BRPI0907267A2 - Inibidores da fosfodiesterase-4 pertencentes à classe das aminas terciárias. - Google Patents

Inibidores da fosfodiesterase-4 pertencentes à classe das aminas terciárias.

Info

Publication number
BRPI0907267A2
BRPI0907267A2 BRPI0907267-5A BRPI0907267A BRPI0907267A2 BR PI0907267 A2 BRPI0907267 A2 BR PI0907267A2 BR PI0907267 A BRPI0907267 A BR PI0907267A BR PI0907267 A2 BRPI0907267 A2 BR PI0907267A2
Authority
BR
Brazil
Prior art keywords
phosphodiesterase
tertiary amine
amine class
inhibitors belonging
inhibitors
Prior art date
Application number
BRPI0907267-5A
Other languages
English (en)
Inventor
Andrea Rizzi
Elisabetta Armani
Ilaria Peretto
Elena La Porta
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of BRPI0907267A2 publication Critical patent/BRPI0907267A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
BRPI0907267-5A 2008-04-14 2009-03-27 Inibidores da fosfodiesterase-4 pertencentes à classe das aminas terciárias. BRPI0907267A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08007284A EP2110375A1 (en) 2008-04-14 2008-04-14 Phosphodiesterase-4 inhibitors belonging to the tertiary amine class
PCT/EP2009/002242 WO2009127320A1 (en) 2008-04-14 2009-03-27 Tertiary amine derivatives as phosphodiesterase-4 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0907267A2 true BRPI0907267A2 (pt) 2015-07-21

Family

ID=39731427

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0907267-5A BRPI0907267A2 (pt) 2008-04-14 2009-03-27 Inibidores da fosfodiesterase-4 pertencentes à classe das aminas terciárias.

Country Status (12)

Country Link
US (1) US7820698B2 (pt)
EP (2) EP2110375A1 (pt)
JP (1) JP5492190B2 (pt)
KR (1) KR101208193B1 (pt)
CN (1) CN102007117B (pt)
AU (1) AU2009238014B2 (pt)
BR (1) BRPI0907267A2 (pt)
CA (1) CA2721240A1 (pt)
EA (1) EA018069B1 (pt)
MX (1) MX2010011016A (pt)
WO (1) WO2009127320A1 (pt)
ZA (1) ZA201007317B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2022783A1 (en) 2007-08-08 2009-02-11 CHIESI FARMACEUTICI S.p.A. "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors"
EP2216327A1 (en) * 2009-02-06 2010-08-11 CHIESI FARMACEUTICI S.p.A. Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors
RU2578975C2 (ru) 2010-08-03 2016-03-27 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Фармацевтический препарат, содержащий ингибитор фосфодиэстеразы
AR086676A1 (es) 2011-06-06 2014-01-15 Chiesi Farma Spa Derivados de alcoholes 1-fenil-2-piridinil alquilicos como inhibidores de fosfodiesterasa
CN103827088B (zh) 2011-09-26 2017-10-13 奇斯药制品公司 作为磷酸二酯酶抑制剂的1‑苯基‑2‑吡啶基烷基醇的衍生物
CN104334542A (zh) * 2012-06-04 2015-02-04 奇斯药制品公司 作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基烷基醇的衍生物
HK1213245A1 (zh) 2012-12-05 2016-06-30 奇斯药制品公司 作为pde4抑制剂的苯乙基吡啶衍生物
KR102192739B1 (ko) 2012-12-05 2020-12-18 키에시 파르마슈티시 엣스. 피. 에이. 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체
HK1212988A1 (zh) 2012-12-05 2016-07-22 奇斯药制品公司 作为pde-4抑制剂的苯基乙基吡啶衍生物
WO2014086852A1 (en) 2012-12-05 2014-06-12 Chiesi Farmaceutici S.P.A. Phenylethylpyridine derivatives as pde4-inhibitors
US9427376B2 (en) 2013-10-10 2016-08-30 Chiesi Farmaceutici S.P.A. Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100856622B1 (ko) * 2001-01-22 2008-09-03 메모리 파마슈티칼스 코포레이션 포스포디에스테라제 4 억제제
AU2003256616B2 (en) * 2002-07-19 2009-08-27 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs
CA2506297A1 (en) * 2002-11-19 2004-06-03 Memory Pharmaceuticals Corporation Pyridine n-oxide compounds as phosphodiesterase 4 inhibitors
EP1443330A1 (en) * 2003-02-03 2004-08-04 Gilson Sas Methods, rack and device for preparing samples for analysis
MY141255A (en) * 2003-12-11 2010-03-31 Memory Pharm Corp Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
JP2008543781A (ja) * 2005-06-10 2008-12-04 メモリー・ファーマシューティカルズ・コーポレイション ホスフオジエステラーゼ４阻害剤
CN101490004B (zh) * 2006-07-14 2012-01-11 奇斯药制品公司 作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基烯基醇的衍生物
BRPI0716408A2 (pt) * 2006-08-09 2013-09-24 Basilea Pharmaceutica Ag macrolÍdeos éteis doenÇa inflamatària e alÉrgica

Also Published As

Publication number Publication date
US20090258905A1 (en) 2009-10-15
AU2009238014B2 (en) 2013-07-18
EP2268632B1 (en) 2012-08-08
EA201001481A1 (ru) 2011-06-30
JP2011517687A (ja) 2011-06-16
CA2721240A1 (en) 2009-10-22
KR101208193B1 (ko) 2012-12-04
EP2110375A1 (en) 2009-10-21
MX2010011016A (es) 2010-11-09
EP2268632A1 (en) 2011-01-05
CN102007117B (zh) 2014-06-25
EA018069B1 (ru) 2013-05-30
JP5492190B2 (ja) 2014-05-14
US7820698B2 (en) 2010-10-26
ZA201007317B (en) 2012-01-25
HK1155450A1 (en) 2012-05-18
KR20100128330A (ko) 2010-12-07
CN102007117A (zh) 2011-04-06
WO2009127320A1 (en) 2009-10-22
AU2009238014A1 (en) 2009-10-22

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]