BRPI0917299A2 - aplicação da monooleína como novo lípido adjuvante em lipogecção - Google Patents
aplicação da monooleína como novo lípido adjuvante em lipogecçãoInfo
- Publication number
- BRPI0917299A2 BRPI0917299A2 BRPI0917299A BRPI0917299A BRPI0917299A2 BR PI0917299 A2 BRPI0917299 A2 BR PI0917299A2 BR PI0917299 A BRPI0917299 A BR PI0917299A BR PI0917299 A BRPI0917299 A BR PI0917299A BR PI0917299 A2 BRPI0917299 A2 BR PI0917299A2
- Authority
- BR
- Brazil
- Prior art keywords
- lipogection
- monoolein
- application
- new adjuvant
- adjuvant lipid
- Prior art date
Links
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 title 1
- 239000002671 adjuvant Substances 0.000 title 1
- RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 title 1
- 150000002632 lipids Chemical class 0.000 title 1
- 229940074096 monoolein Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT104158A PT104158B (pt) | 2008-08-18 | 2008-08-18 | Aplicação da monooleína como novo lípido adjuvante em lipofecção |
| PCT/IB2009/053619 WO2010020935A2 (pt) | 2008-08-18 | 2009-08-17 | Aplicação da monooleína como novo lípido adjuvante em lipofecção |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0917299A2 true BRPI0917299A2 (pt) | 2015-11-17 |
Family
ID=41707522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0917299A BRPI0917299A2 (pt) | 2008-08-18 | 2009-08-17 | aplicação da monooleína como novo lípido adjuvante em lipogecção |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110178164A1 (pt) |
| EP (1) | EP2335687B1 (pt) |
| BR (1) | BRPI0917299A2 (pt) |
| PT (1) | PT104158B (pt) |
| WO (1) | WO2010020935A2 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008141230A1 (en) | 2007-05-09 | 2008-11-20 | Lawrence Livermore National Security, Llc | Methods and systems for monitoring production of a target protein in a nanolipoprotein particle |
| US9644038B2 (en) | 2011-12-21 | 2017-05-09 | The Regents Of The University Of California | Apolipoprotein nanodiscs with telodendrimer |
| WO2017035326A1 (en) | 2015-08-25 | 2017-03-02 | Lawrence Livermore National Security, Llc | Stable nanolipoprotein particles and related compositions methods and systems |
| WO2017044899A1 (en) | 2015-09-11 | 2017-03-16 | Lawrence Livermore National Security, Llc | Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation |
| CN109843312A (zh) | 2016-04-29 | 2019-06-04 | 马德里自治大学 | 用作癌症或免疫失调患者的免疫治疗增效剂或佐剂的包含携带生物活性化合物的脂质体系的制剂 |
| US12083223B2 (en) | 2017-05-02 | 2024-09-10 | Lawrence Livermore National Security, Llc | Nanolipoprotein particles and related compositions methods and systems for loading RNA |
| US11207422B2 (en) | 2017-05-02 | 2021-12-28 | Lawrence Livermore National Security, Llc | MOMP telonanoparticles, and related compositions, methods and systems |
| AU2020384481B2 (en) | 2019-11-12 | 2025-12-11 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing IDO antagonist prodrugs useful in the treatment of cancer and methods thereof |
| JP7829485B2 (ja) | 2019-12-20 | 2026-03-13 | ナミ セラピューティクス， インコーポレイテッド | がんの処置において有用なＴｏｌｌ様受容体（「ＴＬＲ」）アゴニストプロドラッグを含有する製剤化および／または共製剤化リポソーム組成物ならびにその方法 |
| WO2025058654A1 (en) | 2020-02-19 | 2025-03-20 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing tgfb antagonist prodrugs useful in the treatment of cancer and methods thereof |
| WO2021167703A1 (en) | 2020-02-19 | 2021-08-26 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing tgfb antagonist prodrugs useful in the treatment of cancer and methods thereof |
| KR20230066582A (ko) | 2020-09-10 | 2023-05-16 | 남미 테라퓨틱스, 인크. | 암의 치료에 유용한 pd-1 길항제 전구약물을 함유하는 제제화된 및/또는 공동-제제화된 리포솜 조성물 및 그의 방법 |
| CA3211133A1 (en) | 2021-03-18 | 2022-09-22 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing a2ar antagonist prodrugs useful in the treatment of cancer and methods thereof |
| US20230226031A1 (en) | 2021-11-18 | 2023-07-20 | Nammi Therapeutics, Inc. | Formulated and/or Co-Formulated Liposome Compositions Containing Immunogenic Cell Death (ICD) Inducing Prodrugs Useful In The Treatment of Cancer and Methods Thereof |
| WO2023172347A1 (en) | 2022-03-10 | 2023-09-14 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated lipid nanocarriers compositions containing toll-like receptor ("tlr") agonist prodrugs useful in the treatment of cancer and methods thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5651981A (en) * | 1994-03-29 | 1997-07-29 | Northwestern University | Cationic phospholipids for transfection |
| DE59507224D1 (de) * | 1994-12-28 | 1999-12-16 | Max Delbrueck Centrum | Neues cholesterolderivat für den liposomalen gentransfer |
| US7001614B2 (en) | 1996-08-19 | 2006-02-21 | The United States Of America As Represented By The Department Of Health And Human Services | Liposome complexes for increased systemic delivery |
| US6074667A (en) | 1996-11-20 | 2000-06-13 | Kinnunen; Paavo | Liposomal transfection method |
| WO2000030444A1 (en) * | 1998-11-25 | 2000-06-02 | Vanderbilt University | Cationic liposomes for gene transfer |
| US6936469B2 (en) | 2001-03-22 | 2005-08-30 | Chromos Molecular Systems Inc. | Methods for delivering nucleic acid molecules into cells and assessment thereof |
| AU2002359892A1 (en) | 2001-12-31 | 2003-07-24 | Elan Pharmaceuticals, Inc. | Efficient nucleic acid encapsulation into medium sized liposomes |
| US7732420B2 (en) | 2003-10-03 | 2010-06-08 | Northwestern University | Combinations of transfection lipids exhibiting increased transfection efficiencies |
| ATE489942T1 (de) * | 2004-01-23 | 2010-12-15 | Camurus Ab | Ternäre nichtlamellare lipidzusammensetzungen |
| WO2005118612A1 (en) * | 2004-06-04 | 2005-12-15 | Sonus Pharmaceuticals, Inc. | Cholesterol/bile acid/bile acid derivative-modified therapeutic anti-cancer drugs |
-
2008
- 2008-08-18 PT PT104158A patent/PT104158B/pt active IP Right Grant
-
2009
- 2009-08-17 EP EP09804144.5A patent/EP2335687B1/en not_active Not-in-force
- 2009-08-17 BR BRPI0917299A patent/BRPI0917299A2/pt not_active IP Right Cessation
- 2009-08-17 WO PCT/IB2009/053619 patent/WO2010020935A2/pt not_active Ceased
- 2009-08-17 US US13/059,950 patent/US20110178164A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010020935A8 (pt) | 2011-03-31 |
| PT104158B (pt) | 2011-02-24 |
| US20110178164A1 (en) | 2011-07-21 |
| EP2335687B1 (en) | 2017-05-24 |
| PT104158A (pt) | 2010-02-18 |
| EP2335687A2 (en) | 2011-06-22 |
| WO2010020935A2 (pt) | 2010-02-25 |
| WO2010020935A3 (pt) | 2010-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |