BRPI0914167A2 - formas sólidas de (1r,2s,3r)-1-(2-(isoxa-zol-3-il)-1h-imidazol-4il) butano-1,2,3,4-tetraol e métodos de uso das mesmas - Google Patents

formas sólidas de (1r,2s,3r)-1-(2-(isoxa-zol-3-il)-1h-imidazol-4il) butano-1,2,3,4-tetraol e métodos de uso das mesmas

Info

Publication number: BRPI0914167A2
Authority: BR; Brazil
Prior art keywords: tetraol; isoxazol; imidazol; butane; methods
Prior art date: 2008-06-18

Application number

BRPI0914167A

Other languages

English (en)

Inventor

Christopher Stephen Frampton

Hugh Alfred Burgoon Jr

Suzanne Marie Buttar

Original Assignee

Lexicon Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-18

Filing date

2009-06-16

Publication date

2015-10-20

2009-06-16 Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc

2015-10-20 Publication of BRPI0914167A2 publication Critical patent/BRPI0914167A2/pt

Links

WGDPRIZUIYIENM-IWSPIJDZSA-N chembl1851810 Chemical compound N1C([C@@H](O)[C@H](O)[C@H](O)CO)=CN=C1C1=NOC=C1 WGDPRIZUIYIENM-IWSPIJDZSA-N 0.000 title 1
239000007787 solid Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Hematology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Transplantation (AREA)
Ophthalmology & Optometry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

BRPI0914167A 2008-06-18 2009-06-16 formas sólidas de (1r,2s,3r)-1-(2-(isoxa-zol-3-il)-1h-imidazol-4il) butano-1,2,3,4-tetraol e métodos de uso das mesmas BRPI0914167A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7339808P	2008-06-18	2008-06-18
PCT/US2009/047488 WO2010008733A2 (en)	2008-06-18	2009-06-16	Solid forms of (1r,2s,3r)-1-(2-(isoxazol-3-yl)-1h-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use

Publications (1)

Publication Number	Publication Date
BRPI0914167A2 true BRPI0914167A2 (pt)	2015-10-20

Family

ID=41381634

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0914167A BRPI0914167A2 (pt)	2008-06-18	2009-06-16	formas sólidas de (1r,2s,3r)-1-(2-(isoxa-zol-3-il)-1h-imidazol-4il) butano-1,2,3,4-tetraol e métodos de uso das mesmas

Country Status (20)

Country	Link
US (1)	US7998994B2 (pt)
EP (1)	EP2315765B1 (pt)
JP (1)	JP5550644B2 (pt)
KR (1)	KR20110036582A (pt)
CN (1)	CN102131803A (pt)
AR (1)	AR072153A1 (pt)
AU (1)	AU2009271408A1 (pt)
BR (1)	BRPI0914167A2 (pt)
CA (1)	CA2728094A1 (pt)
CL (1)	CL2009001436A1 (pt)
CO (1)	CO6341474A2 (pt)
DK (1)	DK2315765T3 (pt)
ES (1)	ES2401555T3 (pt)
IL (1)	IL209815A0 (pt)
MX (1)	MX2010013991A (pt)
PE (1)	PE20100085A1 (pt)
RU (1)	RU2011101535A (pt)
TW (1)	TW201004943A (pt)
UY (1)	UY31900A (pt)
WO (1)	WO2010008733A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW201002698A (en) *	2008-06-18	2010-01-16	Lexicon Pharmaceuticals Inc	Methods of preparing imidazole-based bicyclic compounds
WO2011102404A1 (ja)	2010-02-18	2011-08-25	第一三共株式会社	イミダゾール誘導体
EP2586874B1 (en)	2010-06-28	2015-04-22	Daiichi Sankyo Company, Limited	Method for screening for s1p lyase inhibitor using cultured cell
DE102011103751A1 (de)	2011-05-31	2012-12-06	Heraeus Precious Metals Gmbh & Co. Kg	Kristallisierung von Epirubicinhydrochlorid
US9120835B2 (en)	2011-06-28	2015-09-01	Daiichi Sankyo Company Limited	Phosphoric acid ester derivatives
EP2545922A1 (en)	2011-07-12	2013-01-16	PregLem S.A.	Treatment of excessive menstrual bleeding associated with uterine fibroids

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4567194A (en)	1983-03-10	1986-01-28	The Coca-Cola Company	2-Acylimidazole compounds, their synthesis and use as medicinal agents
DE4430289A1 (de) *	1993-09-04	1995-03-09	Basf Ag	Verbessertes Verfahren zur Herstellung von Astaxanthin
AU2881797A (en) *	1996-05-31	1998-01-05	University Of Wollongong, The	Acetyl derivatives of thiazoles and analogues
JPH1149972A (ja) *	1997-07-31	1999-02-23	Jiyun Internatl:Kk	殻廃棄物からアスタキサンチン及びキトーサンを同時に生成する方法
AU2006251391B2 (en) *	2005-05-23	2011-10-06	Phares Pharmaceutical Research N.V.	Direct dissolution
EP1898928A2 (en)	2005-06-28	2008-03-19	Merck & Co., Inc.	Non-nucleoside reverse transcriptase inhibitors
ITMI20052486A1 (it) *	2005-12-23	2007-06-24	Italiana Sint Spa	Procedimento di sintesi di intermedi per la preparazione di astaxantina
US7649098B2 (en) *	2006-02-24	2010-01-19	Lexicon Pharmaceuticals, Inc.	Imidazole-based compounds, compositions comprising them and methods of their use
TW200848029A (en) *	2007-03-01	2008-12-16	Lexicon Pharmaceuticals Inc	Heterocyclic compounds, compositions comprising them and methods of their use
TWI412362B (zh)	2007-04-12	2013-10-21	Lexicon Pharmaceuticals Inc	（ｅ）-１-（４-（（１ｒ，２ｓ，３ｒ）-１，２，３，４-四羥丁基）-１ｈ-咪唑-２-基）乙酮肟的固體形式
TW201002698A (en)	2008-06-18	2010-01-16	Lexicon Pharmaceuticals Inc	Methods of preparing imidazole-based bicyclic compounds
AU2009282907A1 (en) *	2008-08-22	2010-02-25	Lexicon Pharmaceuticals, Inc.	Combinations comprising bicyclic S1P lyase inhibitors

2009
- 2009-06-16 RU RU2011101535/04A patent/RU2011101535A/ru unknown
- 2009-06-16 WO PCT/US2009/047488 patent/WO2010008733A2/en not_active Ceased
- 2009-06-16 CN CN2009801233805A patent/CN102131803A/zh active Pending
- 2009-06-16 UY UY0001031900A patent/UY31900A/es not_active Application Discontinuation
- 2009-06-16 DK DK09744242.0T patent/DK2315765T3/da active
- 2009-06-16 KR KR1020117001145A patent/KR20110036582A/ko not_active Withdrawn
- 2009-06-16 US US12/485,444 patent/US7998994B2/en active Active
- 2009-06-16 PE PE2009000873A patent/PE20100085A1/es not_active Application Discontinuation
- 2009-06-16 JP JP2011514746A patent/JP5550644B2/ja not_active Expired - Fee Related
- 2009-06-16 BR BRPI0914167A patent/BRPI0914167A2/pt not_active IP Right Cessation
- 2009-06-16 EP EP09744242A patent/EP2315765B1/en not_active Not-in-force
- 2009-06-16 CA CA2728094A patent/CA2728094A1/en not_active Abandoned
- 2009-06-16 AU AU2009271408A patent/AU2009271408A1/en not_active Abandoned
- 2009-06-16 MX MX2010013991A patent/MX2010013991A/es not_active Application Discontinuation
- 2009-06-16 AR ARP090102172A patent/AR072153A1/es not_active Application Discontinuation
- 2009-06-16 ES ES09744242T patent/ES2401555T3/es active Active
- 2009-06-16 TW TW098120121A patent/TW201004943A/zh unknown
- 2009-06-17 CL CL2009001436A patent/CL2009001436A1/es unknown
2010
- 2010-12-07 IL IL209815A patent/IL209815A0/en unknown
2011
- 2011-01-18 CO CO11004598A patent/CO6341474A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
MX2010013991A (es)	2011-01-14
CL2009001436A1 (es)	2010-10-01
CA2728094A1 (en)	2010-01-21
US7998994B2 (en)	2011-08-16
UY31900A (es)	2010-01-29
WO2010008733A3 (en)	2010-03-25
RU2011101535A (ru)	2012-07-27
KR20110036582A (ko)	2011-04-07
JP2011524915A (ja)	2011-09-08
PE20100085A1 (es)	2010-02-05
EP2315765B1 (en)	2012-12-19
US20090318516A1 (en)	2009-12-24
IL209815A0 (en)	2011-02-28
ES2401555T3 (es)	2013-04-22
CO6341474A2 (es)	2011-11-21
DK2315765T3 (da)	2013-03-25
AU2009271408A1 (en)	2010-01-21
WO2010008733A2 (en)	2010-01-21
TW201004943A (en)	2010-02-01
AR072153A1 (es)	2010-08-11
EP2315765A2 (en)	2011-05-04
JP5550644B2 (ja)	2014-07-16
CN102131803A (zh)	2011-07-20

Legal Events

Date	Code	Title	Description
2015-12-08	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 4A, 5A E 6A ANUIDADES.
2016-04-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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