BRPI0908951A2 - compostos de minociclina e método de uso dos mesmos - Google Patents

compostos de minociclina e método de uso dos mesmos

Info

Publication number
BRPI0908951A2
BRPI0908951A2 BRPI0908951A BRPI0908951A BRPI0908951A2 BR PI0908951 A2 BRPI0908951 A2 BR PI0908951A2 BR PI0908951 A BRPI0908951 A BR PI0908951A BR PI0908951 A BRPI0908951 A BR PI0908951A BR PI0908951 A2 BRPI0908951 A2 BR PI0908951A2
Authority
BR
Brazil
Prior art keywords
minocycline compounds
minocycline
compounds
avaible
abstract
Prior art date
Application number
BRPI0908951A
Other languages
English (en)
Inventor
Dennis P Molnar
Ken S Tanaka
Robert D Arbeit
Sean Johnston
Thomas J Bigger
Original Assignee
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41056527&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0908951(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Paratek Pharm Innc filed Critical Paratek Pharm Innc
Publication of BRPI0908951A2 publication Critical patent/BRPI0908951A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

abstract not avaible
BRPI0908951A 2008-03-05 2009-03-05 compostos de minociclina e método de uso dos mesmos BRPI0908951A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6818008P 2008-03-05 2008-03-05
PCT/US2009/001451 WO2009111064A2 (en) 2008-03-05 2009-03-05 Minocycline compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0908951A2 true BRPI0908951A2 (pt) 2017-01-17

Family

ID=41056527

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0908951A BRPI0908951A2 (pt) 2008-03-05 2009-03-05 compostos de minociclina e método de uso dos mesmos

Country Status (12)

Country Link
US (9) US20090253660A1 (pt)
EP (1) EP2262754A4 (pt)
JP (1) JP2011513404A (pt)
KR (1) KR20100126469A (pt)
CN (1) CN102015602A (pt)
AU (1) AU2009220171A1 (pt)
BR (1) BRPI0908951A2 (pt)
CA (1) CA2717703A1 (pt)
CL (1) CL2010000188A1 (pt)
MX (1) MX2010009693A (pt)
RU (1) RU2010140682A (pt)
WO (1) WO2009111064A2 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
CA2717703A1 (en) 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
TW202216656A (zh) 2008-05-19 2022-05-01 美商Prtk Spv2公司 四環素化合物之甲苯磺酸鹽及同素異形體
WO2010125470A2 (en) 2009-04-28 2010-11-04 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
WO2011064631A1 (en) 2009-10-02 2011-06-03 Foamix Ltd. Surfactant-free, water-free, foamable compositions and breakable foams and their uses
US9255068B2 (en) * 2011-05-12 2016-02-09 Warner Chilcott Company, Llc Crystalline salts of (4S,4AS,5AR,12AS)-4-dimethylamino-3,10,12,12A-tetrahydroxy-7-[methoxy(methyl)amino)-methyl] acid amide and methods of using the same
IL254622B2 (en) * 2015-03-24 2024-01-01 Paratek Minocycline compounds for biodefense
GB201509326D0 (en) 2015-05-29 2015-07-15 Antibio Tx Aps Novel use
BR112018072559A2 (pt) * 2016-05-02 2019-02-19 Paratek Pharmaceuticals, Inc. método de tratar infecção do trato urinário.
TW202206081A (zh) * 2016-08-03 2022-02-16 美商派瑞泰Spv2有限公司 9—胺甲基米諾四環素化合物及其用途
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
GB201615693D0 (en) 2016-09-15 2016-11-02 Combinatorx Infection Ltd Combinations
BR112019008897A2 (pt) * 2016-11-01 2019-08-13 Paratek Pharm Innc método para tratar pneumonia bacteriana adquirida na comunidade.
SG11202106791XA (en) 2019-01-31 2021-07-29 Takeda Pharmaceuticals Co Heterocyclic compound and use thereof
US11419834B2 (en) 2019-02-25 2022-08-23 Rhode Island Hospital Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide
GB201902580D0 (en) * 2019-02-26 2019-04-10 Healx Ltd Treatment
JP7840880B2 (ja) * 2020-06-11 2026-04-06 パラテック ファーマシューティカルズ,インコーポレイテッド オマダサイクリンの結晶形態、その合成方法及びその使用方法
PT117254B (pt) 2021-05-26 2024-04-18 Hovione Farm S A Método de síntese de compostos 9-aminometil tetraciclinas

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) * 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) * 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3454697A (en) * 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (pt) * 1966-05-31 1967-12-01
DE1767891C3 (de) * 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
NL158172B (nl) 1972-09-18 1978-10-16 Farmaceutici Italia Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats.
US3957980A (en) * 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) * 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US4806372A (en) * 1985-02-15 1989-02-21 Georgia Oil & Gas Co., Inc. Nitrite-free-curing of bacon and product thereof
US6756365B2 (en) 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
CA2318580A1 (en) * 1998-01-23 1999-07-29 Mark L. Nelson Pharmaceutically active compounds and methods of use thereof
US6256365B1 (en) * 1999-08-16 2001-07-03 Analogic Corporation Apparatus and method for reconstruction of images in a computed tomography system using oblique slices
EP2327687A3 (en) * 1999-09-14 2012-08-15 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6500812B2 (en) * 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6849615B2 (en) * 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
AU3105801A (en) * 2000-01-24 2001-07-31 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
MXPA02009482A (es) * 2000-03-31 2004-05-14 Tufts College Compuestos tetraciclinas sustituidos con grupos 7- y 9- carbamato, urea, tiourea, tiocarbamato y heteroaril-amino.
WO2001087824A2 (en) * 2000-05-15 2001-11-22 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
CN1450989A (zh) * 2000-07-07 2003-10-22 塔夫茨大学信托人 7-取代的四环素化合物
JP4963771B2 (ja) * 2000-07-07 2012-06-27 トラスティーズ・オブ・タフツ・カレッジ 7、8および9−置換テトラサイクリン化合物
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
EA013908B1 (ru) * 2000-07-07 2010-08-30 Трастис Оф Тафтс Коллидж Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1241160A1 (en) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracycline derivatives and their use as antibiotic agents
WO2002072532A1 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7, 9-substituted tetracycline compounds
JP2004530661A (ja) * 2001-03-14 2004-10-07 パラテック ファーマシューティカルズ インコーポレイテッド 抗真菌剤としての置換テトラサイクリン化合物
WO2002072031A2 (en) * 2001-03-14 2002-09-19 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2329826A1 (en) * 2001-07-13 2011-06-08 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of multiple sclerosis
AU2002365120A1 (en) * 2001-08-02 2003-07-15 Paratek Pharmaceuticals, Inc. Medicaments
WO2003023568A2 (en) * 2001-09-10 2003-03-20 Paratek Pharmaceuticals, Inc. Computational method for determining oral bioavailability
EP2311799A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
JP2005526754A (ja) * 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド アミノメチル置換されたテトラサイクリン化合物
KR101083498B1 (ko) * 2002-03-21 2011-11-16 파라테크 파마슈티컬스, 인크. 치환된 테트라시클린 화합물
CA2492273C (en) * 2002-07-12 2013-02-05 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
CA2503446C (en) * 2002-10-24 2012-12-18 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
WO2004091513A2 (en) * 2003-04-10 2004-10-28 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
CA2531728A1 (en) * 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
JP4738333B2 (ja) * 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド 9−アミノメチルテトラサイクリン化合物のプロドラッグ
CA2553510C (en) * 2004-01-15 2012-09-25 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
AU2005299294B2 (en) * 2004-10-25 2012-06-07 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2269985A3 (en) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
WO2006084265A1 (en) * 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS
JP2009502809A (ja) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド 10−置換テトラサイクリンおよびその使用方法
EP2298324A1 (en) * 2006-01-24 2011-03-23 Paratek Pharmaceuticals, Inc. Methods of increasing oral bioavailability of tetracyclines
AU2007249695A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
WO2008045507A2 (en) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of bacillus anthracis infections
PL2109602T3 (pl) 2006-12-21 2014-09-30 Paratek Pharm Innc Pochodne tetracyliny do leczenia zakażeń bakteryjnych, wirusowych i pasożytniczych
PT2120963T (pt) * 2006-12-21 2018-12-17 Paratek Pharm Innc Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele
JP2010523684A (ja) * 2007-04-12 2010-07-15 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法
JP2010525069A (ja) * 2007-04-27 2010-07-22 パラテック ファーマシューティカルズ インコーポレイテッド アミノアルキルテトラサイクリン化合物の合成方法および精製方法
BRPI0823405A2 (pt) * 2007-07-06 2012-12-25 Paratek Pharmaceuticals, Inc. mÉtodos para sintetizar compostos de tetraciclina substituÍda
CA2717703A1 (en) * 2008-03-05 2009-09-11 Paratek Pharmaceuticals, Inc. Minocycline compounds and methods of use thereof
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
JP2011517697A (ja) * 2008-04-14 2011-06-16 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
TW202216656A (zh) * 2008-05-19 2022-05-01 美商Prtk Spv2公司 四環素化合物之甲苯磺酸鹽及同素異形體
TW202206081A (zh) * 2016-08-03 2022-02-16 美商派瑞泰Spv2有限公司 9—胺甲基米諾四環素化合物及其用途

Also Published As

Publication number Publication date
US20150087711A1 (en) 2015-03-26
RU2010140682A (ru) 2012-04-10
WO2009111064A3 (en) 2010-03-11
US20210121483A1 (en) 2021-04-29
CA2717703A1 (en) 2009-09-11
AU2009220171A1 (en) 2009-09-11
WO2009111064A2 (en) 2009-09-11
US9724358B2 (en) 2017-08-08
US20160228459A1 (en) 2016-08-11
CN102015602A (zh) 2011-04-13
KR20100126469A (ko) 2010-12-01
JP2011513404A (ja) 2011-04-28
US9265740B2 (en) 2016-02-23
US10124014B2 (en) 2018-11-13
US20200289532A1 (en) 2020-09-17
US20250213595A1 (en) 2025-07-03
CL2010000188A1 (es) 2011-04-01
EP2262754A4 (en) 2012-03-14
US20240131037A1 (en) 2024-04-25
US20180015108A1 (en) 2018-01-18
EP2262754A2 (en) 2010-12-22
US20240226119A9 (en) 2024-07-11
US20090253660A1 (en) 2009-10-08
US20190142850A1 (en) 2019-05-16
MX2010009693A (es) 2010-12-20

Similar Documents

Publication Publication Date Title
BRPI0908951A2 (pt) compostos de minociclina e método de uso dos mesmos
BR112012000934A2 (pt) cassetes e métodos de utilizacao destes
SMT201600278B (it) Inibitori della benzossazolo chinasi e metodi d'uso
BRPI1014544A2 (pt) anticorpors anti-il-17f e metodos de uso dos mesmos
BRPI0910346A2 (pt) compostos de benzopirano e benzoxapina inibidores de pi3k e métodos de uso
BRPI0915231A2 (pt) compostos inibidores de quinase e métodos de uso
BR112012003661A2 (pt) "compostos de biarila e métodos de uso dos mesmos."
BRPI0921983A2 (pt) moduladores tgr5 e métodos de uso dos mesmos
BRPI0920145A2 (pt) compostos de tioamida, método de produção e método de uso dos mesmos
BR112012024120A2 (pt) sarms e método de uso dos mesmos
CR20140180A (es) Inhibidores macrocíclicos de serina proteasas de hepatitis c
BRPI0911332A2 (pt) composições e uso de inibidores de epas1
BRPI0916769A2 (pt) derivados de benzilbenzeno deuterados e métodos de uso
PT2424896E (pt) Anticorpos anti-ceacam1 e métodos de utilização dos mesmos
BRPI0922344A2 (pt) inibidores de tfpi e métodos de uso
BRPI0915928A2 (pt) composições e métodos de uso para anticorpos terapêuticos
BRPI0818003A2 (pt) inibidores de csf-1r, composições e métodos de uso
EP2299999A4 (en) STAT3 INHIBITORS
BRPI0921992A2 (pt) moduladores tgr5 e métodos de uso destes
BRPI0913086A2 (pt) Composições antimicrobianas e métodos de uso
BRPI0920263A2 (pt) composto, uso do composto, composição, e, método
BRPI0909954A2 (pt) "diazacarbazóis e métodos de uso"
BRPI0807495A2 (pt) Adjuvantes e métodos de emrpego dos mesmos
ATE543816T1 (de) Azacycloalkanderivate als inhibitoren von stearoyl-coenzym-a-delta-9-desaturase
SMT201600264B (it) POLIMORFI E SOLVATI DI 4-[-2-[[5-METlL-1-(2-NAFTALENlL)-1H-PIRAZOL-3-IL]OSSl]ETlL]MORFOLINA CLORIDRATO

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]