BRPI0916192A2 - adesivos medicinais para hemóstases graves e estancamento de vazamentos - Google Patents

adesivos medicinais para hemóstases graves e estancamento de vazamentos

Info

Publication number: BRPI0916192A2
Authority: BR; Brazil
Prior art keywords: formulation; leakage; organic; mpas; hardener
Prior art date: 2008-07-17

Application number

BRPI0916192-9A

Other languages

English (en)

Inventor

Heckroth Heike

Köhler Burkhard

Dörr Sebastian

Original Assignee

Bayer Materialscience Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-17

Filing date

2009-07-04

Publication date

2018-05-29

2009-07-04 Application filed by Bayer Materialscience Ag filed Critical Bayer Materialscience Ag

2018-05-29 Publication of BRPI0916192A2 publication Critical patent/BRPI0916192A2/pt

Links

239000000853 adhesive Substances 0.000 title 1
230000001070 adhesive effect Effects 0.000 title 1
230000023597 hemostasis Effects 0.000 title 1
238000009472 formulation Methods 0.000 abstract 5
239000000203 mixture Substances 0.000 abstract 5
-1 aliphatic isocyanates Chemical class 0.000 abstract 4
239000012948 isocyanate Substances 0.000 abstract 4
239000012766 organic filler Substances 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
235000003704 aspartic acid Nutrition 0.000 abstract 2
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 2
230000000903 blocking effect Effects 0.000 abstract 2
239000008280 blood Substances 0.000 abstract 2
210000004369 blood Anatomy 0.000 abstract 2
239000007795 chemical reaction product Substances 0.000 abstract 2
239000012530 fluid Substances 0.000 abstract 2
230000002439 hemostatic effect Effects 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
150000002513 isocyanates Chemical class 0.000 abstract 2
239000004848 polyfunctional curative Substances 0.000 abstract 2
229920005862 polyol Polymers 0.000 abstract 2
150000003077 polyols Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000000740 bleeding effect Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
210000003462 vein Anatomy 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0094—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/04—Surgical instruments, devices or methods for suturing wounds; Holders or packages for needles or suture materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/089—Reaction retarding agents
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/48—Polyethers
- C08G18/4833—Polyethers containing oxyethylene units
- C08G18/4837—Polyethers containing oxyethylene units and other oxyalkylene units
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
- C08L75/04—Polyurethanes
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J175/00—Adhesives based on polyureas or polyurethanes; Adhesives based on derivatives of such polymers
- C09J175/04—Polyurethanes
- C09J175/12—Polyurethanes from compounds containing nitrogen and active hydrogen, the nitrogen atom not being part of an isocyanate group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Polymers & Plastics (AREA)
Surgery (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Composite Materials (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Medical Informatics (AREA)
Molecular Biology (AREA)
Vascular Medicine (AREA)
Materials For Medical Uses (AREA)
Polyurethanes Or Polyureas (AREA)
Adhesives Or Adhesive Processes (AREA)
Compositions Of Macromolecular Compounds (AREA)

BRPI0916192-9A 2008-07-17 2009-07-04 adesivos medicinais para hemóstases graves e estancamento de vazamentos BRPI0916192A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08012901A EP2145634A1 (de)	2008-07-17	2008-07-17	Medizinische Klebstoffe zur Stillung schwerwiegender Blutungen und Abdichtung von Leckagen
EP08012901.8		2008-07-17
PCT/EP2009/004833 WO2010006714A2 (de)	2008-07-17	2009-07-04	Medizinische klebstoffe zur stillung schwerwiegender blutungen und abdichtung von leckagen

Publications (1)

Publication Number	Publication Date
BRPI0916192A2 true BRPI0916192A2 (pt)	2018-05-29

Family

ID=39877989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0916192-9A BRPI0916192A2 (pt)	2008-07-17	2009-07-04	adesivos medicinais para hemóstases graves e estancamento de vazamentos

Country Status (13)

Country	Link
US (4)	US9764058B2 (pt)
EP (2)	EP2145634A1 (pt)
JP (1)	JP2011527915A (pt)
KR (1)	KR20110052573A (pt)
CN (1)	CN102089015A (pt)
AU (1)	AU2009270521A1 (pt)
BR (1)	BRPI0916192A2 (pt)
CA (1)	CA2730850A1 (pt)
DK (1)	DK2307063T3 (pt)
ES (1)	ES2533077T3 (pt)
RU (1)	RU2011105724A (pt)
TW (1)	TW201016248A (pt)
WO (1)	WO2010006714A2 (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2145634A1 (de) *	2008-07-17	2010-01-20	Bayer MaterialScience AG	Medizinische Klebstoffe zur Stillung schwerwiegender Blutungen und Abdichtung von Leckagen
DE102010019504A1 (de)	2010-05-06	2011-11-10	Bayer Materialscience Ag	Polyisocyanatprepolymere und deren Verwendung
WO2012013673A1 (de)	2010-07-29	2012-02-02	Bayer Materialscience Ag	Bioabbaubarer gewebekleber
DK2673311T3 (en)	2011-02-09	2014-12-01	Bayer Materialscience Ag	Tissue adhesive based on trifunctional aspartate
WO2012107376A1 (de)	2011-02-09	2012-08-16	Bayer Materialscience Ag	Gewebekleber auf basis aminosubstituierter triacetale
DK2673310T3 (en)	2011-02-09	2015-02-23	Medical Adhesive Revolution Gmbh	Tissue adhesives based on nitrogen-modified aspartates
DK2699614T3 (en) *	2011-04-19	2015-04-27	Medical Adhesive Revolution Gmbh	Tissue adhesive with accelerated hardening
DK2699615T3 (en) *	2011-04-19	2015-09-21	Medical Adhesive Revolution Gmbh	Medical adhesive to stop bleeding
EP2543395A1 (de) *	2011-07-04	2013-01-09	Bayer MaterialScience AG	Schichtaufbau zum Verschließen von Gewebeleckagen
HK1201547A1 (en)	2011-12-20	2015-09-04	Adhesys Medical Gmbh	Isocyanate-functional prepolymer for a biologically degradable fabric adhesive
CN104185646B (zh) *	2012-01-09	2019-01-15	阿德希西斯医疗有限公司	β-氨基酸酯改性的(天冬氨酸酯)硬化剂及其在聚脲组织粘合剂中的用途
EP2695900B1 (en) *	2012-08-06	2019-03-20	Novachem Industriale S.r.l.	Process for preparing a two-component polyurethane adhesive system
WO2016164316A1 (en)	2015-04-06	2016-10-13	3M Innovative Properties Company	Removable film forming gel compositions and methods for their application
JP7155544B2 (ja) *	2018-03-02	2022-10-19	東洋紡株式会社	ポリカルボン酸誘導体
EP3807382B1 (en)	2018-06-14	2025-06-18	ChampionX USA Inc.	Carboxy alkyl-ester anti-agglomerants for the control of natural gas hydrates
EP3698723A1 (de)	2019-02-20	2020-08-26	Adhesys Medical GmbH	Applikator für einen zwei-komponenten gewebekleber
WO2022013345A1 (de)	2020-07-17	2022-01-20	Adhesys Medical Gmbh	Kit aus einem zwei-komponenten gewebekleber und einer textilen struktur zur stärkung des bindegewebes nach einer operation sowie dessen verwendung
EP4267209A1 (en) *	2020-12-23	2023-11-01	Peters Surgical	A hemostatic tissue adhesive composition comprising an nco-terminated urethane preprolymer
DE102021102484A1 (de)	2021-02-03	2022-08-04	Adhesys Medical Gmbh	Kit für die Gefäßanastomose aus einem zwei-Komponenten Gewebekleber und einer Gefäßprothese sowie dessen Verwendung
DE102021106358A1 (de)	2021-03-16	2022-09-22	Adhesys Medical Gmbh	Gewebekleber in Form eines Zweikomponenten-Klebstoffs zur Verwendung bei der Pankreasanastomose im Rahmen der Pankreasresektion
EP4104870A1 (de)	2021-06-15	2022-12-21	Adhesys Medical GmbH	Gewebekleber in form eines zweikomponenten-klebstoffs zur verwendung als bakterielle barriere bei der wundbehandlung, insbesondere nach chirurgischen eingriffen
CN114053474A (zh) *	2021-11-24	2022-02-18	华南理工大学	一种具备止血功能的医用胶粘剂及其使用方法
CN120112276A (zh)	2023-03-28	2025-06-06	浦项工科大学校产学协力团	代谢物的聚合物纳米粒子及其用途

Family Cites Families (15)

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US4740534A (en) *	1985-08-30	1988-04-26	Sanyo Chemical Industries, Ltd.	Surgical adhesive
DE59007601D1 (de) *	1989-06-23	1994-12-08	Bayer Ag	Verfahren zur Herstellung von Überzügen.
US5243012A (en)	1992-06-10	1993-09-07	Miles Inc.	Polyurea coating compositions having improved pot lives
KR20010013105A (ko) *	1997-05-28	2001-02-26	시미즈, 야스히꼬	콜라겐 겔
US6355829B2 (en) *	1999-09-02	2002-03-12	Bayer Corporation	Aspartate-terminated urea/urethane prepolymers and their use in coating compositions
DE10246708A1 (de) *	2002-10-07	2004-04-15	Bayer Ag	Zweikomponenten-Systeme für die Herstellung elastischer Beschichtungen
US20050129733A1 (en) *	2003-12-09	2005-06-16	Milbocker Michael T.	Surgical adhesive and uses therefore
US8044234B2 (en) *	2005-05-05	2011-10-25	Tyco Healthcare Group Lp	Bioabsorbable surgical composition
EP2597457B1 (en) *	2005-07-28	2018-03-14	Bioptigen, Inc.	Frequency-domain optical coherence tomography imaging system
WO2007127198A2 (en) *	2006-04-24	2007-11-08	Incept, Llc	Protein crosslinkers, crosslinking methods and applications thereof
EP2011808A1 (de) *	2007-07-03	2009-01-07	Bayer MaterialScience AG	Medizinische Klebstoffe für die Chirurgie
EP2095832A1 (de) *	2008-02-28	2009-09-02	Bayer MaterialScience AG	Polyharnstoff-Systeme und deren Anwendung als postoperative Adhäsionsbarrieren, Filme und Verbundteile.
EP2145634A1 (de) *	2008-07-17	2010-01-20	Bayer MaterialScience AG	Medizinische Klebstoffe zur Stillung schwerwiegender Blutungen und Abdichtung von Leckagen
EP2275466A1 (de) *	2009-07-16	2011-01-19	Bayer MaterialScience AG	Polyharnstoff-basierter Gewebekleber
DK2673310T3 (en) *	2011-02-09	2015-02-23	Medical Adhesive Revolution Gmbh	Tissue adhesives based on nitrogen-modified aspartates

2008
- 2008-07-17 EP EP08012901A patent/EP2145634A1/de not_active Ceased
2009
- 2009-07-04 JP JP2011517778A patent/JP2011527915A/ja not_active Withdrawn
- 2009-07-04 RU RU2011105724/15A patent/RU2011105724A/ru not_active Application Discontinuation
- 2009-07-04 US US13/054,673 patent/US9764058B2/en not_active Expired - Fee Related
- 2009-07-04 AU AU2009270521A patent/AU2009270521A1/en not_active Abandoned
- 2009-07-04 WO PCT/EP2009/004833 patent/WO2010006714A2/de not_active Ceased
- 2009-07-04 CA CA2730850A patent/CA2730850A1/en not_active Abandoned
- 2009-07-04 ES ES09776953.3T patent/ES2533077T3/es active Active
- 2009-07-04 EP EP09776953.3A patent/EP2307063B1/de not_active Not-in-force
- 2009-07-04 KR KR1020117001034A patent/KR20110052573A/ko not_active Withdrawn
- 2009-07-04 BR BRPI0916192-9A patent/BRPI0916192A2/pt not_active IP Right Cessation
- 2009-07-04 CN CN2009801273319A patent/CN102089015A/zh active Pending
- 2009-07-04 DK DK09776953.3T patent/DK2307063T3/en active
- 2009-07-16 TW TW098124025A patent/TW201016248A/zh unknown
2017
- 2017-08-03 US US15/667,744 patent/US10117963B2/en not_active Expired - Fee Related
2018
- 2018-10-01 US US16/148,272 patent/US10391198B2/en not_active Expired - Fee Related
2019
- 2019-06-25 US US16/451,283 patent/US10722609B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP2307063B1 (de)	2014-12-31
US20200046875A1 (en)	2020-02-13
CN102089015A (zh)	2011-06-08
US10117963B2 (en)	2018-11-06
RU2011105724A (ru)	2012-08-27
EP2307063A2 (de)	2011-04-13
US20190030206A1 (en)	2019-01-31
CA2730850A1 (en)	2010-01-21
WO2010006714A3 (de)	2010-09-30
AU2009270521A1 (en)	2010-01-21
US10722609B2 (en)	2020-07-28
TW201016248A (en)	2010-05-01
EP2145634A1 (de)	2010-01-20
US20170326268A1 (en)	2017-11-16
DK2307063T3 (en)	2015-04-07
US9764058B2 (en)	2017-09-19
ES2533077T3 (es)	2015-04-07
US20110123479A1 (en)	2011-05-26
KR20110052573A (ko)	2011-05-18
US10391198B2 (en)	2019-08-27
JP2011527915A (ja)	2011-11-10
WO2010006714A2 (de)	2010-01-21

Legal Events

Date	Code	Title	Description
2018-06-05	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2018-10-23	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2474 DE 05-06-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0916192A2 (pt)	2018-05-29	adesivos medicinais para hemóstases graves e estancamento de vazamentos
AU2008202473B2 (en)	2014-01-16	Foam control for synthetic adhesive/sealant
CA2499447C (en)	2011-03-29	Fast curing compositions
JP2009518128A (ja)	2009-05-07	生体適合性組織封止剤および接着剤
DK2173782T3 (da)	2011-05-16	Medicinske klæbestoffer til kirurgi
JP2013527281A5 (pt)	2014-06-26
EP3197926A1 (en)	2017-08-02	Flexible polyurea sealant compositions
AU2008202284A1 (en)	2008-12-11	Adhesive formulations
RU2010140659A (ru)	2012-04-20	Медицинские клеи с биоактивными соединениями для хирургии
WO2007089430A1 (en)	2007-08-09	Diisocyanate terminated macromer and method of making
JP2010094513A (ja)	2010-04-30	生体吸収性外科用組成物
BR112018003350B1 (pt)	2022-06-14	Composição adequada como endurecedor em um adesivo de epóxi e método de fabricação de uma composição adequada como um endurecedor em um adesivo de epóxi
US20220395608A1 (en)	2022-12-15	Water soluble bioadhesives
NZ583490A (en)	2013-02-22	Hydrophilic biodegradable adhesives
CA2817916C (en)	2019-02-12	Biodegradable compositions having pressure sensitive adhesive properties
JP2018196738A (ja)	2018-12-13	シラン含有水分硬化性組織シーラント
CA2628580C (en)	2014-07-08	Bioabsorbable compounds and compositions containing them
US20210038761A1 (en)	2021-02-11	Meniscal repair adhesive
EP2575916B1 (en)	2018-04-04	One-part moisture-curable tissue sealant
AU2006321856A1 (en)	2007-06-14	Biocompatible surgical compositions
US7728097B2 (en)	2010-06-01	Method of making a diisocyanate terminated macromer
WO2005092404A1 (ja)	2005-10-06	医療用接着剤
JP4256855B2 (ja)	2009-04-22	医療用接着剤
EP2699615A1 (de)	2014-02-26	Medizinischer klebstoff zur stillung von blutungen