BRPI0911973A2 - derivados de imidazoquinazolina como análogos de anagrelide para tratamento de doenças mieloproliferativas e doenças trombóticas. - Google Patents

derivados de imidazoquinazolina como análogos de anagrelide para tratamento de doenças mieloproliferativas e doenças trombóticas.

Info

Publication number
BRPI0911973A2
BRPI0911973A2 BRPI0911973A BRPI0911973A BRPI0911973A2 BR PI0911973 A2 BRPI0911973 A2 BR PI0911973A2 BR PI0911973 A BRPI0911973 A BR PI0911973A BR PI0911973 A BRPI0911973 A BR PI0911973A BR PI0911973 A2 BRPI0911973 A2 BR PI0911973A2
Authority
BR
Brazil
Prior art keywords
diseases
treatment
thrombotic
myeloproliferative
imidazoquinazoline derivatives
Prior art date
Application number
BRPI0911973A
Other languages
English (en)
Inventor
Angus Macleod
Bernard Golding
Richard Franklin
Original Assignee
Shire Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Llc filed Critical Shire Llc
Publication of BRPI0911973A2 publication Critical patent/BRPI0911973A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI0911973A 2008-05-16 2009-05-13 derivados de imidazoquinazolina como análogos de anagrelide para tratamento de doenças mieloproliferativas e doenças trombóticas. BRPI0911973A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0808944.3A GB0808944D0 (en) 2008-05-16 2008-05-16 Substituted quinazolines
PCT/GB2009/050514 WO2009138794A1 (en) 2008-05-16 2009-05-13 Imidazoquinazoline derivatives as anagrelide analogues for the treatment of myeloprolific diseases and thrombotic diseases

Publications (1)

Publication Number Publication Date
BRPI0911973A2 true BRPI0911973A2 (pt) 2015-10-13

Family

ID=39596024

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911973A BRPI0911973A2 (pt) 2008-05-16 2009-05-13 derivados de imidazoquinazolina como análogos de anagrelide para tratamento de doenças mieloproliferativas e doenças trombóticas.

Country Status (9)

Country Link
US (1) US20110071173A1 (pt)
EP (1) EP2313410A1 (pt)
JP (1) JP2011520864A (pt)
CN (1) CN102076695A (pt)
AU (1) AU2009247795A1 (pt)
BR (1) BRPI0911973A2 (pt)
CA (1) CA2724181A1 (pt)
GB (1) GB0808944D0 (pt)
WO (1) WO2009138794A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7910597B2 (en) * 2006-11-28 2011-03-22 Shire Llc Substituted quinazolines
US8304420B2 (en) * 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
GB201017783D0 (en) * 2010-10-21 2010-12-01 Shire Llc Process for the preparation of anagrelide and analogues thereof
EP3659605A1 (en) * 2014-12-22 2020-06-03 SUDA Pharmaceuticals Ltd Prevention and treatment of metastatic disease in thrombocytotic cancer patients
WO2022199627A1 (en) * 2021-03-23 2022-09-29 National Institute Of Biological Sciences, Beijing Polycyclic compounds and uses thereof
CN117045636A (zh) * 2023-09-19 2023-11-14 浙江省中医院、浙江中医药大学附属第一医院（浙江省东方医院） 羟基红花黄色素a在治疗与血小板相关的疾病中的用途
WO2025228367A1 (en) * 2024-04-29 2025-11-06 Sironax Ltd. Pde3a/slfn12 disruptors, preparations, and uses thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE31617E (en) * 1972-02-04 1984-06-26 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
US3974165A (en) * 1974-02-21 1976-08-10 Bristol-Myers Company Hypotensive agents
US3983119A (en) * 1974-11-06 1976-09-28 Bristol-Myers Company Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
US4146718A (en) * 1978-04-10 1979-03-27 Bristol-Myers Company Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
ZA803535B (en) * 1979-06-20 1981-06-24 Hoffmann La Roche Novel quinazoline derivatives and pharmaceutical preparations
EP0029559A3 (en) * 1979-11-24 1981-09-30 Sandoz Ag 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them
US4490371A (en) * 1983-02-16 1984-12-25 Syntex (U.S.A.) Inc. N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
US4663320A (en) * 1983-02-16 1987-05-05 Syntex (U.S.A.) Inc. (2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
JPS6028979A (ja) * 1983-07-14 1985-02-14 Dai Ichi Seiyaku Co Ltd イミダゾキナゾリン類化合物
US4593029A (en) * 1984-02-15 1986-06-03 Syntex (U.S.A.) Inc. Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
US4670434A (en) * 1985-11-14 1987-06-02 Syntex (U.S.A.) Inc. (2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
NZ234186A (en) * 1989-07-07 1991-10-25 Janssen Pharmaceutica Nv Imidazo quinazolin-one derivatives and pharmaceutical compositions
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
GB0623750D0 (en) * 2006-11-28 2007-01-10 Shire Llc Substituted quinazolines
US8304420B2 (en) * 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count

Also Published As

Publication number Publication date
JP2011520864A (ja) 2011-07-21
GB0808944D0 (en) 2008-06-25
WO2009138794A1 (en) 2009-11-19
CA2724181A1 (en) 2009-11-19
EP2313410A1 (en) 2011-04-27
CN102076695A (zh) 2011-05-25
US20110071173A1 (en) 2011-03-24
AU2009247795A1 (en) 2009-11-19

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.