BRPI0919625A2 - piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína - Google Patents

piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína

Info

Publication number: BRPI0919625A2
Authority: BR; Brazil
Prior art keywords: pyriridine; related analogues; sirtuin modulators; bicyclic pyridine; bicyclic
Prior art date: 2008-10-29

Application number

BRPI0919625A

Other languages

English (en)

Inventor

Chi B Vu

Jeremy S Disch

Radha Narayan

Robert B Perni

Original Assignee

Sirtris Pharmaceutical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-29

Filing date

2009-10-29

Publication date

2015-12-01

2009-10-29 Application filed by Sirtris Pharmaceutical Inc filed Critical Sirtris Pharmaceutical Inc

2015-12-01 Publication of BRPI0919625A2 publication Critical patent/BRPI0919625A2/pt

Links

JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
102000011990 Sirtuin Human genes 0.000 title 1
108050002485 Sirtuin Proteins 0.000 title 1
125000002619 bicyclic group Chemical group 0.000 title 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0919625A 2008-10-29 2009-10-29 piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína BRPI0919625A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19759508P	2008-10-29	2008-10-29
PCT/US2009/062649 WO2010056549A1 (en)	2008-10-29	2009-10-29	Pyridine, bicyclic pyridine and related analogs as sirtuin modulators

Publications (1)

Publication Number	Publication Date
BRPI0919625A2 true BRPI0919625A2 (pt)	2015-12-01

Family

ID=42170258

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0919625A BRPI0919625A2 (pt)	2008-10-29	2009-10-29	piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína

Country Status (11)

Country	Link
US (1)	US20110263564A1 (pt)
EP (1)	EP2350051A4 (pt)
JP (1)	JP2012507556A (pt)
KR (1)	KR20110079763A (pt)
CN (1)	CN102272119A (pt)
AU (1)	AU2009314310A1 (pt)
BR (1)	BRPI0919625A2 (pt)
CA (1)	CA2742297A1 (pt)
MX (1)	MX2011004553A (pt)
RU (1)	RU2011121655A (pt)
WO (1)	WO2010056549A1 (pt)

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AU2009243006B2 (en)	2008-05-01	2013-03-21	Sirtris Pharmaceuticals, Inc.	Quinolines and related analogs as sirtuin modulators
BRPI0914006A2 (pt) *	2008-07-03	2015-10-27	Sirtris Pharmaceuticals Inc	benzimidazóis e análogos relacionados como moduladores de sirtuína
CA2738794C (en)	2008-09-29	2016-01-05	Sirtris Pharmaceuticals, Inc.	Chromenone analogs as sirtuin modulators
WO2011059839A1 (en)	2009-10-29	2011-05-19	Sirtris Pharmaceuticals, Inc.	Bicyclic pyridines and analogs as sirtuin modulators
CA2802952A1 (en) *	2010-06-24	2011-12-29	Arisaph Pharmaceuticals, Inc.	Niacin mimetics, and methods of use thereof
AU2015203711B2 (en) *	2010-06-24	2016-07-21	Arisaph Pharmaceuticals, Inc.	Niacin mimetics, and methods of use thereof
AU2011270719B2 (en) *	2010-06-24	2015-09-24	Arisaph Pharmaceuticals, Inc.	Niacin mimetics, and methods of use thereof
BR112012033490A2 (pt) *	2010-07-02	2015-09-15	Syngenta Participations Ag	derivados de éter dioxima microbicida
WO2012145617A2 (en) *	2011-04-22	2012-10-26	Jasco Pharmaceuticals, LLC	Aminopyrimidine kinase inhibitors
DE102011083271A1 (de)	2011-09-23	2013-03-28	Beiersdorf Ag	Aromatische Amidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Aromatischen Amidothiazolen
BR112014010563B1 (pt)	2011-11-04	2021-01-12	Jasco Pharmaceuticals, LLC	compostos inibidores da aminopirimidina quinase
WO2013090369A1 (en) *	2011-12-12	2013-06-20	Smb Innovation	Novel heterocyclic compounds useful in sirtuin binding and modulation
WO2013169563A1 (en) *	2012-05-09	2013-11-14	Merck Sharp & Dohme Corp.	Pyridine cgrp receptor antagonists
ES2654143T3 (es) *	2012-10-02	2018-02-12	Gilead Sciences, Inc.	Inhibidores de desmetilasas de histonas
SG10201707027SA (en)	2013-02-27	2017-09-28	Epitherapeutics Aps	Inhibitors of histone demethylases
JP6376707B2 (ja)	2013-05-13	2018-08-22	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅＬＬＣ	サーチュイン調節剤としての置換架橋尿素類似体
US10172915B2 (en)	2013-10-20	2019-01-08	Duke University	Methods and compositions for activation of sirtuins with Annexin A1 peptides
JP2017512804A (ja) *	2014-03-31	2017-05-25	ギリアードサイエンシーズ，インコーポレイテッド	ヒストン脱メチル化酵素の阻害剤
JP2017526675A (ja)	2014-08-27	2017-09-14	ギリアードサイエンシーズ，インコーポレイテッド	ヒストンデメチラーゼを阻害するための化合物および方法
EA202190558A1 (ru) *	2018-09-17	2022-02-03	Янгчжин Фарм. Ко., Лтд.	Новые производные тиазола и их фармацевтически приемлемые соли
PH12022551081A1 (en)	2019-11-06	2024-06-19	Remedy Plan Inc	Cancer treatments targeting cancer stem cells
CA3213068A1 (en)	2021-03-25	2022-09-29	Ramot At Tel-Aviv University Ltd.	Compositions and articles comprising an adnf polypeptide
CA3268270A1 (en)	2022-09-26	2024-04-04	Edgewise Therapeutics, Inc.	1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND ASSOCIATED USES
KR20250174911A (ko)	2023-03-27	2025-12-15	엣지와이즈 테라퓨틱스, 인크.	퀴놀리논 아미드 화합물 및 이의 용도
JP7858148B1 (ja)	2023-03-27	2026-05-13	エッジワイズセラピューティクス，インコーポレイテッド	キナゾリンジオン化合物およびその使用
AR132248A1 (es) *	2023-03-29	2025-06-11	Merck Sharp & Dohme Llc	Inhibidores de il4i1 y métodos para su uso

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WO2006061638A2 (en) *	2004-12-10	2006-06-15	Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa	Heterocycle derivatives as histone deacetylase (hdac) inhibitors
US7414006B2 (en) *	2005-03-09	2008-08-19	Exxonmobil Chemical Patents Inc.	Methods for oligomerizing olefins
US7345178B2 (en) *	2005-08-04	2008-03-18	Sirtris Pharmaceuticals, Inc.	Sirtuin modulating compounds

2009
- 2009-10-29 EP EP09826554A patent/EP2350051A4/en not_active Withdrawn
- 2009-10-29 AU AU2009314310A patent/AU2009314310A1/en not_active Abandoned
- 2009-10-29 US US13/125,788 patent/US20110263564A1/en not_active Abandoned
- 2009-10-29 CN CN2009801532987A patent/CN102272119A/zh active Pending
- 2009-10-29 JP JP2011534786A patent/JP2012507556A/ja not_active Withdrawn
- 2009-10-29 WO PCT/US2009/062649 patent/WO2010056549A1/en not_active Ceased
- 2009-10-29 BR BRPI0919625A patent/BRPI0919625A2/pt not_active Application Discontinuation
- 2009-10-29 RU RU2011121655/04A patent/RU2011121655A/ru unknown
- 2009-10-29 MX MX2011004553A patent/MX2011004553A/es not_active Application Discontinuation
- 2009-10-29 KR KR1020117012084A patent/KR20110079763A/ko not_active Withdrawn
- 2009-10-29 CA CA2742297A patent/CA2742297A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2012507556A (ja)	2012-03-29
CN102272119A (zh)	2011-12-07
CA2742297A1 (en)	2010-05-20
KR20110079763A (ko)	2011-07-07
WO2010056549A1 (en)	2010-05-20
EP2350051A1 (en)	2011-08-03
US20110263564A1 (en)	2011-10-27
RU2011121655A (ru)	2012-12-10
MX2011004553A (es)	2011-07-20
EP2350051A4 (en)	2012-05-30
AU2009314310A1 (en)	2010-05-20

Legal Events

Date	Code	Title	Description
2016-04-19	B11A	Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
2016-08-02	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]

Publication	Publication Date	Title
BRPI0913117A2 (pt)	2016-01-05	imidazopiridina e análogos relacionados como moduladores de sirtuína
EP2350051A4 (en)	2012-05-30	PYRIDINE, BICYCLIC PYRIDINE AND ITS ANALOGS AS SIRTUINE MODULATORS
BRPI0914006A2 (pt)	2015-10-27	benzimidazóis e análogos relacionados como moduladores de sirtuína
BRPI0919389A2 (pt)	2016-01-19	análogos de cromenona como moduladores de sirtuína
BRPI1011477A2 (pt)	2016-03-22	quinolinas 8-substituidas e analogos relacionados como moduladores de sirtuina
BRPI0922597A8 (pt)	2018-09-25	ftalazinona e análogos relacionados como moduladores de sirtuína
BRPI0915918A2 (pt)	2018-07-10	análogos de piridona e piridazona como moduladores de gpr119
BRPI0911118A2 (pt)	2015-10-06	composto e compisições como moduladores de atividade de gpr119
BRPI0922180A2 (pt)	2015-12-29	insoindolinona e análogos correlatos como moduladores de sirtuína
BRPI0915867A2 (pt)	2017-06-20	4-fenoximetilpiperidinas como moduladores de atividade de gpr119
CU24152B1 (es)	2016-02-29	1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
BRPI1008939A2 (pt)	2016-03-15	2-mercaptoquinolina-3-carboxamidas substituídas como moduladores de kncq2/3.
BR112014009531A8 (pt)	2018-01-16	aza-heterociclos bicíclicos substituídos e análogos como moduladores de sirtuína
BR112014009348A2 (pt)	2017-04-18	aza-heterociclos substituídos bicíclicos e análogos como moduladores de sirtuina
BRPI0917634A2 (pt)	2015-11-17	benzoxazolas, benztiazolas e análogos relacionados como moduladores de sirtuína
BRPI0905850A2 (pt)	2015-06-30	Unidade de aeronave
FIC20170031I1 (fi)	2017-07-03	alirokumabi
BRPI0809930A2 (pt)	2014-10-07	Derivados de carboxamida imidazolidina como moduladores de p2x7
BR112013015260A2 (pt)	2016-09-13	derivados de enxofre como moduladores de receptor de quimiocina
BRPI0911269A2 (pt)	2015-09-29	análogos de halicondrina b
BRPI0907844A2 (pt)	2018-01-30	moduladores seletivos do receptor de andrógeno
BRPI1008948A2 (pt)	2016-03-15	nicotinamida substituída como moduladores kcnq2/3.
BRPI0919898A2 (pt)	2016-02-16	4,5,6,7-tetra-hidrotienopiridinas substituídas como moduladores de kcnq2/3
BRPI0822058A2 (pt)	2015-06-23	Derivados de 5-oxo-3-pirrolidinacarboxamida como moduladores de p2x7
DK2297100T3 (da)	2012-12-17	Tetrahydrocyclopenta[b]indol-androgenreceptor-modulatorer