BRPI0908951A2 - compostos de minociclina e método de uso dos mesmos - Google Patents
compostos de minociclina e método de uso dos mesmosInfo
- Publication number
- BRPI0908951A2 BRPI0908951A2 BRPI0908951A BRPI0908951A BRPI0908951A2 BR PI0908951 A2 BRPI0908951 A2 BR PI0908951A2 BR PI0908951 A BRPI0908951 A BR PI0908951A BR PI0908951 A BRPI0908951 A BR PI0908951A BR PI0908951 A2 BRPI0908951 A2 BR PI0908951A2
- Authority
- BR
- Brazil
- Prior art keywords
- minocycline compounds
- minocycline
- compounds
- avaible
- abstract
- Prior art date
Links
- DYKFCLLONBREIL-KVUCHLLUSA-N minocycline Chemical class C([C@H]1C2)C3=C(N(C)C)C=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O DYKFCLLONBREIL-KVUCHLLUSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
abstract not avaible
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6818008P | 2008-03-05 | 2008-03-05 | |
| PCT/US2009/001451 WO2009111064A2 (en) | 2008-03-05 | 2009-03-05 | Minocycline compounds and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0908951A2 true BRPI0908951A2 (pt) | 2017-01-17 |
Family
ID=41056527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0908951A BRPI0908951A2 (pt) | 2008-03-05 | 2009-03-05 | compostos de minociclina e método de uso dos mesmos |
Country Status (12)
| Country | Link |
|---|---|
| US (9) | US20090253660A1 (pt) |
| EP (1) | EP2262754A4 (pt) |
| JP (1) | JP2011513404A (pt) |
| KR (1) | KR20100126469A (pt) |
| CN (1) | CN102015602A (pt) |
| AU (1) | AU2009220171A1 (pt) |
| BR (1) | BRPI0908951A2 (pt) |
| CA (1) | CA2717703A1 (pt) |
| CL (1) | CL2010000188A1 (pt) |
| MX (1) | MX2010009693A (pt) |
| RU (1) | RU2010140682A (pt) |
| WO (1) | WO2009111064A2 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| WO2009090495A2 (en) | 2007-12-07 | 2009-07-23 | Foamix Ltd. | Oil and liquid silicone foamable carriers and formulations |
| AU2009220171A1 (en) * | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| TW202332671A (zh) | 2008-05-19 | 2023-08-16 | 美商Prtk Spv2公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| WO2010125470A2 (en) | 2009-04-28 | 2010-11-04 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
| CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| MX359879B (es) | 2009-10-02 | 2018-10-12 | Foamix Pharmaceuticals Ltd | Composiciones tópicas de tetraciclina. |
| EP3574908B8 (en) * | 2011-05-12 | 2024-09-11 | Almirall LLC | Pharmaceutical composition for oral administration comprising crystalline salts of (4s, 4as, 5ar, 12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2carboxylic acid amide |
| KR20240051297A (ko) * | 2015-03-24 | 2024-04-19 | 파라테크 파마슈티컬스, 인크. | 생물방어를 위한 미노시클린 화합물 |
| GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
| MX2018013271A (es) * | 2016-05-02 | 2019-03-28 | Paratek Pharm Innc | Compuestos 9-aminometil minociclina y metodos para utilizarlos en el tratamiento de infeccion de vias urinarias (ivu). |
| TWI746610B (zh) * | 2016-08-03 | 2021-11-21 | 美商派瑞泰Spv2有限公司 | 9-胺甲基米諾四環素化合物及其用途 |
| CA2978573A1 (en) | 2016-09-08 | 2018-03-08 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
| GB201615693D0 (en) | 2016-09-15 | 2016-11-02 | Combinatorx Infection Ltd | Combinations |
| US10383884B2 (en) * | 2016-11-01 | 2019-08-20 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl minocycline compounds and use thereof in treating community-acquired bacterial pneumonia (CABP) |
| LT3917616T (lt) | 2019-01-31 | 2025-08-11 | Takeda Pharmaceutical Company Limited | Heterocikliniai junginiai ir jų naudojimas |
| US11419834B2 (en) | 2019-02-25 | 2022-08-23 | Rhode Island Hospital | Methods for treating diseases or infections caused by or associated with H. pylori using a halogenated salicylanilide |
| GB201902580D0 (en) * | 2019-02-26 | 2019-04-10 | Healx Ltd | Treatment |
| JP2023530415A (ja) * | 2020-06-11 | 2023-07-18 | パラテック ファーマシューティカルズ,インコーポレイテッド | オマダサイクリンの結晶形態、その合成方法及びその使用方法 |
| PT117254B (pt) | 2021-05-26 | 2024-04-18 | Hovione Farm S A | Método de síntese de compostos 9-aminometil tetraciclinas |
Family Cites Families (71)
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|---|---|---|---|---|
| US2990331A (en) * | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
| US2980584A (en) * | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3062717A (en) * | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3165531A (en) * | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
| US3454697A (en) * | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
| NL6607516A (pt) | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| CA999855A (en) | 1972-09-18 | 1976-11-16 | Societa' Farmaceutici Italia S.P.A. | Process for the preparation of tetracyclines derivatives in the 7 position |
| US3957980A (en) * | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| DE2442829A1 (de) * | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
| US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
| US4126680A (en) * | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
| US5064821A (en) * | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
| US4806529A (en) * | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5589470A (en) * | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US4806372A (en) * | 1985-02-15 | 1989-02-21 | Georgia Oil & Gas Co., Inc. | Nitrite-free-curing of bacon and product thereof |
| US6756365B2 (en) | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US20020123637A1 (en) * | 1998-01-23 | 2002-09-05 | Stuart B. Levy | Pharmaceutically active compounds and methods of use thereof |
| US6256365B1 (en) * | 1999-08-16 | 2001-07-03 | Analogic Corporation | Apparatus and method for reconstruction of images in a computed tomography system using oblique slices |
| EP1666454B1 (en) * | 1999-09-14 | 2011-09-07 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| US6849615B2 (en) * | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| US6500812B2 (en) * | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| JP2003523963A (ja) * | 2000-01-24 | 2003-08-12 | トラスティーズ・オブ・タフツ・カレッジ | クリプトスポリジウム・パルヴム関連疾患の治療のためのテトラサイクリン化合物 |
| BR0109725A (pt) * | 2000-03-31 | 2003-02-04 | Tufts College | Composto de tetraciclina substituìdo, método para tratar um estado responsivo a tetraciclina em um mamìfero, composição farmacêutica, método para sintetizar um composto de tetraciclina 7- ou 9-substituìdo, e, intermediário reativo |
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| US20040224927A1 (en) * | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| AU2001268475A1 (en) * | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US20020132798A1 (en) * | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
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| WO2002004404A2 (en) * | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| CN1450989A (zh) * | 2000-07-07 | 2003-10-22 | 塔夫茨大学信托人 | 7-取代的四环素化合物 |
| KR100674047B1 (ko) * | 2000-07-07 | 2007-01-25 | 트러스티즈 오브 터프츠 칼리지 | 9-치환된 미노사이클린 화합물 |
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| US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
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| CA2457234A1 (en) * | 2001-03-14 | 2002-09-19 | Mark L. Nelson | Substituted tetracycline compounds as antifungal agents |
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| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| EP2332547A1 (en) * | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of inflammatory bowel disease |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| WO2003055441A2 (en) * | 2001-08-02 | 2003-07-10 | Paratek Pharmaceuticals, Inc. | Medicaments |
| WO2003023568A2 (en) * | 2001-09-10 | 2003-03-20 | Paratek Pharmaceuticals, Inc. | Computational method for determining oral bioavailability |
| EP2311798A1 (en) * | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| WO2003075857A2 (en) * | 2002-03-08 | 2003-09-18 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
| CA2479877C (en) * | 2002-03-21 | 2012-08-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| AU2003261161B2 (en) * | 2002-07-12 | 2009-09-10 | Paratek Pharmaceuticals, Inc | 3, 10, and 12a substituted tetracycline compounds |
| EP1562608A4 (en) * | 2002-10-24 | 2010-09-01 | Paratek Pharm Innc | METHOD OF USE OF SUBSTITUTED TETRACYCLINE COMPOUNDS FOR MODULATING THE RNA |
| WO2004091513A2 (en) * | 2003-04-10 | 2004-10-28 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| WO2005009943A2 (en) * | 2003-07-09 | 2005-02-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP1656341A1 (en) * | 2003-07-09 | 2006-05-17 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
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| EP2301916A3 (en) * | 2004-10-25 | 2011-09-28 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| CA2597212A1 (en) * | 2005-02-04 | 2006-08-10 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| US20070093455A1 (en) * | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
| EP2298324A1 (en) * | 2006-01-24 | 2011-03-23 | Paratek Pharmaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| CA2652347A1 (en) | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| US8440646B1 (en) | 2006-10-11 | 2013-05-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of Bacillus anthracis infections |
| IL270446B2 (en) | 2006-12-21 | 2023-10-01 | Paratek Pharm Innc | A tetracycline compound, a pharmaceutical preparation containing the tetracycline compound, and the tetracycline compound or the pharmaceutical preparation for the treatment of the tetracycline-responsive condition |
| EP2120963B1 (en) * | 2006-12-21 | 2018-09-12 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| JP2010523684A (ja) * | 2007-04-12 | 2010-07-15 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法 |
| EP2213655A1 (en) * | 2007-04-27 | 2010-08-04 | Paratek Pharmaceuticals, Inc. | Methods For Purifying Aminoalkyl Tetracycline Compounds |
| EA201070233A1 (ru) * | 2007-07-06 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Способы синтеза замещённых соединений тетрациклина (варианты) |
| AU2009220171A1 (en) * | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| JP2011517697A (ja) * | 2008-04-14 | 2011-06-16 | パラテック ファーマシューティカルズ インコーポレイテッド | 置換テトラサイクリン化合物 |
| TW202332671A (zh) * | 2008-05-19 | 2023-08-16 | 美商Prtk Spv2公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| TWI746610B (zh) * | 2016-08-03 | 2021-11-21 | 美商派瑞泰Spv2有限公司 | 9-胺甲基米諾四環素化合物及其用途 |
-
2009
- 2009-03-05 AU AU2009220171A patent/AU2009220171A1/en not_active Abandoned
- 2009-03-05 BR BRPI0908951A patent/BRPI0908951A2/pt not_active IP Right Cessation
- 2009-03-05 RU RU2010140682/15A patent/RU2010140682A/ru not_active Application Discontinuation
- 2009-03-05 CA CA2717703A patent/CA2717703A1/en not_active Abandoned
- 2009-03-05 US US12/398,980 patent/US20090253660A1/en not_active Abandoned
- 2009-03-05 KR KR1020107022101A patent/KR20100126469A/ko not_active Withdrawn
- 2009-03-05 MX MX2010009693A patent/MX2010009693A/es not_active Application Discontinuation
- 2009-03-05 CN CN2009801140162A patent/CN102015602A/zh active Pending
- 2009-03-05 JP JP2010549673A patent/JP2011513404A/ja active Pending
- 2009-03-05 EP EP09717098A patent/EP2262754A4/en not_active Withdrawn
- 2009-03-05 WO PCT/US2009/001451 patent/WO2009111064A2/en not_active Ceased
-
2010
- 2010-03-04 CL CL2010000188A patent/CL2010000188A1/es unknown
-
2014
- 2014-04-22 US US14/258,847 patent/US9265740B2/en active Active
-
2016
- 2016-02-02 US US14/995,896 patent/US9724358B2/en active Active
-
2017
- 2017-06-29 US US15/637,144 patent/US10124014B2/en active Active
-
2018
- 2018-10-11 US US16/157,290 patent/US20190142850A1/en not_active Abandoned
-
2020
- 2020-01-17 US US16/745,435 patent/US20200289532A1/en not_active Abandoned
-
2021
- 2021-01-05 US US17/141,763 patent/US20210121483A1/en not_active Abandoned
-
2023
- 2023-08-28 US US18/238,666 patent/US20240226119A9/en not_active Abandoned
-
2024
- 2024-11-12 US US18/944,434 patent/US20250213595A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011513404A (ja) | 2011-04-28 |
| CN102015602A (zh) | 2011-04-13 |
| MX2010009693A (es) | 2010-12-20 |
| WO2009111064A3 (en) | 2010-03-11 |
| US20210121483A1 (en) | 2021-04-29 |
| EP2262754A4 (en) | 2012-03-14 |
| US20090253660A1 (en) | 2009-10-08 |
| CL2010000188A1 (es) | 2011-04-01 |
| KR20100126469A (ko) | 2010-12-01 |
| US9724358B2 (en) | 2017-08-08 |
| EP2262754A2 (en) | 2010-12-22 |
| US20240131037A1 (en) | 2024-04-25 |
| US20240226119A9 (en) | 2024-07-11 |
| RU2010140682A (ru) | 2012-04-10 |
| US20160228459A1 (en) | 2016-08-11 |
| US20200289532A1 (en) | 2020-09-17 |
| WO2009111064A2 (en) | 2009-09-11 |
| US20180015108A1 (en) | 2018-01-18 |
| CA2717703A1 (en) | 2009-09-11 |
| AU2009220171A1 (en) | 2009-09-11 |
| US9265740B2 (en) | 2016-02-23 |
| US10124014B2 (en) | 2018-11-13 |
| US20150087711A1 (en) | 2015-03-26 |
| US20250213595A1 (en) | 2025-07-03 |
| US20190142850A1 (en) | 2019-05-16 |
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