BRPI0910457A2 - variante de fitase, ácido nucléico, vetor, célula hospedeira, método de produção de uma variante de fitase, composição enzimática, usos, método para a produção de um alimento ou ração para animal e respectivos alimento ou composição de ração para animal e método de redução dos níveis de redução de fósforo em estrume animal - Google Patents
variante de fitase, ácido nucléico, vetor, célula hospedeira, método de produção de uma variante de fitase, composição enzimática, usos, método para a produção de um alimento ou ração para animal e respectivos alimento ou composição de ração para animal e método de redução dos níveis de redução de fósforo em estrume animalInfo
- Publication number
- BRPI0910457A2 BRPI0910457A2 BRPI0910457A BRPI0910457A BRPI0910457A2 BR PI0910457 A2 BRPI0910457 A2 BR PI0910457A2 BR PI0910457 A BRPI0910457 A BR PI0910457A BR PI0910457 A BRPI0910457 A BR PI0910457A BR PI0910457 A2 BRPI0910457 A2 BR PI0910457A2
- Authority
- BR
- Brazil
- Prior art keywords
- feed
- producing
- phytase variant
- composition
- animal
- Prior art date
Links
- 108010011619 6-Phytase Proteins 0.000 title abstract 4
- 229940085127 phytase Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title 1
- 230000002255 enzymatic effect Effects 0.000 title 1
- 210000003608 fece Anatomy 0.000 title 1
- 239000010871 livestock manure Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 229910052698 phosphorus Inorganic materials 0.000 title 1
- 239000011574 phosphorus Substances 0.000 title 1
- 241001480566 Buttiauxella sp. Species 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/06—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03026—4-Phytase (3.1.3.26), i.e. 6-phytase
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Animal Husbandry (AREA)
- Nutrition Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
variantes de fitase de buttiauxella sp a presente invenção refere-se a variantes de fitase de buttiauxella sp. que podem ser usadas em aplicações industriais, incluindo métodos para liquefação de amido, fermentações de álcool e para 5 intensificação de digestão de fosfato em alimentos e rações para animais.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4632408P | 2008-04-18 | 2008-04-18 | |
| US61/046,324 | 2008-04-18 | ||
| PCT/US2009/041011 WO2009129489A2 (en) | 2008-04-18 | 2009-04-17 | Buttiauxella sp. phytase variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0910457A2 true BRPI0910457A2 (pt) | 2019-05-07 |
| BRPI0910457B1 BRPI0910457B1 (pt) | 2020-12-29 |
Family
ID=41090325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0910457-7A BRPI0910457B1 (pt) | 2008-04-18 | 2009-04-17 | variante de fitase, usos da mesma, composição enzimática, alimento e métodos de produção do mesmo, bem como para redução dos níveis de fósforo em estrume animal |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US8673609B2 (pt) |
| EP (2) | EP3118309B1 (pt) |
| JP (1) | JP5273686B2 (pt) |
| CN (1) | CN102007211B (pt) |
| BR (1) | BRPI0910457B1 (pt) |
| CA (1) | CA2721691C (pt) |
| DK (2) | DK2283124T3 (pt) |
| ES (1) | ES2835955T3 (pt) |
| HU (1) | HUE052318T2 (pt) |
| MX (2) | MX2010010982A (pt) |
| PL (1) | PL3118309T3 (pt) |
| WO (1) | WO2009129489A2 (pt) |
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| PL2419521T3 (pl) | 2009-04-17 | 2018-10-31 | Danisco Us Inc. | Sposoby przetwarzania zboża bez regulacji ph |
| GB0922467D0 (en) * | 2009-04-24 | 2010-02-03 | Danisco | Feed supplement |
| GB201102865D0 (en) | 2011-02-18 | 2011-04-06 | Danisco | Feed additive composition |
| GB201102857D0 (en) | 2011-02-18 | 2011-04-06 | Danisco | Feed additive composition |
| ES2705533T3 (es) | 2011-07-07 | 2019-03-25 | Dupont Nutrition Biosci Aps | Ensayo |
| EP2788491B1 (en) | 2011-12-09 | 2019-01-23 | Danisco US Inc. | Ribosomal promotors from b. subtilis for protein production in microorganisms |
| ES2736036T3 (es) * | 2012-01-05 | 2019-12-23 | Dupont Nutrition Biosci Aps | Procedimiento de alimentación |
| US9894917B2 (en) | 2012-02-07 | 2018-02-20 | Danisco Us Inc | Glycosylation as a stabilizer for phytase |
| US9668500B2 (en) | 2012-04-24 | 2017-06-06 | Purina Animal Nutrition Llc | Feeding methods and systems for young livestock animals using sensory compounds |
| GB201213801D0 (en) | 2012-08-03 | 2012-09-12 | Dupont Nutrition Biosci Aps | Feed additive composition |
| EP2799531A1 (de) | 2013-05-03 | 2014-11-05 | Clariant Produkte (Deutschland) GmbH | Einsatz von Phosphatasen zur enzymatischen Entschleimung von Triglyceriden |
| EP3712274A1 (en) | 2013-09-11 | 2020-09-23 | Novozymes A/S | Processes for producing fermentation products |
| JP6130283B2 (ja) * | 2013-10-29 | 2017-05-17 | 株式会社えんばく生活 | えん麦のふすま由来の食品組成物およびその製造方法 |
| EP3068879B1 (en) * | 2013-11-14 | 2019-12-25 | Danisco US Inc. | Stable enzymes by glycation reduction |
| AU2015279057B2 (en) | 2014-06-27 | 2019-02-28 | Novonesis Animal Biosolutions Ag | A method for improving the nutritional value of animal feed |
| US11213051B2 (en) | 2014-07-02 | 2022-01-04 | Purina Animal Nutrition Llc | Milk replacer products containing halides and sources of hydrogen peroxide and methods of feeding same |
| FI3259358T3 (fi) | 2015-02-19 | 2024-09-17 | Danisco Us Inc | Tehostunut proteiiniekspressio |
| CN108699572A (zh) | 2015-12-22 | 2018-10-23 | 诺维信公司 | 使用磷脂酶c增加发酵产物得率的方法 |
| US20170202928A1 (en) * | 2016-01-14 | 2017-07-20 | Purina Animal Nutrition Llc | Method of feeding animals phytase products |
| EP4095152A3 (en) | 2016-03-04 | 2022-12-28 | Danisco US Inc. | Engineered ribosomal promoters for protein production in microorganisms |
| EP3825399A1 (en) | 2016-06-30 | 2021-05-26 | Danisco US Inc. | Aspartic proteases |
| WO2018004627A1 (en) * | 2016-06-30 | 2018-01-04 | Fornia Biosolutions, Inc. | Novel phytases and uses thereof |
| MX2019007335A (es) | 2016-12-21 | 2019-09-09 | Dupont Nutrition Biosci Aps | Métodos para usar serina proteasas termoestables. |
| US10940172B2 (en) | 2017-01-03 | 2021-03-09 | Purina Animal Nutrition Llc | Methods of feeding animals phytogenic products |
| US20200015499A1 (en) | 2017-03-15 | 2020-01-16 | Dupont Nutrition Biosciences Aps | Trypsin-like serine proteases and uses thereof |
| MX386582B (es) | 2017-03-15 | 2025-03-19 | Int N&H Denmark Aps | Métodos para usar una serina proteasa de arqueas. |
| WO2018169750A1 (en) | 2017-03-15 | 2018-09-20 | Danisco Us Inc | Trypsin-like serine proteases and uses thereof |
| WO2019055455A1 (en) | 2017-09-15 | 2019-03-21 | Novozymes A/S | MIXTURES OF ENZYMES AND METHODS FOR IMPROVING THE NUTRITIONAL QUALITY OF ANIMAL FEED |
| BR112020007814A2 (pt) | 2017-10-23 | 2020-10-20 | Novozymes A/S | processos para reduzir e/ou prevenir um aumento nos níveis de ácido lático em um sistema de fermentação de biocombustível e para produção de um produto de fermentação a partir de um material contendo amido, e, uso de um polipeptídeo, ou uma composição enzimática |
| WO2019089898A1 (en) | 2017-11-02 | 2019-05-09 | Danisco Us Inc | Freezing point depressed solid matrix compositions for melt granulation of enzymes |
| MX2020008302A (es) | 2018-02-08 | 2020-10-14 | Danisco Us Inc | Partículas de matriz de cera térmicamente resistentes para encapsulación de enzimas. |
| MX2020011305A (es) | 2018-04-26 | 2021-01-08 | Danisco Us Inc | Método para aumentar la estabilidad de una fitasa en una composición sólida y una composición granulada que comprende fosfato y fitasa. |
| MX2020012754A (es) | 2018-05-31 | 2021-02-26 | Novozymes As | Procesos para mejorar el crecimiento y la productividad de la levadura. |
| CN112654703A (zh) | 2018-07-06 | 2021-04-13 | 杜邦营养生物科学有限公司 | 用于基于谷类的动物饲料的含木聚糖酶饲料添加剂 |
| EP3608402A1 (en) * | 2018-08-08 | 2020-02-12 | Clariant Produkte (Deutschland) GmbH | Optimized 3-phytase and its use in food or feed production |
| CA3120360A1 (en) * | 2018-11-20 | 2020-05-28 | Dupont Nutrition Biosciences Aps | Engineered robust high tm-phytase clade polypeptides and fragments thereof |
| WO2020131691A2 (en) * | 2018-12-17 | 2020-06-25 | Gro Biosciences Inc. | Diselenide-stabilized feed enzymes |
| WO2020160126A1 (en) | 2019-01-31 | 2020-08-06 | Novozymes A/S | Polypeptides having xylanase activity and use thereof for improving the nutritional quality of animal feed |
| BR112022000351A2 (pt) | 2019-07-09 | 2022-05-10 | Dupont Nutrition Biosci Aps | Composições de enzima particuladas revestidas de gordura |
| AR119596A1 (es) | 2019-08-05 | 2021-12-29 | Novozymes As | Mezclas de enzimas y procesos para producir un ingrediente alimenticio de alto contenido proteico a partir de un subproducto de la vinaza entera |
| CN114615894B (zh) | 2019-08-16 | 2024-09-06 | 国际N&H丹麦有限公司 | 包含乳杆菌菌株组合的用于消化道健康的组合物 |
| WO2021046073A1 (en) | 2019-09-05 | 2021-03-11 | Dupont Nutrition Biosciences Aps | Feed composition |
| BR112022007613A2 (pt) | 2019-10-21 | 2022-08-23 | Dupont Nutrition Biosci Aps | Composição para a saúde do intestino |
| WO2021102238A1 (en) * | 2019-11-20 | 2021-05-27 | Dupont Nutrition Biosciences Aps | Thermostable phytase variants |
| US20230023446A1 (en) | 2019-12-16 | 2023-01-26 | Novozymes A/S | Processes for producing fermentation products |
| CN115867146B (zh) | 2020-02-07 | 2025-01-17 | 国际N&H丹麦有限公司 | 用于动物健康的饲料组合物 |
| CN117241678A (zh) | 2020-10-16 | 2023-12-15 | 杜邦营养生物科学有限公司 | 用于动物健康的饲料组合物 |
| EP4258875A4 (en) | 2020-12-09 | 2024-11-20 | Purina Animal Nutrition LLC | Feed compositions and methods for inhibiting focal ulcerative dermatitis |
| WO2022169933A2 (en) | 2021-02-03 | 2022-08-11 | Dupont Nutrition Biosciences Aps | Compositions for gut health |
| AU2022349014A1 (en) | 2021-09-27 | 2024-04-04 | International N&H Denmark Aps | Feed additive compositions and methods for using the same |
| WO2024137704A2 (en) | 2022-12-19 | 2024-06-27 | Novozymes A/S | Processes for producing fermentation products using fiber-degrading enzymes with engineered yeast |
| CN120380140A (zh) | 2022-12-19 | 2025-07-25 | 诺维信公司 | 具有阿魏酸酯酶和/或乙酰木聚糖酯酶活性的碳水化合物酯酶家族1(ce1)多肽和编码其的多核苷酸 |
| CN120693401A (zh) | 2022-12-19 | 2025-09-23 | 诺维信公司 | 包含阿拉伯呋喃糖苷酶和木聚糖酶的组合物及其用于增加半纤维素纤维溶解的用途 |
| WO2024137252A1 (en) | 2022-12-19 | 2024-06-27 | Novozymes A/S | Process for reducing syrup viscosity in the backend of a process for producing a fermentation product |
| KR20250117643A (ko) | 2022-12-19 | 2025-08-05 | 다니스코 유에스 인크. | 일관된 단백질을 생산하기 위한 재조합 진균 균주 및 이의 방법 |
| WO2024137250A1 (en) | 2022-12-19 | 2024-06-27 | Novozymes A/S | Carbohydrate esterase family 3 (ce3) polypeptides having acetyl xylan esterase activity and polynucleotides encoding same |
| WO2024227153A1 (en) | 2023-04-28 | 2024-10-31 | International N&H Denmark Aps | Ruminant feed additive compositions |
| MX2025015096A (es) | 2023-06-13 | 2026-02-03 | Novozymes As | Procesos para producir productos de fermentacion usando levaduras modificadas que expresan una beta-xilosidasa |
| WO2025059013A1 (en) | 2023-09-11 | 2025-03-20 | International N&H Denmark Aps | Bacillus-based components for inhibiting or delaying the growth of enterococcus spp. in animals |
| WO2025128568A1 (en) | 2023-12-11 | 2025-06-19 | Novozymes A/S | Composition and use thereof for increasing hemicellulosic fiber solubilization |
| WO2026008449A2 (en) | 2024-07-04 | 2026-01-08 | Novozymes A/S | A process for producing a fermentation product and a concentrated protein co-product |
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2009
- 2009-04-17 HU HUE16168636A patent/HUE052318T2/hu unknown
- 2009-04-17 CA CA2721691A patent/CA2721691C/en active Active
- 2009-04-17 BR BRPI0910457-7A patent/BRPI0910457B1/pt active IP Right Grant
- 2009-04-17 CN CN2009801135446A patent/CN102007211B/zh active Active
- 2009-04-17 US US12/988,363 patent/US8673609B2/en active Active
- 2009-04-17 EP EP16168636.5A patent/EP3118309B1/en active Active
- 2009-04-17 MX MX2010010982A patent/MX2010010982A/es active IP Right Grant
- 2009-04-17 DK DK09732532.8T patent/DK2283124T3/en active
- 2009-04-17 MX MX2014012519A patent/MX364988B/es unknown
- 2009-04-17 EP EP09732532.8A patent/EP2283124B1/en active Active
- 2009-04-17 DK DK16168636.5T patent/DK3118309T3/da active
- 2009-04-17 WO PCT/US2009/041011 patent/WO2009129489A2/en not_active Ceased
- 2009-04-17 JP JP2011505239A patent/JP5273686B2/ja active Active
- 2009-04-17 ES ES16168636T patent/ES2835955T3/es active Active
- 2009-04-17 PL PL16168636T patent/PL3118309T3/pl unknown
-
2014
- 2014-01-22 US US14/161,548 patent/US20140234490A1/en not_active Abandoned
-
2016
- 2016-07-25 US US15/219,107 patent/US20170143004A1/en not_active Abandoned
-
2017
- 2017-06-08 US US15/617,164 patent/US9999238B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3118309A3 (en) | 2017-03-29 |
| EP3118309B1 (en) | 2020-09-16 |
| HK1156071A1 (en) | 2012-06-01 |
| WO2009129489A2 (en) | 2009-10-22 |
| US20180125094A1 (en) | 2018-05-10 |
| US20140234490A1 (en) | 2014-08-21 |
| EP3118309A2 (en) | 2017-01-18 |
| EP2283124A2 (en) | 2011-02-16 |
| PL3118309T3 (pl) | 2021-05-31 |
| DK2283124T3 (en) | 2016-09-05 |
| WO2009129489A3 (en) | 2010-04-22 |
| MX2010010982A (es) | 2010-11-09 |
| BRPI0910457B1 (pt) | 2020-12-29 |
| CN102007211A (zh) | 2011-04-06 |
| US8673609B2 (en) | 2014-03-18 |
| CA2721691C (en) | 2019-07-09 |
| US20170143004A1 (en) | 2017-05-25 |
| US20110201081A1 (en) | 2011-08-18 |
| CN102007211B (zh) | 2013-11-06 |
| ES2835955T3 (es) | 2021-06-23 |
| JP5273686B2 (ja) | 2013-08-28 |
| DK3118309T3 (da) | 2020-12-14 |
| HUE052318T2 (hu) | 2021-04-28 |
| CA2721691A1 (en) | 2009-10-22 |
| EP2283124B1 (en) | 2016-05-25 |
| US9999238B2 (en) | 2018-06-19 |
| WO2009129489A9 (en) | 2009-12-23 |
| MX364988B (es) | 2019-05-17 |
| JP2011519274A (ja) | 2011-07-07 |
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