BRPI0919625A2 - piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína - Google Patents

piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína

Info

Publication number: BRPI0919625A2
Authority: BR; Brazil
Prior art keywords: pyriridine; related analogues; sirtuin modulators; bicyclic pyridine; bicyclic
Prior art date: 2008-10-29

Application number

BRPI0919625A

Other languages

English (en)

Inventor

Chi B Vu

Jeremy S Disch

Radha Narayan

Robert B Perni

Original Assignee

Sirtris Pharmaceutical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-29

Filing date

2009-10-29

Publication date

2015-12-01

2009-10-29 Application filed by Sirtris Pharmaceutical Inc filed Critical Sirtris Pharmaceutical Inc

2015-12-01 Publication of BRPI0919625A2 publication Critical patent/BRPI0919625A2/pt

Links

JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
102000011990 Sirtuin Human genes 0.000 title 1
108050002485 Sirtuin Proteins 0.000 title 1
125000002619 bicyclic group Chemical group 0.000 title 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0919625A 2008-10-29 2009-10-29 piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína BRPI0919625A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19759508P	2008-10-29	2008-10-29
PCT/US2009/062649 WO2010056549A1 (en)	2008-10-29	2009-10-29	Pyridine, bicyclic pyridine and related analogs as sirtuin modulators

Publications (1)

Publication Number	Publication Date
BRPI0919625A2 true BRPI0919625A2 (pt)	2015-12-01

Family

ID=42170258

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0919625A BRPI0919625A2 (pt)	2008-10-29	2009-10-29	piriridina, piridina bicíclica e análogos relacionados como moduladores de sirtuína

Country Status (11)

Country	Link
US (1)	US20110263564A1 (pt)
EP (1)	EP2350051A4 (pt)
JP (1)	JP2012507556A (pt)
KR (1)	KR20110079763A (pt)
CN (1)	CN102272119A (pt)
AU (1)	AU2009314310A1 (pt)
BR (1)	BRPI0919625A2 (pt)
CA (1)	CA2742297A1 (pt)
MX (1)	MX2011004553A (pt)
RU (1)	RU2011121655A (pt)
WO (1)	WO2010056549A1 (pt)

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EA021938B1 (ru)	2008-05-01	2015-10-30	Сертрис Фармасьютикалз, Инк.	Хинолины и их аналоги в качестве модуляторов сиртуина
KR20110036602A (ko) *	2008-07-03	2011-04-07	서트리스 파마슈티컬즈, 인코포레이티드	시르투인 조절제로서의 벤즈이미다졸 및 관련 유사체
AU2009295948B2 (en)	2008-09-29	2013-12-05	GlaxoSmithKline, LLC	Quinazolinone, quinolone and related analogs as sirtuin modulators
US9556201B2 (en)	2009-10-29	2017-01-31	Glaxosmithkline Llc	Bicyclic pyridines and analogs as sirtuin modulators
WO2011163612A1 (en) *	2010-06-24	2011-12-29	Trustees Of Tufts College	Niacin mimetics, and methods of use thereof
US8450316B2 (en) *	2010-06-24	2013-05-28	Trustees Of Tufts College	Niacin mimetics, and methods of use thereof
AU2015203711B2 (en) *	2010-06-24	2016-07-21	Arisaph Pharmaceuticals, Inc.	Niacin mimetics, and methods of use thereof
WO2012001040A1 (en) *	2010-07-02	2012-01-05	Syngenta Participations Ag	Novel microbiocidal dioxime ether derivatives
WO2012145617A2 (en) *	2011-04-22	2012-10-26	Jasco Pharmaceuticals, LLC	Aminopyrimidine kinase inhibitors
DE102011083271A1 (de)	2011-09-23	2013-03-28	Beiersdorf Ag	Aromatische Amidothiazole, deren kosmetische oder dermatologische Verwendung sowie kosmetische oder dermatologische Zubereitungen mit einem Gehalt an solchen Aromatischen Amidothiazolen
EP2776432B1 (en)	2011-11-04	2017-03-29	Jasco Pharmaceuticals LLC	Aminopyrimidine kinase inhibitors
EP2790701A1 (en) *	2011-12-12	2014-10-22	SMB Innovation	Novel heterocyclic compounds useful in sirtuin binding and modulation
US9227973B2 (en)	2012-05-09	2016-01-05	Merck Sharp & Dohme Corp.	Pyridine CGRP receptor antagonists
BR112015007083A2 (pt) *	2012-10-02	2017-07-04	Epitherapeutics Aps	inibidores de histona demetilases
PE20151667A1 (es)	2013-02-27	2015-11-27	Epitherapeutics Aps	Inhibidores de histona desmetilasas
ES2718550T3 (es)	2013-05-13	2019-07-02	Glaxosmithkline Llc	Análogos de urea con puente sustituidos como moduladores de sirtuinas
US10172915B2 (en)	2013-10-20	2019-01-08	Duke University	Methods and compositions for activation of sirtuins with Annexin A1 peptides
EP3126345A1 (en) *	2014-03-31	2017-02-08	Gilead Sciences, Inc.	Inhibitors of histone demethylases
EA201790154A1 (ru)	2014-08-27	2017-08-31	Джилид Сайэнс, Инк.	Соединения и способы для ингибирования гистоновых деметилаз
EP3853225B1 (en) *	2018-09-17	2023-11-29	Yungjin Pharm. Co., Ltd.	N-(5-(3-(1-((thiazol-2-yl)amino)-1-oxopropan-2-yl)phenyl)pyridin-2-yl)acrylamide derivatives as cdk7 inhibitors for the treatment of cancer
KR20220110744A (ko)	2019-11-06	2022-08-09	레미디 플랜, 인크.	암 줄기 세포를 표적화하는 암 치료
IL319671A (en)	2022-09-26	2025-05-01	Edgewise Therapeutics Inc	4,1-Dihydroquinazolinone compounds and their uses
JP7858148B1 (ja)	2023-03-27	2026-05-13	エッジワイズセラピューティクス，インコーポレイテッド	キナゾリンジオン化合物およびその使用
EP4688748A1 (en)	2023-03-27	2026-02-11	Edgewise Therapeutics, Inc.	Quinolinone amide compounds and uses thereof
AR132248A1 (es) *	2023-03-29	2025-06-11	Merck Sharp & Dohme Llc	Inhibidores de il4i1 y métodos para su uso

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AU2005313108B2 (en) *	2004-12-10	2011-05-26	Msd Italia S.R.L.	Heterocycle derivatives as histone deacetylase (HDAC) inhibitors
US7414006B2 (en) *	2005-03-09	2008-08-19	Exxonmobil Chemical Patents Inc.	Methods for oligomerizing olefins
EP1909910A1 (en) *	2005-08-04	2008-04-16	Sirtris Pharmaceuticals, Inc.	Benzimidazole derivatives as sirtuin modulators

2009
- 2009-10-29 AU AU2009314310A patent/AU2009314310A1/en not_active Abandoned
- 2009-10-29 KR KR1020117012084A patent/KR20110079763A/ko not_active Withdrawn
- 2009-10-29 WO PCT/US2009/062649 patent/WO2010056549A1/en not_active Ceased
- 2009-10-29 MX MX2011004553A patent/MX2011004553A/es not_active Application Discontinuation
- 2009-10-29 US US13/125,788 patent/US20110263564A1/en not_active Abandoned
- 2009-10-29 CN CN2009801532987A patent/CN102272119A/zh active Pending
- 2009-10-29 JP JP2011534786A patent/JP2012507556A/ja not_active Withdrawn
- 2009-10-29 EP EP09826554A patent/EP2350051A4/en not_active Withdrawn
- 2009-10-29 BR BRPI0919625A patent/BRPI0919625A2/pt not_active Application Discontinuation
- 2009-10-29 RU RU2011121655/04A patent/RU2011121655A/ru unknown
- 2009-10-29 CA CA2742297A patent/CA2742297A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP2350051A1 (en)	2011-08-03
AU2009314310A1 (en)	2010-05-20
KR20110079763A (ko)	2011-07-07
EP2350051A4 (en)	2012-05-30
WO2010056549A1 (en)	2010-05-20
CN102272119A (zh)	2011-12-07
MX2011004553A (es)	2011-07-20
CA2742297A1 (en)	2010-05-20
RU2011121655A (ru)	2012-12-10
US20110263564A1 (en)	2011-10-27
JP2012507556A (ja)	2012-03-29

Legal Events

Date	Code	Title	Description
2016-04-19	B11A	Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
2016-08-02	B11Y	Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]

Publication	Publication Date	Title
BRPI0913117A2 (pt)	2016-01-05	imidazopiridina e análogos relacionados como moduladores de sirtuína
BRPI0914006A2 (pt)	2015-10-27	benzimidazóis e análogos relacionados como moduladores de sirtuína
EP2350051A4 (en)	2012-05-30	PYRIDINE, BICYCLIC PYRIDINE AND ITS ANALOGS AS SIRTUINE MODULATORS
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