BRPI0920650A2 - métodos para produzir um aldeído graxo, microrganismo geneticamente modificado, aldeído graxo - Google Patents

métodos para produzir um aldeído graxo, microrganismo geneticamente modificado, aldeído graxo

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Publication number
BRPI0920650A2
BRPI0920650A2 BRPI0920650A BRPI0920650A BRPI0920650A2 BR PI0920650 A2 BRPI0920650 A2 BR PI0920650A2 BR PI0920650 A BRPI0920650 A BR PI0920650A BR PI0920650 A BRPI0920650 A BR PI0920650A BR PI0920650 A2 BRPI0920650 A2 BR PI0920650A2
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Brazil
Prior art keywords
fatty aldehyde
methods
producing
genetically modified
modified microorganism
Prior art date
Application number
BRPI0920650A
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English (en)
Inventor
F Alibhai Murtaza
Hu Zhihao
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Ls9 Inc
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Publication of BRPI0920650A2 publication Critical patent/BRPI0920650A2/pt

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    • C12N15/09Recombinant DNA-technology
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    • C12N15/52Genes encoding for enzymes or proenzymes
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
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    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12P7/00Preparation of oxygen-containing organic compounds
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    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/64Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436Fatty acid esters
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P30/00Technologies relating to oil refining and petrochemical industry

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

métodos para produzir um aldeído graxo, microrganismo geneticamente modificado, aldeído graxo métodos e composições, incluindo seqüências de nucleotídeos, seqüências de aminoácidos e, células hospedeiras, para produzir aldeídos graxos são descritos.
BRPI0920650A 2008-10-07 2009-10-07 métodos para produzir um aldeído graxo, microrganismo geneticamente modificado, aldeído graxo BRPI0920650A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10344708P 2008-10-07 2008-10-07
PCT/US2009/059904 WO2010042664A2 (en) 2008-10-07 2009-10-07 Method and compositions for producing fatty aldehydes

Publications (1)

Publication Number Publication Date
BRPI0920650A2 true BRPI0920650A2 (pt) 2019-08-27

Family

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BRPI0920650A BRPI0920650A2 (pt) 2008-10-07 2009-10-07 métodos para produzir um aldeído graxo, microrganismo geneticamente modificado, aldeído graxo

Country Status (11)

Country Link
US (1) US8097439B2 (pt)
EP (2) EP2352824B1 (pt)
JP (1) JP2012504963A (pt)
KR (2) KR101717569B1 (pt)
CN (2) CN105274043B (pt)
AU (1) AU2009302325A1 (pt)
BR (1) BRPI0920650A2 (pt)
CA (2) CA3038491A1 (pt)
ES (2) ES2692918T3 (pt)
MX (1) MX2011003597A (pt)
WO (1) WO2010042664A2 (pt)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20090004715A1 (en) * 2007-06-01 2009-01-01 Solazyme, Inc. Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing
US8355671B2 (en) * 2008-01-04 2013-01-15 Kopin Corporation Method and apparatus for transporting video signal over Bluetooth wireless interface
CA3101888A1 (en) 2008-05-16 2009-11-19 REG Life Sciences, LLC Methods and compositions for producing hydrocarbons
KR101717569B1 (ko) 2008-10-07 2017-03-17 알이지 라이프 사이언시스, 엘엘씨 지방족 알데히드를 생산하기 위한 방법과 조성물들
KR101636403B1 (ko) * 2008-10-28 2016-07-05 알이지 라이프 사이언시스, 엘엘씨 지방족 알코올들을 생산하기 위한 방법들과 조성물들
AU2009319722B2 (en) 2008-11-28 2016-08-04 Corbion Biotech, Inc. Production of tailored oils in heterotrophic microorganisms
AU2009330014A1 (en) 2008-12-23 2011-08-11 Matrix Genetics, Llc Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products
CA3055144C (en) 2008-12-23 2022-07-19 REG Life Sciences, LLC Methods and compositions related to thioesterase enzymes
BRPI1015313B1 (pt) 2009-04-27 2021-06-01 Genomatica, Inc. Método fermentativo para produzir um éster de ácido graxo empregando um microorganismo geneticamente modificado e método para a produção de ésteres de ácidos graxos
US20120115195A1 (en) * 2009-05-01 2012-05-10 The Regents Of The University Of California Product of fatty acid esters from biomass polymers
BRPI1010920B1 (pt) * 2009-05-22 2020-04-28 Codexis Inc processo para a produção biológica de álcoois graxos
CA3056664A1 (en) 2009-09-25 2011-03-31 Alfred Gaertner Production of fatty acid derivatives in recombinant bacterial cells expressing an ester synthase variant
MX2012003604A (es) 2009-09-27 2012-09-12 Opx Biotechnologies Inc Metodo para producir acido 3-hidroxipropionico y otros productos.
US8530221B2 (en) 2010-01-14 2013-09-10 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
WO2011100667A1 (en) 2010-02-14 2011-08-18 Ls9, Inc. Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols
WO2011127069A1 (en) 2010-04-06 2011-10-13 Targeted Growth, Inc. Modified photosynthetic microorganisms for producing lipids
US20110250663A1 (en) 2010-04-08 2011-10-13 Ls9, Inc. Methods and compositions related to fatty alcohol biosynthetic enzymes
US8592188B2 (en) 2010-05-28 2013-11-26 Solazyme, Inc. Tailored oils produced from recombinant heterotrophic microorganisms
WO2012009523A2 (en) 2010-07-15 2012-01-19 The Procter & Gamble Company A personal care composition comprising a near-terminal branched compound
BR112013003003A2 (pt) 2010-08-06 2016-06-14 Mascoma Corp produção de produtos malonil-coa derivados através de rotas anaeróbicas
US8372610B2 (en) 2010-09-15 2013-02-12 Ls9, Inc. Production of odd chain fatty acid derivatives in recombinant microbial cells
US20120108692A1 (en) 2010-10-27 2012-05-03 John Collins Dyer Preparation of foam materials derived from renewable resources
EP2635663B1 (en) 2010-11-03 2019-05-08 Corbion Biotech, Inc. Microbial oils with lowered pour points, dielectric fluids produced therefrom, and related methods
WO2012096686A1 (en) 2011-01-14 2012-07-19 Ls9, Inc. Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells
KR101964965B1 (ko) 2011-02-02 2019-04-03 테라비아 홀딩스 인코포레이티드 재조합 유지성 미생물로부터 생산된 맞춤 오일
CN103380107B (zh) 2011-02-17 2015-06-10 宝洁公司 生物基直链烷基苯基磺酸盐
WO2012138423A1 (en) 2011-02-17 2012-10-11 The Procter & Gamble Company Compositions comprising mixtures of c10-c13 alkylphenyl sulfonates
US9206443B2 (en) 2011-03-14 2015-12-08 Easel Biotechnologies, Llc Microbial synthesis of aldehydes and corresponding alcohols
WO2012154329A1 (en) 2011-04-01 2012-11-15 Ls9, Inc. Methods and compositions for improved production of fatty acids and derivatives thereof
MX339607B (es) 2011-05-06 2016-05-31 Solazyme Inc Microorganismos geneticamente modificados que metabolizan xilosa.
WO2012177943A1 (en) * 2011-06-22 2012-12-27 Genomatica, Inc. Microorganisms for producing 1,4-butanediol and methods related thereto
DE102011110946A1 (de) 2011-08-15 2016-01-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen
DE102011110945A1 (de) 2011-08-15 2013-02-21 Evonik Degussa Gmbh Biotechnologisches Syntheseverfahren von organischen Verbindungen mit alkIL-Genprodukt
WO2013028792A2 (en) * 2011-08-22 2013-02-28 Joule Unlimited Technologies, Inc. Improved compositions and methods for the biosynthesis of 1-alkenes in engineered microorganisms
BR112014007115A2 (pt) 2011-09-27 2017-04-25 Exxonmobil Res & Eng Co éster sintases de cera acil-acp
CA2854450C (en) 2011-11-03 2020-04-21 Easel Biotechnologies, Llc Microbial production of n-butyraldehyde
ES2795842T3 (es) 2012-02-24 2020-11-24 Exxonmobil Res & Eng Co Producción mejorada de ácidos grasos y derivados de ácidos grasos por microorganismos recombinantes
US9096834B2 (en) 2012-02-24 2015-08-04 Exxonmobil Research And Engineering Company Recombinant microorganisms comprising thioesterase and lysophosphatidic acid acyltransferase genes for fatty acid production
US8962299B2 (en) 2012-02-29 2015-02-24 Exxonmobil Research And Engineering Company Four-gene pathway for wax ester synthesis
EP2834352B1 (en) 2012-04-02 2020-01-08 Genomatica, Inc. Improved production of fatty acid derivatives
BR122019026987B1 (pt) 2012-04-02 2022-01-18 Genomatica, Inc Polipeptídeo variante da ácido carboxílico redutase (car), célula hospedeira recombinante, cultura de células e método de produzir uma composição de álcool graxo com alto título, rendimento ou produtividade
US9163267B2 (en) 2012-04-11 2015-10-20 REG Life Sciences, LLC Metathesis transformations of microbially-produced fatty acids and fatty acid derivatives
MX391947B (es) 2012-04-13 2025-03-21 Genomatica Inc Produccion microbiana de alcanolamidas y amidoaminas y usos de las mismas.
US8945908B2 (en) 2012-04-18 2015-02-03 Solazyme, Inc. Tailored oils
US9719114B2 (en) 2012-04-18 2017-08-01 Terravia Holdings, Inc. Tailored oils
US9181568B2 (en) 2012-04-23 2015-11-10 Exxonmobil Research And Engineering Company Cell systems and methods for improving fatty acid synthesis by expression of dehydrogenases
DE102012207921A1 (de) 2012-05-11 2013-11-14 Evonik Industries Ag Mehrstufiges Syntheseverfahren mit Synthesegas
MX2015001780A (es) 2012-08-10 2015-09-28 Opx Biotechnologies Inc Microorganismos y métodos para la producción de ácidos grasos y productos derivados de ácidos grasos.
ES2647412T3 (es) 2012-09-14 2017-12-21 REG Life Sciences, LLC Variantes enzimáticas con propiedades de éster sintasa mejoradas
EP2931742A2 (en) 2012-12-12 2015-10-21 REG Life Sciences, LLC Acp-mediated production of fatty acid derivatives
EP2746400A1 (de) * 2012-12-21 2014-06-25 Evonik Industries AG Herstellung von Aminen und Diaminen aus einer Carbonsäure oder Dicarbonsäure oder eines Monoesters davon
JP6063585B2 (ja) 2013-01-16 2017-01-18 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 改良された特性を有するアシル−acpレダクターゼ
US9567615B2 (en) 2013-01-29 2017-02-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US9816079B2 (en) 2013-01-29 2017-11-14 Terravia Holdings, Inc. Variant thioesterases and methods of use
US20150119601A1 (en) 2013-03-15 2015-04-30 Opx Biotechnologies, Inc. Monofunctional mcr + 3-hp dehydrogenase
US9783836B2 (en) 2013-03-15 2017-10-10 Terravia Holdings, Inc. Thioesterases and cells for production of tailored oils
US9290749B2 (en) 2013-03-15 2016-03-22 Solazyme, Inc. Thioesterases and cells for production of tailored oils
SI2984490T1 (sl) 2013-06-14 2020-10-30 Genomatica, Inc. Metode proizvodnje derivatov omega hidroksilirane maščobne kisline
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP3022310B1 (en) 2013-07-19 2019-10-16 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US9469586B2 (en) 2013-08-19 2016-10-18 REG Life Sciences, LLC Production of partially refined waste glycerol
KR20190017074A (ko) 2013-08-19 2019-02-19 알이지 라이프 사이언시스, 엘엘씨 부분 정제된 폐글리세롤의 생성
AU2014318531B2 (en) 2013-09-13 2020-10-08 Genomatica, Inc. Improved acetyl-CoA carboxylase variants
MX369685B (es) 2013-10-04 2019-11-19 Terravia Holdings Inc Aceites adaptables.
EP2886651B1 (en) * 2013-10-21 2018-08-22 Ajinomoto Co., Inc. Method for producing l-amino acid
EP3081643B1 (en) * 2013-12-04 2019-05-29 Kabushiki Kaisha Yakult Honsha Method for regulating acid resistance of microbes
WO2015085271A1 (en) 2013-12-05 2015-06-11 REG Life Sciences, LLC Microbial production of fatty amines
EP3129492B1 (en) 2014-04-10 2020-06-03 Genomatica, Inc. Chemo-enzymatic process for the preparation of lactones and macrocyclic ketones
CN106604990B (zh) 2014-06-16 2022-04-05 基因组股份公司 具有改进的特性的ω-羟化酶相关的融合多肽
US9969990B2 (en) 2014-07-10 2018-05-15 Corbion Biotech, Inc. Ketoacyl ACP synthase genes and uses thereof
EP4089176A1 (en) 2014-07-18 2022-11-16 Genomatica, Inc. Microbial production of 1,3 diols
US9765368B2 (en) 2014-07-24 2017-09-19 Terravia Holdings, Inc. Variant thioesterases and methods of use
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
US10125382B2 (en) 2014-09-18 2018-11-13 Corbion Biotech, Inc. Acyl-ACP thioesterases and mutants thereof
CA2897454C (en) 2015-07-03 2023-03-14 Governing Council Of The University Of Toronto Microorganisms and methods for biosynthesis of adipic acid
WO2017101987A1 (en) 2015-12-15 2017-06-22 REG Life Sciences, LLC Omega-hydroxylase-related fusion polypeptide variants with improved properties
WO2018022440A2 (en) * 2016-07-25 2018-02-01 Invista North America S.A.R.L. Materials and methods for directing carbon flux and increased production of carbon based chemicals
EP3512825B1 (en) 2016-09-14 2020-10-21 Genomatica, Inc. 1,3-fatty diol compounds and derivatives thereof
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
CN106947727B (zh) * 2017-02-20 2019-08-16 波顿(上海)生物技术有限公司 一种基因工程菌及其构建方法与生产香兰素的方法
CN108624628B (zh) * 2017-03-22 2022-09-13 中国科学院天津工业生物技术研究所 催化甲酸合成甲醛car酶的制备及其应用
MY205555A (en) 2017-04-03 2024-10-25 Genomatica Inc Thioesterase variants having improved activity for the production of medium-chain fatty acid derivatives
WO2019209187A1 (en) * 2018-04-25 2019-10-31 Vidyasirimedhi Institute Of Science And Technology A luciferase reporter system and an assay for gene expression profiling using the same
EP3794017A4 (en) 2018-05-17 2022-03-09 Lumen Bioscience, Inc. ARTHROSPIRA PLATENSIS ORAL VACCINE DELIVERY PLATFORM
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US12252513B2 (en) 2018-07-16 2025-03-18 Lumen Bioscience, Inc. Thermostable phycobiliproteins produced from recombinant arthrospira
EP3844179A4 (en) 2018-08-31 2022-08-31 Genomatica, Inc. XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE
US10808265B2 (en) 2018-09-26 2020-10-20 Nantbio, Inc. Microbes and methods for improved conversion of a feedstock
CA3143735A1 (en) 2019-07-03 2021-01-07 Lumen Bioscience, Inc. Arthrospira platensis non-parenteral therapeutic delivery platform
WO2026011089A1 (en) * 2024-07-03 2026-01-08 Genomatica, Inc. Carboxylic acid reductase and alcohol dehydrogenase variants and methods of use
CN120924506B (zh) * 2025-08-19 2026-04-03 深圳瑞德林生物技术有限公司 酶突变体的组合物及其在制备二(月桂酰胺谷氨酰胺)赖氨酸盐中的应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482846A (en) 1988-08-31 1996-01-09 University Of Florida Ethanol production in Gram-positive microbes
US5424202A (en) 1988-08-31 1995-06-13 The University Of Florida Ethanol production by recombinant hosts
US5028539A (en) * 1988-08-31 1991-07-02 The University Of Florida Ethanol production using engineered mutant E. coli
US5000000A (en) 1988-08-31 1991-03-19 University Of Florida Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes
US7053267B2 (en) * 1990-03-16 2006-05-30 Calgene Llc Plant seed oils
WO1991016427A1 (en) 1990-04-24 1991-10-31 Stratagene Methods for phenotype creation from multiple gene populations
US5807893A (en) * 1993-11-18 1998-09-15 Voelker; Toni Alois Plant thioesterases and use for modification of fatty acid composition in plant seed oils
US5602030A (en) * 1994-03-28 1997-02-11 University Of Florida Research Foundation Recombinant glucose uptake system
US6428767B1 (en) 1995-05-12 2002-08-06 E. I. Du Pont De Nemours And Company Method for identifying the source of carbon in 1,3-propanediol
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US20080172931A1 (en) * 1996-11-18 2008-07-24 Bp Oil Internationa Limited Fuel composition
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
JP3571354B2 (ja) 1999-01-18 2004-09-29 三菱電機株式会社 圧接型半導体装置
US20040121322A9 (en) * 2001-02-22 2004-06-24 Cole Stewart T. Comparative mycobacterial genomics as a tool for identifying targets for the diagnosis, prophylaxis or treatment of mycobacterioses
US7314974B2 (en) * 2002-02-21 2008-01-01 Monsanto Technology, Llc Expression of microbial proteins in plants for production of plants with improved properties
US7118896B2 (en) * 2002-03-01 2006-10-10 Monsanto Technology, L.L.C. Methods and compositions for modification of lipid biosynthesis
US7160708B2 (en) * 2002-04-19 2007-01-09 Cognis Corporation Fatty alcohol oxidase genes and proteins from Candida tropicalis and methods relating thereto
US7273966B2 (en) * 2002-12-19 2007-09-25 Monsanto Technology Llc Elevation of fatty acid synthase levels in plants
US7056714B2 (en) * 2003-03-11 2006-06-06 University Of Iowa Research Foundation, Inc. Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use
US7608700B2 (en) * 2004-03-08 2009-10-27 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
CN1283357C (zh) * 2004-09-08 2006-11-08 厦门大学 用于制备芳香醛或脂肪醛的催化剂及其制备方法
US7960519B2 (en) * 2005-05-31 2011-06-14 Pierce Biotechnology, Inc. Extraction of cellular components with fatty acid derivatives
FR2888034B1 (fr) 2005-06-29 2010-10-08 Philippe Magnier Dispositif de prevention contre l'explosion d'un transformateur electrique
CA2650773C (en) 2006-05-19 2014-12-02 Jay D. Keasling Microorganisms transformed with acetyl-coa carboxylase and wax synthase for production of fatty acid derivatives
US8110670B2 (en) * 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20100242345A1 (en) * 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
WO2007142784A1 (en) * 2006-05-31 2007-12-13 Archer-Daniels-Midland Company Enzymatic method of making aldehydes from fatty acids
DE102006054324A1 (de) 2006-11-17 2008-05-21 Robert Bosch Gmbh Verfahren zur bildbasierten Vermessung
CN101680009B (zh) * 2007-03-28 2017-02-22 Reg生命科学有限责任公司 提高脂肪酸衍生物的产量
CN101802208B (zh) 2007-09-27 2016-05-18 Reg生命科学有限责任公司 通过提取式发酵减少原料中杂质的毒性作用
EP2285948B1 (en) 2008-03-03 2014-01-08 Joule Unlimited Technologies, Inc. Engineered co2 fixing microorganisms producing carbon-based products of interest
DK2262901T3 (en) 2008-03-05 2019-01-21 Genomatica Inc ORGANISMS PRODUCING PRIMARY ALCOHOL
CA3101888A1 (en) 2008-05-16 2009-11-19 REG Life Sciences, LLC Methods and compositions for producing hydrocarbons
KR101717569B1 (ko) 2008-10-07 2017-03-17 알이지 라이프 사이언시스, 엘엘씨 지방족 알데히드를 생산하기 위한 방법과 조성물들
KR101636403B1 (ko) * 2008-10-28 2016-07-05 알이지 라이프 사이언시스, 엘엘씨 지방족 알코올들을 생산하기 위한 방법들과 조성물들
CA3055144C (en) 2008-12-23 2022-07-19 REG Life Sciences, LLC Methods and compositions related to thioesterase enzymes
WO2011062987A2 (en) 2009-11-17 2011-05-26 Ls9, Inc. Methods and compositions for producing hydrocarbons

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