BRPI0919932A2 - pirrolina-carbóxi-lisina gerada biossinteticamente e modificações sítio-específicas de proteína através da derivação química de pirrolina-carbóxi-lisina e resíduos de pirrolisina - Google Patents
pirrolina-carbóxi-lisina gerada biossinteticamente e modificações sítio-específicas de proteína através da derivação química de pirrolina-carbóxi-lisina e resíduos de pirrolisinaInfo
- Publication number
- BRPI0919932A2 BRPI0919932A2 BRPI0919932A BRPI0919932A BRPI0919932A2 BR PI0919932 A2 BRPI0919932 A2 BR PI0919932A2 BR PI0919932 A BRPI0919932 A BR PI0919932A BR PI0919932 A BRPI0919932 A BR PI0919932A BR PI0919932 A2 BRPI0919932 A2 BR PI0919932A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrroline
- lysine
- pyrrolysin
- residues
- site
- Prior art date
Links
- HFVPBQOSFYXKQZ-DTWKUNHWSA-N N6-[(2R)-3,4-Dihydro-2H-pyrrol-2-ylcarbonyl]-L-lysine Chemical compound [O-]C(=O)[C@@H]([NH3+])CCCCNC(=O)[C@H]1CCC=N1 HFVPBQOSFYXKQZ-DTWKUNHWSA-N 0.000 title 2
- ZFOMKMMPBOQKMC-KXUCPTDWSA-N L-pyrrolysine Chemical group C[C@@H]1CC=N[C@H]1C(=O)NCCCC[C@H]([NH3+])C([O-])=O ZFOMKMMPBOQKMC-KXUCPTDWSA-N 0.000 title 1
- 238000009795 derivation Methods 0.000 title 1
- 230000009145 protein modification Effects 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10843408P | 2008-10-24 | 2008-10-24 | |
| PCT/US2009/061954 WO2010048582A1 (en) | 2008-10-24 | 2009-10-23 | Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0919932A2 true BRPI0919932A2 (pt) | 2017-10-24 |
| BRPI0919932A8 BRPI0919932A8 (pt) | 2018-02-06 |
Family
ID=41479140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0919932A BRPI0919932A8 (pt) | 2008-10-24 | 2009-10-23 | Pirrolina-carbóxi-lisina gerada biossinteticamente, bem como processo para preparar método para derivatizar uma proteína |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8785151B2 (pt) |
| EP (1) | EP2356092B1 (pt) |
| JP (1) | JP5542832B2 (pt) |
| KR (2) | KR101316159B1 (pt) |
| CN (1) | CN102264697B (pt) |
| AU (1) | AU2009308163B2 (pt) |
| BR (1) | BRPI0919932A8 (pt) |
| CA (2) | CA2871855C (pt) |
| EA (1) | EA021001B1 (pt) |
| ES (1) | ES2477543T3 (pt) |
| MX (1) | MX342677B (pt) |
| WO (1) | WO2010048582A1 (pt) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9023791B2 (en) | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| EP2750681B1 (en) * | 2011-08-30 | 2020-05-27 | Quanta Biodesign, Ltd. | Branched discrete peg constructs |
| TWI593708B (zh) | 2011-09-26 | 2017-08-01 | 諾華公司 | 治療代謝病症之融合蛋白質 |
| UY34347A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| CN102504022A (zh) * | 2011-11-30 | 2012-06-20 | 苏州元基生物技术有限公司 | 含有保护赖氨酸的胰岛素原及使用其制备胰岛素的方法 |
| EP2820033A1 (en) * | 2012-02-29 | 2015-01-07 | Ambrx, Inc. | Interleukin-10 polypeptide conjugates and their uses |
| UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
| EP2953976B1 (en) | 2013-02-08 | 2021-03-24 | Novartis Ag | Specific sites for modifying antibodies to make immunoconjugates |
| WO2014124258A2 (en) | 2013-02-08 | 2014-08-14 | Irm Llc | Specific sites for modifying antibodies to make immunoconjugates |
| CN103073627B (zh) * | 2013-02-22 | 2014-03-19 | 哈尔滨工业大学 | 微波辅助反胶束分离纯化芸豆凝集素的方法 |
| AU2014229999B2 (en) | 2013-03-15 | 2019-09-12 | Medimmune Limited | Novel nucleic acid molecules |
| HK1218252A1 (zh) | 2013-07-25 | 2017-02-10 | Novartis Ag | 合成apelin多肽之生物结合物 |
| KR20160031551A (ko) | 2013-07-25 | 2016-03-22 | 노파르티스 아게 | 심부전의 치료를 위한 시클릭 폴리펩티드 |
| JP2017509337A (ja) * | 2014-03-12 | 2017-04-06 | ノバルティス アーゲー | イムノコンジュゲートを作製する抗体を修飾するための特定部位 |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| SG11201609706VA (en) | 2014-06-23 | 2017-01-27 | Novartis Ag | Site specific protein modifications |
| EP4657446A3 (en) * | 2014-11-14 | 2026-03-04 | D.E. Shaw Research, LLC | Suppressing interaction between bonded particles |
| MA41580A (fr) | 2015-01-23 | 2017-11-29 | Novartis Ag | Conjugués d'acides gras de l'apeline synthétique présentant une demi-vie améliorée |
| JP6946304B2 (ja) | 2015-12-22 | 2021-10-06 | ノバルティス アーゲー | 増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を処置するまたは軽快させる方法 |
| US11149058B2 (en) | 2016-03-18 | 2021-10-19 | Department Of Biotechnology | Multi-functional chemical agents, and the method for protein modification |
| US10583199B2 (en) * | 2016-04-26 | 2020-03-10 | Northwestern University | Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs |
| CN109715196A (zh) | 2016-06-13 | 2019-05-03 | 转矩医疗股份有限公司 | 用于促进免疫细胞功能的组合物和方法 |
| WO2019050977A1 (en) | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | REVERSIBLE LINKS AND THEIR USE |
| CA3074826A1 (en) * | 2017-09-05 | 2019-03-14 | Torque Therapeutics, Inc. | Therapeutic protein compositions and methods of making and using the same |
| CN108395474B (zh) * | 2018-01-30 | 2021-02-19 | 武汉大学 | 一种可见光诱导吡唑偶联苯丙氨酸类化合物的方法 |
| CN119264211A (zh) | 2018-08-27 | 2025-01-07 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| JP7657151B2 (ja) | 2018-11-27 | 2025-04-04 | ノバルティス アーゲー | 代謝性障害の処置のためのプロタンパク質コンバターゼスブチリシン／ケキシン９型（ｐｃｓｋ９）阻害剤としての環状ペプチド |
| US20220098252A1 (en) | 2019-01-25 | 2022-03-31 | Ospedale San Raffaele S.R.L. | Inhibitor of dux4 and uses thereof |
| CN112978709A (zh) * | 2019-12-12 | 2021-06-18 | 中国科学院大连化学物理研究所 | 一种碳量子点前驱体组合物、一种碳量子点及其制备方法 |
| WO2021156792A1 (en) | 2020-02-07 | 2021-08-12 | Novartis Ag | Targeted plasma protein degradation |
| CN112147132B (zh) * | 2020-09-23 | 2021-07-09 | 山东大学 | 一种光谱型的近红外电化学发光免疫传感器的制备方法 |
| TWI741843B (zh) | 2020-10-20 | 2021-10-01 | 新加坡商億恩診斷有限公司 | 體液蛋白質濃度檢測裝置及其運作方法 |
| AU2021433713A1 (en) | 2021-03-17 | 2023-09-28 | Suzhou Zanrong Pharma Limited | Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof |
| CN113582881B (zh) * | 2021-07-29 | 2022-10-11 | 浙江新码生物医药有限公司 | 一种非天然氨基酸及其应用、包含其的重组蛋白以及重组蛋白偶联物 |
| KR20240024235A (ko) * | 2021-07-29 | 2024-02-23 | 노보코덱스 바이오파마슈티컬즈 컴퍼니 리미티드 | 비천연 아미노산, 및 이의 용도, 이를 함유하는 재조합 단백질, 및 재조합 단백질 컨주게이트 |
| CN113698468B (zh) * | 2021-09-01 | 2022-10-11 | 浙江新码生物医药有限公司 | 人白细胞介素2-聚乙二醇偶联物及其应用 |
| CN116626180B (zh) * | 2022-02-11 | 2025-12-02 | 北京大学 | 一种卤代有机物的高灵敏高通量扫描分析方法 |
| CN115928111A (zh) * | 2022-11-23 | 2023-04-07 | 华南理工大学 | 一种电化学合成7-硫氰基-3,4-二氢喹喔啉-2(1h)-酮类化合物的方法 |
| EP4389762A1 (en) | 2022-12-23 | 2024-06-26 | Ospedale San Raffaele S.r.l. | Inhibitors of dux4 activity and their use in therapy. |
| CN116286890B (zh) * | 2022-12-28 | 2025-10-31 | 安徽大学 | 一种三组分氧化体系及其在降解4-羟基雌酮中的应用 |
| CN117417292B (zh) * | 2023-02-20 | 2024-07-12 | 浙江新码生物医药有限公司 | 一种含有杂芳基的非天然氨基酸及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7266613B1 (en) | 2000-08-09 | 2007-09-04 | Microsoft Corporation | Fast dynamic measurement of bandwidth in a TCP network environment |
| WO2002085923A2 (en) | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| EP2410331B1 (en) * | 2003-06-18 | 2015-09-23 | The Scripps Research Institute | Aminoacyl-tRNA synthetase for aminoacylation tRNA with unnatural amino acids |
| US20060183888A1 (en) * | 2004-08-13 | 2006-08-17 | Chan Michael K | Pyrrolysine synthesis and modification |
| US20060166319A1 (en) * | 2004-08-13 | 2006-07-27 | Chan Michael K | Charging tRNA with pyrrolysine |
| EP1992698B1 (en) | 2006-02-22 | 2018-09-05 | Riken | METHOD FOR SYNTHESIS OF SUPPRESSOR tRNA, DNA CONSTRUCT, AND PRODUCTION OF PROTEIN HAVING NON-NATURAL AMINO ACID INTEGRATED THEREIN BY USING THE DNA CONSTRUCT |
-
2009
- 2009-10-23 WO PCT/US2009/061954 patent/WO2010048582A1/en not_active Ceased
- 2009-10-23 JP JP2011533389A patent/JP5542832B2/ja not_active Expired - Fee Related
- 2009-10-23 MX MX2011004246A patent/MX342677B/es active IP Right Grant
- 2009-10-23 CN CN200980152207.8A patent/CN102264697B/zh not_active Expired - Fee Related
- 2009-10-23 EA EA201100659A patent/EA021001B1/ru not_active IP Right Cessation
- 2009-10-23 ES ES09744017.6T patent/ES2477543T3/es active Active
- 2009-10-23 KR KR1020117011641A patent/KR101316159B1/ko not_active Expired - Fee Related
- 2009-10-23 AU AU2009308163A patent/AU2009308163B2/en not_active Ceased
- 2009-10-23 BR BRPI0919932A patent/BRPI0919932A8/pt not_active IP Right Cessation
- 2009-10-23 EP EP09744017.6A patent/EP2356092B1/en not_active Not-in-force
- 2009-10-23 CA CA2871855A patent/CA2871855C/en not_active Expired - Fee Related
- 2009-10-23 CA CA2742043A patent/CA2742043C/en not_active Expired - Fee Related
- 2009-10-23 KR KR1020137017122A patent/KR20130086386A/ko not_active Ceased
- 2009-10-23 US US13/125,547 patent/US8785151B2/en not_active Expired - Fee Related
-
2014
- 2014-05-15 US US14/279,085 patent/US9624520B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0919932A8 (pt) | 2018-02-06 |
| US20140302553A1 (en) | 2014-10-09 |
| KR20130086386A (ko) | 2013-08-01 |
| JP5542832B2 (ja) | 2014-07-09 |
| US8785151B2 (en) | 2014-07-22 |
| AU2009308163B2 (en) | 2013-01-10 |
| CN102264697B (zh) | 2015-09-09 |
| EA201100659A1 (ru) | 2011-12-30 |
| CA2742043C (en) | 2014-11-25 |
| CA2871855C (en) | 2017-08-15 |
| EA021001B1 (ru) | 2015-03-31 |
| US9624520B2 (en) | 2017-04-18 |
| KR101316159B1 (ko) | 2013-10-15 |
| JP2012506869A (ja) | 2012-03-22 |
| AU2009308163A1 (en) | 2010-04-29 |
| US20110262963A1 (en) | 2011-10-27 |
| EP2356092A1 (en) | 2011-08-17 |
| CN102264697A (zh) | 2011-11-30 |
| KR20110089145A (ko) | 2011-08-04 |
| WO2010048582A1 (en) | 2010-04-29 |
| MX342677B (es) | 2016-10-07 |
| CA2742043A1 (en) | 2010-04-29 |
| CA2871855A1 (en) | 2010-04-29 |
| MX2011004246A (es) | 2011-07-13 |
| ES2477543T3 (es) | 2014-07-17 |
| EP2356092B1 (en) | 2014-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) |
|
| B25A | Requested transfer of rights approved |
Owner name: NOVARTIS AG (CH) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2485 DE 21-08-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |