BRPI0914889A2 - peptídeo glp-1 adicionado de cadeia oligossacarídica - Google Patents
peptídeo glp-1 adicionado de cadeia oligossacarídicaInfo
- Publication number
- BRPI0914889A2 BRPI0914889A2 BRPI0914889A BRPI0914889A BRPI0914889A2 BR PI0914889 A2 BRPI0914889 A2 BR PI0914889A2 BR PI0914889 A BRPI0914889 A BR PI0914889A BR PI0914889 A BRPI0914889 A BR PI0914889A BR PI0914889 A2 BRPI0914889 A2 BR PI0914889A2
- Authority
- BR
- Brazil
- Prior art keywords
- peptide
- oligosaccharide chain
- chain added
- added glp
- glp
- Prior art date
Links
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
- 150000002482 oligosaccharides Polymers 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008157583 | 2008-06-17 | ||
| JP2008326609 | 2008-12-22 | ||
| PCT/JP2009/002709 WO2009153960A1 (ja) | 2008-06-17 | 2009-06-15 | 糖鎖付加glp-1ペプチド |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0914889A2 true BRPI0914889A2 (pt) | 2015-11-24 |
Family
ID=41433882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0914889A BRPI0914889A2 (pt) | 2008-06-17 | 2009-06-15 | peptídeo glp-1 adicionado de cadeia oligossacarídica |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8765669B2 (pt) |
| EP (1) | EP2298801A4 (pt) |
| JP (1) | JP5604297B2 (pt) |
| KR (1) | KR101609005B1 (pt) |
| CN (1) | CN102083854A (pt) |
| AU (1) | AU2009261441B2 (pt) |
| BR (1) | BRPI0914889A2 (pt) |
| CA (1) | CA2727147A1 (pt) |
| RU (1) | RU2543157C2 (pt) |
| TW (1) | TWI459960B (pt) |
| WO (1) | WO2009153960A1 (pt) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101870728A (zh) * | 2009-04-23 | 2010-10-27 | 派格生物医药(苏州)有限公司 | 新型Exendin变体及其缀合物 |
| EP2495255A4 (en) * | 2009-10-30 | 2013-05-15 | Otsuka Chemical Co Ltd | GLYCOSYLATED FORM OF AN ANTIGENIC GLP-1 ANALOG |
| DE102010015123A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi-Aventis Deutschland Gmbh | Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| US9234023B2 (en) * | 2010-06-24 | 2016-01-12 | Biousian Biosystems, Inc. | Glucagon-like peptide-1 glycopeptides |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| CN102718858B (zh) * | 2011-03-29 | 2014-07-02 | 天津药物研究院 | 胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用 |
| AU2012302636B2 (en) | 2011-09-04 | 2016-09-15 | Glytech, Inc. | Glycosylated polypeptide and drug composition containing said polypeptide |
| EP2752425A4 (en) * | 2011-09-04 | 2015-04-22 | Glytech Inc | GLYCOSYLATED POLYPEPTIDE AND MEDICAMENT COMPOSITION WITH THIS POLYPEPTIDE |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| KR101979045B1 (ko) * | 2011-10-01 | 2019-05-15 | 가부시키가이샤 도우사 고가쿠 겐큐쇼 | 당쇄 부가 폴리펩티드 및 상기 폴리펩티드를 포함하는 의약 조성물 |
| LT3401402T (lt) | 2012-06-08 | 2020-12-28 | Alkermes Pharma Ireland Limited | Ligandai, modifikuoti cirkuliarinės permutacijos pagalba, kaip agonistai ir antagonistai |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
| WO2014080730A1 (ja) | 2012-11-22 | 2014-05-30 | 株式会社糖鎖工学研究所 | 糖鎖付加リンカー、糖鎖付加リンカー部分と生理活性物質部分とを含む化合物またはその塩、及びそれらの製造方法 |
| US10202469B2 (en) | 2012-11-30 | 2019-02-12 | Glytech, Inc. | Sugar chain-attached linker, compound containing sugar chain-attached linker and physiologically active substance or salt thereof, and method for producing same |
| SG10201705097PA (en) | 2012-12-21 | 2017-07-28 | Sanofi Sa | Functionalized exendin-4 derivatives |
| DK2982686T3 (en) | 2013-03-29 | 2018-10-08 | Glytech Inc | POLYPEPTIDE WITH SIALYLED SUGAR CHAIN CONNECTED |
| TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| ES2805743T3 (es) | 2015-03-24 | 2021-02-15 | Inst Nat Sante Rech Med | Método y composición farmacéutica para uso en el tratamiento de la diabetes |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| AR105284A1 (es) | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| JP2019218265A (ja) * | 2016-09-14 | 2019-12-26 | 生化学工業株式会社 | ペプチドの血中滞留性を増強させる方法 |
| CN109021093B (zh) * | 2018-08-29 | 2021-09-07 | 上海生物制品研究所有限责任公司 | 聚乙二醇修饰的glp-1衍生物及其药用盐 |
| CN110713517B (zh) * | 2019-10-11 | 2022-11-01 | 润辉生物技术(威海)有限公司 | 一种乙酰透明质酸寡肽及其制备与应用方法 |
| PT4065585T (pt) | 2019-11-25 | 2025-09-30 | Alkermes Inc | Compostos macrocíclicos substituídos e métodos de tratamento relacionados |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| CN117440972A (zh) | 2021-03-24 | 2024-01-23 | 奥克梅斯公司 | Upar抗体和具有所述抗体的融合蛋白 |
| US20240270811A1 (en) * | 2021-05-13 | 2024-08-15 | Tokyo University Of Science Foundation | Glycosylated Neuropeptide Derivative, Pharmaceutical Composition, Intranasal/Nasal Drop Formulation, and Use of Pharmaceutical Composition |
| CN115215948B (zh) * | 2022-06-02 | 2023-07-11 | 润辉生物技术(威海)有限公司 | 一种低分子的乙酰透明质酸脱羧肌肽衍生物、制备方法及应用 |
| CN120202226A (zh) * | 2022-11-10 | 2025-06-24 | 株式会社糖锁工学研究所 | 用于治疗眼部疾病的生理活性肽衍生物、医药组合物、经鼻·滴鼻制剂以及生理活性肽衍生物的用途 |
| EP4617288A1 (en) * | 2022-11-10 | 2025-09-17 | Tokyo University Of Science Foundation | Glycosylated neuropeptide derivative including neuropeptide sequence and sugar chain, pharmaceutical composition, transnasal/nasal drip formulation, and use of glycosylated neuropeptide derivative |
| WO2025234425A1 (ja) * | 2024-05-08 | 2025-11-13 | 株式会社糖鎖工学研究所 | 新規ペプチド誘導体およびその用途 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277819B1 (en) | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| SE9802080D0 (sv) | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
| MY155270A (en) | 1998-09-24 | 2015-09-30 | Lilly Co Eli | Use of glp-1 or analogs in treatment of stroke |
| EP1283054A4 (en) * | 2000-03-17 | 2006-04-12 | Ajinomoto Kk | MEDICAMENTS FOR TREATING THE COMPLICATIONS OF DIABETES AND NEUROPATHIES AND USE THEREOF |
| EP2322533A1 (en) | 2001-06-19 | 2011-05-18 | Otsuka Chemical Co., Ltd. | Process for producing sugar chain asparagine derivative |
| US7265085B2 (en) * | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycoconjugation methods and proteins/peptides produced by the methods |
| US7943763B2 (en) | 2002-07-05 | 2011-05-17 | Otsuka Chemical Holdings Co., Ltd. | Process for preparing glycopeptides having asparagine-linked oligosaccharides, and the glycopeptides |
| TWI335920B (en) | 2002-12-24 | 2011-01-11 | Yasuhiro Kajihara | Sugar chain asparagine derivatives, sugar chain asparagine and sugar chain and manufacture thereof |
| AU2003292641B2 (en) | 2002-12-26 | 2007-11-29 | Glytech, Inc. | Three-branched sugar-chain asparagine derivatives, the sugar-chain asparagines, the sugar chains, and processes for producing these |
| US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| CN100378225C (zh) | 2003-02-04 | 2008-04-02 | 大塚化学株式会社 | 糖链天冬酰胺衍生物的制造方法 |
| TWI325430B (en) | 2003-07-28 | 2010-06-01 | Yasuhiro Kajihara | Aminated complex type sugar chain derivative and its production method |
| WO2005095331A1 (ja) | 2004-03-31 | 2005-10-13 | Shionogi & Co., Ltd. | 糖鎖-ペプチド結合剤 |
| WO2006010143A2 (en) * | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| TWI376234B (en) | 2005-02-01 | 2012-11-11 | Msd Oss Bv | Conjugates of a polypeptide and an oligosaccharide |
| TW200643033A (en) | 2005-03-08 | 2006-12-16 | Chugai Pharmaceutical Co Ltd | Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue |
| TWI466897B (zh) | 2005-07-19 | 2015-01-01 | Glytech Inc | 癌細胞之檢測方法、糖鏈之構造解析方法,以及糖鏈衍生物 |
| JPWO2007063907A1 (ja) | 2005-11-30 | 2009-05-07 | 塩野義製薬株式会社 | ペプチド糖鎖付加体およびそれを有効成分とする医薬 |
| BRPI0714334A2 (pt) * | 2006-07-18 | 2013-05-14 | Centocor Inc | mimeticorpos de glp-1 humano aperfeiÇoados, composiÇÕes, mÉtodos e usos |
| US9187532B2 (en) * | 2006-07-21 | 2015-11-17 | Novo Nordisk A/S | Glycosylation of peptides via O-linked glycosylation sequences |
| TWI423821B (zh) * | 2007-06-19 | 2014-01-21 | Glucose-containing glucagon-like peptide-1 peptide |
-
2009
- 2009-06-15 JP JP2010517710A patent/JP5604297B2/ja active Active
- 2009-06-15 EP EP09766408A patent/EP2298801A4/en not_active Withdrawn
- 2009-06-15 AU AU2009261441A patent/AU2009261441B2/en not_active Ceased
- 2009-06-15 WO PCT/JP2009/002709 patent/WO2009153960A1/ja not_active Ceased
- 2009-06-15 BR BRPI0914889A patent/BRPI0914889A2/pt not_active Application Discontinuation
- 2009-06-15 CN CN2009801226623A patent/CN102083854A/zh active Pending
- 2009-06-15 RU RU2011101464/10A patent/RU2543157C2/ru active
- 2009-06-15 US US12/999,654 patent/US8765669B2/en active Active
- 2009-06-15 CA CA2727147A patent/CA2727147A1/en not_active Abandoned
- 2009-06-15 KR KR1020117000771A patent/KR101609005B1/ko not_active Expired - Fee Related
- 2009-06-16 TW TW098120124A patent/TWI459960B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2543157C2 (ru) | 2015-02-27 |
| JPWO2009153960A1 (ja) | 2011-11-24 |
| AU2009261441A1 (en) | 2009-12-23 |
| AU2009261441B2 (en) | 2013-01-10 |
| CN102083854A (zh) | 2011-06-01 |
| TWI459960B (zh) | 2014-11-11 |
| EP2298801A4 (en) | 2011-08-03 |
| US8765669B2 (en) | 2014-07-01 |
| WO2009153960A1 (ja) | 2009-12-23 |
| RU2011101464A (ru) | 2012-07-27 |
| CA2727147A1 (en) | 2009-12-23 |
| US20110195897A1 (en) | 2011-08-11 |
| TW201004643A (en) | 2010-02-01 |
| EP2298801A1 (en) | 2011-03-23 |
| JP5604297B2 (ja) | 2014-10-08 |
| KR101609005B1 (ko) | 2016-04-04 |
| KR20110031458A (ko) | 2011-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: GLYTECH, INC. (JP) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |