BRPI0909791A8 - Cartucho, dispositivo sensor e método para detecção de componentes alvo em uma amostra líquida, e, uso do cartucho ou do dispositivo sensor. - Google Patents

Cartucho, dispositivo sensor e método para detecção de componentes alvo em uma amostra líquida, e, uso do cartucho ou do dispositivo sensor.

Info

Publication number
BRPI0909791A8
BRPI0909791A8 BRPI0909791A BRPI0909791A BRPI0909791A8 BR PI0909791 A8 BRPI0909791 A8 BR PI0909791A8 BR PI0909791 A BRPI0909791 A BR PI0909791A BR PI0909791 A BRPI0909791 A BR PI0909791A BR PI0909791 A8 BRPI0909791 A8 BR PI0909791A8
Authority
BR
Brazil
Prior art keywords
cartridge
sensing device
target components
liquid sample
detecting target
Prior art date
Application number
BRPI0909791A
Other languages
English (en)
Inventor
J J Sijbers Mara
J W Van Lankvelt Petrus
K De Theije Femke
H Nieuwenhuis Jeroen
Original Assignee
Koninklije Philips Electronics N V
Koninklijke Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklije Philips Electronics N V, Koninklijke Philips Nv filed Critical Koninklije Philips Electronics N V
Publication of BRPI0909791A2 publication Critical patent/BRPI0909791A2/pt
Publication of BRPI0909791A8 publication Critical patent/BRPI0909791A8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/282—Magnetic plugs and dipsticks with associated accumulation indicator, e.g. Hall sensor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/946—CNS-stimulants, e.g. cocaine, amphetamines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9486—Analgesics, e.g. opiates, aspirine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrochemistry (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

CARTUCHO, DISPOSITIVO SENSOR E MÉTODO PARA DETECÇÃO DE COMPONENTES ALVO EM UMA AMOSTRA LÍQUIDA, E, USO DO CARTUCHO OU DO DISPOSITIVO SENSOR. A invenção diz respeito a um cartucho (100) e um correspondente dispositivo sensor para a detecção de componentes-alvo em uma amostra líquida. O cartucho (100) compreende uma câmara de amostra (SC), pelo menos, dois reservatórios (131, 132) que podem ser fornecidos com partículas magnéticas (MP, MP'), e, pelo menos duas correspondentes zonas sensitivas (121, 122) nas quais as partículas magnéticas dissolvidas e/ou os componentes-alvo podem ser detectados. Quando um campo de acionamento magnético (B) de uma dada configuração é estabelecido na câmara de amostra, as partículas magnéticas de diferentes reservatórios migram predominantemente para diferentes zonas sensitivas. Desta forma, a mistura de partículas magnéticas pode ser evitada.
BRPI0909791A 2008-03-17 2009-03-11 Cartucho, dispositivo sensor e método para detecção de componentes alvo em uma amostra líquida, e, uso do cartucho ou do dispositivo sensor. BRPI0909791A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08102671 2008-03-17
PCT/IB2009/051021 WO2009115951A1 (en) 2008-03-17 2009-03-11 Cartridge for assays with magnetic particles

Publications (2)

Publication Number Publication Date
BRPI0909791A2 BRPI0909791A2 (pt) 2015-08-11
BRPI0909791A8 true BRPI0909791A8 (pt) 2016-08-02

Family

ID=40641647

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0909791A BRPI0909791A8 (pt) 2008-03-17 2009-03-11 Cartucho, dispositivo sensor e método para detecção de componentes alvo em uma amostra líquida, e, uso do cartucho ou do dispositivo sensor.

Country Status (8)

Country Link
US (2) US20110014719A1 (pt)
EP (1) EP2263084B1 (pt)
JP (1) JP5628784B2 (pt)
CN (1) CN101978267B (pt)
BR (1) BRPI0909791A8 (pt)
RU (1) RU2505816C2 (pt)
WO (1) WO2009115951A1 (pt)
ZA (1) ZA201007366B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2329269A1 (en) * 2008-09-26 2011-06-08 Koninklijke Philips Electronics N.V. Magnetic-label sensor and cartridge
RU2011121883A (ru) * 2008-10-31 2012-12-10 Конинклейке Филипс Электроникс Н.В. Биосенсор с многокамерным контейнером
US9086396B2 (en) 2008-11-28 2015-07-21 Roche Molecular Systems, Inc. System and method for the automated processing of fluids, method for determining the matching of objects
WO2011036597A1 (en) * 2009-09-23 2011-03-31 Koninklijke Philips Electronics N.V. Binding assay with multiple magnetically labelled tracer binding agents.
WO2011073866A1 (en) * 2009-12-18 2011-06-23 Koninklijke Philips Electronics N.V. Substance determining apparatus
WO2011161499A1 (en) * 2010-06-22 2011-12-29 Koninklijke Philips Electronics N.V. Detection of magnetic particles and their clustering
CN102985823B (zh) * 2010-07-05 2015-09-30 皇家飞利浦电子股份有限公司 带样本培育的检查系统
CN103229056B (zh) 2010-11-30 2015-06-24 皇家飞利浦电子股份有限公司 用于磁致动粒子的传感器装置
EP2541230A1 (en) * 2011-06-30 2013-01-02 Koninklijke Philips Electronics N.V. Detection of clusters of magnetic particles
EP2800970B1 (en) 2012-01-04 2016-09-28 Magnomics, S.A. Monolithic device combining cmos with magnetoresistive sensors
RU2014133714A (ru) * 2012-01-16 2016-03-10 Конинклейке Филипс Н.В. Определение присутствия целевых молекул в биологической текучей среде, содержащей клетки
CN102600966A (zh) * 2012-03-06 2012-07-25 南昌大学 简易磁珠分离装置
CN102600967A (zh) * 2012-03-06 2012-07-25 南昌大学 一种智能控制磁分离器
EP2906928A4 (en) 2012-10-15 2016-11-09 Nanocellect Biomedical Inc SYSTEMS, DEVICES AND METHOD FOR SORTING PARTICLES
CN102935996B (zh) * 2012-10-18 2015-04-22 上海交通大学 血清肿瘤标志物检测的微型化磁通门生物传感器制作方法
JP2014232032A (ja) * 2013-05-29 2014-12-11 独立行政法人国立長寿医療研究センター 化学・物理現象検出方法及びその装置
RU2569766C2 (ru) * 2014-01-24 2015-11-27 Общество с ограниченной ответственностью "Химмотолог" Устройство для автоматического определения качества смазочных материалов
CN104407113B (zh) * 2014-11-04 2016-09-07 上海交通大学 食品中致病菌检测的微型化磁通门生物传感器
JP6594995B2 (ja) * 2015-03-26 2019-10-23 コーニンクレッカ フィリップス エヌ ヴェ バイオセンサカートリッジの製造
US10261076B2 (en) * 2015-10-02 2019-04-16 The Board Of Trustees Of The Leland Stanford Junior University Method for detecting small molecule analytes using magnetoresistant sensors
US9702748B2 (en) 2015-10-14 2017-07-11 International Business Machines Corporation Graphene-based magnetic hall sensor for fluid flow analysis at nanoscale level
US10578614B2 (en) * 2016-03-11 2020-03-03 Qorvo Biotechnologies, Llc BAW sensor fluidic device with increased dynamic measurement range
CN112566726A (zh) * 2019-02-22 2021-03-26 Tdk株式会社 血液净化装置和血液净化方法
US11977086B2 (en) 2019-03-21 2024-05-07 Hound Labs, Inc. Biomarker detection from breath samples
CN116391126A (zh) 2020-08-07 2023-07-04 维塔生物科技公司 磁性分析物检测的动力学调节
US12392769B1 (en) * 2021-01-12 2025-08-19 Hound Labs, Inc. Ambient contamination in breath analyte detection and measurement
GB2631114A (en) * 2023-06-20 2024-12-25 Tachmed Holdings Ltd Sensor unit
IL311308A (en) * 2024-03-06 2025-10-01 M S Tech Ltd Substance sampling setups and methods
FR3162657A1 (fr) * 2024-05-30 2025-12-05 Inkjet Engine Technology Procédé de préparation d'un produit comprenant un substrat souple avec au moins une couche à motifs

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5981297A (en) * 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
US6300138B1 (en) * 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US7390675B2 (en) * 1999-10-15 2008-06-24 Christopher Feistel Multi-functional and configurable assay
US6875619B2 (en) * 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
WO2002021130A2 (en) * 2000-08-21 2002-03-14 Darashkevitch Oleg N Method and device for simultaneous detection of multiple components in a mixture
US7232691B2 (en) * 2001-11-27 2007-06-19 Los Alamos National Security, Llc Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
TWI306153B (en) * 2002-01-29 2009-02-11 Asahi Chemical Ind Biosensor, magnetic molecule measurement method, and measurement object measuring method
US20060134713A1 (en) * 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
US20040197845A1 (en) * 2002-08-30 2004-10-07 Arjang Hassibi Methods and apparatus for pathogen detection, identification and/or quantification
EP1697755A1 (en) 2003-07-30 2006-09-06 Koninklijke Philips Electronics N.V. On-chip magnetic sensor device with suppressed cross-talk
JP2007500347A (ja) 2003-07-30 2007-01-11 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 改善されたｓｎｒを持つチップ上磁性粒子センサ
JP2005315677A (ja) * 2004-04-28 2005-11-10 Canon Inc 検出装置および検出方法
JP4680587B2 (ja) * 2004-12-28 2011-05-11 旭化成株式会社 バイオセンサ、対象物測定方法、バイオセンサ用カートリッジ及び不織布
JP5311445B2 (ja) 2005-01-31 2013-10-09 コーニンクレッカ フィリップス エヌ ヴェ 高速かつ高感度バイオセンシング
MX2007013985A (es) * 2005-05-09 2008-02-22 Theranos Inc Sistemas de fluidos de punto de cuidado y usos de los mismos.
CN101198870A (zh) * 2005-06-17 2008-06-11 皇家飞利浦电子股份有限公司 精密磁性生物传感器
US20070031283A1 (en) * 2005-06-23 2007-02-08 Davis Charles Q Assay cartridges and methods for point of care instruments
JP5188091B2 (ja) * 2006-03-31 2013-04-24 キヤノン株式会社 センサ素子、ならびにこの素子を用いた磁性粒子の検出方法及び標的物質の検出方法
CN101438142B (zh) * 2006-05-10 2013-10-30 皇家飞利浦电子股份有限公司 快速磁生物传感器
CN101021530B (zh) * 2007-03-26 2011-08-31 南京大学 自动化通道分辨化学发光多组分免疫检测系统及分析方法
EP2034324A3 (en) * 2007-07-20 2010-06-16 Koninklijke Philips Electronics N.V. Sensor cartridge
EP2017618A1 (en) * 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Methods and systems for detecting

Also Published As

Publication number Publication date
EP2263084A1 (en) 2010-12-22
JP2011516832A (ja) 2011-05-26
EP2263084B1 (en) 2017-02-22
RU2505816C2 (ru) 2014-01-27
RU2010142278A (ru) 2012-04-27
ZA201007366B (en) 2012-03-28
CN101978267B (zh) 2017-04-26
CN101978267A (zh) 2011-02-16
WO2009115951A1 (en) 2009-09-24
US20110014719A1 (en) 2011-01-20
US20160291004A1 (en) 2016-10-06
JP5628784B2 (ja) 2014-11-19
BRPI0909791A2 (pt) 2015-08-11
US10006907B2 (en) 2018-06-26

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Owner name: KONINKLIJKE PHILIPS N.V. (NL)

B25G Requested change of headquarter approved

Owner name: KONINKLIJKE PHILIPS N.V. (NL)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]