BRPI0915989A2 - sinal de poliadenilação, seu vetor, seu uso e seu kit, bem como célula compreendendo o vetor e método para produzir um polipeptídeo de interesse - Google Patents
sinal de poliadenilação, seu vetor, seu uso e seu kit, bem como célula compreendendo o vetor e método para produzir um polipeptídeo de interesseInfo
- Publication number
- BRPI0915989A2 BRPI0915989A2 BRPI0915989-4A BRPI0915989A BRPI0915989A2 BR PI0915989 A2 BRPI0915989 A2 BR PI0915989A2 BR PI0915989 A BRPI0915989 A BR PI0915989A BR PI0915989 A2 BRPI0915989 A2 BR PI0915989A2
- Authority
- BR
- Brazil
- Prior art keywords
- vector
- well
- regulatory elements
- polypeptide
- kit
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 239000013598 vector Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000008488 polyadenylation Effects 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 abstract 4
- 238000001415 gene therapy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Landscapes
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
elementos reguladores a presente invenção refere-se a novos elementos reguladores bem como a vetores e células relacionados. além disso, refere-se a métodos para aumentar a expressão de polipeptídeos de ácidos nucleicos tais como genes clonados e à produção de vários polipeptídeos em células hospedeiras usando os referidos novos elementos reguladores. adicionalmente, a invenção refere-se a usos dos referidos novos elementos reguladores como isolamentos, em terapia genética ou para aprimorar linhagens celulares hospedeiras.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08161029 | 2008-07-23 | ||
| EP08161029.7 | 2008-07-23 | ||
| PCT/EP2009/059399 WO2010010107A1 (en) | 2008-07-23 | 2009-07-22 | Novel regulatory elements |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0915989A2 true BRPI0915989A2 (pt) | 2019-03-26 |
Family
ID=40085605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0915989-4A BRPI0915989A2 (pt) | 2008-07-23 | 2009-07-22 | sinal de poliadenilação, seu vetor, seu uso e seu kit, bem como célula compreendendo o vetor e método para produzir um polipeptídeo de interesse |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8466271B2 (pt) |
| EP (1) | EP2310501B1 (pt) |
| JP (1) | JP5481478B2 (pt) |
| KR (1) | KR101837925B1 (pt) |
| CN (1) | CN102165060B (pt) |
| AR (1) | AR072531A1 (pt) |
| AU (1) | AU2009273239B2 (pt) |
| BR (1) | BRPI0915989A2 (pt) |
| CA (1) | CA2724908C (pt) |
| CY (1) | CY1114483T1 (pt) |
| DK (1) | DK2310501T3 (pt) |
| EA (1) | EA201100225A1 (pt) |
| ES (1) | ES2421152T3 (pt) |
| HR (1) | HRP20130888T1 (pt) |
| IL (1) | IL208700A (pt) |
| MX (1) | MX2011000535A (pt) |
| MY (1) | MY156855A (pt) |
| NZ (1) | NZ589268A (pt) |
| PL (1) | PL2310501T3 (pt) |
| PT (1) | PT2310501E (pt) |
| SG (2) | SG188882A1 (pt) |
| SI (1) | SI2310501T1 (pt) |
| TW (1) | TW201011104A (pt) |
| WO (1) | WO2010010107A1 (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201100225A1 (ru) | 2008-07-23 | 2011-08-30 | Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг | Новые регуляторные элементы |
| KR100882240B1 (ko) * | 2008-09-11 | 2009-02-25 | (주)플러스텍 | 질화물 반도체 발광소자 및 제조방법 |
| WO2014102101A1 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Novel intron sequences |
| EP2938726B1 (en) | 2012-12-31 | 2017-09-27 | Boehringer Ingelheim International GmbH | Heterologous intron within a signal peptide |
| CN104293737B (zh) * | 2014-09-16 | 2017-06-13 | 太原博奥特生物技术有限公司 | 一种包含表达功能性重组人凝血因子ⅶ载体的宿主细胞及其高水平表达方法 |
| NZ751966A (en) | 2016-09-20 | 2023-03-31 | Boehringer Ingelheim Vetmedica Gmbh | New promoters |
| CA3036310A1 (en) | 2016-09-20 | 2018-03-29 | Boehringer Ingelheim Vetmedica Gmbh | New swine influenza vaccine |
| WO2018057441A1 (en) | 2016-09-20 | 2018-03-29 | Boehringer Ingelheim Vetmedica Gmbh | Canine adenovirus vectors |
| MX2019003161A (es) | 2016-09-20 | 2019-05-27 | Boehringer Ingelheim Vetmedica Gmbh | Nuevo sitio de insercion orf70 de ehv. |
| EP3612635A2 (en) * | 2017-04-18 | 2020-02-26 | GlaxoSmithKline Intellectual Property Development Limited | Methods for adeno-associated viral vector production |
| GB201706121D0 (en) * | 2017-04-18 | 2017-05-31 | Glaxosmithkline Ip Dev Ltd | Stable cell lines for retroviral production |
| MX2020003071A (es) | 2017-09-23 | 2020-07-28 | Boehringer Ingelheim Vetmedica Gmbh | Sistema de expresion de paramyxoviridae. |
| WO2019162294A1 (en) | 2018-02-23 | 2019-08-29 | Boehringer Ingelheim Vetmedica Gmbh | Recombinant viral vector systems expressing exogenous feline paramyxovirus genes and vaccines made therefrom |
| US11384365B2 (en) | 2018-03-19 | 2022-07-12 | Boehringer Ingelheim Vetmedica Gmbh | EHV with inactivated UL18 and/or UL8 |
| EA202092165A1 (ru) | 2018-03-19 | 2021-02-25 | Бёрингер Ингельхайм Ветмедика Гмбх | Новый ehv сайт инсерции ul43 |
| US10905758B2 (en) | 2018-09-20 | 2021-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Intranasal vector vaccine against porcine epidemic diarrhea |
| CN109486859A (zh) * | 2018-11-21 | 2019-03-19 | 新乡医学院 | 人工合成的polyA、哺乳动物细胞重组表达载体、哺乳动物宿主细胞、表达方法及应用 |
| WO2021138559A1 (en) * | 2019-12-31 | 2021-07-08 | Swanbio Therapeutics Limited | Improved aav-abcd1 constructs and use for treatment or prevention of adrenoleukodystrophy (ald) and/or adrenomyeloneuropathy (amn) |
| EP4243866A1 (en) | 2020-11-13 | 2023-09-20 | Boehringer Ingelheim Vetmedica GmbH | New feline herpes virus vaccine |
| CR20230363A (es) * | 2021-01-29 | 2024-02-20 | Biocad Joint Stock Co | Efecto sinérgico de smn1 y mir-23a en el tratamiento de la atrofia muscular espinal |
| AU2024257493A1 (en) * | 2023-04-18 | 2025-12-04 | Siren Biotechnology, Inc. | Adeno-associated viral vector compositions and methods of use |
| EP4713463A1 (en) * | 2023-05-18 | 2026-03-25 | Decibel Therapeutics, Inc. | Compositions and methods for treating gjb2-related hearing loss |
| CN121006370A (zh) * | 2024-05-23 | 2025-11-25 | 深圳市深研生物科技有限公司 | 提高腺相关病毒生产效率的方法 |
| WO2026013161A1 (en) | 2024-07-10 | 2026-01-15 | Boehringer Ingelheim Vetmedica Gmbh | Prime and boost vaccination for the treatment and prevention of avian influenza infections in avians |
| WO2026013162A1 (en) | 2024-07-10 | 2026-01-15 | Boehringer Ingelheim Vetmedica Gmbh | Herpes virus of turkey vector based h5ha vaccine for the treatment and prevention of avian influenza infections in turkeys |
| WO2026044087A1 (en) | 2024-08-21 | 2026-02-26 | Shape Therapeutics Inc. | Increased cellular stability for aav production |
| WO2026073032A1 (en) | 2024-09-27 | 2026-04-02 | Shape Therapeutics Inc. | Constructs for improved aav production |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0173552B1 (en) | 1984-08-24 | 1991-10-09 | The Upjohn Company | Recombinant dna compounds and the expression of polypeptides such as tpa |
| FR2629098B1 (fr) * | 1988-03-23 | 1990-08-10 | Rhone Poulenc Agrochimie | Gene chimerique de resistance herbicide |
| US7351813B2 (en) * | 2000-06-20 | 2008-04-01 | The Board Of Trustees Of The Leland Stanford Junior University | Liver-specific gene expression cassettes, and methods of use |
| UY26317A1 (es) * | 2000-08-30 | 2000-10-31 | Alfonso Cayota Carlos Pritsch | Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo |
| PT1685251E (pt) | 2003-10-10 | 2014-04-15 | Powderject Vaccines Inc | Construções de ácido nucleico |
| CA2553676A1 (en) | 2004-01-28 | 2005-08-11 | Research Development Foundation | Human soluble neuropilin-1 primary polyadenylation signal and uses thereof |
| CN101238214A (zh) | 2005-05-19 | 2008-08-06 | 拜尔先灵制药股份公司 | 使用改进的调节表达系统治疗疾病 |
| EA201100225A1 (ru) | 2008-07-23 | 2011-08-30 | Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг | Новые регуляторные элементы |
-
2009
- 2009-07-22 EA EA201100225A patent/EA201100225A1/ru unknown
- 2009-07-22 SG SG2013017686A patent/SG188882A1/en unknown
- 2009-07-22 CN CN2009801371650A patent/CN102165060B/zh active Active
- 2009-07-22 MY MYPI2011000262A patent/MY156855A/en unknown
- 2009-07-22 NZ NZ589268A patent/NZ589268A/en not_active IP Right Cessation
- 2009-07-22 JP JP2011517177A patent/JP5481478B2/ja active Active
- 2009-07-22 BR BRPI0915989-4A patent/BRPI0915989A2/pt not_active IP Right Cessation
- 2009-07-22 AR ARP090102796A patent/AR072531A1/es unknown
- 2009-07-22 AU AU2009273239A patent/AU2009273239B2/en active Active
- 2009-07-22 ES ES09800055T patent/ES2421152T3/es active Active
- 2009-07-22 MX MX2011000535A patent/MX2011000535A/es active IP Right Grant
- 2009-07-22 SG SG2013055439A patent/SG192541A1/en unknown
- 2009-07-22 CA CA2724908A patent/CA2724908C/en active Active
- 2009-07-22 SI SI200930705T patent/SI2310501T1/sl unknown
- 2009-07-22 US US13/055,017 patent/US8466271B2/en active Active
- 2009-07-22 PL PL09800055T patent/PL2310501T3/pl unknown
- 2009-07-22 KR KR1020107027579A patent/KR101837925B1/ko active Active
- 2009-07-22 DK DK09800055.7T patent/DK2310501T3/da active
- 2009-07-22 HR HRP20130888AT patent/HRP20130888T1/hr unknown
- 2009-07-22 TW TW098124746A patent/TW201011104A/zh unknown
- 2009-07-22 WO PCT/EP2009/059399 patent/WO2010010107A1/en not_active Ceased
- 2009-07-22 EP EP09800055.7A patent/EP2310501B1/en active Active
- 2009-07-22 PT PT98000557T patent/PT2310501E/pt unknown
-
2010
- 2010-10-14 IL IL208700A patent/IL208700A/en not_active IP Right Cessation
-
2013
- 2013-02-22 US US13/773,845 patent/US8975391B2/en active Active
- 2013-09-18 CY CY20131100820T patent/CY1114483T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 7A, 8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2517 DE 02-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |