BRPI0921081A2 - síntese de peptídeos usando a ativação e o acoplamento enzimático. - Google Patents

síntese de peptídeos usando a ativação e o acoplamento enzimático.

Info

Publication number
BRPI0921081A2
BRPI0921081A2 BRPI0921081A BRPI0921081A BRPI0921081A2 BR PI0921081 A2 BRPI0921081 A2 BR PI0921081A2 BR PI0921081 A BRPI0921081 A BR PI0921081A BR PI0921081 A BRPI0921081 A BR PI0921081A BR PI0921081 A2 BRPI0921081 A2 BR PI0921081A2
Authority
BR
Brazil
Prior art keywords
activation
peptide synthesis
enzymatic coupling
enzymatic
coupling
Prior art date
Application number
BRPI0921081A
Other languages
English (en)
Inventor
Catharina Hubertina Maria Schepers
Claudia Cusan
Peter Jan Leonard Mario Quaedflieg
Timo Nuijens
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Publication of BRPI0921081A2 publication Critical patent/BRPI0921081A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
BRPI0921081A 2008-11-19 2009-11-19 síntese de peptídeos usando a ativação e o acoplamento enzimático. BRPI0921081A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08169425 2008-11-19
PCT/EP2009/065512 WO2010057961A1 (en) 2008-11-19 2009-11-19 Peptide synthesis using enzymatic activation and coupling

Publications (1)

Publication Number Publication Date
BRPI0921081A2 true BRPI0921081A2 (pt) 2015-12-15

Family

ID=40848060

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0921081A BRPI0921081A2 (pt) 2008-11-19 2009-11-19 síntese de peptídeos usando a ativação e o acoplamento enzimático.

Country Status (9)

Country Link
US (1) US8883444B2 (pt)
EP (1) EP2365982A1 (pt)
JP (1) JP2012509089A (pt)
KR (1) KR20110088519A (pt)
CN (1) CN102216324B (pt)
BR (1) BRPI0921081A2 (pt)
CA (1) CA2744243A1 (pt)
EA (1) EA019536B1 (pt)
WO (1) WO2010057961A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2634193T3 (en) * 2012-02-29 2015-03-02 Enzypep B V Condensation of the side-chain protected oligopeptidfragmenter using subtilisins in organic solvents
WO2013135786A1 (en) * 2012-03-14 2013-09-19 Dsm Fine Chemicals Austria Nfg. Gmbh & Co Kg Enzymatic peptide synthesis
US10138268B2 (en) * 2014-10-10 2018-11-27 Enzypep B.V. Peptide fragment condensation and cyclisation using a subtilisin variant with improved synthesis over hydrolysis ratio
EP3299085A1 (en) 2016-09-26 2018-03-28 Enzypep B.V. Peptide coupling molecule
WO2021026492A1 (en) 2019-08-07 2021-02-11 Humanwell Pharmaceutical US Kappa opioid receptor peptide amide agonists
EP4175944A4 (en) 2020-06-25 2024-03-06 Humanwell Pharmaceutical US PEPTIDES FOR THE TREATMENT OF MEDICAL DISORDERS
BR112023018676A2 (pt) 2021-03-18 2023-10-10 Seagen Inc Conjugado anticorpo-fármaco, composição farmacêutica, métodos de tratamento de uma doença ou condição e de um câncer, e, composição de conjugado ligante-fármaco
US20260015313A1 (en) 2022-06-03 2026-01-15 Peptidream Inc. Amino acid active ester and salt thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5272885A (en) * 1975-10-23 1977-06-17 Sagami Chem Res Center Preparation of peptide
JPH06237784A (ja) * 1993-02-18 1994-08-30 Daiwa Kasei Kk オリゴペプチドの合成法
NL1005901C2 (nl) * 1997-04-25 1998-10-27 Dsm Nv Werkwijze voor de verestering van aminozuren en peptiden.
EP1937826B1 (en) * 2005-10-20 2009-04-15 DSMIP Assets B.V. Enzymatic conversion of oligopeptide amides to oligopeptide alkyl esters
WO2009047311A1 (en) * 2007-10-12 2009-04-16 Dsm Ip Assets B.V. Chemo-enzymatic peptide synthesis via c-terminal ester interconversion
WO2009047354A1 (en) * 2007-10-12 2009-04-16 Dsm Ip Assets B.V. Chemo-enzymatic synthesis of a c-terminal thioester of an amino acid or a peptide

Also Published As

Publication number Publication date
KR20110088519A (ko) 2011-08-03
WO2010057961A1 (en) 2010-05-27
EA019536B1 (ru) 2014-04-30
EA201100802A1 (ru) 2011-12-30
CA2744243A1 (en) 2010-05-27
CN102216324A (zh) 2011-10-12
US20120129214A1 (en) 2012-05-24
EP2365982A1 (en) 2011-09-21
JP2012509089A (ja) 2012-04-19
US8883444B2 (en) 2014-11-11
CN102216324B (zh) 2014-02-12

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A.ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2355 DE 23-02-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.