BRPI0909028A2 - nitroimidazóis bicíclicos covalentemente ligados a fenil oxazolidinonas substituídas, composições farmacêuticas e uso dos mesmos - Google Patents

nitroimidazóis bicíclicos covalentemente ligados a fenil oxazolidinonas substituídas, composições farmacêuticas e uso dos mesmos

Info

Publication number
BRPI0909028A2
BRPI0909028A2 BRPI0909028A BRPI0909028A BRPI0909028A2 BR PI0909028 A2 BRPI0909028 A2 BR PI0909028A2 BR PI0909028 A BRPI0909028 A BR PI0909028A BR PI0909028 A BRPI0909028 A BR PI0909028A BR PI0909028 A2 BRPI0909028 A2 BR PI0909028A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
substituted phenyl
covalently linked
linked bicyclic
phenyl oxazolidinones
Prior art date
Application number
BRPI0909028A
Other languages
English (en)
Inventor
Adrian Blaser
Andrew M Thompson
Brian Desmond Palmer
Charles Z Ding
Dianjun D Chen
Genliang Lu
Hamish Scott Sutherland
Iveta Kmentova
Jiancheng Wang
Keith Combrink
Minsoo Song
William Alexander Denny
Zhenkun Ma
Original Assignee
Global Alliance For Tb Drug Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Global Alliance For Tb Drug Dev filed Critical Global Alliance For Tb Drug Dev
Publication of BRPI0909028A2 publication Critical patent/BRPI0909028A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BRPI0909028A 2008-03-26 2009-03-25 nitroimidazóis bicíclicos covalentemente ligados a fenil oxazolidinonas substituídas, composições farmacêuticas e uso dos mesmos BRPI0909028A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7085508P 2008-03-26 2008-03-26
PCT/US2009/038266 WO2009120789A1 (en) 2008-03-26 2009-03-25 Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones

Publications (1)

Publication Number Publication Date
BRPI0909028A2 true BRPI0909028A2 (pt) 2015-09-22

Family

ID=40821727

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0909028A BRPI0909028A2 (pt) 2008-03-26 2009-03-25 nitroimidazóis bicíclicos covalentemente ligados a fenil oxazolidinonas substituídas, composições farmacêuticas e uso dos mesmos

Country Status (11)

Country Link
US (1) US7666864B2 (pt)
EP (1) EP2254892B1 (pt)
JP (1) JP5613656B2 (pt)
CN (1) CN101965353B (pt)
AU (1) AU2009228293B2 (pt)
BR (1) BRPI0909028A2 (pt)
CA (1) CA2712613C (pt)
NZ (1) NZ587096A (pt)
RU (1) RU2504547C2 (pt)
WO (1) WO2009120789A1 (pt)
ZA (1) ZA201006824B (pt)

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US9198913B2 (en) 2009-07-31 2015-12-01 Global Alliance For Tb Drug Development Nitroimidazooxazines and their uses in anti-tubercular therapy
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BR112012002214B1 (pt) 2009-07-31 2022-01-25 Global Alliance For Tb Drug Development Análogos de nitroimidazooxazina e nitroimidazooxazol, seus usos e composição farmacêutica
CN102234287B (zh) * 2010-04-26 2015-08-05 上海阳帆医药科技有限公司 硝基咪唑类化合物、其制备方法和用途
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WO2012033952A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. 3 - phenyl- 2 -oxo- 1, 3 -oxazolidines for treatment of bacterial infections
AU2011303597A1 (en) * 2010-09-17 2013-04-11 Purdue Pharma L.P. Pyridine compounds and the uses thereof
US9051333B2 (en) 2011-04-15 2015-06-09 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
UA112876C2 (uk) 2011-09-29 2016-11-10 Сюаньчжу Фарма Ко., Лтд. Біарилгетероциклзаміщені оксазолідинонові антибактеріальні засоби
WO2013072903A1 (en) 2011-11-17 2013-05-23 Ithemba Pharmaceuticals (Proprietary) Limited Nitroimidazoxadiazocine compounds
KR101650716B1 (ko) * 2012-11-22 2016-08-24 한국화학연구원 바이시클릭니트로이미다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 결핵의 예방 또는 치료용 약학적 조성물
IN2013DE02954A (pt) * 2013-10-04 2015-04-10 Council Scient Ind Res
KR101564425B1 (ko) 2013-11-26 2015-10-30 한국화학연구원 신규한 바이사이클릭 니트로이미다졸 카바메이트 화합물, 이를 제조하는 방법 및 이를 유효성분으로 함유하는 결핵 질환의 예방 또는 치료용 약제학적 조성물
CN104725330B (zh) * 2013-12-18 2017-06-13 四川好医生药业集团有限公司 噁唑烷酮类化合物及其制备方法和用途
CN104496979A (zh) * 2014-09-17 2015-04-08 博瑞生物医药技术(苏州)有限公司 一种噁唑烷酮类化合物及其中间体的制备方法
KR101682356B1 (ko) 2014-11-04 2016-12-06 한국화학연구원 이미다조 옥사진 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학이성질체 및 이를 유효성분으로 함유하는 약제학적 조성물
CN105732659B (zh) * 2014-12-12 2019-07-16 上海阳帆医药科技有限公司 硝基咪唑类化合物及其制备方法和在制药中的用途
WO2016119706A1 (zh) 2015-01-29 2016-08-04 南京明德新药研发股份有限公司 抗肺结核病的硝基咪唑衍生物
CN106317072B (zh) * 2015-06-17 2020-03-17 盟科医药技术(上海)有限公司 用于分枝杆菌感染治疗的杂环化合物及其应用
BR112017028318B1 (pt) 2015-07-02 2024-02-20 Janssen Sciences Ireland Uc Composto antibacteriano, seu uso, processo para sua preparação,produto que o contém, composição farmacêutica e combinação
EA202190167A1 (ru) 2015-07-17 2021-07-30 Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. Замещенные фенилоксазолидиноны для антимикробной терапии
BR112018076126A2 (pt) 2016-06-16 2019-03-26 Janssen Sciences Ireland Unlimited Company compostos heterocíclicos como antibacterianos
EP4417262A3 (en) 2017-03-01 2024-11-27 Janssen Sciences Ireland Unlimited Company Combination therapy
CN107827927B (zh) * 2017-09-05 2019-08-09 陕西思尔生物科技有限公司 一种镍催化合成磷酸泰地唑利的方法
CN108047248A (zh) * 2018-02-12 2018-05-18 丹诺医药(苏州）有限公司 噁唑烷酮-硝基咪唑类偶联分子的应用
CN111606900A (zh) * 2019-02-24 2020-09-01 陕西合成药业股份有限公司 一种抗感染药物及其制备方法和应用
CN112300192B (zh) * 2019-08-02 2023-08-11 南京长澳医药科技有限公司 硝基咪唑类化合物及其制备方法和用途
CN113527331B (zh) * 2020-04-17 2024-05-28 南京长澳医药科技有限公司 硝基咪唑类衍生物及其制备方法和用途

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US4921869A (en) 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
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JP4805139B2 (ja) 2003-04-30 2011-11-02 モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用
US7687627B2 (en) 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
PT1678185E (pt) 2003-10-31 2009-01-13 Otsuka Pharma Co Ltd Compostos 2,3-di-hidro-6-nitroimidazo[2,1-b]oxazole para o tratamento da tuberculose
AR046782A1 (es) 2003-12-17 2005-12-21 Rib X Pharmaceuticals Inc Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos.
BRPI0417193B8 (pt) * 2003-12-18 2021-05-25 Morphochem Ag Fuer Komb Chemie antibióticos híbridos de oxazolidinona-quinolona, seus sais monossódicos, dissódicos ou trissódicos e seus pró-fármacos, composições farmacêuticas, e seu uso
JP4787529B2 (ja) * 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
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Also Published As

Publication number Publication date
US20090281088A1 (en) 2009-11-12
AU2009228293A1 (en) 2009-10-01
CA2712613A1 (en) 2009-10-01
EP2254892B1 (en) 2014-04-23
RU2504547C2 (ru) 2014-01-20
EP2254892A1 (en) 2010-12-01
NZ587096A (en) 2011-11-25
CN101965353B (zh) 2014-12-17
US7666864B2 (en) 2010-02-23
CA2712613C (en) 2017-02-28
WO2009120789A1 (en) 2009-10-01
AU2009228293B2 (en) 2012-11-08
RU2010143541A (ru) 2012-05-10
JP5613656B2 (ja) 2014-10-29
ZA201006824B (en) 2011-06-29
JP2011515487A (ja) 2011-05-19
WO2009120789A8 (en) 2010-10-28
CN101965353A (zh) 2011-02-02

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: TENNOR THERAPEUTICS LIMITED (CN)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]