BRPI0916657A2 - pirrolidin-3-ilmetil-amina como antagonistas de orexina - Google Patents

pirrolidin-3-ilmetil-amina como antagonistas de orexina

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Publication number
BRPI0916657A2
BRPI0916657A2 BRPI0916657-2A BRPI0916657A BRPI0916657A2 BR PI0916657 A2 BRPI0916657 A2 BR PI0916657A2 BR PI0916657 A BRPI0916657 A BR PI0916657A BR PI0916657 A2 BRPI0916657 A2 BR PI0916657A2
Authority
BR
Brazil
Prior art keywords
pyrrolidin
orexin antagonists
ylmethyl amine
orexin
ylmethyl
Prior art date
Application number
BRPI0916657-2A
Other languages
English (en)
Inventor
Knust Henner
Nettekoven Matthias
Pinard Emmanuel
Roche Olivier
Rogers-Evans Mark
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of BRPI0916657A2 publication Critical patent/BRPI0916657A2/pt

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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

pirrolidin-3-ilmetil-amina como antagonistasde orexina". a presente invenção refere-se a compostos de fórmula (i) em que r1, r2, ar, hetarila, m e n são como descritos na descrição e reivindicações. os compostos são antagonistas de receptores de orexina que podem ser úteis no tratamento de distúrbios, em que trilhas de orexina estão envolvidas.
BRPI0916657-2A 2008-07-29 2009-07-20 pirrolidin-3-ilmetil-amina como antagonistas de orexina BRPI0916657A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08161316.3 2008-07-29
EP08161316 2008-07-29
PCT/EP2009/059271 WO2010012620A1 (en) 2008-07-29 2009-07-20 Pyrrolidin-3-ylmethyl-amine as orexin antagonists

Publications (1)

Publication Number Publication Date
BRPI0916657A2 true BRPI0916657A2 (pt) 2019-03-26

Family

ID=41056722

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0916657-2A BRPI0916657A2 (pt) 2008-07-29 2009-07-20 pirrolidin-3-ilmetil-amina como antagonistas de orexina

Country Status (13)

Country Link
US (3) US7923470B2 (pt)
EP (1) EP2303871B1 (pt)
JP (1) JP5301665B2 (pt)
KR (1) KR101359852B1 (pt)
CN (1) CN102083820B (pt)
AT (1) ATE557019T1 (pt)
AU (1) AU2009276091A1 (pt)
BR (1) BRPI0916657A2 (pt)
CA (1) CA2731403C (pt)
ES (1) ES2386526T3 (pt)
IL (1) IL209629A0 (pt)
MX (1) MX2011000462A (pt)
WO (1) WO2010012620A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20032990A3 (cs) * 2001-05-05 2004-04-14 Smithkline Beecham P. L. C. N-aroylové cyklické aminy
ES2585806T3 (es) 2009-10-23 2016-10-10 Janssen Pharmaceutica N.V. Octahidropirrolo [3,4-c] pirroles disustituidos como moduladores de receptores de orexina
WO2013119639A1 (en) 2012-02-07 2013-08-15 Eolas Therapeutics, Inc. Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
TW201613902A (en) 2014-08-13 2016-04-16 Eolas Therapeutics Inc Difluoropyrrolidines as orexin receptor modulators
LT3414241T (lt) 2016-02-12 2022-08-25 Astrazeneca Ab Halogenu pakeisti piperidinai kaip oreksino receptoriaus moduliatoriai
HRP20220642T1 (hr) 2016-03-10 2022-06-24 Janssen Pharmaceutica Nv Postupci za liječenje depresije uporabom antagonista receptora oreksina 2
CN115667224A (zh) * 2020-02-26 2023-01-31 斯克里普斯研究学院 具有抗炎活性的scl15a4小分子的抑制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20032990A3 (cs) * 2001-05-05 2004-04-14 Smithkline Beecham P. L. C. N-aroylové cyklické aminy
AR053712A1 (es) * 2005-04-18 2007-05-16 Neurogen Corp Heteroarilos sustituidos, antagonistas de cb1 (receptor 1 canabinoide)
CA2705411A1 (en) * 2007-12-21 2009-07-02 F. Hoffmann-La Roche Ag Heteroaryl derivatives as orexin receptor antagonists

Also Published As

Publication number Publication date
CN102083820B (zh) 2013-07-17
CA2731403A1 (en) 2010-02-04
WO2010012620A1 (en) 2010-02-04
EP2303871B1 (en) 2012-05-09
AU2009276091A1 (en) 2010-02-04
US20110071154A1 (en) 2011-03-24
US8207220B2 (en) 2012-06-26
MX2011000462A (es) 2011-04-05
EP2303871A1 (en) 2011-04-06
US20100029664A1 (en) 2010-02-04
ES2386526T3 (es) 2012-08-22
CA2731403C (en) 2013-11-05
US8748430B2 (en) 2014-06-10
US7923470B2 (en) 2011-04-12
US20120232084A1 (en) 2012-09-13
IL209629A0 (en) 2011-02-28
KR101359852B1 (ko) 2014-02-06
JP5301665B2 (ja) 2013-09-25
CN102083820A (zh) 2011-06-01
JP2011529096A (ja) 2011-12-01
KR20110013535A (ko) 2011-02-09
ATE557019T1 (de) 2012-05-15

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