BRPI0921868A2 - inibidores de fosfodiesterase tipo iii (pde iii) ou agentes de sensibilizacao de ca2+ para o tratamento de cardiomiopatia hipertrofica - Google Patents

inibidores de fosfodiesterase tipo iii (pde iii) ou agentes de sensibilizacao de ca2+ para o tratamento de cardiomiopatia hipertrofica

Info

Publication number: BRPI0921868A2
Authority: BR; Brazil
Prior art keywords: iii; inhibitors; treatment; hypertrophic cardiomyopathy; phosphodiesterase type
Prior art date: 2008-11-25

Application number

BRPI0921868A

Other languages

English (en)

Inventor

Juergen Daemmgen

Olaf Joens

Original Assignee

Boehringer Ingelheim Vetmed

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-25

Filing date

2009-11-23

Publication date

2015-12-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40491062&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0921868(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-11-23 Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed

2015-12-29 Publication of BRPI0921868A2 publication Critical patent/BRPI0921868A2/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI0921868A 2008-11-25 2009-11-23 inibidores de fosfodiesterase tipo iii (pde iii) ou agentes de sensibilizacao de ca2+ para o tratamento de cardiomiopatia hipertrofica BRPI0921868A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08169897		2008-11-25
PCT/EP2009/065618 WO2010060874A1 (en)	2008-11-25	2009-11-23	Phosphodiesterase type iii (pde iii) inhibitors or ca2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy

Publications (1)

Publication Number	Publication Date
BRPI0921868A2 true BRPI0921868A2 (pt)	2015-12-29

Family

ID=40491062

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0921868A BRPI0921868A2 (pt)	2008-11-25	2009-11-23	inibidores de fosfodiesterase tipo iii (pde iii) ou agentes de sensibilizacao de ca2+ para o tratamento de cardiomiopatia hipertrofica

Country Status (24)

Country	Link
US (1)	US8664252B2 (pt)
EP (3)	EP2702986A1 (pt)
JP (1)	JP5643213B2 (pt)
KR (1)	KR20110089851A (pt)
CN (1)	CN102223882B (pt)
AR (1)	AR074214A1 (pt)
AU (1)	AU2009319076A1 (pt)
BR (1)	BRPI0921868A2 (pt)
CA (1)	CA2744505A1 (pt)
CL (1)	CL2011001026A1 (pt)
CO (1)	CO6400188A2 (pt)
CY (1)	CY1114791T1 (pt)
DK (1)	DK2370070T3 (pt)
ES (1)	ES2436716T3 (pt)
HR (1)	HRP20131150T1 (pt)
MX (1)	MX2011005444A (pt)
NZ (1)	NZ592927A (pt)
PL (1)	PL2370070T3 (pt)
PT (1)	PT2370070E (pt)
SG (1)	SG171783A1 (pt)
SI (1)	SI2370070T1 (pt)
TW (1)	TW201026684A (pt)
WO (1)	WO2010060874A1 (pt)
ZA (1)	ZA201103108B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102004011512B4 (de)	2004-03-08	2022-01-13	Boehringer Ingelheim Vetmedica Gmbh	Pharmazeutische Zubereitung enthaltend Pimobendan
EP1579862A1 (en)	2004-03-25	2005-09-28	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
US8980894B2 (en)	2004-03-25	2015-03-17	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1920785A1 (en)	2006-11-07	2008-05-14	Boehringer Ingelheim Vetmedica Gmbh	Liquid preparation comprising a complex of pimobendan and cyclodextrin
ES2924478T3 (es)	2012-03-15	2022-10-07	Boehringer Ingelheim Vetmedica Gmbh	Formulación de comprimidos farmacéuticos para el sector médico veterinario, método de producción y uso de los mismos
PL3021832T3 (pl)	2013-07-19	2021-08-23	Boehringer Ingelheim Vetmedica Gmbh	Konserwowana ciekła wodna kompozycja farmaceutyczna zawierająca eteryfikowane pochodne cyklodekstryny
BR122019024673B1 (pt)	2013-12-04	2023-04-11	Boehringer Ingelheim Vetmedica Gmbh	Composições farmacêuticas aprimoradas de pimobendan
US10537570B2 (en)	2016-04-06	2020-01-21	Boehringer Ingelheim Vetmedica Gmbh	Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
WO2022073954A1 (en)	2020-10-08	2022-04-14	Boehringer Ingelheim Vetmedica Gmbh	Use of pimobendan in the anaesthesia of non-human mammals

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JP2004532838A (ja)	2001-03-02	2004-10-28	ブリストル−マイヤーズスクイブカンパニー	メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物
JP2004536614A (ja)	2001-08-01	2004-12-09	ユニバーシティオブユタ	Ｐｄｅ３環状ヌクレオチド・ホスホジエステラーゼのアイソフォーム選択的な阻害剤および活性化剤
DE10228049A1 (de)	2002-06-24	2004-01-15	Merck Patent Gmbh	Flüssige Zubereitung enthaltend Oligopeptide
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DE102004011512B4 (de)	2004-03-08	2022-01-13	Boehringer Ingelheim Vetmedica Gmbh	Pharmazeutische Zubereitung enthaltend Pimobendan
US8980894B2 (en)	2004-03-25	2015-03-17	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) *	2004-03-25	2005-09-28	Boehringer Ingelheim Vetmedica Gmbh	Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
JP2005281283A (ja)	2004-03-31	2005-10-13	Akira Matsumori	ベンズイミダゾール系薬剤の併用医薬
FI20040675A0 (fi) *	2004-05-12	2004-05-12	Orion Corp	Menetelmä sydämen hypertrofian hoitoon ja estoon
NZ534939A (en)	2004-08-26	2007-04-27	Bomac Research Ltd	Injectable formulation comprising an anthelmintic compound with complexing compound for improved solubility
EP1833480A2 (en) *	2004-11-30	2007-09-19	Artesian Therapeutics, Inc.	Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase
JP2008521806A (ja) *	2004-11-30	2008-06-26	アーテシアンセラピューティクス，インコーポレイテッド	心不全を治療するための混合型のＰＤＥ−阻害活性およびβ−アドレナリン作用性アンタゴニスト活性または部分アゴニスト活性を有する化合物
CN1702243A (zh)	2005-05-31	2005-11-30	刘坚雄	无壁板框架结构装配组合式房屋建筑及其建造方法
PL1951227T3 (pl)	2005-11-14	2017-09-29	Boehringer Ingelheim Vetmedica Gmbh	Zastosowania pimobendanu do leczenia bezobjawowej(utajonej) niewydolności serca
EP1920785A1 (en)	2006-11-07	2008-05-14	Boehringer Ingelheim Vetmedica Gmbh	Liquid preparation comprising a complex of pimobendan and cyclodextrin

2009
- 2009-11-23 US US13/126,541 patent/US8664252B2/en active Active
- 2009-11-23 SI SI200930760T patent/SI2370070T1/sl unknown
- 2009-11-23 CA CA2744505A patent/CA2744505A1/en not_active Abandoned
- 2009-11-23 HR HRP20131150AT patent/HRP20131150T1/hr unknown
- 2009-11-23 MX MX2011005444A patent/MX2011005444A/es active IP Right Grant
- 2009-11-23 DK DK09756311.8T patent/DK2370070T3/da active
- 2009-11-23 AU AU2009319076A patent/AU2009319076A1/en not_active Abandoned
- 2009-11-23 PL PL09756311T patent/PL2370070T3/pl unknown
- 2009-11-23 WO PCT/EP2009/065618 patent/WO2010060874A1/en not_active Ceased
- 2009-11-23 SG SG2011036803A patent/SG171783A1/en unknown
- 2009-11-23 BR BRPI0921868A patent/BRPI0921868A2/pt not_active IP Right Cessation
- 2009-11-23 EP EP13182285.0A patent/EP2702986A1/en not_active Withdrawn
- 2009-11-23 PT PT97563118T patent/PT2370070E/pt unknown
- 2009-11-23 KR KR1020117011533A patent/KR20110089851A/ko not_active Withdrawn
- 2009-11-23 EP EP13182286.8A patent/EP2702987A1/en not_active Withdrawn
- 2009-11-23 EP EP09756311.8A patent/EP2370070B9/en active Active
- 2009-11-23 JP JP2011536885A patent/JP5643213B2/ja not_active Expired - Fee Related
- 2009-11-23 NZ NZ592927A patent/NZ592927A/xx not_active IP Right Cessation
- 2009-11-23 CN CN200980146944.7A patent/CN102223882B/zh not_active Expired - Fee Related
- 2009-11-23 ES ES09756311.8T patent/ES2436716T3/es active Active
- 2009-11-24 AR ARP090104533A patent/AR074214A1/es unknown
- 2009-11-24 TW TW098139973A patent/TW201026684A/zh unknown
2011
- 2011-04-28 ZA ZA2011/03108A patent/ZA201103108B/en unknown
- 2011-05-06 CL CL2011001026A patent/CL2011001026A1/es unknown
- 2011-05-24 CO CO11063885A patent/CO6400188A2/es not_active Application Discontinuation
2013
- 2013-11-18 CY CY20131101017T patent/CY1114791T1/el unknown

Also Published As

Publication number	Publication date
JP2012509858A (ja)	2012-04-26
EP2370070B9 (en)	2014-04-23
SG171783A1 (en)	2011-07-28
HRP20131150T1 (hr)	2014-01-03
NZ592927A (en)	2013-07-26
EP2702986A1 (en)	2014-03-05
KR20110089851A (ko)	2011-08-09
ZA201103108B (en)	2014-03-26
CY1114791T1 (el)	2016-12-14
AU2009319076A1 (en)	2010-06-03
CA2744505A1 (en)	2010-06-03
PT2370070E (pt)	2013-11-18
SI2370070T1 (sl)	2013-12-31
US8664252B2 (en)	2014-03-04
CN102223882B (zh)	2016-02-03
EP2702987A1 (en)	2014-03-05
CO6400188A2 (es)	2012-03-15
AR074214A1 (es)	2010-12-29
JP5643213B2 (ja)	2014-12-17
EP2370070A1 (en)	2011-10-05
MX2011005444A (es)	2011-06-09
PL2370070T3 (pl)	2014-02-28
CL2011001026A1 (es)	2011-09-02
DK2370070T3 (da)	2013-12-02
TW201026684A (en)	2010-07-16
ES2436716T3 (es)	2014-01-03
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