BRPI0915404A2 - gotículas microfluídicas para engenharia metabólica e outras aplicações - Google Patents
gotículas microfluídicas para engenharia metabólica e outras aplicaçõesInfo
- Publication number
- BRPI0915404A2 BRPI0915404A2 BRPI0915404A BRPI0915404A BRPI0915404A2 BR PI0915404 A2 BRPI0915404 A2 BR PI0915404A2 BR PI0915404 A BRPI0915404 A BR PI0915404A BR PI0915404 A BRPI0915404 A BR PI0915404A BR PI0915404 A2 BRPI0915404 A2 BR PI0915404A2
- Authority
- BR
- Brazil
- Prior art keywords
- applications
- metabolic engineering
- microfluidic droplets
- microfluidic
- droplets
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
- B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7647308P | 2008-06-27 | 2008-06-27 | |
| PCT/US2009/003822 WO2009158024A2 (en) | 2008-06-27 | 2009-06-26 | Microfluidic droplets for metabolic engineering and other applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0915404A2 true BRPI0915404A2 (pt) | 2015-11-03 |
Family
ID=41206368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0915404A BRPI0915404A2 (pt) | 2008-06-27 | 2009-06-26 | gotículas microfluídicas para engenharia metabólica e outras aplicações |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100124759A1 (pt) |
| EP (1) | EP2307560A2 (pt) |
| JP (1) | JP2011525811A (pt) |
| CN (1) | CN102439165A (pt) |
| AU (1) | AU2009262959A1 (pt) |
| BR (1) | BRPI0915404A2 (pt) |
| CA (1) | CA2729255A1 (pt) |
| WO (1) | WO2009158024A2 (pt) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
| US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
| GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
| US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| WO2007081385A2 (en) | 2006-01-11 | 2007-07-19 | Raindance Technologies, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
| EP2530167A1 (en) | 2006-05-11 | 2012-12-05 | Raindance Technologies, Inc. | Microfluidic Devices |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| EP2077912B1 (en) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
| WO2008097559A2 (en) | 2007-02-06 | 2008-08-14 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
| US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| EP4047367A1 (en) | 2008-07-18 | 2022-08-24 | Bio-Rad Laboratories, Inc. | Method for detecting target analytes with droplet libraries |
| US8450094B1 (en) | 2009-03-03 | 2013-05-28 | Poet Research, Inc. | System for management of yeast to facilitate the production of ethanol |
| WO2010111231A1 (en) | 2009-03-23 | 2010-09-30 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
| US10520500B2 (en) | 2009-10-09 | 2019-12-31 | Abdeslam El Harrak | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
| US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
| US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| DE102010032203A1 (de) * | 2010-07-26 | 2012-01-26 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren und Vorrichtung zur passiven Trennung und Sortierung von Tropfen, insbesondere in einem mikrofluidischen System, durch Verwendung von nicht-optischen Markern für Reaktionen innerhalb der Tropfen |
| US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
| EP3412778A1 (en) | 2011-02-11 | 2018-12-12 | Raindance Technologies, Inc. | Methods for forming mixed droplets |
| WO2012112804A1 (en) | 2011-02-18 | 2012-08-23 | Raindance Technoligies, Inc. | Compositions and methods for molecular labeling |
| EP3216872B1 (en) | 2011-06-02 | 2020-04-01 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
| JP2014077733A (ja) * | 2012-10-11 | 2014-05-01 | Hiroshima Univ | 分析用チップ、分析装置及び分析方法 |
| US9340767B2 (en) * | 2013-03-13 | 2016-05-17 | Poet Research, Inc. | Propagating an organism and related methods and compositions |
| US9034631B2 (en) | 2013-03-14 | 2015-05-19 | Poet Research, Inc. | Systems and methods for yeast propagation |
| US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
| AU2014352822B2 (en) * | 2013-11-22 | 2019-06-20 | The General Hospital Corporation | Microfluidic methods and systems for isolating particle clusters |
| US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
| WO2015103367A1 (en) | 2013-12-31 | 2015-07-09 | Raindance Technologies, Inc. | System and method for detection of rna species |
| EP3161052A4 (en) * | 2014-06-26 | 2018-03-21 | Northeastern University | Microfluidic device and method for analysis of tumor cell microenvironments |
| CN107209170A (zh) * | 2014-10-28 | 2017-09-26 | 多伦多大学管理委员会 | 电化学代谢活性检测装置 |
| DE102015106870B3 (de) | 2014-11-10 | 2016-02-25 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut | System zur Inkubation von mikrofluidischen Tropfen und Verfahren zur Bereitstellung von homogenen Inkubationsbedingungen in einer Tropfeninkubationseinheit |
| CN116064731A (zh) * | 2015-03-13 | 2023-05-05 | 哈佛学院院长及董事 | 使用扩增测定细胞 |
| US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
| JP7179329B2 (ja) * | 2016-01-14 | 2022-11-29 | ヨーロピアン モレキュラー バイオロジー ラボラトリー | リガンド誘発型の細胞発現のマイクロ流体分析 |
| US20190127789A1 (en) | 2016-04-19 | 2019-05-02 | President And Fellows Of Harvard College | Immobilization-based systems and methods for genetic analysis and other applications |
| US10258741B2 (en) | 2016-12-28 | 2019-04-16 | Cequr Sa | Microfluidic flow restrictor and system |
| US10839948B2 (en) | 2016-12-29 | 2020-11-17 | Intel Corporation | Microfluidic information-encoding polymer data storage |
| RU2656216C1 (ru) * | 2017-03-24 | 2018-06-01 | Федеральное государственное бюджетное учреждение науки Институт биоорганической химии им. М.М. Шемякина и Ю.А. Овчинникова Российской академии наук | Способ ультравысокопроизводительного скрининга клеток или микроорганизмов и средство для ультравысокопроизводительного скрининга клеток или микроорганизмов |
| US10858674B2 (en) | 2017-12-14 | 2020-12-08 | Poet Research, Inc. | Methods and systems for propagating microorganisms on stillage compositions |
| CN112714674B (zh) * | 2018-07-20 | 2022-12-09 | 布赖顿技术有限责任公司 | 用于从液体微滴分配系统收集的样本数据确定微滴的质量的方法和装置 |
| GB201909514D0 (en) * | 2018-11-20 | 2019-08-14 | Lightcast Discovery Ltd | Device and method for microdroplet detection of cells |
| US12383900B2 (en) * | 2019-05-14 | 2025-08-12 | The Regents Of The University Of California | Platform for the deterministic assembly of microfluidic droplets |
| CN110302849B (zh) * | 2019-05-31 | 2021-04-30 | 昆明理工大学 | 一种基于介电电泳原理分选液滴的微流控装置及方法 |
| US10960394B2 (en) * | 2019-05-31 | 2021-03-30 | Amberstone Biosciences, Inc. | Microfluidic determination of low abundance events |
| CN112304950A (zh) * | 2020-10-06 | 2021-02-02 | 清华大学 | 微液滴观测装置及基于形状匹配的微液滴图像识别方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512131A (en) * | 1993-10-04 | 1996-04-30 | President And Fellows Of Harvard College | Formation of microstamped patterns on surfaces and derivative articles |
| US6355198B1 (en) * | 1996-03-15 | 2002-03-12 | President And Fellows Of Harvard College | Method of forming articles including waveguides via capillary micromolding and microtransfer molding |
| JP2006507921A (ja) * | 2002-06-28 | 2006-03-09 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 流体分散のための方法および装置 |
| GB0215879D0 (en) * | 2002-07-09 | 2002-08-14 | Univ Cambridge Tech | Monitoring of cells |
| AU2004229440B2 (en) * | 2003-04-10 | 2010-08-12 | President And Fellows Of Harvard College | Formation and control of fluidic species |
| WO2005021151A1 (en) * | 2003-08-27 | 2005-03-10 | President And Fellows Of Harvard College | Electronic control of fluidic species |
| US20070054119A1 (en) * | 2005-03-04 | 2007-03-08 | Piotr Garstecki | Systems and methods of forming particles |
| DE602007009811D1 (de) * | 2006-01-27 | 2010-11-25 | Harvard College | Koaleszenz fluider tröpfchen |
-
2009
- 2009-06-26 AU AU2009262959A patent/AU2009262959A1/en not_active Abandoned
- 2009-06-26 CA CA2729255A patent/CA2729255A1/en not_active Abandoned
- 2009-06-26 CN CN2009801306401A patent/CN102439165A/zh active Pending
- 2009-06-26 WO PCT/US2009/003822 patent/WO2009158024A2/en not_active Ceased
- 2009-06-26 BR BRPI0915404A patent/BRPI0915404A2/pt not_active IP Right Cessation
- 2009-06-26 JP JP2011516319A patent/JP2011525811A/ja active Pending
- 2009-06-26 US US12/492,830 patent/US20100124759A1/en not_active Abandoned
- 2009-06-26 EP EP09770562A patent/EP2307560A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009158024A3 (en) | 2010-03-18 |
| CA2729255A1 (en) | 2009-12-30 |
| WO2009158024A2 (en) | 2009-12-30 |
| AU2009262959A1 (en) | 2009-12-30 |
| JP2011525811A (ja) | 2011-09-29 |
| EP2307560A2 (en) | 2011-04-13 |
| CN102439165A (zh) | 2012-05-02 |
| US20100124759A1 (en) | 2010-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |