BRPI0919581A2 - métodos para reduzir a disponibilidade de células procarióticas, para aumentar suscetibilidade antibiótica procariótica, para tratar infecção bacteriana em um paciente, e para exterminar bactérias, inibir o desenvolvimento bacteriano ou reduzir a virulência bacteriana, polinucleotídeo isca, célula, usos de um polinucleotídeo isca, e de isca de fator de transição, composição farmacêutica, composição de limpeza, kit, e, isca de fator de transição. - Google Patents

métodos para reduzir a disponibilidade de células procarióticas, para aumentar suscetibilidade antibiótica procariótica, para tratar infecção bacteriana em um paciente, e para exterminar bactérias, inibir o desenvolvimento bacteriano ou reduzir a virulência bacteriana, polinucleotídeo isca, célula, usos de um polinucleotídeo isca, e de isca de fator de transição, composição farmacêutica, composição de limpeza, kit, e, isca de fator de transição.

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Publication number
BRPI0919581A2
BRPI0919581A2 BRPI0919581A BRPI0919581A BRPI0919581A2 BR PI0919581 A2 BRPI0919581 A2 BR PI0919581A2 BR PI0919581 A BRPI0919581 A BR PI0919581A BR PI0919581 A BRPI0919581 A BR PI0919581A BR PI0919581 A2 BRPI0919581 A2 BR PI0919581A2
Authority
BR
Brazil
Prior art keywords
bait
polynucleotide
reducing
transition factor
bacterial
Prior art date
Application number
BRPI0919581A
Other languages
English (en)
Inventor
Jane Marion Moore
Michael Mcarthur
Original Assignee
Procarta Biosystems Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2008/003353 external-priority patent/WO2009044154A2/en
Application filed by Procarta Biosystems Ltd filed Critical Procarta Biosystems Ltd
Publication of BRPI0919581A2 publication Critical patent/BRPI0919581A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BRPI0919581A 2008-10-03 2009-10-02 métodos para reduzir a disponibilidade de células procarióticas, para aumentar suscetibilidade antibiótica procariótica, para tratar infecção bacteriana em um paciente, e para exterminar bactérias, inibir o desenvolvimento bacteriano ou reduzir a virulência bacteriana, polinucleotídeo isca, célula, usos de um polinucleotídeo isca, e de isca de fator de transição, composição farmacêutica, composição de limpeza, kit, e, isca de fator de transição. BRPI0919581A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10241408P 2008-10-03 2008-10-03
PCT/GB2008/003353 WO2009044154A2 (en) 2007-10-03 2008-10-03 Transcription factor decoys, compositions and methods
US16759209P 2009-04-08 2009-04-08
GBGB0906130.0A GB0906130D0 (en) 2008-10-03 2009-04-08 Transcription factor decoys
PCT/GB2009/051301 WO2010038083A2 (en) 2008-10-03 2009-10-02 Transcription factor decoys

Publications (1)

Publication Number Publication Date
BRPI0919581A2 true BRPI0919581A2 (pt) 2015-12-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919581A BRPI0919581A2 (pt) 2008-10-03 2009-10-02 métodos para reduzir a disponibilidade de células procarióticas, para aumentar suscetibilidade antibiótica procariótica, para tratar infecção bacteriana em um paciente, e para exterminar bactérias, inibir o desenvolvimento bacteriano ou reduzir a virulência bacteriana, polinucleotídeo isca, célula, usos de um polinucleotídeo isca, e de isca de fator de transição, composição farmacêutica, composição de limpeza, kit, e, isca de fator de transição.

Country Status (17)

Country Link
US (2) US20110251264A1 (pt)
EP (1) EP2334819B1 (pt)
JP (3) JP2012504411A (pt)
KR (1) KR20110084213A (pt)
CN (1) CN102292453A (pt)
AU (2) AU2009299552A1 (pt)
BR (1) BRPI0919581A2 (pt)
CA (1) CA2738743A1 (pt)
ES (1) ES2444640T3 (pt)
GB (1) GB0906130D0 (pt)
IL (1) IL211846A (pt)
MX (1) MX2011003582A (pt)
NZ (1) NZ591594A (pt)
RU (1) RU2011117228A (pt)
SG (1) SG191684A1 (pt)
WO (1) WO2010038083A2 (pt)
ZA (1) ZA201102118B (pt)

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* Cited by examiner, † Cited by third party
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GB0719367D0 (en) 2007-10-03 2007-11-14 Procarta Biosystems Ltd Transcription factor decoys, compositions and methods
GB201002413D0 (en) 2010-02-12 2010-03-31 Procarta Biosystems Ltd Nucleic acid complexes
GB201005545D0 (en) * 2010-04-01 2010-05-19 Procarta Biosystems Ltd Transcription factor decoys
WO2014140581A1 (en) * 2013-03-13 2014-09-18 Procarta Biosystems Ltd Transcription factor decoys
US20170067097A1 (en) * 2014-04-11 2017-03-09 Redvault Biosciences, Lp Systems and methods for clonal replication and amplification of nucleic acid molecules for genomic and therapeutic applications
JP6705807B2 (ja) * 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
CN106188302A (zh) * 2015-05-08 2016-12-07 复旦大学 YycG-PAS单克隆抗体及其用途
US11339396B2 (en) 2016-06-08 2022-05-24 President And Fellows Of Harvard College Engineered viral vector reduces induction of inflammatory and immune responses
AU2018364542A1 (en) 2017-11-08 2020-04-16 President And Fellows Of Harvard College Compositions and methods for inhibiting viral vector-induced inflammatory responses
CN114616338A (zh) 2019-08-22 2022-06-10 新加坡国立大学 生成哑铃形dna载体的方法
CN110484484A (zh) * 2019-08-29 2019-11-22 西北农林科技大学 一株布鲁氏菌S2疫苗株ArsR基因缺失菌株、其构建方法及应用
CN111197019B (zh) * 2020-01-10 2022-04-15 安徽大学 一种通过糖多孢红霉菌sace_1906基因途径提高红霉素产量的方法
CN111944874B (zh) * 2020-07-20 2023-06-30 广东省微生物研究所（广东省微生物分析检测中心） 一种筛选鉴定胁迫应答基因表达调控因子的方法
CN113073073A (zh) * 2021-04-08 2021-07-06 四川大学华西医院 粪肠球菌突变菌、粪肠球菌感染的治疗药物以及应用
JP2026504522A (ja) * 2023-02-08 2026-02-05 キューペックス バイオファーマ， インコーポレイテッド シデロフォアベータ－ラクタムの感受性を決定するための方法
CN119746072A (zh) * 2024-12-18 2025-04-04 浙江大学 莫拉氏菌科中的全局性胁迫响应元件DdaA的应用

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Also Published As

Publication number Publication date
KR20110084213A (ko) 2011-07-21
IL211846A (en) 2015-07-30
US20110251264A1 (en) 2011-10-13
WO2010038083A2 (en) 2010-04-08
EP2334819B1 (en) 2013-10-30
RU2011117228A (ru) 2012-11-10
MX2011003582A (es) 2011-08-12
CN102292453A (zh) 2011-12-21
SG191684A1 (en) 2013-07-31
IL211846A0 (en) 2011-06-30
WO2010038083A3 (en) 2010-06-10
CA2738743A1 (en) 2010-04-08
ES2444640T3 (es) 2014-02-26
ZA201102118B (en) 2013-08-28
JP2012504411A (ja) 2012-02-23
AU2009299552A1 (en) 2010-04-08
US20180265915A1 (en) 2018-09-20
EP2334819A2 (en) 2011-06-22
JP2015231368A (ja) 2015-12-24
AU2016202080A1 (en) 2016-04-28
GB0906130D0 (en) 2009-05-20
JP2018023367A (ja) 2018-02-15
NZ591594A (en) 2013-07-26

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