BRPI0921665A2 - humanizado anti-il-6 anticorpos - Google Patents
humanizado anti-il-6 anticorposInfo
- Publication number
- BRPI0921665A2 BRPI0921665A2 BRPI0921665-0A BRPI0921665A BRPI0921665A2 BR PI0921665 A2 BRPI0921665 A2 BR PI0921665A2 BR PI0921665 A BRPI0921665 A BR PI0921665A BR PI0921665 A2 BRPI0921665 A2 BR PI0921665A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- humanized anti
- methods
- humanized
- cdranti
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- Engineering & Computer Science (AREA)
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- Diabetes (AREA)
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- Hematology (AREA)
- Neurology (AREA)
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- Neurosurgery (AREA)
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- Obesity (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11429508P | 2008-11-13 | 2008-11-13 | |
| US61/114.295 | 2008-11-13 | ||
| PCT/US2009/064321 WO2010056948A2 (en) | 2008-11-13 | 2009-11-13 | Humanized anti-il-6 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0921665A2 true BRPI0921665A2 (pt) | 2019-04-16 |
Family
ID=42170719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0921665-0A BRPI0921665A2 (pt) | 2008-11-13 | 2009-11-13 | humanizado anti-il-6 anticorpos |
Country Status (10)
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| US (2) | US8062866B2 (pt) |
| EP (1) | EP2349331A4 (pt) |
| JP (2) | JP5789192B2 (pt) |
| KR (1) | KR20110094307A (pt) |
| CN (1) | CN102245207B (pt) |
| AU (1) | AU2009313958B2 (pt) |
| BR (1) | BRPI0921665A2 (pt) |
| CA (1) | CA2742786A1 (pt) |
| RU (1) | RU2532826C2 (pt) |
| WO (1) | WO2010056948A2 (pt) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2164514T3 (en) | 2007-05-21 | 2017-02-27 | Alderbio Holdings Llc | Antibodies to IL-6 and its use |
| US7906117B2 (en) * | 2007-05-21 | 2011-03-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever |
| US8178101B2 (en) | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US9701747B2 (en) | 2007-05-21 | 2017-07-11 | Alderbio Holdings Llc | Method of improving patient survivability and quality of life by anti-IL-6 antibody administration |
| US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
| US8252286B2 (en) | 2007-05-21 | 2012-08-28 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8404235B2 (en) | 2007-05-21 | 2013-03-26 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8992920B2 (en) | 2008-11-25 | 2015-03-31 | Alderbio Holdings Llc | Anti-IL-6 antibodies for the treatment of arthritis |
| US9212223B2 (en) | 2008-11-25 | 2015-12-15 | Alderbio Holdings Llc | Antagonists of IL-6 to prevent or treat thrombosis |
| US8323649B2 (en) | 2008-11-25 | 2012-12-04 | Alderbio Holdings Llc | Antibodies to IL-6 and use thereof |
| US8420089B2 (en) | 2008-11-25 | 2013-04-16 | Alderbio Holdings Llc | Antagonists of IL-6 to raise albumin and/or lower CRP |
| US8337847B2 (en) | 2008-11-25 | 2012-12-25 | Alderbio Holdings Llc | Methods of treating anemia using anti-IL-6 antibodies |
| US9452227B2 (en) * | 2008-11-25 | 2016-09-27 | Alderbio Holdings Llc | Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments |
| CN102740888B (zh) | 2009-11-24 | 2016-10-12 | 奥尔德生物制药公司 | Il-6抗体及其用途 |
| US9775921B2 (en) | 2009-11-24 | 2017-10-03 | Alderbio Holdings Llc | Subcutaneously administrable composition containing anti-IL-6 antibody |
| KR101712874B1 (ko) * | 2010-09-30 | 2017-03-07 | 쳉두 캉홍 바이오테크놀로지스 코. 리미티드 | 인간화 항 TNF α 항체 및 그의 항원 결합 단편 (Fab) 및 용도 |
| CA2818813C (en) | 2010-11-23 | 2020-10-06 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of oral mucositis |
| CN103620032B (zh) * | 2010-12-31 | 2016-02-24 | 生物蛋白有限公司 | 抗体的快速人源化 |
| FR2978964B1 (fr) | 2011-08-09 | 2015-02-20 | Conservatoire Nat Arts | Composition vaccinale anti-il-6 |
| WO2013059548A1 (en) | 2011-10-19 | 2013-04-25 | Sanofi | Compositions and methods for treating cancer using jak2 inhibitor |
| CA2850572A1 (en) * | 2011-10-20 | 2013-04-25 | Esbatech, A Novartis Company Llc | Stable multiple antigen-binding antibody |
| WO2013175276A1 (en) * | 2012-05-23 | 2013-11-28 | Argen-X B.V | Il-6 binding molecules |
| WO2014013334A2 (en) * | 2012-07-20 | 2014-01-23 | Agency For Science, Technology And Research | In vitro assay for predicting renal proximal tubular cell toxicity |
| EP2896291B1 (en) * | 2012-09-13 | 2019-03-20 | Chugai Seiyaku Kabushiki Kaisha | Gene knock-in non-human animal |
| RU2656162C2 (ru) | 2012-10-22 | 2018-05-31 | Фоунтейн Биофарма Инк. | Антитела к интерлейкину 6 и их применение |
| WO2015054293A1 (en) * | 2013-10-07 | 2015-04-16 | Alder Biopharmaceuticals, Inc. | Anti-il-6 antibodies for the treatment of psoriatic arthritis |
| CN103739673B (zh) * | 2013-12-31 | 2015-08-19 | 浙江元太生物科技有限公司 | 一种聚乙二醇修饰的抑制白介素-6多肽及其应用 |
| CN105037548B (zh) * | 2014-04-21 | 2018-08-03 | 上海市免疫学研究所 | 抗人白介素-6受体β链单克隆抗体、其制备方法和用途 |
| TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| KR20210013299A (ko) | 2014-10-17 | 2021-02-03 | 코디악 사이언시스 인코포레이티드 | 부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트 |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| CN109867723B (zh) * | 2017-12-05 | 2022-06-17 | 南京金斯瑞生物科技有限公司 | 抗人il6单克隆抗体及其制备方法和用途 |
| EP3730150A4 (en) * | 2017-12-22 | 2021-10-06 | Rophibio, Inc. | ANTI-STAT3 BISPECIFIC ANTIBODY WITH CELL-PENETRATING ABILITY AND THIS PHARMACEUTICAL COMPOSITION |
| EP3758737A4 (en) * | 2018-03-02 | 2022-10-12 | Kodiak Sciences Inc. | IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF |
| US20240124889A1 (en) | 2019-05-07 | 2024-04-18 | Voyager Therapeutics, Inc. | Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation |
| CN114375205A (zh) | 2019-06-20 | 2022-04-19 | 武田药品工业株式会社 | 用基于病毒的基因疗法进行治疗的方法 |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN111304246B (zh) * | 2019-12-17 | 2021-05-04 | 百奥赛图江苏基因生物技术有限公司 | 一种人源化细胞因子动物模型、制备方法及应用 |
| WO2025226628A1 (en) * | 2024-04-22 | 2025-10-30 | Recordati Rare Diseases Inc. | Use of il-6 inhibitors for preventing or inhibiting lung transplantation rejection in a subject |
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| IL88375A (en) | 1988-11-14 | 1995-07-31 | Yeda Res & Dev | Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US20040049014A1 (en) * | 1988-12-28 | 2004-03-11 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| AU6808194A (en) * | 1993-05-31 | 1994-12-20 | Chugai Seiyaku Kabushiki Kaisha | Reconstructed human antibody against human interleukin-6 |
| CN1162922A (zh) * | 1994-10-07 | 1997-10-22 | 中外制药株式会社 | 以il-6拮抗剂作为有效成分治疗慢性类风湿性关节炎 |
| EP0800829B2 (en) * | 1994-12-29 | 2012-07-25 | Chugai Seiyaku Kabushiki Kaisha | Use of a pm-1 antibody or of a mh 166 antibody for enhancing the anti-tumor effect of cisplatin or carboplatin |
| DE60236735D1 (de) * | 2001-04-13 | 2010-07-29 | Biogen Idec Inc | Antikörper gegen vla-1 |
| PT2308888T (pt) * | 2001-11-14 | 2017-05-03 | Janssen Biotech Inc | Anticorpos anti-il-6, composições, métodos e utilizações |
| US7482436B2 (en) * | 2002-08-30 | 2009-01-27 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Human antihuman interleukin-6 antibody and fragment of antibody |
| JO3058B1 (ar) * | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| SI1960430T1 (sl) * | 2005-12-09 | 2015-01-30 | Ucb Pharma, S.A. | Molekule protiteles s specifiäśnostjo za äśloveĺ ki il-6 |
| US20110059101A9 (en) * | 2006-03-13 | 2011-03-10 | Ablynx N.V. | Amino Acid Sequences Directed Against Il-6 And Polypetides Comprising The Same For The Treatment Of Diseases And Disorders Associated With Il-6 Mediated Signalling |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトil−6受容体に対する高親和性抗体 |
| CN101563365B (zh) * | 2006-08-03 | 2012-10-31 | 瓦西尼斯公司 | 抗-il-6单克隆抗体及其用途 |
| US8178101B2 (en) * | 2007-05-21 | 2012-05-15 | Alderbio Holdings Inc. | Use of anti-IL-6 antibodies having specific binding properties to treat cachexia |
| US8188235B2 (en) | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
-
2009
- 2009-11-13 AU AU2009313958A patent/AU2009313958B2/en not_active Expired - Fee Related
- 2009-11-13 CN CN200980150072.1A patent/CN102245207B/zh not_active Expired - Fee Related
- 2009-11-13 RU RU2011123870/10A patent/RU2532826C2/ru not_active IP Right Cessation
- 2009-11-13 KR KR1020117013558A patent/KR20110094307A/ko not_active Ceased
- 2009-11-13 EP EP09826807A patent/EP2349331A4/en not_active Withdrawn
- 2009-11-13 US US12/617,915 patent/US8062866B2/en not_active Expired - Fee Related
- 2009-11-13 BR BRPI0921665-0A patent/BRPI0921665A2/pt not_active IP Right Cessation
- 2009-11-13 WO PCT/US2009/064321 patent/WO2010056948A2/en not_active Ceased
- 2009-11-13 JP JP2011536496A patent/JP5789192B2/ja not_active Expired - Fee Related
- 2009-11-13 CA CA2742786A patent/CA2742786A1/en not_active Abandoned
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2011
- 2011-09-23 US US13/243,915 patent/US8173398B2/en not_active Expired - Fee Related
-
2015
- 2015-04-08 JP JP2015079320A patent/JP2015172048A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20100138945A1 (en) | 2010-06-03 |
| JP5789192B2 (ja) | 2015-10-07 |
| US20120006716A1 (en) | 2012-01-12 |
| RU2011123870A (ru) | 2012-12-20 |
| US8062866B2 (en) | 2011-11-22 |
| WO2010056948A2 (en) | 2010-05-20 |
| JP2015172048A (ja) | 2015-10-01 |
| KR20110094307A (ko) | 2011-08-23 |
| US8173398B2 (en) | 2012-05-08 |
| AU2009313958B2 (en) | 2015-09-10 |
| CN102245207A (zh) | 2011-11-16 |
| CN102245207B (zh) | 2015-11-25 |
| JP2012508762A (ja) | 2012-04-12 |
| CA2742786A1 (en) | 2010-05-20 |
| WO2010056948A3 (en) | 2010-07-22 |
| EP2349331A4 (en) | 2012-12-12 |
| RU2532826C2 (ru) | 2014-11-10 |
| EP2349331A2 (en) | 2011-08-03 |
| AU2009313958A1 (en) | 2010-05-20 |
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