルココルチコイド受容体モジュレーターおよびその使用方法

Also Published As

Publication number Publication date
US20100280062A1 (en) 2010-11-04
CN101910179B (zh) 2013-06-19
US8101761B2 (en) 2012-01-24
MX2010007607A (es) 2010-08-23
KR101237296B1 (ko) 2013-03-04
CN101910179A (zh) 2010-12-08
EA017288B1 (ru) 2012-11-30
EA201070844A1 (ru) 2011-02-28
ES2370148T3 (es) 2011-12-13
EP2231676A1 (en) 2010-09-29
AU2009204155A1 (en) 2009-07-16
CA2711885A1 (en) 2009-07-16
EP2231676B1 (en) 2011-08-31
AU2009204155A8 (en) 2010-07-08
WO2009089312A1 (en) 2009-07-16
KR20100090808A (ko) 2010-08-17
JP2011525474A (ja) 2011-09-22
ATE522537T1 (de) 2011-09-15

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BRPI0906945A2 (pt) (e)-n-{3-[1-(8-flúor-11h-10-oxa-1-aza-dibenzo[a,d]ciclo-h epten-5-ilideno)-propil]-fenil}-metinsulfona amida como modulador de receptores de glicocorticoides para o tratamento de reumatoide.

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.