BRPI0918213A2 - compostos de pirazolila policíclicos de n-sulfonamido, composição famacêutica que os compreende e uso dos referidos compostos - Google Patents

compostos de pirazolila policíclicos de n-sulfonamido, composição famacêutica que os compreende e uso dos referidos compostos

Info

Publication number: BRPI0918213A2
Authority: BR; Brazil
Prior art keywords: compounds; sulfonamido; polycyclic; pharmaceutical composition; pyrazolyl
Prior art date: 2008-09-05

Application number

BRPI0918213A

Other languages

English (en)

Inventor

Albert W Garofalo

Andrei W Konradi

Anh P Truong

Christopher M Semko

Danielle L Aubele

Darren Dressen

Gary Probst

Michael S Dappen

Minghua Sun

Raymond Ng

Simeon Bowers

Xiaocong Michael Ye

Original Assignee

Elan Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-09-05

Filing date

2009-09-04

Publication date

2015-12-08

2009-09-04 Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc

2015-12-08 Publication of BRPI0918213A2 publication Critical patent/BRPI0918213A2/pt

Links

150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000003367 polycyclic group Chemical group 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BRPI0918213A 2008-09-05 2009-09-04 compostos de pirazolila policíclicos de n-sulfonamido, composição famacêutica que os compreende e uso dos referidos compostos BRPI0918213A2 (pt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US9479908P	2008-09-05	2008-09-05
US9924108P	2008-09-23	2008-09-23
US17327809P	2009-04-28	2009-04-28
US22653209P	2009-07-17	2009-07-17
PCT/US2009/055987 WO2010028213A2 (en)	2008-09-05	2009-09-04	N-sulfonamido polycyclic pyrazolyl compounds

Publications (1)

Publication Number	Publication Date
BRPI0918213A2 true BRPI0918213A2 (pt)	2015-12-08

Family

ID=41258775

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0918213A BRPI0918213A2 (pt)	2008-09-05	2009-09-04	compostos de pirazolila policíclicos de n-sulfonamido, composição famacêutica que os compreende e uso dos referidos compostos

Country Status (20)

Country	Link
US (1)	US8283358B2 (pt)
EP (1)	EP2346863A2 (pt)
JP (1)	JP2012502051A (pt)
KR (1)	KR20110055715A (pt)
CN (1)	CN102203089A (pt)
AR (1)	AR073497A1 (pt)
AU (1)	AU2009289579A1 (pt)
BR (1)	BRPI0918213A2 (pt)
CA (1)	CA2736767A1 (pt)
CL (1)	CL2011000405A1 (pt)
CO (1)	CO6362008A2 (pt)
EA (1)	EA201170421A1 (pt)
EC (1)	ECSP11010947A (pt)
IL (1)	IL211263A0 (pt)
MA (1)	MA32688B1 (pt)
MX (1)	MX2011002047A (pt)
PE (1)	PE20110418A1 (pt)
TW (1)	TW201014856A (pt)
WO (1)	WO2010028213A2 (pt)
ZA (1)	ZA201101994B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2009289649B2 (en)	2008-09-03	2016-05-05	Biomarin Pharmaceutical Inc.	Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
WO2010028213A2 (en)	2008-09-05	2010-03-11	Elan Pharmaceuticals, Inc.	N-sulfonamido polycyclic pyrazolyl compounds
US8957066B2 (en)	2011-02-28	2015-02-17	Biomarin Pharmaceutical Inc.	Histone deacetylase inhibitors
JP6250403B2 (ja)	2011-02-28	2017-12-20	バイオマリンファーマシューティカルインク	ヒストン脱アセチル化酵素阻害剤
US10059723B2 (en)	2011-02-28	2018-08-28	Biomarin Pharmaceutical Inc.	Histone deacetylase inhibitors
PT2970139T (pt)	2013-03-15	2018-08-01	Biomarin Pharm Inc	Inibidores de hdac
AU2020416203A1 (en) *	2020-01-03	2022-06-16	Blue Oak Pharmaceuticals, Inc.	Compounds and compositions for treating CNS disorders
CN111909217B (zh) *	2020-08-20	2023-05-02	昆明贵金属研究所	一种双（二叔丁基-4-二甲氨基苯基膦）四溴双钯(ⅱ)化合物及其制备方法和用途
CN115448892B (zh) *	2022-09-19	2023-07-07	郑州铁路职业技术学院	一种苯并噻二唑杂环化合物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8727989D0 (en) *	1987-11-30	1988-01-06	Merck Sharp & Dohme	Therapeutic agents
EP0330788A1 (en)	1988-03-01	1989-09-06	Merrell Dow Pharmaceuticals Inc.	Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmia
EP1758884A2 (en) *	2004-05-20	2007-03-07	Elan Pharmaceuticals, Inc.	N-cyclic sulfonamido inhibitors of gamma secretase
EP1916985A4 (en) *	2005-08-19	2010-06-09	Elan Pharm Inc	BRIDGED N-CYCLIC SULPHONAMIDE INHIBITORS OF THE GAMMED CRYSTETRY
TW200813054A (en) *	2006-06-02	2008-03-16	Elan Pharm Inc	Fused, tricyclic sulfonamide inhibitors of gamma secretase
CN101128035B (zh)	2006-08-18	2011-08-24	中兴通讯股份有限公司	时分码分多址系统中信道间的定时方法
NZ582039A (en) *	2007-05-25	2012-02-24	Elan Pharm Inc	Pyrazolopyrrolidines as inhibitors of gamma secretase
WO2010028213A2 (en)	2008-09-05	2010-03-11	Elan Pharmaceuticals, Inc.	N-sulfonamido polycyclic pyrazolyl compounds

2009
- 2009-09-04 WO PCT/US2009/055987 patent/WO2010028213A2/en not_active Ceased
- 2009-09-04 JP JP2011526217A patent/JP2012502051A/ja active Pending
- 2009-09-04 CA CA2736767A patent/CA2736767A1/en not_active Abandoned
- 2009-09-04 EA EA201170421A patent/EA201170421A1/ru unknown
- 2009-09-04 US US12/554,134 patent/US8283358B2/en not_active Expired - Fee Related
- 2009-09-04 KR KR1020117007863A patent/KR20110055715A/ko not_active Withdrawn
- 2009-09-04 AR ARP090103413A patent/AR073497A1/es not_active Application Discontinuation
- 2009-09-04 MX MX2011002047A patent/MX2011002047A/es unknown
- 2009-09-04 BR BRPI0918213A patent/BRPI0918213A2/pt not_active IP Right Cessation
- 2009-09-04 TW TW098129931A patent/TW201014856A/zh unknown
- 2009-09-04 CN CN2009801426386A patent/CN102203089A/zh active Pending
- 2009-09-04 PE PE2011000438A patent/PE20110418A1/es not_active Application Discontinuation
- 2009-09-04 AU AU2009289579A patent/AU2009289579A1/en not_active Abandoned
- 2009-09-04 EP EP09792258A patent/EP2346863A2/en not_active Withdrawn
2011
- 2011-02-17 IL IL211263A patent/IL211263A0/en unknown
- 2011-02-24 CL CL2011000405A patent/CL2011000405A1/es unknown
- 2011-03-16 ZA ZA2011/01994A patent/ZA201101994B/en unknown
- 2011-03-31 CO CO11039494A patent/CO6362008A2/es not_active Application Discontinuation
- 2011-04-01 MA MA33737A patent/MA32688B1/fr unknown
- 2011-04-01 EC EC2011010947A patent/ECSP11010947A/es unknown

Also Published As

Publication number	Publication date
JP2012502051A (ja)	2012-01-26
CO6362008A2 (es)	2012-01-20
CN102203089A (zh)	2011-09-28
MX2011002047A (es)	2011-06-17
US20100081680A1 (en)	2010-04-01
MA32688B1 (fr)	2011-10-02
PE20110418A1 (es)	2011-06-22
WO2010028213A3 (en)	2010-06-03
EA201170421A1 (ru)	2012-01-30
US8283358B2 (en)	2012-10-09
AU2009289579A1 (en)	2010-03-11
KR20110055715A (ko)	2011-05-25
ZA201101994B (en)	2011-11-30
AR073497A1 (es)	2010-11-10
CL2011000405A1 (es)	2011-07-01
EP2346863A2 (en)	2011-07-27
IL211263A0 (en)	2011-04-28
CA2736767A1 (en)	2010-03-11
WO2010028213A2 (en)	2010-03-11
TW201014856A (en)	2010-04-16
ECSP11010947A (es)	2011-07-29

Legal Events

Date	Code	Title	Description
2016-09-13	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.
2017-01-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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