BRPI0908906A2 - compostos heterocíclicos e usos dos mesmos - Google Patents
compostos heterocíclicos e usos dos mesmosInfo
- Publication number
- BRPI0908906A2 BRPI0908906A2 BRPI0908906A BRPI0908906A BRPI0908906A2 BR PI0908906 A2 BRPI0908906 A2 BR PI0908906A2 BR PI0908906 A BRPI0908906 A BR PI0908906A BR PI0908906 A BRPI0908906 A BR PI0908906A BR PI0908906 A2 BRPI0908906 A2 BR PI0908906A2
- Authority
- BR
- Brazil
- Prior art keywords
- heterocyclic compounds
- heterocyclic
- compounds
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3872308P | 2008-03-21 | 2008-03-21 | |
| US20845809P | 2009-02-24 | 2009-02-24 | |
| PCT/EP2009/053245 WO2009115572A2 (en) | 2008-03-21 | 2009-03-19 | Novel heterocyclic compounds and uses therof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0908906A2 true BRPI0908906A2 (pt) | 2019-09-24 |
Family
ID=40734805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0908906A BRPI0908906A2 (pt) | 2008-03-21 | 2009-03-19 | compostos heterocíclicos e usos dos mesmos |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8129394B2 (pt) |
| EP (1) | EP2274300A2 (pt) |
| JP (2) | JP5384611B2 (pt) |
| KR (2) | KR20130040258A (pt) |
| CN (1) | CN102015686B (pt) |
| AR (1) | AR071283A1 (pt) |
| AU (1) | AU2009227013B2 (pt) |
| BR (1) | BRPI0908906A2 (pt) |
| CA (1) | CA2718936A1 (pt) |
| CL (1) | CL2009000687A1 (pt) |
| CO (1) | CO6311078A2 (pt) |
| CR (1) | CR11681A (pt) |
| DO (1) | DOP2010000280A (pt) |
| EA (1) | EA201001456A1 (pt) |
| EC (1) | ECSP10010559A (pt) |
| IL (1) | IL208063A0 (pt) |
| MA (1) | MA32232B1 (pt) |
| MX (1) | MX2010010317A (pt) |
| NI (1) | NI201000156A (pt) |
| PE (1) | PE20091656A1 (pt) |
| SM (1) | SMAP201000115A (pt) |
| SV (1) | SV2010003673A (pt) |
| TW (1) | TW201000457A (pt) |
| UY (1) | UY31724A (pt) |
| WO (1) | WO2009115572A2 (pt) |
| ZA (1) | ZA201006505B (pt) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103214484B (zh) | 2005-12-13 | 2016-07-06 | 因塞特控股公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶 |
| US8470859B2 (en) * | 2006-10-23 | 2013-06-25 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
| HUE029236T2 (en) | 2007-06-13 | 2017-02-28 | Incyte Holdings Corp | (R) -3- (4- (7H-Pyrrolo [2,3-d] pyrimidin-4-yl) -1H-pyrazol-1-yl) -3-cyclopentylpropanenitrile Crystalline salts of Janus kinase inhibitor |
| US8268834B2 (en) | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
| US8865732B2 (en) * | 2008-03-21 | 2014-10-21 | Novartis Ag | Heterocyclic compounds and uses thereof |
| US20110039892A1 (en) * | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
| CL2009000964A1 (es) * | 2008-04-23 | 2010-03-26 | Takeda Pharmaceuticals Co | Compuestos derivados de 1-aril-2-imino-1,2-dihidropiridina-3-carboxamida, antagonista del receptor adrenergico alfa 1d, composicion farmaceutica que los comprende; y su uso para el tratamiento o profilaxis de enfermedades del tracto urinario inferior. |
| US8481569B2 (en) * | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
| EP2432472B1 (en) | 2009-05-22 | 2019-10-02 | Incyte Holdings Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| MY156727A (en) | 2009-05-22 | 2016-03-15 | Incyte Corp | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| AR077975A1 (es) * | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| US8242260B2 (en) * | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
| TW201113285A (en) | 2009-09-01 | 2011-04-16 | Incyte Corp | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| EP2937345B1 (en) | 2009-12-29 | 2018-03-21 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
| EP3028699B1 (en) | 2010-02-25 | 2018-03-21 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
| EP3354652B1 (en) | 2010-03-10 | 2020-05-06 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| AR084691A1 (es) | 2010-05-21 | 2013-06-05 | Incyte Corp | Formulacion de uso topico para un inhibidor de jak y metodo para tratar trastorno de la piel |
| EP2592130B1 (en) * | 2010-07-09 | 2015-01-21 | Mitsubishi Gas Chemical Company, Inc. | Photochromic material |
| JP5830094B2 (ja) | 2010-07-12 | 2015-12-09 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 置換イミダゾ［１，２−ａ］ピリミジンおよび−ピリジン |
| CA2818542A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| WO2012068440A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors |
| US8791112B2 (en) * | 2011-03-30 | 2014-07-29 | Arrien Pharmaceuticals Llc | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors |
| MY165963A (en) | 2011-06-20 | 2018-05-18 | Incyte Holdings Corp | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| WO2013059634A1 (en) | 2011-10-20 | 2013-04-25 | The Regents Of The University Of California | Use of cdk9 inhibitors to reduce cartilage degradation |
| US11007194B2 (en) | 2011-11-11 | 2021-05-18 | Array Biopharma Inc. | Method of treating a proliferative disease |
| WO2013078264A1 (en) | 2011-11-23 | 2013-05-30 | Novartis Ag | Pharmaceutical formulations |
| US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
| CN103159735B (zh) * | 2011-12-10 | 2015-12-09 | 通化济达医药有限公司 | 取代的咪唑激酶抑制剂 |
| UY34539A (es) * | 2011-12-23 | 2013-06-28 | Millennium Pharm Inc | Heteroarilos y usos de los mismos |
| CN104470515B (zh) | 2012-05-03 | 2016-12-07 | 圣路易斯药学院 | 用于增加神经营养肽的组合物和方法 |
| TW201406761A (zh) | 2012-05-18 | 2014-02-16 | Incyte Corp | 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物 |
| US20150232452A1 (en) * | 2012-09-19 | 2015-08-20 | Ruga Corporation | Novel raf kinase inhibitors |
| TWI761825B (zh) | 2012-11-15 | 2022-04-21 | 美商英塞特控股公司 | 盧梭利替尼之緩釋性劑型 |
| MX384910B (es) | 2013-03-06 | 2025-03-14 | Incyte Holdings Corp | Procesos e intermedios para hacer un inhibidor de jak. |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| SG11201600815WA (en) | 2013-08-07 | 2016-03-30 | Incyte Corp | Sustained release dosage forms for a jak1 inhibitor |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| US10300073B2 (en) | 2014-10-14 | 2019-05-28 | The Regents Of The University Of California | Use of CDK9 and BRD4 inhibitors to inhibit inflammation |
| AU2015371251B2 (en) | 2014-12-23 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| KR101665231B1 (ko) * | 2015-01-30 | 2016-10-13 | 순천향대학교 산학협력단 | 티오페닐 그룹을 갖는 티아졸계 화합물 및 이를 유효성분으로 포함하는 항진균제 |
| ES2939969T3 (es) * | 2015-02-04 | 2023-04-28 | Medpacto Inc | Composición farmacéutica para prevenir o tratar la leucemia mieloide crónica y métodos de uso de la misma |
| CN107427521B (zh) | 2015-03-27 | 2021-08-03 | 达纳-法伯癌症研究所股份有限公司 | 细胞周期蛋白依赖性激酶的抑制剂 |
| GB201614934D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Intellectual Property (No 2) Ltd | Chemical compounds |
| GB201614940D0 (en) * | 2016-09-02 | 2016-10-19 | Glaxosmithkline Intellectual Property (No 2) Ltd | Chemical compounds |
| EP3515446B1 (en) | 2016-09-19 | 2023-12-20 | Novartis AG | Therapeutic combinations comprising a raf inhibitor and a erk inhibitor |
| EP3544971B1 (en) | 2016-11-22 | 2022-07-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 12 (cdk12) and uses thereof |
| UY37556A (es) | 2017-01-10 | 2018-07-31 | Bayer Ag | Derivados heterocíclicos como pesticidas |
| AU2018208422B2 (en) | 2017-01-10 | 2021-11-11 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| US11471538B2 (en) | 2017-02-10 | 2022-10-18 | INSERM (Institut National de la Santéet de la Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the MAPK pathway |
| ES3053505T3 (en) * | 2017-03-23 | 2026-01-22 | Clavius Pharmaceuticals Llc | Tri-substituted imidazoles for the inhibition of tgf beta and methods of treatment |
| US11266653B2 (en) | 2017-05-02 | 2022-03-08 | Novartis Ag | Combination therapy |
| JP7038994B2 (ja) * | 2017-10-16 | 2022-03-22 | 国立大学法人金沢大学 | 炭素繊維強化プラスチックの製造方法、炭素繊維強化プラスチック及びセルロース系樹脂 |
| US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
| EP3732285A1 (en) | 2017-12-28 | 2020-11-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
| JP7393348B2 (ja) | 2018-01-30 | 2023-12-06 | インサイト・コーポレイション | （１－（３－フルオロ－２（トリフルオロメチル）イソニコチニル）ピぺリジン―４－オン）を作製するためのプロセス及び中間体 |
| CN113768934A (zh) | 2018-03-30 | 2021-12-10 | 因赛特公司 | 使用jak抑制剂治疗化脓性汗腺炎 |
| JP7590185B2 (ja) | 2018-06-25 | 2024-11-26 | ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド | Ｔａｉｒｅファミリーキナーゼインヒビターおよびそれらの使用 |
| CN110256408B (zh) | 2018-07-12 | 2022-03-22 | 深圳市塔吉瑞生物医药有限公司 | 一种二芳基吡唑化合物及包含该化合物的组合物及其用途 |
| US12077548B2 (en) | 2018-08-22 | 2024-09-03 | Clavius Pharmaceuticals, LLC. | Substituted imidazoles for the inhibition of TGF-β and methods of treatment |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020140098A1 (en) | 2018-12-28 | 2020-07-02 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 and uses thereof |
| WO2020150091A1 (en) | 2019-01-15 | 2020-07-23 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020192302A1 (zh) * | 2019-03-27 | 2020-10-01 | 广州必贝特医药技术有限公司 | 含嘧啶的三取代咪唑类化合物及其应用 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| ES3025633T3 (en) | 2019-05-13 | 2025-06-09 | Novartis Ag | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer |
| CN116348458A (zh) | 2019-08-14 | 2023-06-27 | 因赛特公司 | 作为cdk2抑制剂的咪唑基嘧啶基胺化合物 |
| CN119930611A (zh) | 2019-10-11 | 2025-05-06 | 因赛特公司 | 作为cdk2抑制剂的双环胺 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
| US20230247994A1 (en) | 2020-07-02 | 2023-08-10 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| US11905272B1 (en) | 2023-09-12 | 2024-02-20 | King Faisal University | 3-(2-(4-methoxypyridin-3-yl)-4,5-diphenyl-1H-imidazol-1-yl)-N,N-dimethylpropan-1-amine as an anti-cancer compound |
| US11993579B1 (en) | 2023-09-13 | 2024-05-28 | King Faisal University | 3-(1-(3-(dimethylamino)propyl)-4,5-diphenyl-1h-imidazol-2-yl)pyridin-4-ol as an anti-microbial compound |
| US11932619B1 (en) | 2023-09-13 | 2024-03-19 | King Faisal University | 3-(2-(6-Methoxypyridin-3-yl)-4,5-diphenyl-1H-imidazol-1-yl)-N,N-dimethylpropan-1-amine as an anticancer compound |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3707475A (en) * | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
| JPS5613715A (en) * | 1979-07-13 | 1981-02-10 | Nec Corp | Manufacture of coil |
| DE3029376A1 (de) * | 1980-07-31 | 1982-03-18 | Nepera Chemical Co. Inc., Harriman, N.Y. | Verfahren zur herstellung von 2,4,5-tris-pyridylimidazolen |
| US5243517A (en) * | 1988-08-03 | 1993-09-07 | Westinghouse Electric Corp. | Method and apparatus for physiological evaluation of short films and entertainment materials |
| JP2722586B2 (ja) * | 1989-01-13 | 1998-03-04 | 大正製薬株式会社 | インドリルイミダゾール誘導体 |
| JP2808460B2 (ja) * | 1989-11-16 | 1998-10-08 | 大正製薬株式会社 | イミダゾール誘導体 |
| US6850252B1 (en) * | 1999-10-05 | 2005-02-01 | Steven M. Hoffberg | Intelligent electronic appliance system and method |
| US5436830A (en) * | 1993-02-01 | 1995-07-25 | Zaltman; Gerald | Metaphor elicitation method and apparatus |
| US5676148A (en) * | 1995-03-31 | 1997-10-14 | Siemens Medical Systems Inc. | Method and system for doppler ultrasound audio dealiasing |
| DE69637948D1 (de) * | 1995-10-06 | 2009-07-23 | Merck & Co Inc | Substituierte imidazole mit krebsremmender und cytokininhibierender wirkung |
| US5717100A (en) * | 1995-10-06 | 1998-02-10 | Merck & Co., Inc. | Substituted imidazoles having anti-cancer and cytokine inhibitory activity |
| US5676138A (en) * | 1996-03-15 | 1997-10-14 | Zawilinski; Kenneth Michael | Emotional response analyzer system with multimedia display |
| US6268308B1 (en) * | 1996-08-27 | 2001-07-31 | Syngenta Crop Protection, Inc. | Herbicidal S-substituted 1,2,4,6-thiatriazines |
| US6099319A (en) * | 1998-02-24 | 2000-08-08 | Zaltman; Gerald | Neuroimaging as a marketing tool |
| US6315569B1 (en) * | 1998-02-24 | 2001-11-13 | Gerald Zaltman | Metaphor elicitation technique with physiological function monitoring |
| US6358201B1 (en) * | 1999-03-02 | 2002-03-19 | Doc L. Childre | Method and apparatus for facilitating physiological coherence and autonomic balance |
| JP2000302680A (ja) * | 1999-04-23 | 2000-10-31 | Takeda Chem Ind Ltd | 脳保護剤 |
| US7189745B1 (en) * | 1999-11-22 | 2007-03-13 | Smithkline Beecham Corporation | Compounds |
| AU782883B2 (en) * | 2000-01-18 | 2005-09-08 | Vertex Pharmaceuticals Incorpoated | Gyrase inhibitors and uses thereof |
| CO5271680A1 (es) | 2000-02-21 | 2003-04-30 | Smithkline Beecham Corp | Compuestos |
| GB0005357D0 (en) * | 2000-03-06 | 2000-04-26 | Smithkline Beecham Plc | Compounds |
| GB0007405D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| US6852875B2 (en) * | 2000-05-19 | 2005-02-08 | The Nutrasweet Co. | Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives |
| WO2002039954A2 (en) * | 2000-11-20 | 2002-05-23 | Smithkline Beecham Corporation | Novel compounds |
| DE60215139T2 (de) * | 2001-01-26 | 2007-08-16 | Chugai Seiyaku K.K. | Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren |
| AR039241A1 (es) * | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| KR20050057392A (ko) * | 2002-09-18 | 2005-06-16 | 화이자 프로덕츠 인크. | 전환성장인자(ｔｇｆ) 억제제로서의 신규한 이미다졸 화합물 |
| DK1692113T3 (en) | 2003-11-14 | 2018-01-08 | Lorus Therapeutics Inc | ARYLIMIDAZOLES AND USE THEREOF AS ANTICANCES |
| US7678810B2 (en) * | 2004-03-05 | 2010-03-16 | Taisho Pharmaceutical Co., Ltd | Thiazole derivative |
| KR100749566B1 (ko) * | 2004-04-21 | 2007-08-16 | 이화여자대학교 산학협력단 | Ａｌｋ5 및/또는 ａｌｋ4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체 |
| WO2005105814A1 (en) * | 2004-04-28 | 2005-11-10 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| PE20060315A1 (es) * | 2004-05-24 | 2006-05-15 | Irm Llc | Compuestos de tiazol como moduladores de ppar |
| US7453002B2 (en) * | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
| JP2007246520A (ja) * | 2006-02-15 | 2007-09-27 | Takeda Yuichiro | Ｒａｇｅ阻害剤 |
-
2009
- 2009-03-19 BR BRPI0908906A patent/BRPI0908906A2/pt not_active IP Right Cessation
- 2009-03-19 CN CN200980114791.8A patent/CN102015686B/zh not_active Expired - Fee Related
- 2009-03-19 WO PCT/EP2009/053245 patent/WO2009115572A2/en not_active Ceased
- 2009-03-19 CA CA2718936A patent/CA2718936A1/en not_active Abandoned
- 2009-03-19 EA EA201001456A patent/EA201001456A1/ru unknown
- 2009-03-19 JP JP2011500226A patent/JP5384611B2/ja not_active Expired - Fee Related
- 2009-03-19 KR KR1020137005251A patent/KR20130040258A/ko not_active Abandoned
- 2009-03-19 US US12/383,035 patent/US8129394B2/en not_active Expired - Fee Related
- 2009-03-19 KR KR1020107023491A patent/KR101408517B1/ko not_active Expired - Fee Related
- 2009-03-19 EP EP09722890A patent/EP2274300A2/en not_active Withdrawn
- 2009-03-19 MX MX2010010317A patent/MX2010010317A/es active IP Right Grant
- 2009-03-19 AU AU2009227013A patent/AU2009227013B2/en not_active Ceased
- 2009-03-20 AR ARP090101010A patent/AR071283A1/es unknown
- 2009-03-20 PE PE2009000430A patent/PE20091656A1/es not_active Application Discontinuation
- 2009-03-20 UY UY0001031724A patent/UY31724A/es not_active Application Discontinuation
- 2009-03-20 TW TW098109220A patent/TW201000457A/zh unknown
- 2009-03-20 CL CL2009000687A patent/CL2009000687A1/es unknown
-
2010
- 2010-09-07 IL IL208063A patent/IL208063A0/en unknown
- 2010-09-10 ZA ZA2010/06505A patent/ZA201006505B/en unknown
- 2010-09-20 DO DO2010000280A patent/DOP2010000280A/es unknown
- 2010-09-20 NI NI201000156A patent/NI201000156A/es unknown
- 2010-09-21 CR CR11681A patent/CR11681A/es not_active Application Discontinuation
- 2010-09-21 SV SV2010003673A patent/SV2010003673A/es not_active Application Discontinuation
- 2010-10-15 MA MA33252A patent/MA32232B1/fr unknown
- 2010-10-20 SM SM201000115T patent/SMAP201000115A/it unknown
- 2010-10-21 EC EC2010010559A patent/ECSP10010559A/es unknown
- 2010-10-21 CO CO10130723A patent/CO6311078A2/es not_active Application Discontinuation
-
2013
- 2013-10-02 JP JP2013207483A patent/JP2014040452A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112012003709A2 (pt) | compostos heterocíclicos e usos dos mesmos | |
| BRPI0920927A2 (pt) | derivados de azaquinolinona e usos dos mesmos | |
| BRPI0914682A2 (pt) | compostos de heteroarila e usos dos mesmos | |
| BRPI1014997A2 (pt) | compostos heteroarila e usos dos mesmos | |
| NL300891I2 (nl) | Lotilaner en zouten daarvan | |
| BRPI0909469A2 (pt) | compostos de oximetileno de arila e usos dos mesmos | |
| BRPI0912198A2 (pt) | anticorpos anti-fn14 e usos dos mesmos | |
| BR112013013790A2 (pt) | compostos heterocíclos nitrogenosos 6,6-fundidos substituídos e usos dos mesmos | |
| BRPI0819909A2 (pt) | anticorpos antimesotelina e usos dos mesmos | |
| BRPI1013943A2 (pt) | Composto cetais e usos dos mesmos. | |
| HRP20180718T1 (hr) | Oligopeptidni spojevi i njihova upotreba | |
| PT3037529T (pt) | Polipéptidos ph20 estendidos solúveis e suas utilizações | |
| BRPI0912480A2 (pt) | compostos de monoalquiltina de alta pureza e usos dos mesmos | |
| BRPI1011970A2 (pt) | compostos pirazolil-acrilonitrila e usos dos mesmos. | |
| BRPI1015315A2 (pt) | composto heterocíclico fundido e uso dos mesmos | |
| BRPI1009455A2 (pt) | anticorpos anti-c40 e usos dos mesmos | |
| BRPI0907231A2 (pt) | pirrolpirimidinas e pirrolpiridinas | |
| BRPI0918045A2 (pt) | compostos de carboxamida heterocíclicos | |
| BRPI1011404A2 (pt) | mutantes e usos dos mesmos | |
| DOP2010000044A (es) | Derivado de oxopirazina y herbicida | |
| DK2594567T3 (da) | Heterocykliske alkynylbenzenforbindelser og anvendelser deraf | |
| BRPI0906980A2 (pt) | Composição de derivados e maleatados | |
| BRPI1008752A2 (pt) | compostos alquilamido e usos dos mesmos | |
| BRPI1010024A2 (pt) | derivados de aminopirrolidinona e uso dos mesmos | |
| BR112012006501A2 (pt) | polipeptídios e usos dos mesmos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |