BRPI0916092A2 - "isoformas específicas de anticorpos anti-her4" - Google Patents

"isoformas específicas de anticorpos anti-her4"

Info

Publication number
BRPI0916092A2
BRPI0916092A2 BRPI0916092A BRPI0916092A BRPI0916092A2 BR PI0916092 A2 BRPI0916092 A2 BR PI0916092A2 BR PI0916092 A BRPI0916092 A BR PI0916092A BR PI0916092 A BRPI0916092 A BR PI0916092A BR PI0916092 A2 BRPI0916092 A2 BR PI0916092A2
Authority
BR
Brazil
Prior art keywords
specific anti
her4 antibody
antibody isoforms
isoforms
her4
Prior art date
Application number
BRPI0916092A
Other languages
English (en)
Inventor
Klaus Elenius
Maija Hollmen
Mark X Sliwkowski
Original Assignee
Genentech Inc
Univ Turku
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Univ Turku filed Critical Genentech Inc
Publication of BRPI0916092A2 publication Critical patent/BRPI0916092A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cardiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BRPI0916092A 2008-11-25 2009-11-24 "isoformas específicas de anticorpos anti-her4" BRPI0916092A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11790308P 2008-11-25 2008-11-25
PCT/US2009/065712 WO2010068437A1 (en) 2008-11-25 2009-11-24 Isoform specific anti-her4 antibodies

Publications (1)

Publication Number Publication Date
BRPI0916092A2 true BRPI0916092A2 (pt) 2015-11-17

Family

ID=42021645

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0916092A BRPI0916092A2 (pt) 2008-11-25 2009-11-24 "isoformas específicas de anticorpos anti-her4"

Country Status (15)

Country Link
US (2) US20110293614A1 (pt)
EP (1) EP2365987B1 (pt)
JP (1) JP5894436B2 (pt)
KR (1) KR101789338B1 (pt)
CN (2) CN102725310A (pt)
AU (1) AU2009324939B2 (pt)
BR (1) BRPI0916092A2 (pt)
CA (1) CA2744512C (pt)
DK (1) DK2365987T3 (pt)
ES (1) ES2528929T3 (pt)
IL (1) IL212900A0 (pt)
MX (1) MX2011005382A (pt)
PL (1) PL2365987T3 (pt)
SI (1) SI2365987T1 (pt)
WO (1) WO2010068437A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011005382A (es) 2008-11-25 2011-07-20 Genentech Inc Anticuerpos anti-her4 especificos de isoforma.
US10083108B1 (en) * 2017-12-18 2018-09-25 Clover Network, Inc. Automated stack-based computerized application crawler
CN112753956A (zh) * 2021-01-20 2021-05-07 重庆周师兄餐饮文化有限公司 一种腰片的加工方法
CN113999228B (zh) * 2021-11-08 2022-11-04 南京卓康医药科技有限公司 一种他达拉非的合成方法
CN119823275A (zh) * 2023-10-12 2025-04-15 徕特康(苏州)生物制药有限公司 抗her4抗体及其制备方法和用途
CN119823276A (zh) * 2023-10-12 2025-04-15 徕特康(苏州)生物制药有限公司 抗her4抗体及其制备方法和用途
CN119823274A (zh) * 2023-10-12 2025-04-15 徕特康(苏州)生物制药有限公司 抗her4抗体及其制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
DK0752248T3 (da) 1992-11-13 2000-11-13 Idec Pharma Corp Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
CA2103323A1 (en) 1992-11-24 1994-05-25 Gregory D. Plowman Her4 human receptor tyrosine kinase
US5811098A (en) * 1992-11-24 1998-09-22 Bristol-Myers Squibb Company Antibodies to HER4, human receptor tyrosine kinase
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
CA2258721C (en) 1996-07-12 2014-09-09 Genentech, Inc. Chimeric heteromultimer adhesins
US6121415A (en) 1997-07-09 2000-09-19 Genentech, Inc. ErbB4 receptor-specific neuregolin related ligands and uses therefor
AU9805398A (en) * 1997-10-15 1999-05-03 Children's Medical Center Corporation Novel human egf receptors and use thereof
US20020119148A1 (en) 2000-09-01 2002-08-29 Gerritsen Mary E. ErbB4 antagonists
MX2011005382A (es) 2008-11-25 2011-07-20 Genentech Inc Anticuerpos anti-her4 especificos de isoforma.

Also Published As

Publication number Publication date
AU2009324939A1 (en) 2010-06-17
US9963517B2 (en) 2018-05-08
SI2365987T1 (sl) 2015-03-31
CA2744512C (en) 2018-05-15
EP2365987B1 (en) 2014-11-12
DK2365987T3 (en) 2015-01-12
ES2528929T3 (es) 2015-02-13
PL2365987T3 (pl) 2015-04-30
CN109608545A (zh) 2019-04-12
CA2744512A1 (en) 2010-06-17
US20110293614A1 (en) 2011-12-01
AU2009324939B2 (en) 2015-07-09
WO2010068437A1 (en) 2010-06-17
MX2011005382A (es) 2011-07-20
KR101789338B1 (ko) 2017-10-23
US20160075798A1 (en) 2016-03-17
IL212900A0 (en) 2011-07-31
JP2012509896A (ja) 2012-04-26
JP5894436B2 (ja) 2016-03-30
CN102725310A (zh) 2012-10-10
KR20110098756A (ko) 2011-09-01
EP2365987A1 (en) 2011-09-21

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements