BRPI0907224A2 - formulações narcórticas em emulsão para tratamento de dor cirúrgica - Google Patents

formulações narcórticas em emulsão para tratamento de dor cirúrgica

Info

Publication number
BRPI0907224A2
BRPI0907224A2 BRPI0907224-1A BRPI0907224A BRPI0907224A2 BR PI0907224 A2 BRPI0907224 A2 BR PI0907224A2 BR PI0907224 A BRPI0907224 A BR PI0907224A BR PI0907224 A2 BRPI0907224 A2 BR PI0907224A2
Authority
BR
Brazil
Prior art keywords
emulsion formulations
narcotic
surgical pain
emulsion
methods
Prior art date
Application number
BRPI0907224-1A
Other languages
English (en)
Inventor
Nabeta Kiichiro
Hibi Toru
Original Assignee
Teikoku Pharma Usa, Inc.
Techno Guard Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Pharma Usa, Inc., Techno Guard Co., Ltd. filed Critical Teikoku Pharma Usa, Inc.
Publication of BRPI0907224A2 publication Critical patent/BRPI0907224A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

formulações narcóticas em emulsão para tratamento de dor cirúrgica. a presente invenção refere-se a métodos e composições de tratamento de um indivíduo em relação a dor pós-cirúrgica. nos presentes mé- todos destinados, um indivíduo é tratado em relação a dor pós-cirúrgica me-diante administração ao indivíduo de uma quantidade eficaz de uma emul-são narcótica, por exemplo, formulação de fentanila em emulsão. em certas modalidades, as formulações de emulsão incluem um agente narcótico ativo, óleo e um tensoativo. também proporcionados são métodos de produção das formulações de emulsão objetos desta invenção, bem como kits que incluem as formulações de emulsão.
BRPI0907224-1A 2008-05-15 2009-04-28 formulações narcórticas em emulsão para tratamento de dor cirúrgica BRPI0907224A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5357108P 2008-05-15 2008-05-15
US61/053,571 2008-05-15
US12/424,382 US20090286832A1 (en) 2008-05-15 2009-04-15 Narcotic emulsion formulations for treatment of surgical pain
US12/424,382 2009-04-15
PCT/US2009/041991 WO2009140059A2 (en) 2008-05-15 2009-04-28 Narcotic emulsion formulations for treatment of surgical pain

Publications (1)

Publication Number Publication Date
BRPI0907224A2 true BRPI0907224A2 (pt) 2019-02-26

Family

ID=41316744

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0907224-1A BRPI0907224A2 (pt) 2008-05-15 2009-04-28 formulações narcórticas em emulsão para tratamento de dor cirúrgica

Country Status (16)

Country Link
US (1) US20090286832A1 (pt)
EP (1) EP2276440A4 (pt)
JP (2) JP5689053B2 (pt)
KR (1) KR101361479B1 (pt)
CN (1) CN101938963A (pt)
AR (1) AR071779A1 (pt)
AU (1) AU2009246713B2 (pt)
BR (1) BRPI0907224A2 (pt)
CA (1) CA2710546A1 (pt)
EA (1) EA201000991A1 (pt)
IL (1) IL209145A0 (pt)
MX (1) MX2010007698A (pt)
NZ (1) NZ586461A (pt)
TW (2) TW201406403A (pt)
WO (1) WO2009140059A2 (pt)
ZA (1) ZA201004392B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090286832A1 (en) * 2008-05-15 2009-11-19 Kiichiro Nabeta Narcotic emulsion formulations for treatment of surgical pain
EA201190135A1 (ru) * 2009-02-26 2012-07-30 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Композиции на основе эмульгированных наркотических веществ для лечения боли при раке
JP6081240B2 (ja) * 2013-03-13 2017-02-15 テルモ株式会社 レミフェンタニル注射液剤
EP3192509B1 (en) 2014-09-12 2021-03-31 Terumo Kabushiki Kaisha Remifentanil injection
US20230248719A1 (en) * 2020-06-08 2023-08-10 Harm Reduction Therapeutics, Inc. Sterilized formulations

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0647533B2 (ja) * 1984-08-10 1994-06-22 裕 水島 ４−ビフエニリル酢酸系化合物含有脂肪乳剤
US4816247A (en) * 1985-09-11 1989-03-28 American Cyanamid Company Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs
ES2138130T3 (es) * 1995-10-28 2000-01-01 Braun Melsungen Ag Composicion farmaceutica que contiene un anestesico local y/o un analgesico de accion central.
GB9721746D0 (en) * 1997-10-15 1997-12-10 Panos Therapeutics Limited Compositions
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6455525B1 (en) * 1999-11-04 2002-09-24 Cephalon, Inc. Heterocyclic substituted pyrazolones
US7211596B2 (en) * 2001-05-11 2007-05-01 Mitsubishi Pharma Corporation Stable high-concentration injection containing pyrazolone derivative
BRPI0307017B1 (pt) * 2002-01-25 2015-11-10 Theravance Biopharma R & D Ip Llc compostos de éster de ácido fenilacético, composições farmacêuticas e uso de ditos compostos para preparar um medicamento útil para induzir ou manter a anestesia ou sedação
JP2004043479A (ja) * 2002-07-11 2004-02-12 Taiho Yakuhin Kogyo Kk 経鼻吸収用組成物
UA80447C2 (en) * 2002-10-08 2007-09-25 Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic
US7252822B2 (en) * 2002-10-08 2007-08-07 Rinat Neuroscience Corp. Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist
US7648982B2 (en) * 2003-02-28 2010-01-19 Ym Biosciences Inc. Opioid delivery system
JP2004275852A (ja) * 2003-03-14 2004-10-07 Mitsubishi Heavy Ind Ltd 排煙脱硝触媒及びその製造方法
JP2007538091A (ja) * 2004-05-17 2007-12-27 ファーマコフォア・インコーポレイテッド 痛みを処置または予防するための組成物および方法
DE102004025357B4 (de) * 2004-05-19 2007-03-29 Beiersdorf Ag Emulsionskonzentrat mit wasserlöslichen und öllöslichen Polymeren und kosmetische Zubereitung enthaltend Emulsionskonzentrat sowie ein Verfahren zu dessen Herstellung und dessen Verwendung
US7871632B2 (en) * 2004-07-12 2011-01-18 Adventrx Pharmaceuticals, Inc. Compositions for delivering highly water soluble drugs
US20060189682A1 (en) * 2005-02-02 2006-08-24 Payne Joseph E Water soluble prodrugs of COX-2 inhibitors
CN101137395B (zh) * 2005-03-14 2012-10-31 株式会社大塚制药工场 含有水难溶性药物的医药组合物
CA2608111A1 (en) * 2005-04-22 2006-11-02 Novacardia, Inc. Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
DK1976521T3 (en) * 2006-01-25 2015-04-27 Insys Therapeutics Inc Sublingual fentanyl spray
US20090286832A1 (en) * 2008-05-15 2009-11-19 Kiichiro Nabeta Narcotic emulsion formulations for treatment of surgical pain
EA201190135A1 (ru) * 2009-02-26 2012-07-30 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Композиции на основе эмульгированных наркотических веществ для лечения боли при раке

Also Published As

Publication number Publication date
MX2010007698A (es) 2010-11-22
JP5889364B2 (ja) 2016-03-22
KR101361479B1 (ko) 2014-02-12
ZA201004392B (en) 2011-06-29
CA2710546A1 (en) 2009-11-19
AU2009246713B2 (en) 2012-10-25
TW201006508A (en) 2010-02-16
JP5689053B2 (ja) 2015-03-25
US20090286832A1 (en) 2009-11-19
AU2009246713A1 (en) 2009-11-19
WO2009140059A2 (en) 2009-11-19
EA201000991A1 (ru) 2011-06-30
JP2014205681A (ja) 2014-10-30
JP2011520883A (ja) 2011-07-21
TW201406403A (zh) 2014-02-16
AR071779A1 (es) 2010-07-14
EP2276440A2 (en) 2011-01-26
CN101938963A (zh) 2011-01-05
NZ586461A (en) 2012-07-27
KR20100126270A (ko) 2010-12-01
TWI413531B (zh) 2013-11-01
EP2276440A4 (en) 2011-06-29
IL209145A0 (en) 2011-01-31
WO2009140059A3 (en) 2010-01-07

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A, 7A, 8A, 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2513 DE 06-03-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]