BRPI0909182A2 - Usos de agente de ruptura das junções epiteliais da córnea, de agente de dissociação das pontes moleculares entre fibras de colágeno do estroma e de agente de restabelecimento da rede de colágeno do estroma - Google Patents

Usos de agente de ruptura das junções epiteliais da córnea, de agente de dissociação das pontes moleculares entre fibras de colágeno do estroma e de agente de restabelecimento da rede de colágeno do estroma

Info

Publication number
BRPI0909182A2
BRPI0909182A2 BRPI0909182-3A BRPI0909182A BRPI0909182A2 BR PI0909182 A2 BRPI0909182 A2 BR PI0909182A2 BR PI0909182 A BRPI0909182 A BR PI0909182A BR PI0909182 A2 BRPI0909182 A2 BR PI0909182A2
Authority
BR
Brazil
Prior art keywords
agent
stromal collagen
corneal epithelial
dissociating
molecular bridge
Prior art date
Application number
BRPI0909182-3A
Other languages
English (en)
Inventor
Bruce Dewoolfson
Dale Devore
Original Assignee
Euclid Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euclid Systems Corp filed Critical Euclid Systems Corp
Publication of BRPI0909182A2 publication Critical patent/BRPI0909182A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2093—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically including concentration setting means

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Materials For Medical Uses (AREA)
BRPI0909182-3A 2008-03-24 2009-03-18 Usos de agente de ruptura das junções epiteliais da córnea, de agente de dissociação das pontes moleculares entre fibras de colágeno do estroma e de agente de restabelecimento da rede de colágeno do estroma BRPI0909182A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6473008P 2008-03-24 2008-03-24
US6473108P 2008-03-24 2008-03-24
PCT/US2009/037497 WO2009120549A2 (en) 2008-03-24 2009-03-18 Methods to increase permeability of corneal epithelium and destabilize stromal collagen fibril network

Publications (1)

Publication Number Publication Date
BRPI0909182A2 true BRPI0909182A2 (pt) 2015-08-11

Family

ID=41114589

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0909182-3A BRPI0909182A2 (pt) 2008-03-24 2009-03-18 Usos de agente de ruptura das junções epiteliais da córnea, de agente de dissociação das pontes moleculares entre fibras de colágeno do estroma e de agente de restabelecimento da rede de colágeno do estroma
BRPI0909121-1A BRPI0909121A2 (pt) 2008-03-24 2009-03-18 equipamentos de concentração localizada de fluidos em ambientes oculares

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0909121-1A BRPI0909121A2 (pt) 2008-03-24 2009-03-18 equipamentos de concentração localizada de fluidos em ambientes oculares

Country Status (8)

Country Link
US (1) US20110086802A1 (pt)
EP (2) EP2262445A2 (pt)
JP (2) JP2011515476A (pt)
KR (2) KR20100127846A (pt)
CN (2) CN101977652A (pt)
BR (2) BRPI0909182A2 (pt)
CA (2) CA2719067A1 (pt)
WO (2) WO2009120550A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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US9622911B2 (en) 2010-09-30 2017-04-18 Cxl Ophthalmics, Llc Ophthalmic treatment device, system, and method of use
US9555111B2 (en) 2012-03-29 2017-01-31 Cxl Ophthalmics, Llc Ocular cross-linking system and method for sealing corneal wounds
US9566301B2 (en) 2012-03-29 2017-02-14 Cxl Ophthalmics, Llc Compositions and methods for treating or preventing diseases associated with oxidative stress
EP4420725A3 (en) 2012-03-29 2025-04-16 Epion Therapeutics, Inc. Ocular treatment solutions, delivery devices and delivery augmentation methods
US9642742B2 (en) 2012-10-02 2017-05-09 Harold D. Mansfield Eye drop applicator and drop transfer method
US20150305933A1 (en) * 2014-04-23 2015-10-29 Carl Zeiss Meditec Ag Integrated device system and method for noninvasive corneal refractive corrections
GB201519450D0 (en) 2015-11-03 2015-12-16 Univ Liverpool Novel treatment
US10342697B2 (en) 2016-04-13 2019-07-09 Avedro, Inc. Systems and methods for delivering drugs to an eye
JP2023517179A (ja) * 2020-02-14 2023-04-24 ケイロス パター イノヴァサオ エス．エー 脱細胞化生体材料を製造する方法、脱細胞化生体材料、及びその使用
CN111297552A (zh) * 2020-03-18 2020-06-19 复旦大学附属眼耳鼻喉科医院 一种用于角膜交联手术的上皮环钻
US20210324025A1 (en) 2020-04-20 2021-10-21 D&D Biopharmaceuticals, Inc. Compositions and methods for treating corneal endothelium
US11259959B1 (en) 2020-11-03 2022-03-01 D&D Biopharmaceuticals, Inc. Devices and methods for cornea treatment
US11938092B1 (en) 2022-11-30 2024-03-26 D&D Biopharmaceuticals, Inc. Devices and methods for cornea treatment
US12295882B1 (en) 2024-09-17 2025-05-13 D&D Biopharmaceuticals, Llc Baffle devices and related methods for delivery of therapeutic compositions to the eye
CN121177582B (zh) * 2025-11-26 2026-02-17 江苏博创生物科技有限公司 一种可在体内长期稳定存在的胶原膜材料及其制备方法

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US3016898A (en) * 1959-09-08 1962-01-16 Weldon C Erwin Combination eye cup and eye fluid applicator
US3760807A (en) * 1972-04-07 1973-09-25 C Neefe Method of reshaping the cornea to eliminate refractive errors
US3831604A (en) * 1973-04-18 1974-08-27 C Neefe Method of reshaping the cornea
US3776230A (en) * 1973-04-18 1973-12-04 C Neefe Method of rapidly reshaping the cornea to eliminate refractive errors
US4851513A (en) * 1985-09-06 1989-07-25 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for opthalmic use and method of preparation
US4713446A (en) * 1985-09-06 1987-12-15 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for ophthalmic use and method of preparation
US4685906A (en) * 1986-03-31 1987-08-11 Murphy William F Eye-drops application device
US4969912A (en) * 1988-02-18 1990-11-13 Kelman Charles D Human collagen processing and autoimplant use
US5201764A (en) * 1990-02-28 1993-04-13 Autogenesis Technologies, Inc. Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom
US5219895A (en) * 1991-01-29 1993-06-15 Autogenesis Technologies, Inc. Collagen-based adhesives and sealants and methods of preparation and use thereof
US5492135A (en) * 1992-09-09 1996-02-20 Devore; Dale P. Collagen modulators for use in photoablation excimer laser keratectomy
US6161544A (en) * 1998-01-28 2000-12-19 Keratoform, Inc. Methods for accelerated orthokeratology
US6161554A (en) * 1998-11-12 2000-12-19 Dunlap-Harris; Angela L. Removable tattoo eyebrows
US6946440B1 (en) * 1999-09-15 2005-09-20 Dewoolfson Bruce H Composition for stabilizing corneal tissue during or after orthokeratology lens wear
WO2002017936A1 (en) * 2000-08-28 2002-03-07 Collagenesis, Inc. Methods for processing animal tissues
US6945440B1 (en) * 2003-03-20 2005-09-20 Ford Kevin B Paint bucket

Also Published As

Publication number Publication date
WO2009120549A2 (en) 2009-10-01
CN101977652A (zh) 2011-02-16
WO2009120550A2 (en) 2009-10-01
CA2719061A1 (en) 2009-10-01
BRPI0909121A2 (pt) 2019-04-16
JP2011515476A (ja) 2011-05-19
KR20100127846A (ko) 2010-12-06
JP2011515195A (ja) 2011-05-19
WO2009120550A3 (en) 2009-12-30
CA2719067A1 (en) 2009-10-01
US20110086802A1 (en) 2011-04-14
EP2278988A2 (en) 2011-02-02
EP2262445A2 (en) 2010-12-22
KR20100135839A (ko) 2010-12-27
WO2009120549A3 (en) 2009-12-30
CN101977622A (zh) 2011-02-16

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 3A, 4A, 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.