BRPI0920171A2 - processos e composições para liberação lipossômica e eficiente de terapêuticos de silenciamento de gene. - Google Patents
processos e composições para liberação lipossômica e eficiente de terapêuticos de silenciamento de gene.Info
- Publication number
- BRPI0920171A2 BRPI0920171A2 BRPI0920171A BRPI0920171A BRPI0920171A2 BR PI0920171 A2 BRPI0920171 A2 BR PI0920171A2 BR PI0920171 A BRPI0920171 A BR PI0920171A BR PI0920171 A BRPI0920171 A BR PI0920171A BR PI0920171 A2 BRPI0920171 A2 BR PI0920171A2
- Authority
- BR
- Brazil
- Prior art keywords
- liposomal
- compositions
- processes
- gene silencing
- efficient release
- Prior art date
Links
- 230000030279 gene silencing Effects 0.000 title 1
- 238000012226 gene silencing method Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10606208P | 2008-10-16 | 2008-10-16 | |
| US16737909P | 2009-04-07 | 2009-04-07 | |
| PCT/US2009/060930 WO2010045512A2 (fr) | 2008-10-16 | 2009-10-16 | Procédés et compositions pour une administration liposomale et efficace de produits thérapeutiques de silençage de gène |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0920171A2 true BRPI0920171A2 (pt) | 2016-07-12 |
Family
ID=41560381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0920171A BRPI0920171A2 (pt) | 2008-10-16 | 2009-10-16 | processos e composições para liberação lipossômica e eficiente de terapêuticos de silenciamento de gene. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20100112042A1 (fr) |
| EP (2) | EP2349210B1 (fr) |
| JP (2) | JP2012505913A (fr) |
| KR (1) | KR20110071017A (fr) |
| CN (2) | CN102231979B (fr) |
| AU (3) | AU2009305639B2 (fr) |
| BR (1) | BRPI0920171A2 (fr) |
| CA (1) | CA2739046A1 (fr) |
| IL (1) | IL212329A0 (fr) |
| SG (1) | SG196818A1 (fr) |
| WO (1) | WO2010045512A2 (fr) |
| ZA (1) | ZA201102319B (fr) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2476756A1 (fr) | 2005-06-15 | 2012-07-18 | Massachusetts Institute of Technology | Lipides contenant des amines et utilisations associées |
| LT2494993T (lt) | 2007-05-04 | 2018-12-27 | Marina Biotech, Inc. | Aminorūgščių lipidai ir jų panaudojimas |
| MX2011004859A (es) | 2008-11-07 | 2011-08-03 | Massachusetts Inst Technology | Lipidoides de aminoalcohol y usos de los mismos. |
| WO2010059829A2 (fr) * | 2008-11-19 | 2010-05-27 | Mdrna, Inc. | Compositions et procédés pour la libération déclenchée de produits thérapeutiques à base d'arn |
| WO2011057020A1 (fr) | 2009-11-04 | 2011-05-12 | Marina Biotech, Inc. | Molécules d'administration génératrices d'activité |
| PL3338765T3 (pl) | 2009-12-01 | 2019-06-28 | Translate Bio, Inc. | Pochodna steroidowa dla dostarczania mrna w ludzkich chorobach genetycznych |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| WO2012112730A2 (fr) * | 2011-02-15 | 2012-08-23 | Merrimack Pharmaceuticals, Inc. | Compositions et procédés pour délivrer un acide nucléique à une cellule |
| US9238716B2 (en) | 2011-03-28 | 2016-01-19 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| PT2717893T (pt) | 2011-06-08 | 2019-08-20 | Translate Bio Inc | Composições de nanopartículas lipídicas e métodos para transferência de arnm |
| JP6129844B2 (ja) | 2011-09-14 | 2017-05-17 | ラナ セラピューティクス インコーポレイテッド | 多量体オリゴヌクレオチド化合物 |
| KR20150000461A (ko) | 2011-10-27 | 2015-01-02 | 메사추세츠 인스티튜트 오브 테크놀로지 | 약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체 |
| ES2721325T3 (es) * | 2011-11-04 | 2019-07-31 | Nitto Denko Corp | Método para producir de manera estéril partículas de lípido-ácido nucleico |
| KR20150030205A (ko) | 2012-05-16 | 2015-03-19 | 라나 테라퓨틱스, 인크. | Smn 유전자 패밀리 발현을 조절하기 위한 조성물 및 방법 |
| EA201492121A1 (ru) | 2012-05-16 | 2015-10-30 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии семейства генов гемоглобина |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| JP2015523853A (ja) | 2012-05-16 | 2015-08-20 | ラナ セラピューティクス インコーポレイテッド | Ａｔｐ２ａ２発現を調節するための組成物及び方法 |
| SG11201407486PA (en) | 2012-05-16 | 2014-12-30 | Rana Therapeutics Inc | Compositions and methods for modulating utrn expression |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| WO2013185067A1 (fr) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Polynucléotides résistant à la nucléase et leurs utilisations |
| EP2882706A1 (fr) | 2012-08-13 | 2015-06-17 | Massachusetts Institute of Technology | Lipidoïdes contenant des amines et leurs utilisations |
| CA2884608C (fr) | 2012-09-14 | 2025-05-20 | Translate Bio Ma, Inc. | Composés oligonucléotidiques multimères |
| EP2968586B1 (fr) | 2013-03-14 | 2018-07-25 | Translate Bio, Inc. | Composition à base d'arnm du gène cftr et procédés et utilisations associés |
| ES2981185T3 (es) | 2013-03-14 | 2024-10-07 | Translate Bio Inc | Métodos para la purificación de ARN mensajero |
| CN103172701B (zh) * | 2013-03-18 | 2015-09-30 | 中国科学院过程工程研究所 | 一种新型穿膜肽及其应用 |
| HUE040425T2 (hu) | 2013-04-30 | 2019-03-28 | Delta Fly Pharma Inc | Liposzóma topikális adagoláshoz és alkalmazása |
| WO2014179562A1 (fr) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | Dérivés de 1,3,5-triazinane-2,4,6-trione et leurs utilisations |
| US10195291B2 (en) | 2013-09-24 | 2019-02-05 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for the manufacture of lipid nanoparticles |
| MX2016005239A (es) | 2013-10-22 | 2016-08-12 | Shire Human Genetic Therapies | Tratamiento con acido ribonucleico mensajero para la fenilcetonuria. |
| US11224642B2 (en) | 2013-10-22 | 2022-01-18 | Translate Bio, Inc. | MRNA therapy for argininosuccinate synthetase deficiency |
| WO2015061467A1 (fr) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Formulations de lipide pour l'administration d'arn messager |
| DK3134131T3 (en) | 2014-04-23 | 2022-02-07 | Modernatx Inc | Nucleic acid vaccines |
| JP6571679B2 (ja) | 2014-04-25 | 2019-09-04 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａの精製方法 |
| US10022455B2 (en) | 2014-05-30 | 2018-07-17 | Translate Bio, Inc. | Biodegradable lipids for delivery of nucleic acids |
| CA2952824C (fr) | 2014-06-24 | 2023-02-21 | Shire Human Genetic Therapies, Inc. | Compositions enrichies stereochimiquement pour l'administration d'acides nucleiques |
| WO2016004202A1 (fr) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Lipidoïdes dérivés de polyamine-acide gras et leurs utilisations |
| WO2016068160A1 (fr) * | 2014-10-30 | 2016-05-06 | Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 | Nouveau procédé de fabrication de lipoplexe pour une administration par voie locale, et médicament antitumoral utilisant le lipoplexe |
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| EP4412591A1 (fr) * | 2021-10-06 | 2024-08-14 | leon-nanodrugs GmbH | Procédé de préparation de nanoparticules lipidiques |
| CN114569703B (zh) * | 2022-02-25 | 2023-06-13 | 纽柏抗衰老国际医生集团(广州)有限公司 | 一种助睡眠的脂质体包裹复合氨基酸的组合物及制备方法 |
| CN116370437A (zh) * | 2023-05-26 | 2023-07-04 | 北京因诺惟康医药科技有限公司 | 包含胆固醇琥珀酸单酯的核酸脂质纳米颗粒组合物及其用途 |
| WO2025207519A1 (fr) * | 2024-03-23 | 2025-10-02 | Texas Tech University System | Nanodisques polymères biocompatibles et biodégradables utilisés comme nanosupports imitant des lipoprotéines présentant une stabilité élevée et un temps de circulation long pour l'administration de médicaments |
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-
2009
- 2009-10-16 EP EP09744527.4A patent/EP2349210B1/fr not_active Not-in-force
- 2009-10-16 AU AU2009305639A patent/AU2009305639B2/en not_active Ceased
- 2009-10-16 US US12/580,250 patent/US20100112042A1/en not_active Abandoned
- 2009-10-16 BR BRPI0920171A patent/BRPI0920171A2/pt not_active Application Discontinuation
- 2009-10-16 EP EP15153333.8A patent/EP2902013A1/fr not_active Withdrawn
- 2009-10-16 WO PCT/US2009/060930 patent/WO2010045512A2/fr not_active Ceased
- 2009-10-16 CA CA2739046A patent/CA2739046A1/fr not_active Abandoned
- 2009-10-16 CN CN200980148321.3A patent/CN102231979B/zh not_active Expired - Fee Related
- 2009-10-16 KR KR1020117011136A patent/KR20110071017A/ko not_active Ceased
- 2009-10-16 SG SG2014002885A patent/SG196818A1/en unknown
- 2009-10-16 CN CN201410524574.9A patent/CN104382853A/zh active Pending
- 2009-10-16 JP JP2011532268A patent/JP2012505913A/ja active Pending
-
2011
- 2011-03-29 ZA ZA2011/02319A patent/ZA201102319B/en unknown
- 2011-04-14 IL IL212329A patent/IL212329A0/en unknown
-
2012
- 2012-06-20 US US13/527,723 patent/US20130039970A1/en not_active Abandoned
-
2014
- 2014-12-11 JP JP2014251287A patent/JP6126072B2/ja active Active
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2015
- 2015-04-09 US US14/682,314 patent/US20150209283A1/en not_active Abandoned
-
2016
- 2016-08-31 AU AU2016222371A patent/AU2016222371A1/en not_active Abandoned
-
2018
- 2018-06-25 AU AU2018204605A patent/AU2018204605A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016222371A1 (en) | 2016-09-15 |
| AU2009305639B2 (en) | 2016-06-23 |
| ZA201102319B (en) | 2012-09-26 |
| EP2349210B1 (fr) | 2015-03-18 |
| EP2902013A1 (fr) | 2015-08-05 |
| AU2009305639A1 (en) | 2010-04-22 |
| JP2015096529A (ja) | 2015-05-21 |
| US20130039970A1 (en) | 2013-02-14 |
| CN102231979B (zh) | 2014-10-29 |
| KR20110071017A (ko) | 2011-06-27 |
| CN104382853A (zh) | 2015-03-04 |
| IL212329A0 (en) | 2011-06-30 |
| SG196818A1 (en) | 2014-02-13 |
| WO2010045512A3 (fr) | 2011-01-27 |
| JP2012505913A (ja) | 2012-03-08 |
| CN102231979A (zh) | 2011-11-02 |
| EP2349210A2 (fr) | 2011-08-03 |
| US20150209283A1 (en) | 2015-07-30 |
| WO2010045512A2 (fr) | 2010-04-22 |
| JP6126072B2 (ja) | 2017-05-10 |
| AU2018204605A1 (en) | 2018-07-12 |
| US20100112042A1 (en) | 2010-05-06 |
| CA2739046A1 (fr) | 2010-04-22 |
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