BRPI0919625A2 - piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína - Google Patents

piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína

Info

Publication number: BRPI0919625A2
Authority: BR; Brazil
Prior art keywords: pyriridine; related analogues; sirtuin modulators; bicyclic pyridine; bicyclic
Prior art date: 2008-10-29

Application number

BRPI0919625A

Other languages

English (en)

Inventor

Chi B Vu

Jeremy S Disch

Radha Narayan

Robert B Perni

Original Assignee

Sirtris Pharmaceutical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-29

Filing date

2009-10-29

Publication date

2015-12-01

2009-10-29 Application filed by Sirtris Pharmaceutical Inc filed Critical Sirtris Pharmaceutical Inc

2015-12-01 Publication of BRPI0919625A2 publication Critical patent/BRPI0919625A2/pt

Links

JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
102000011990 Sirtuin Human genes 0.000 title 1
108050002485 Sirtuin Proteins 0.000 title 1
125000002619 bicyclic group Chemical group 0.000 title 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

BRPI0919625A 2008-10-29 2009-10-29 piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína BRPI0919625A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19759508P	2008-10-29	2008-10-29
PCT/US2009/062649 WO2010056549A1 (en)	2008-10-29	2009-10-29	Pyridine, bicyclic pyridine and related analogs as sirtuin modulators

Publications (1)

Publication Number	Publication Date
BRPI0919625A2 true BRPI0919625A2 (pt)	2015-12-01

Family

ID=42170258

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0919625A BRPI0919625A2 (pt)	2008-10-29	2009-10-29	piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína

Country Status (11)

Country	Link
US (1)	US20110263564A1 (pt)
EP (1)	EP2350051A4 (pt)
JP (1)	JP2012507556A (pt)
KR (1)	KR20110079763A (pt)
CN (1)	CN102272119A (pt)
AU (1)	AU2009314310A1 (pt)
BR (1)	BRPI0919625A2 (pt)
CA (1)	CA2742297A1 (pt)
MX (1)	MX2011004553A (pt)
RU (1)	RU2011121655A (pt)
WO (1)	WO2010056549A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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ES2586459T3 (es)	2008-05-01	2016-10-14	Glaxosmithkline Llc	Quinolinas y análogos relacionados como moduladores de sirtuina
CA2729128C (en) *	2008-07-03	2016-05-31	Sirtris Pharmaceuticals, Inc.	Benzimidazoles and related analogs as sirtuin modulators
MX2011003373A (es)	2008-09-29	2011-06-09	Sirtris Pharmaceuticals Inc	Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina.
MX2012004995A (es)	2009-10-29	2012-10-03	Sirtris Pharmaceuticals Inc	Piridinas biciclicas y analogos como moduladores de sirtuina.
AU2015203711B2 (en) *	2010-06-24	2016-07-21	Arisaph Pharmaceuticals, Inc.	Niacin mimetics, and methods of use thereof
US8450316B2 (en) *	2010-06-24	2013-05-28	Trustees Of Tufts College	Niacin mimetics, and methods of use thereof
WO2011163612A1 (en) *	2010-06-24	2011-12-29	Trustees Of Tufts College	Niacin mimetics, and methods of use thereof
WO2012001040A1 (en) *	2010-07-02	2012-01-05	Syngenta Participations Ag	Novel microbiocidal dioxime ether derivatives
EP2699569B1 (en) *	2011-04-22	2017-08-30	Jasco Pharmaceuticals, LLC	Aminopyrimidine kinase inhibitors
DE102011083271A1 (de)	2011-09-23	2013-03-28	Beiersdorf Ag	Aromatische Amidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Aromatischen Amidothiazolen
KR101990605B1 (ko)	2011-11-04	2019-06-18	자스코 파머수티컬스, 엘엘씨	아미노피리미딘 키나아제 억제제
EP2790701A1 (en) *	2011-12-12	2014-10-22	SMB Innovation	Novel heterocyclic compounds useful in sirtuin binding and modulation
EP2846801B1 (en) *	2012-05-09	2017-04-05	Merck Sharp & Dohme Corp.	Pyridine cgrp receptor antagonists
DK2903968T3 (en) *	2012-10-02	2017-01-30	Gilead Sciences Inc	INHIBITORS OF HISTON DEMETHYLASES
PE20151667A1 (es)	2013-02-27	2015-11-27	Epitherapeutics Aps	Inhibidores de histona desmetilasas
CN105392788B (zh)	2013-05-13	2018-10-23	葛兰素史密斯克莱有限责任公司	用作沉默调节蛋白调节剂的取代的桥连脲类似物
US10172915B2 (en)	2013-10-20	2019-01-08	Duke University	Methods and compositions for activation of sirtuins with Annexin A1 peptides
CA2943824A1 (en) *	2014-03-31	2015-10-08	Gilead Sciences, Inc.	Inhibitors of histone demethylases
SG11201701182VA (en)	2014-08-27	2017-03-30	Gilead Sciences Inc	Compounds and methods for inhibiting histone demethylases
JP7235859B2 (ja) *	2018-09-17	2023-03-08	ユンジンファーム．カンパニー、リミテッド	新規なチアゾール誘導体及びその薬学的に許容される塩
EP4055008A1 (en)	2019-11-06	2022-09-14	Remedy Plan, Inc.	Cancer treatments targeting cancer stem cells
JP2025534288A (ja)	2022-09-26	2025-10-15	エッジワイズセラピューティクス，インコーポレイテッド	１，４－ジヒドロキナゾリノン化合物およびその使用
EP4688756A1 (en)	2023-03-27	2026-02-11	Edgewise Therapeutics, Inc.	Quinazoline dione compounds and uses thereof
WO2024206339A1 (en)	2023-03-27	2024-10-03	Edgewise Therapeutics, Inc.	Quinolinone amide compounds and uses thereof
AR132248A1 (es) *	2023-03-29	2025-06-11	Merck Sharp & Dohme Llc	Inhibidores de il4i1 y métodos para su uso

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Publication number	Priority date	Publication date	Assignee	Title
EP1828171B1 (en) *	2004-12-10	2014-03-12	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A.	Heterocycle derivatives as histone deacetylase (hdac) inhibitors
US7414006B2 (en) *	2005-03-09	2008-08-19	Exxonmobil Chemical Patents Inc.	Methods for oligomerizing olefins
DK1910384T3 (da) *	2005-08-04	2012-12-17	Sirtris Pharmaceuticals Inc	Imidazo [2,1-b] thiazol-derivater som sirtuinmodulerende forbindelser

2009
- 2009-10-29 RU RU2011121655/04A patent/RU2011121655A/ru unknown
- 2009-10-29 KR KR1020117012084A patent/KR20110079763A/ko not_active Withdrawn
- 2009-10-29 BR BRPI0919625A patent/BRPI0919625A2/pt not_active Application Discontinuation
- 2009-10-29 AU AU2009314310A patent/AU2009314310A1/en not_active Abandoned
- 2009-10-29 JP JP2011534786A patent/JP2012507556A/ja not_active Withdrawn
- 2009-10-29 EP EP09826554A patent/EP2350051A4/en not_active Withdrawn
- 2009-10-29 CA CA2742297A patent/CA2742297A1/en not_active Abandoned
- 2009-10-29 CN CN2009801532987A patent/CN102272119A/zh active Pending
- 2009-10-29 US US13/125,788 patent/US20110263564A1/en not_active Abandoned
- 2009-10-29 WO PCT/US2009/062649 patent/WO2010056549A1/en not_active Ceased
- 2009-10-29 MX MX2011004553A patent/MX2011004553A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2010056549A1 (en)	2010-05-20
KR20110079763A (ko)	2011-07-07
CN102272119A (zh)	2011-12-07
AU2009314310A1 (en)	2010-05-20
CA2742297A1 (en)	2010-05-20
EP2350051A1 (en)	2011-08-03
RU2011121655A (ru)	2012-12-10
EP2350051A4 (en)	2012-05-30
MX2011004553A (es)	2011-07-20
US20110263564A1 (en)	2011-10-27
JP2012507556A (ja)	2012-03-29

Legal Events

Date	Code	Title	Description
2016-04-19	B11A	Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
2016-08-02	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]

Publication	Publication Date	Title
BRPI0919625A2 (pt)	2015-12-01	piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína
BRPI0913117A2 (pt)	2016-01-05	imidazopiridina e análogos relacionados como moduladores de sirtuína
BRPI0914006A2 (pt)	2015-10-27	benzimidazóis e análogos relacionados como moduladores de sirtuína
BRPI0919389A2 (pt)	2016-01-19	análogos de cromenona como moduladores de sirtuína
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