BRPI0911634A2 - processo para a preparação de 5-(2-amino-pirimidin-4-il)-2-aril-1h-pirrol-3-carboxamidas - Google Patents

processo para a preparação de 5-(2-amino-pirimidin-4-il)-2-aril-1h-pirrol-3-carboxamidas

Info

Publication number
BRPI0911634A2
BRPI0911634A2 BRPI0911634A BRPI0911634A BRPI0911634A2 BR PI0911634 A2 BRPI0911634 A2 BR PI0911634A2 BR PI0911634 A BRPI0911634 A BR PI0911634A BR PI0911634 A BRPI0911634 A BR PI0911634A BR PI0911634 A2 BRPI0911634 A2 BR PI0911634A2
Authority
BR
Brazil
Prior art keywords
carboxamides
pyrrol
pyrimidin
aryl
amino
Prior art date
Application number
BRPI0911634A
Other languages
English (en)
Inventor
Carlo Battistini
Ermes Vanotti
Maria Gioia Fornaretto
Matteo D Anello
Original Assignee
Nerviano Medical Sciences Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl
Publication of BRPI0911634A2 publication Critical patent/BRPI0911634A2/pt
Publication of BRPI0911634B1 publication Critical patent/BRPI0911634B1/pt
Publication of BRPI0911634B8 publication Critical patent/BRPI0911634B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BRPI0911634A 2008-04-30 2009-04-30 processo para a preparação de 5-(2-amino-pirimidin-4-il)-2-aril-1h-pirrol-3-carboxamidas BRPI0911634B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08155501 2008-04-30
IT08155501.3 2008-04-30
PCT/EP2009/055262 WO2009133170A1 (en) 2008-04-30 2009-04-30 Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1h-pyrrole-3-carboxamides

Publications (3)

Publication Number Publication Date
BRPI0911634A2 true BRPI0911634A2 (pt) 2016-06-14
BRPI0911634B1 BRPI0911634B1 (pt) 2021-05-04
BRPI0911634B8 BRPI0911634B8 (pt) 2021-05-25

Family

ID=40897697

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911634A BRPI0911634B8 (pt) 2008-04-30 2009-04-30 processo para a preparação de 5-(2-amino-pirimidin-4-il)-2-aril-1h-pirrol-3-carboxamidas

Country Status (14)

Country Link
US (1) US8399668B2 (pt)
EP (1) EP2285801B1 (pt)
JP (1) JP5490100B2 (pt)
KR (1) KR20110044835A (pt)
CN (1) CN102036983B (pt)
AU (1) AU2009242076B2 (pt)
BR (1) BRPI0911634B8 (pt)
CA (1) CA2723209C (pt)
EA (1) EA019036B1 (pt)
ES (1) ES2436433T3 (pt)
IL (1) IL208951A0 (pt)
MX (1) MX2010011456A (pt)
TW (1) TWI426074B (pt)
WO (1) WO2009133170A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2173728A2 (en) 2007-07-17 2010-04-14 Amgen Inc. Heterocyclic modulators of pkb
US7919504B2 (en) 2007-07-17 2011-04-05 Amgen Inc. Thiadiazole modulators of PKB
WO2010108921A1 (en) * 2009-03-27 2010-09-30 Nerviano Medical Sciences S.R.L. N-aryl-2-(2-arylaminopyrimidin-4-yl)pyrrol-4-carboxamide derivatives as mps1 kinase inhibitors
JP5715146B2 (ja) * 2009-11-04 2015-05-07 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ ５−（２−アミノ−ピリミジン−４−イル）−２−アリール−１ｈ−ピロール−３−カルボキサミドの調製方法
CN102666528B (zh) * 2009-11-11 2014-04-16 内尔维阿诺医学科学有限公司 晶体cdc7 抑制剂盐
TW201127384A (en) 2009-11-18 2011-08-16 Nerviano Medical Sciences Srl Therapeutic combination comprising a Cdc7 inhibitor and an antineoplastic agent
JP5970537B2 (ja) * 2011-04-19 2016-08-17 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害薬として活性な置換ピリミジニル−ピロール
JP6016915B2 (ja) * 2011-07-28 2016-10-26 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ キナーゼ阻害剤として活性なアルキニル置換ピリミジニルピロール
WO2022174031A1 (en) * 2021-02-12 2022-08-18 Relay Therapeutics, Inc. Cdk inhibitors and methods of use thereof
CN117157289A (zh) * 2021-04-02 2023-12-01 内尔维亚诺医疗科学公司 被取代的吡咯甲酰胺、其制备工艺及其作为激酶抑制剂的用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA805280B (en) * 1979-08-27 1982-04-28 Du Pont Antiinflammatory 4,5-diaryl-a-polyfluoroalkyl-1h-pyrrole-2-methanols and 1-(4,5-diaryl-1h-pyrrol-2-yl)polyfluoralkanones
US5284863A (en) * 1991-12-04 1994-02-08 American Cyanamid Company Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents
JPH06135961A (ja) * 1992-10-23 1994-05-17 Nippon Iyakuhin Kogyo Kk 新規ジフェニルピロリルフラン誘導体
US5559137A (en) * 1994-05-16 1996-09-24 Smithkline Beecham Corp. Compounds
GB0121488D0 (en) * 2001-09-05 2001-10-24 Smithkline Beecham Plc Compounds
GB0229243D0 (en) * 2002-12-16 2003-01-22 Avecia Ltd Compounds and process
BR122019010200B8 (pt) * 2003-05-22 2021-07-27 Nerviano Medical Science S R L compostos de pirazol-quinazolina, seus sais, produtos ou kits e composições farmacêuticas
WO2005095386A1 (en) * 2004-03-30 2005-10-13 Chiron Corporation Substituted thiophene derivatives as anti-cancer agents
CA2596737A1 (en) * 2005-03-21 2006-09-28 Eisai R & D Management Co., Ltd. Pyrimidine compound crystal or amorphous form and process for producing the same
BRPI0709680B8 (pt) * 2006-03-27 2021-05-25 Nerviano Medical Sciences Srl derivados de pirrol, tiofeno e furano substituídos por piridil e piridimil como inibidores de quinase

Also Published As

Publication number Publication date
CN102036983A (zh) 2011-04-27
US20110040090A1 (en) 2011-02-17
AU2009242076B2 (en) 2013-10-10
AU2009242076A1 (en) 2009-11-05
CN102036983B (zh) 2014-02-19
CA2723209C (en) 2016-06-21
JP2011518866A (ja) 2011-06-30
EP2285801A1 (en) 2011-02-23
EP2285801B1 (en) 2013-10-09
EA201071252A1 (ru) 2011-06-30
MX2010011456A (es) 2010-11-30
BRPI0911634B1 (pt) 2021-05-04
TW200951124A (en) 2009-12-16
ES2436433T3 (es) 2014-01-02
KR20110044835A (ko) 2011-05-02
BRPI0911634B8 (pt) 2021-05-25
CA2723209A1 (en) 2009-11-05
TWI426074B (zh) 2014-02-11
EA019036B1 (ru) 2013-12-30
IL208951A0 (en) 2011-01-31
US8399668B2 (en) 2013-03-19
JP5490100B2 (ja) 2014-05-14
HK1151794A1 (en) 2012-02-10
WO2009133170A1 (en) 2009-11-05

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B15G Petition not considered as such [chapter 15.7 patent gazette]

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B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/04/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME MEDIDA CAUTELAR DE 07/04/2021 - ADI 5.529/DF

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2825 DE 25-02-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.