BRPI0912092A2 - quinazolinas substituídas - Google Patents
quinazolinas substituídasInfo
- Publication number
- BRPI0912092A2 BRPI0912092A2 BRPI0912092-0A BRPI0912092A BRPI0912092A2 BR PI0912092 A2 BRPI0912092 A2 BR PI0912092A2 BR PI0912092 A BRPI0912092 A BR PI0912092A BR PI0912092 A2 BRPI0912092 A2 BR PI0912092A2
- Authority
- BR
- Brazil
- Prior art keywords
- present
- relates
- platelet
- substituted
- substituted quinazolines
- Prior art date
Links
- 150000003246 quinazolines Chemical class 0.000 title abstract 2
- 239000003638 chemical reducing agent Substances 0.000 abstract 2
- KJMFQJFNQYWQAV-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinazoline Chemical class C1=NC=NC2=C(NC=N3)C3=CC=C21 KJMFQJFNQYWQAV-UHFFFAOYSA-N 0.000 abstract 1
- 208000014767 Myeloproliferative disease Diseases 0.000 abstract 1
- OTBXOEAOVRKTNQ-UHFFFAOYSA-N anagrelide Chemical compound N1=C2NC(=O)CN2CC2=C(Cl)C(Cl)=CC=C21 OTBXOEAOVRKTNQ-UHFFFAOYSA-N 0.000 abstract 1
- 229960001694 anagrelide Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
quinazolinas substituídas. a presente invenção refere-se à descoberta de análogos substituídos do agente redutor de plaquetas seletivo anagrelide com potencial reduzido para efeitos colaterais cardiovasculares, 5 que deve levar à melhor complacência do paciente e segurança no tratamento de doenças mieloproliferativas. mais especificamente, a presente invenção se refere a certos derivados de imidazoquinazolina que têm a fórmula geral mostrada abaixo, em que os substituintes têm os significados definidos na reivindicação 1: e que são úteis como agentes redutores de plaquetas em seres humanos. os compostos da presente invenção funcionam pela inibição da megacariocitopoiese e, portanto, da formação de plaquetas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0810005.9A GB0810005D0 (en) | 2008-06-02 | 2008-06-02 | Substituted quinazolines |
| GB0810005.9 | 2008-06-02 | ||
| PCT/GB2009/050516 WO2009147418A1 (en) | 2008-06-02 | 2009-05-13 | Substituted quinazolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0912092A2 true BRPI0912092A2 (pt) | 2019-03-06 |
Family
ID=39637989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0912092-0A BRPI0912092A2 (pt) | 2008-06-02 | 2009-05-13 | quinazolinas substituídas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110065735A1 (pt) |
| EP (1) | EP2303849A1 (pt) |
| JP (1) | JP2011522022A (pt) |
| KR (1) | KR20110011667A (pt) |
| CN (1) | CN102076668A (pt) |
| AU (1) | AU2009254988A1 (pt) |
| BR (1) | BRPI0912092A2 (pt) |
| CA (1) | CA2724376A1 (pt) |
| GB (1) | GB0810005D0 (pt) |
| WO (1) | WO2009147418A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7910597B2 (en) * | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
| US8304420B2 (en) * | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
| CN111072575A (zh) * | 2019-12-28 | 2020-04-28 | 深圳市祥根生物科技有限公司 | 一种阿那格雷杂质c的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7807507A (nl) * | 1977-07-25 | 1979-01-29 | Hoffmann La Roche | Tricyclische verbindingen. |
| DE10301105B4 (de) * | 2003-01-09 | 2005-11-24 | Chemisch-Pharmazeutisches Labor, Rolf Sachse Gmbh | Verwendung von 2-Amino-2H-chinazolin-Derivaten zur Behandlung von myeloproliferativen Erkrankungen, Bluthochdruck und Bronchodilation |
-
2008
- 2008-06-02 GB GBGB0810005.9A patent/GB0810005D0/en not_active Ceased
-
2009
- 2009-05-13 BR BRPI0912092-0A patent/BRPI0912092A2/pt not_active IP Right Cessation
- 2009-05-13 JP JP2011512207A patent/JP2011522022A/ja active Pending
- 2009-05-13 CA CA2724376A patent/CA2724376A1/en not_active Abandoned
- 2009-05-13 EP EP09757790A patent/EP2303849A1/en not_active Withdrawn
- 2009-05-13 KR KR1020107027624A patent/KR20110011667A/ko not_active Withdrawn
- 2009-05-13 WO PCT/GB2009/050516 patent/WO2009147418A1/en not_active Ceased
- 2009-05-13 US US12/993,069 patent/US20110065735A1/en not_active Abandoned
- 2009-05-13 CN CN2009801248872A patent/CN102076668A/zh active Pending
- 2009-05-13 AU AU2009254988A patent/AU2009254988A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009147418A1 (en) | 2009-12-10 |
| AU2009254988A1 (en) | 2009-12-10 |
| JP2011522022A (ja) | 2011-07-28 |
| CN102076668A (zh) | 2011-05-25 |
| EP2303849A1 (en) | 2011-04-06 |
| US20110065735A1 (en) | 2011-03-17 |
| KR20110011667A (ko) | 2011-02-08 |
| GB0810005D0 (en) | 2008-07-09 |
| CA2724376A1 (en) | 2009-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A, 7A, 8A, 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2514 DE 12-03-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |